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Determination of Enantiopurity of Chiral Epoxides by Vibrational Circular Dichroism Spectroscopy  

Lee, Joo-Hyun (Department of Chemical Engineering, Inha University)
Lee, Choong-Young (Department of Chemical Environmental Technology, Inha Technical College)
Kim, Geon-Joong (Department of Chemical Engineering, Inha University)
Publication Information
Applied Chemistry for Engineering / v.23, no.6, 2012 , pp. 577-582 More about this Journal
Abstract
In this work, vibrational circular dichroism (VCD) technique was applied for the determination of %EE of chiral compounds. It may provide an easy way to determine the %EE with a proper accuracy within 2% error ranges as well as the absolute configuration of enantiomers. We demonstrated herein a flow cell VCD (FT-VCD) technique for time-dependent %EE measurements. The simultaneous monitoring of the mole fraction and %EE for two chiral species (epichlorohydrin and glycidol mixture) in the mixture was shown to be successful without any further separation steps. Thus, we demonstrate that FT-VCD is an appropriate analytical tool to monitor the kinetics of reactions involving chiral molecules. FT-VCD also provides a convenient nondestructive approach for the time dependent determination of the optical purity of individual components in a reaction mixture containing chiral molecules.
Keywords
vibrational circular dichroism; absolute configuration; enantiomer; chirality; epichlorohydrin;
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