• Korean Journal of Biological Psychiatry
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• v.28 no.2
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• pp.36-49
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• 2021

Suicide is a leading cause of death worldwide, especially among adolescents and young adults. Considering this fact, it is imperative that we understand the neural mechanisms underlying suicidal thoughts and behaviors in youth from a neurodevelopmental perspective. In this review, we focused on the magnetic resonance imaging studies that examined the neural correlates of suicidal ideations (SI) or attempts (SA) in youth. We reviewed twenty-three cross-sectional studies reporting the structural and functional alterations in association with SI or SA among adolescents and young adults with various mental disorders. The previous literature suggests that the dorsolateral prefrontal cortex, anterior cingulate cortex, and ventral frontolimbic circuit, may play an important role in the pathophysiology of suicidal behavior in youth through altered top-down control over emotion and impulsivity. Future studies with a longitudinal design and using multimodal imaging techniques may be of help to identify novel therapeutic targets specific for youth with suicidal thoughts and behaviors.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.215-222
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• 2017

The study aimed to determine the characteristics of human brains and to identify the students' aptitude and interests by developing and applying the program for recognizing students' desired future careers. A total of 135 students (59 elementary school children and 76 middle school adolescents) were surveyed for 2 days and 1 night. The study conclusions are as follows. First, the program proved effective in forming the constructive recognition for their future jobs because they could explore careers in the future and because they could raise their consciousness of perspectives on careers. Second, the program makes it possible to explore future jobs that are appropriate to them based on their aptitude and interests and to enhance their career competencies. Further research is required because more consideration is needed. First, the present research applied the same program to all student participants despite the differences in developmental levels. Therefore, future research needs to involve elements that reflect their distinct psychological proficiency levels. Second, to show the evidence of the effectiveness, further studies need to focus on diverse dependent variables that may influence the results other than their distinct psychological proficiency levels.

• Science of Emotion and Sensibility
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• v.8 no.4
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• pp.365-374
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• 2005

Pain has at least two dimensions such as somatosensory qualities and affect and patients are frequently asked to score the intensity of their pain on a numerical pain rating scale. However, the use of a undimensional scale is questionable in view of the belief, overwhelmingly supported by clinical experience as well as by empirical evidence from multidimensional scaling and other sources, that pain has multidimensions such as sensory-discrimitive, motivational-affective and cognitive-evaluative The study of pain has recently received much attention, especially in understanding its neurophysiology by using new brain imaging techniques, such as positron emission tomography(PET) and functional magnetic resonance imaging (fMRI), both of which allow us to visualize brain function in vivo. Also the new brainimaging devices allow us to evaluate the patients pain status and plan To treat patients objectively. Base4 on our findings we presented what are the new brain imaging devices and the results of study by using brain imaging devices.

• Tuberculosis and Respiratory Diseases
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• v.63 no.4
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• pp.346-352
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• 2007

Background: Pulmonary hypertension is one of the cardiovascular complications of in COPD. However, a diagnosis of pulmonary hypertension requires an invasive test, such as right heart catheterization. NT-proBNP is a cardiac hormone that is elevated when a cardiac volume or pressure overload is present. It was hypothesized that NT-proBNP might play a role in detecting of pulmonary hypertension in COPD patients. Method: The 31 COPD patients, who underwent all of NT-proBNP, echocardiography, and spirometry in Seoul National University Bundang Hospital during the period from November 2003 to July 2005, were retrospectively analyzed. Result: Of the 31 COPD patients, 9 patients had pulmonary hypertension. A significant positive correlation was observed between the NT-proBNP and pulmonary arterial pressure (r=0.589, p=0.002). However, there was no significant correlation observed between the $FEV_1$ and NT-proBNP and $FEV_1$ and pulmonary arterial pressure. Conclusion: NT-proBNP might indicate the presence of pulmonary hypertension in COPD patients.

• Development and Reproduction
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• v.4 no.1
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• pp.95-100
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• 2000

A large number of man-made chemicals that have been released into the environment have the potential to disrupt the endocrine system of animals and humans. There is a critical developmental period during which sexual brain differentiation proceeds irreversibly under the influence of gonadal hormone. Recently we identified KAP3 gene expressed during the critical period of rat brain sexual differentiation. KAP3 functions as a microtubule-based motor that transports membranous organelles anterogradely in cells, including neurons. In the present study, we aimed to investigate the effect of endocrine disrupter, Dichlorodiphenyl trichloroethane (DDT), on the KAP3 gene expression during critical period of rat brain development. Maternal exposure to DDT increased the level of KAP3 mRNA in male and female fetus brains when examined on the gestational day 17 (GDl7). In postnatal day 6, DDT suppressed the expression of KAP3 gene in male and female rat brain. Also, the body weight and fertilization rate were decreased in the DDT exposured rats. These results showed that endocrine disrupter, DDT, can affect the transcriptional level of brain sexual differentiation related gene, KAP3, in the prenatal and the neonatal rat brain and that maternal exposure to endocrine disruptors may lead to a toxic response in embryonic differentiation of brain. And so KAP3 gene may be used a gene maker to analyse the molecular mechanism for toxic response in animal nerve tissues exposed to endocrine disruptors.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.477-485
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• 2018

The aim of this study was to improve the 'self-directed learning ability and attitudeselementary school students by applying a brain education-based learning program based on brain science in the form of a short term camp in consideration of the elementary school students' brain characteristics and mechanisms. For this purpose, this study was conducted on 4, 5, and 6 elementary school students in Korea. The brain training based learning camp program was conducted for two nights and three days. The camps were conducted twice from February 3 to 5, 2017 with 45 students from grade 6 and from February 22 to July 24, 2017, with 56 students from grades 4 and 5, 101 students in total. The conclusions of this study are as follows. The brain education-based learning camp program was found to be effective in improving the elementary school students' self-directed learning ability and learning attitude. First, the brain education-based learning camp program can increase the learning concentration through brain gymnastics, breathing, and meditation. Second, brain training called 'Brain Screen' among the brain education-based learning camp program can improve the brain ability of memory. Third, it can establish a self - directed learning philosophy of 'My study is done by me' by giving reason and motivation to study through the brain education-based learning camp program.

• Korean Journal of Child Education & Care
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• v.17 no.2
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• pp.45-73
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• 2017

The purpose of this study was to suggest the effects of early childhood design program based on brain-compatible learning principles. Subjects were thirty-six children from two class of I kindergarten and S kindergarten in K city. One class was assigned to an experimental group and had early childhood education program activities based on brain-compatible learning principles and the other class was assigned to a comparative group the general art education program activities. The results of this study are as follows. First, there was a significant difference between the experimental group and the comparative group in their fluency, originality, sensitivity of creativity. Second, participants in the experimental group also score higher on the helpful act, communication skill, sharing skill, empathy, and regulation of emotion. Therefore, early childhood design education program based on brain-compatible learning principles should be considered as a meaningful alternative method for promoting children's creativity and prosocial behaviors.

• Journal of Korean Elementary Science Education
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• v.41 no.4
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• pp.616-626
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• 2022

This study aims to investigate the effect of the application of the brain-based learning model on the self-efficacy, creative problem-solving ability, and academic achievement of elementary school students in science classes. The participants consisted of 22 students from one class (experimental group) and 22 students from another class (comparison group) of J Elementary School in B Metropolitan city. The experimental group conducted science classes that applied the brain-based learning model, and the comparison group conducted general explanatory science classes according to textbooks and the guide books of the teachers. The study found that science classes that applied the brain-based learning model exerted positive effects on the three abovementioned skills. Based on the results, the study confirmed that the application of the model is an effective learning tool that increases the self-efficacy, creative problem-solving ability, and academic achievement of for elementary school students in science classes.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.2
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• pp.173-182
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• 2005

This review is a clinical and research update of recent literature related to childhood onset schizophrenia (with an onset of psychosis by age 12). Childhood onset schizophrenia(COS) is a rare disorder, but that may represent a more homogeneous patient population in which to search for risk or etiologic factors of schizophrenia. These overview data show that COS shares the same clinical and neurobiological features as later onset forms of the disorder. Compared with later onset schizophrenia, however, this subgroup of patients appear to have more severe premorbid neurodevelopmental abnormalities, more cytogenic abnormalies, poor outcome, and potentially greater family histories of schizophrenia and associated spectrum disorders. Future studies of this subgroup may provide important clues as to the genetic basis for schizophrenia and how gene products influence certain feature of the disease, such as age of onset and mode of inheritance.

• 전기의세계
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• v.46 no.5
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• pp.3-10
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• 1997

뇌파, 즉 뇌전도는 뇌에서 일어나는 전위의 변화를 기록하는 것이다. 이는 두개골의 두피에 전극을 부착하거나 뇌 표면 또는 뇌속에 전극을 삽입하여 기록할 수 있다. 종래에는 뇌파는 활동전위의 동기화와 통합의 결과로서, 어떤 피질 영역에서의 뉴론의 활동을 직접 반영하는 것이라고 생각되어 왔다. 그러나 EEG 활동에서 상당한 부분은 뉴론의 막전위에 기인하며, 특히 느린 시냅스 후 전위의 가중에 기인한다고 할 수 있다. 그렇지만 활동전위가 EEG에 전혀 공헌하지 않는 것은 아니다. EEG는 그 파형에 따라 동기화 또는 비동기화로 나눌 수 있는데, 그 근간을 이루는 뇌 구조물은 상이하다. 그리고 피질의 활동에서 유래한 EEG는 피질하 구조물에 의해서도 영향을 받는다. 이러한 EEG를 활용한 연구는 인간 정신 과정을 이해하는데 이바지하는 바가 클 것이다.