• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.2
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• pp.219-226
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• 2010

The objective of this study was to determine the effects of a Scutellaria baicalensis water extract (SDWE) on lipid levels, lipid peroxidation and antioxidant enzyme activities on rats fed a high fat diet for 6 weeks. Thirty-two male Sprague-Dawley rats (4-weeks-old) were randomly divided into four groups: normal diet and deionized water (ND), normal diet and Scutellaria baicalensis water extract (NDS), high fat diet and deionized water (HFD), high fat diet and Scutellaria baicalensis water extract (HFDS). The food intakes were significantly lower, but the food efficiency ratios were significantly higher in the high fat diet groups than those in other groups. The level of HDL-cholesterol and HDL-cholesterol/total cholesterol ratio in plasma were significantly higher and AI (atherogenic index) in HFDS group was significantly lower than that in HFD group. The level of triglyceride in plasma was significantly decreased in SDWE groups. The triglyceride of liver was significantly increased in the high fat diet groups and the total cholesterol of liver in the HFDS group was significantly lower than that in the HFD group. The plasma and liver concentrations of thiobarbituric acid reactive substances (TBARS) in the NDS group were significantly lower than those in the ND group. The total antioxidant status (TAS) in plasma was significantly increased in the HFDS group compared to the HFD group. The activities of SOD, catalase and GST were significantly increased in SDWE groups compared to ionized water groups. The activity of GSH-Px and the concentration of GSH in liver in the HFDS group were significantly higher than those in the HFD group. These results suggest that a supplement of SDWE on rats fed high fat diet reduce levels of lipid and lipid peroxidation in plasma and liver and improve the antioxidant defense systems.

• Economic and Environmental Geology
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• v.56 no.4
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• pp.409-419
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• 2023

Acid mine drainage(AMD) treatment is classified as both passive and active treatment. During the treatment, about 5,000 tons of neutralization sludge is generated as a by-product per year in Korea. This study was conducted to evaluate the characteristics of sludge generated from physico·chemical treatment processes as an active treatment from 5 different sources (D, H, S, T, Y) and the possibility of the sludges being recycled. The sludges have a pH range of 5.86 ~ pH 7.89, and a water content range of 51% ~ 82%. Most of particle sizes were less than 25 ㎛. In analysis of inorganic elements, the concentration of Al, Fe, and Mn were between 1,189 mg/kg ~ 129,344 mg/kg, 106,132 mg/kg ~ 338,011 mg/kg, and 3,472 mg/kg ~ 11,743 mg/kg, respectively. The concentration of As and Zn in sludge-T, Cd in sludge-D, Ni in sludge-H, Zn in sludge-S, and Cd in sludge-Y exceeded the soil contamination standards of Korea. The results from 2 separate kinds of leaching test, the Korea Standard Leaching Test(KSLT) and Toxicity Characteristic Leaching Procedure(TCLP), showed that all the sludges met the Korea groundwater standards. From the XRD and SEM-EDS analysis, the peaks of calcite and quartz were found in the sludges. The sludge also had a high proportion of Fe and O, and the majority of the composition was amorphous iron hydroxide.

• Applied Chemistry for Engineering
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• v.23 no.6
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• pp.577-582
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• 2012

In this work, vibrational circular dichroism (VCD) technique was applied for the determination of %EE of chiral compounds. It may provide an easy way to determine the %EE with a proper accuracy within 2% error ranges as well as the absolute configuration of enantiomers. We demonstrated herein a flow cell VCD (FT-VCD) technique for time-dependent %EE measurements. The simultaneous monitoring of the mole fraction and %EE for two chiral species (epichlorohydrin and glycidol mixture) in the mixture was shown to be successful without any further separation steps. Thus, we demonstrate that FT-VCD is an appropriate analytical tool to monitor the kinetics of reactions involving chiral molecules. FT-VCD also provides a convenient nondestructive approach for the time dependent determination of the optical purity of individual components in a reaction mixture containing chiral molecules.

• Journal of the Korean Society of Food Science and Nutrition
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• v.25 no.2
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• pp.232-239
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• 1996

돌연변이 유발 물질인 mitomycin C(MMC)를 처리하여 배양한 Chinese hamster ovary(CHO) cell에 대한 감잎차 추출액의 항돌연변이 효과를 자매 염색 분체 교환(sister chromatid exchange, SCE) 시험법을 사용하여 측정하여 보았다. 감잎차 추출액 자체는 CHO 세포의 SCE 빈도수를 변화시키지 않았으며, 세포의 분열 주기중 S phase에 S9 mixture 없이 감잎차 추출액이 처리되었을 경우 MMC로 유도된 SCE 빈도수를 감소시키지 않았다. 그러나 S9 mixture 존재하에 $G_{1}$ phase에서 MMC 처리 후 감잎차를 처리하는 후처리 방식으로 감잎차 추출액을 처리하였을 때, 저농도($\leq$40$\mu\textrm{g}$/ml)에서 MMC로 인해 유발된 SCE 빈도수가 낮아지는 것을 볼 수 있었다. 이에 비해 고농도(>40$\mu\textrm{g}$/ml)에서는 SCE 빈도수의 감소 효과가 없었다. 본 연구결과, MMC 처리된 CHO 세포에 대한 감잎차 추출액의 항돌연변이 효과를 볼 수 있었고, 이 효과는 S9 mixture 존재하에서 저농도의 감잎차 추출액이 $G_{1}$ phase에 처리되었을 때 나타났다. 감잎차 추출액의 이러한 항돌연변이의 효과의 기전은 감잎차 추출액의 대사산물이 MMC 처리된 CHO 세포에 대한 DNA-excision repair activity를 촉진시키기 때문인 것으로 생각된다.

• Proceedings of the KIEE Conference
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• 2002.07c
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• pp.1566-1568
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• 2002

본 논문은 혈당, 콜레스테롤센서에 적용이 가능한 과산화수소($H_2O_2$) 검출방식인 전기화학발광(Electrochemiluminescence:ECL)법 사용에 필요한 전극특성에 관한 연구이다. 전기화학전극으로 Pt박막전극을 사용하였으며, luminol(5-amino-2, 3-dihydro-1, 4-phthala edione)과 과산화수소($H_2O_2$)의 반응으로 발생한 빛을 포토다이오드(photodiode)를 사용하여 전류를 측정하였다. 사용된 전극은 직사각형(rectangular-type), 교차형(interdigitated-type)의 두 가지 형태를 사용하여, 전극간의 거리와 면적에 따른 ECL특성을 측정하였다. ECL 발광 특성은 전극 면적이 증가함에 따라, 전극거리가 감소함에 따라 증가함을 관찰할 수 있었다.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.62-62
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• 2010

근래 실리콘 나노선을 이용한 FET타입의 바이오 센서로의 응용 연구가 활발하다. 본 연구에서는 top-down 방식으로 제작한 실리콘 나노선의 전자수송 특성을 측정 분석하여 실리콘 나노선의 기하학적 변수에 따른 수송 변수를 추출하였다. 두께가 40 nm인 SOI wafer로부터 출발하여 일반적인 포토리소그라피와 건식식각 공정을 통하여 선폭이 100-300 nm 그리고 길이가 2-20 mm인 실리콘 나노선을 제작하고 resistance 및 transconductance를 측정하여 전하농도와 이동도의 선폭에 대한 의존도를 얻었다. 이를 바탕으로 bare surface, OH-activated surface, APTES-treated surface등 실리콘 표면상태에 따른 표면전하의 시간에 대한 진화과정을 모니터 할 수 있었으며, 또한 PBS 용액상태에서 pH를 변화시킴에 따른 전하수송 특성곡선의 변화를 연구하였다.

• Clinical and Experimental Pediatrics
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• v.46 no.2
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• pp.183-187
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• 2003

Purpose : Long-term stress to the fetus causes alterations in adrenal steroidogenesis. The purpose of this study was to analyze the association of cord blood cortisol with stress during delivery. Methods : Cord blood samples were collected from 58 neonates at once to labor. Cortisol was measured by RIA method(DPC, USA). Cortisol level according to gestational age(<34, 34-37, >38 wks) and method of delivery(Cesarean section vs. vaginal delivery), Apgar score and uterine contraction, were compared to know stress during labor. Results : Cortisol of cord blood had considerable differences between each group, according to gestational age(P<0.001). It was statistically higher in the cases of vaginal delivery than cessarian delivery(P<0.001). The concentration of cortisol was significantly higher according to duration of labor (P<0.05). There was a significant relationship between cortisol level and uterine contraction(P<0.05). The concentration of cortisol was significantly low when Apgar score at 1 min was low(P<0.05). Conclusion : Cord cortisol has close association with stress during labor. And so do with post birth prognosis of neonate.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.10
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• pp.1544-1551
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• 2013

This study was performed to investigate anti-oxidant of red pepper and Zanthoxylum schinifolium ethanol extract, main ingredient of mara source. Anti-obesity effects of red pepper and Zanthoxylum schinifolium ethanol extract were investigated with mice fed high fat diet for 8 weeks. Sixty mice were classified to 6 groups of ND (normal diet), HFD (high fat diet), RP (high fat diet+red pepper (0.1 g/60 kg)), CP (high fat diet+Chinese pepper (0.1 g/60 kg)), RCP (high fat diet+red pepper : Chinese pepper=1:1 (0.1 g/60 kg)), HCA (high fat diet+HCA (0.1 g/60 kg)) experiments. This research showed that final weight, weight gain, food efficiency ratio, and river weight were decreased by the addition of red pepper and Zanthoxylum schinifolium ethanol extract comparing to those of HFD group. The plasma triglyceride and LDL cholesterol concentration of red pepper ethanol extract and Zanthoxylum schinifolium ethanol extract group was lower than that of high fat diet group. HDL-cholesterol concentration of red pepper ethanol extract and Zanthoxylum schinifolium ethanol extract group was higher than those of high fat diet group. These results suggested that red pepper and Zanthoxylum schinifolium ethanol extract might be useful for obesity control and good source of functional materials.

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.355-361
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• 2014

The aim of the present study was to evaluate a relative emission of image plate (IP) in computed radiography (CR) system by using relative sensitivity in film/screen methods. The characteristic curve was obtained by using the uniform aluminum 11-step wedge penetrometer. X-ray exposure factors on radiographic digital image were 50 kVp, 10 mAs. We adjusted zero of all parameter of algorithms (MUSICA) so proximate to raw data and applied to 200 of exposure class. Modeling on relative emission of IP are used IP without fading time and IP after 4 hours, 8 hours, 12 hours, 24 hours in the respective storage after X-ray exposure. The results of this study showed that the sensitivity point density at the measuring of relative sensitivity in CR was suited pixel values of the 2000 easy to relatively measure the characteristic curve and when relative sensitivity is decreased, the amount of light emitted from the image signal for generating was also decreased. In conclusion, the proposed method of measurement of relative sensitivity can be utilized to evaluate the quantity of relative emission of IP in CR system.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.175-175
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• 2022

하천 합류부는 서로 다른 지형학적 특성과 수리학적 특성을 가지는 두 개의 하천이 하나로 합쳐지는 구간으로 급격한 흐름의 변화 및 퇴적물의 유입과 수리학적 지형변화가 발생하는 구간이다. 합류부 구간에서는 물질의 종류 또는 온도차로 인해 밀도 차이로 유체의 흐름이 발생하게 되는데 이것을 밀도류라고 한다. 밀도차이에 의해 성층이 생긴 수체혼합거동을 파악하기 위해서는 본류 및 지류의 일정 구간을 포함하는 합류부 구간에 대한 정밀한 계측 및 관찰이 필요하다. 이러한 수체 혼합에 대한 종합적인 분석은 유속장 및 유량정보를 취득하여 파악할 수 있지만, 성층류가 흐르는 하천의 서로 상이한 물리적 특성과 수질특성을 가지는 수체의 혼합양상 및 그에 따른 물질혼합양상을 파악하는데 한계가 있다. 따라서 본 연구에서는 합류부 구간에서의 수온 분포를 통하여 밀도류를 파악하고자 한다. 하천의 광범위한 데이터 중 연직 자료와 수표면 자료를 취득하였고, 이를 통해 합류부의 성층현상을 확인하고자 하였다. ADCP를 보트 측면에 설치하여 저속운행으로 수리량을 측정하는 방식과 YSI를 이용해 측선설치 없이 측선 선정 후 보트를 이용하여 흐름에 직각인 방향으로 이동하며 실시간 농도를 측정하는 방식으로 얻은 연직자료 중 수온, EC 등의 직독식 센서 데이터 값을 사용하여 수온차에 따른 수체혼합 패턴을 분석하여 합류부의 혼합 양상을 분석 하고자 하였다. 본 연구에서는 기존 수질측정의 한계였던 1차원적인 측정결과가 나타내는 분석결과를 2차원적으로 보완이 가능하며, 비교 분석한 결과를 토대로 밀도류에 따른 혼합양상 결과가 지니는 혼합패턴을 분석한다면 향후 하천 하류구간의 취수장 취수 시스템에 많은 도움을 줄 뿐만 아니라 합류부 구간의 혼합패턴에 따라 수층 내 성층구간의 현황조사 및 혼합특성 파악을 통해 관리방안제시에 사용될 것으로 사료된다.