Browse > Article
http://dx.doi.org/10.14406/acu.2013.30.2.135

EEG Changes due to Low-Frequency Electrical Stimulation to the BL62 and KI6 of Elderly Women  

Lee, Sanghun (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine)
Choi, Kwang-Ho (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine)
Cho, Seong Jin (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine)
Choi, Sun-Mi (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine)
Hong, Kwon Eui (Department of Acupuncture and Moxibustion, Daejeon University)
Ryu, Yeon-Hee (Acupuncture, Moxibustion & Meridian Research Group, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Acupuncture / v.30, no.2, 2013 , pp. 135-142 More about this Journal
Abstract
Objectives : This study aimed to investigate the general effects of low-frequency electrical stimulation of the ankle joint acupuncture points(BL62 and KI6) on the brain waves of elderly women as a pilot study to figure out the possibility of candidate non-invasive and non-chemical stimulation method for the enhancing the brain function. Methods : A randomized, controlled, double-blinded clinical trial was performed in 31 healthy women(mean age, 54.5 years) within a treatment duration of 12 sessions. In the experimental group, low-frequency electrical stimulation was applied using the maximum range of the individual insensible strength(mean current, $0.04{\mu}A$). The control group received sham stimulation. The background electroencephalographic activity was measured before and after the12 sessions. Results : After 12 sessions of stimulation, the relative power of the alpha wave increased(32 of 32 channels: significant difference in 11 channels, p<0.05); the theta(30 of 32 channels: significant difference in 10 channels, p<0.05), beta(31 of 32 channels), and gamma(30 of 32 channels: significant difference in 7 channels, p<0.05) powers were also decreased compared with the sham group. Conclusions : Electrical stimulation on the ankle joint acupuncture points(BL62 and KI6) seemed to stabilize the elderly women brain by inducing the alpha power and reducing beta, theta, and gamma powers. These results provide insight into the action mechanism of the stimulation and can assist the future developement of a non-invasive and non-chemical treatment technique for stressor related cognitive problems.
Keywords
randomized controlled trial; brainwaves; electrical stimulation; background EEG; BL62; KI6;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Garrido P. Aging and stress: past hypotheses, present approaches and perspectives. Aging Dis 2011 ; 2 : 80-99.
2 Wilson RS, Begeny CT, Boyle PA, Schneider JA, Bennett DA. Vulnerability to stress, anxiety, and development of dementia in old age. Am J Geriatr Psychiatry. 2011 ; 19 : 327-34.   DOI   ScienceOn
3 Crowley K. Sleep and sleep disorders in older adults. Neuropsychol Rev. 2011 ; 21 : 41-53.   DOI
4 Altena E, Ramautar JR, Van Der Werf YD, Van Someren EJ W. Do sleep complaints contribute to age-related cognitive decline? Prog Brain Res. 2010 ; 185 : 181-205.   DOI   ScienceOn
5 Pace-Schott EF, Spencer RMC. Age-related changes in the cognitive function of sleep. Prog Brain Res. 2011 ; 191 : 75-89.   DOI
6 Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch. 2003 ; 70 : 334-41.   DOI   ScienceOn
7 Yoon JH, Hwang MS, Bae GT, Lee SH, Lee SD, Jang JH, et al. The new finding on BOLD response of motor acupoint KI6 by fMRI. The Journal of Korean Acupuncture & Moxibustion Society. 2001 ; 18 : 60-9.
8 Lee TY, Lee KG, Jang YS, Yuk SW, Lee CH, Lee SR. The effect of electroacupuncture at the BL60(Kollyun) on the EEG. The Korean Journal of Meridian & Acupoint. 2003 ; 20 : 31-46.
9 Woo YM, Lee MS, Nam Y, Cho HJ, Shin BC. Effects of Contralateral Electroacupuncture on Brain Function: A double-blind, randomized, pilot clinical trial. J Altern Complement Med. 2006 ; 2 : 813-5.
10 Bussell J. The effect of acupuncture on working memory and anxiety, J Acupunct Meridian Stud 2013; http://dx.doi.org/10.1016/j.jams. 2012.12.006
11 Korea Society of Acupuncture and Moxibustion. Acupuncture Medicine.1st ed. Jipmun-dang. 2012 : 523-43.
12 World Health Organization, Ed. WHO standard acupuncture point locations in the western pacific region. 1st ed. World Health Organization. 2008 : 130, 138.
13 Han JS, Chen XH, Sun SL, Xu XJ, Yuan Y, Yan SC, et al. Effect of low-and high-frequency TENS on met-enkephalin-arg-phe and dynorphin Aimmunore activity in human lumbar CSF. Pain 1991 ; 47 : 295-8.   DOI   ScienceOn
14 Patterson MA. Effects of neuro-electric therapy(N.E.T.) in drug addiction: interim report. Bull Narc. 1976 ; 28 : 55-62.
15 Patterson MA. Electrotherapy: addictions and neuroelectric therapy. Nurs Times. 1979 ; 75 : 2080-3.
16 Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature 2010 ; 464 : 529-35.   DOI   ScienceOn
17 Cabeza R, Nyberg L, Park D, Eds. Cognitive neuroscience of aging: linking cognitive and cerebral aging. 1st ed. USA : Oxford University Press. 2009 : 2-5.
18 Jamie DF, Sarah M, Teena DM, Cara B, Emily H, Susan YB, et al. Effects of cranial electrotherapy stimulation on resting state brain activity. Brain Behav. 2012 ; 2 : 211-20.   DOI   ScienceOn
19 Hanslmayr S, Sauseng P, Doppelmayr M, Schabus M, Klimesch W. Increasing individual upper alpha power by neurofeedback improves cognitive performance in human subjects. Appl. Psychophysiol Biofeedback. 2005 ; 30 : 1-10.   DOI
20 Marius G, Daniel G, Maria I, Anda G. Effects of monotonous auditory stimulation on the human EEG. Neuroscience & Medicine 2012 ; 3 : 337-43.   DOI
21 Jang HS, Kim JY, Kim KS, Pak CH. Human brain activity and emotional responses to plant Color Res. Appl. doi: 10.1002/col.21788.
22 Teplan M, Krakovska A, Stolc S. Direct effects of audio-visual stimulation on EEG. Comput Methods Programs Biomed 2011 ; 102 : 17-24.   DOI   ScienceOn
23 Kopruner V, Pfurtscheller G, Auer L M. Quantitative EEG in normals and in patients with cerebral ischemia. Progress in Brain Research. 1984 ; 62 : 29-50.   DOI