• 대한본초학회지
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• 제29권5호
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• pp.45-53
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• 2014

Objectives : The purpose of the study is to test the antibacterial, anti-inflammatory and antioxidant effects of BPH, which is composed of Pini Densiflorae Nodi Lignum and Querci Acutissimae Fructus, Angelicae Gigantis Radix, Cnidii Rhizoma, Angelicae Dahuricae Radix, Angelicae Tenuissimae Radix. Method : Antibacterial and anti-inflammatory effects of BPH on Propionibacterium acnes, one of anaerobic bacteria species were evaluated by measuring the levels of 2,2-diphenyl-1-picrylhydrazyl (DPPH) elimination and lipid peroxidation. Result : When BPH was applied to CCD-986sk (Human normal fibroblast) to confirm the level of cytokine(tumor necrosis factor-alpha, interleukin-8), its level increased in proportion to that of BPH's concentration, which indicated dose-dependent relationship. Using the Disk diffusion to measure the bacterial growth inhibition zone varying BPH concentration, it was found that the antibacterial effect of BPH was less than that of erythromycin, the control group, but was higher than that of saline, and it increased with higher concentrations. In a liquid culture medium containing BPH, the growth rate of Propionibacterium acnes was decreased by more than 10% at 25% BPH. After adding P. acnes to THP-1 monocyte, and treated it with BPH, and measuring the concentration of TNF-a and IL-8, it was observed that the amount of TNF-alpha and IL-8 significantly decreased depending on the level of BPH concentration. The ability to eliminate DPPH increased with higher BPH concentration. The inhibition of lipid peroxidation was increased by BHT treatment in a dose-dependent manner. Conclusion : Using Propionibacterium acnes, an anaerobic bacteria, we confirmed that BPH has antibacterial, anti-inflammatory and antioxidant effects.

• 한국강구조학회 논문집
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• 제25권4호
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• pp.421-430
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• 2013

수평하중이 지배적인 해상 풍력발전기 설계 시에는 지반-기초구조물 거동을 정확히 모사하여야 상부구조물에 대한 정확한 거동예측이 가능하며, 합리적 설계가 이루어질 수 있다. 현재 다양한 지반 모델링 기법이 존재하나, 모노파일 기초 설계 시, 각 해석 기법에 대한 충분한 검증 절차 없이 해석 결과를 그대로 사용할 경우 구조물을 과다 및 과소하게 설계할 우려가 있다. 이에 본 연구에서는 지반 모델링 기법 차에 따른 모노파일의 부재력 및 수평변위 차를 비교 분석하였다. 검토 결과 고정단 모델은 최대 수평변위를 과소평가 하여 사용성 검토 측면에서 적합하지 않은 것으로 나타났으며, 고정단 모델, 지반강성행렬 모델은 모노파일의 부재력을 과소평가하는 것으로 나타났다. 반면 가상고정점 모델은 모노파일의 부재력을 과대평가하여 경제성 측면에서 적합하지 않은 것으로 나타났다. 지반반력계수 모델과 p-y곡선 모델의 경우 3D 지반 모델링 해석 결과와 비교적 유사한 수평변위 및 부재력을 나타냈으며, 지반을 2D로 모델링한 경우 타 모델링 기법에 비해 과대한 수평변위와 부재력을 산정했다.

• Journal of Acupuncture Research
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• 제33권1호
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• pp.103-116
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• 2016

Objectives : This study was performed to assess the effectiveness of conservative Korean traditional medical treatment on lumbar intervertebral disc herniation in 12 adolescents. Methods : Data were collected from adolescent patients diagnosed with lumbar intervertebral herniation by MRI, hospitalized at Jaseng Korean Medicine Hospital from January 1, 2014 to December 31, 2015. A total of 12 patients were included in the study. Patients were treated by acupuncture, pharmacopuncture, electroacupuncture, herbal medicine, chuna manual therapy, physical therapy during hospitalization period. To measure treatment outcomes, a verbal numerical rating scale (VNRS), Oswestry disability index (ODI), range of motion (ROM), Straight leg raising test (SLR), and EQ-5D were used. Results : The average age of the participants was $16.05{\pm}1.62$. The average of duration of symptom was $19.25{\pm}26.83(weeks)$ and the average length of hospitalization was $23.8{\pm}16.4(days)$. 2 patients (17 %) suffered from only lumbar pain, while 10 patients (83 %) suffered from lumbar and leg pain. No participant suffered from only leg pain. 8 patients (67 %) were diagnosed with disc herniation in one segment, and 4 patients (33 %) were diagnosed with disc herniation in multiple segments. A total of 17 disc segments (28 %) were herniated. The most herniated lumbar level was L4-5. 3 segments were diagnosed with bulging (17 %), 6 with protrusion (35 %), and 8 with extrusion (47 %). Extrusion was the most frequent herniated type. After treatment, the average VNRS of lumbar pain significantly decreased from $5.58{\pm}1.62$ to $2.91{\pm}1.56$ (p<0.001) and the average VNRS of leg pain significantly decreased from $5.16{\pm}2.51$ to $3.08{\pm}1.8$ (p<0.001). ODI significantly decreased from $48.87{\pm}18.72$ to $28.57{\pm}15.05$ (p<0.05), and EQ-5D significantly increased $0.58{\pm}0.31$ to $0.80{\pm}0.12$ (p<0.05). Range of flexion significantly improved from $61.25{\pm}32.62$ to $68.33{\pm}26.22$ (p<0.05). Conclusion : Conservative Korean Traditional Medical Treatment may be effective in the treatment of lumbar intervertebral disc herniation in adolescence. However, more case reports and clinical research are needed.

• Journal of Acupuncture Research
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• 제32권4호
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• pp.37-45
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• 2015

Objectives : The main aim of this study is to evaluate changes in the microbiological safety of pharmacopuncture exposed to room temperature for an elapsed period of time. Methods : The four most frequently used pharmacopuncture products were stored in syringes at room temperature at three different hospitals for 24 hours and 48 hours respectively, and they were compared with pharmacopuncture products stored in vials through a sterility and microbial limited test. Results : Storage forms and duration of exposure to room temperature did not show significant difference in bacterial or fungal contamination, which was confirmed by the sterility and microbial limited test. Conclusions : Pharmacopuncture products stored in syringes at room temperature for 24 hours and 48 hours demonstrated their safety in terms of lack of microbiological contamination.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.29-32
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• 2014

Objectives : Jakyakgamcho decoction is a traditional prescription known to be an effective pain control medication and muscle relaxant. For more localized treatment outcomes achieved in a shorter period of time, Jakyakgamcho decoction was reprocessed into a form of pharmacopuncture. An analysis of Jakyakgamcho decoction pharmacopuncture showed that there was a significant loss of paeoniflorin(Jakyak's index component). This study was designed to investigate ways to minimize this loss. Methods : After making changes to the processing methods of Jakyakgamcho decoction pharmacopuncture, we measured the quantity of paeoniflorin using high performance liquid chromatography(HPLC) for a before-and-after analysis Results : Paeoniflorin loss was observed 15 minutes after sterilization with $Na_2HPO_4$ at $121^{\circ}C$ Conclusions : It was found that paeoniflorin loss did not occur when pH was not controlled for during processing.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.109-119
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• 2014

Objectives : The aim of this study is to observe clinical characteristics and treatment outcomes of inpatients admitted to a Korean medicine hospital for shoulder pain based on magnetic resonance imaging(MRI) findings. Methods : 28 patients with MRI data were included. Data on MRI findings, duration of pain, and treatment effects were collected. To measure treatment outcomes, verbal numerical rating scale(VNRS), range of motion(ROM), and a clinical condition grading system were used. Results : 1. The patient population was 75.0 % female and 39.3 %(n=11) belonged to the 51~60-year-old age group. In the under 40 population, 1 or less MRI findings were found. 2. As for the type of disorder, 82.1 % of the patients were diagnosed with 'Supraspinatus lesion', 39.3 % with 'subacromial-subdeltoid(SA-SA) bursitis', and 28.6 % with 'Adhesive capsulitis' 3. Numerous correlations could be made between duration of pain and MRI findings. 'rotator cuff full thickness tear' was more prevalent in acute shoulder pain patients, and 'Adhesive capsulitis' in chronic patients. 4. VNRS and ROM at the time of discharge had significantly improved as compared to VNRS and ROM at the time of admission. 5. As for correlation between MRI findings and clinical condition grade, patients diagnosed with 'rotator cuff partial tear' reported to be in 'good' condition or better whereas those with 'rotator cuff full thickness tear' reported to be in 'fair' condition or worse. Conclusions : Patients admitted to a Korean Medicine hospital for shoulder pain had varying degrees of severity as shown on MRI. Almost all lesions responded well to Korean medicine treatment.

• 척추신경추나의학회지
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• 제10권1호
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• pp.117-127
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• 2015

Objectives : Most of pains are important symptoms caused by cancer transpered to spine. Harpagophyti Radix Pharmacopuncture is highly effective in reducing fever, pain, inflammation but was never used to reduce pain from cancer transpered to spine. So I intended to use Harpagophyti Radix Pharmacopuncture to control pain. The purpose of this study is to evaluate the clinical application of Harpagophyti Radix Pharmacopuncture for Bone Metastasis of Breast Cancer and Spinal Stenosis. Methods : We examined patient with Bone Metastasis of Breast Cancer and Spinal Stenosis who admitted Jaseng Korean Medicine Hospital. The patient was treated by Korean Medicine treatment and Harpagophyti Radix Pharmacopuncture. This case was assessed by Numerical Rating Scale(NRS), Oswestry Low Back Pain Disability Index(ODI), Short-Form 36 Health Survey(SF-36), ROM(Range of Movement) and Special Test. Results : In this study, the patient's pain was controlled and NRS, ODI were decreased. I could identify the improvement in life quality from the positive change of SF-36 and also found out that treatment was successful from the improvement of ROM, Special test. Conclusions : Harpagophyti Radix Pharmacopuncture with Korean Medicine treatment for Bone Metastasis of Breast Cancer and Spinal Stenosis was proved to be useful to the pain relief and function recovery, but further research should take place for clear understanding of the exact amount of dosage and safety. Moreover it must be accompanied by long term follow up research.

• 척추신경추나의학회지
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• 제9권2호
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• pp.81-92
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• 2014

Objectives : The Purpose of this study is to investigate the clinical application of Bee venom pharmacopuncture and conservative treatment for lumbar HIVD(Herniated Intervertebral Disc) and Femoroacetabular Impingement. Methods : Patient is hospitalized at Dept. of Oriental Internal Medicine, Jaseng Oriental Medicine Hospital, diagnosed as lumbar HIVD(Herniated Intervertebral Disc) and Femoroacetabular Impingement and treated by Bee venom pharmacopuncture, herbal medicine, acupuncture and moxibustion. This study was measured by NRS(Numerical Rating Scale), ODI and EQ-5D. Results : After Bee venom pharmacopuncture and conservative oriental medical treatment, the patient's pain was controlled and NRS score was decreased. ODI and EQ-5D also were improved. Conclusions : As seen in this one case, Oriental conservative treatment and Bee venom pharmacopuncture have a positive effect to control pain with lumbar HIVD(Herniated Intervertebral Disc) and Femoroacetabular Impingement.

• 대한한의학회지
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• 제32권1호
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• pp.36-55
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• 2011

Objective: This study was performed to compare knowledge of and expectations for traditional medicine between Korean, Chinese and Taiwanese, to figure out whether these factors influence the intention to use traditional medical treatment in the future. Methods: One-hundred ninety-nine Korean, eighty-five Chinese, and one-hundred seventy-four Taiwanese subjects responded to the survey. A one-way ANOVA was performed to compare experiences of traditional medical treatment, knowledge of both traditional medicine and western medicine, expectations for traditional medicine, and future intention to use traditional medical treatment. Multiple regression analyses were also performed to evaluate a possible correlation between the other factors and the intention to use traditional medical treatment in the future. Results: The experiences of traditional medical treatment were in the order of Taiwanese, Korean, and Chinese, from more frequent to less frequent. Chinese had more knowledge of traditional medicine compared to Taiwanese and Koreans, and the expectations for traditional medicine were in the order of Chinese, Korean and Taiwanese, from higher to lower. The intentions to use traditional medical treatment in the future were in the order of Korean, Chinese and Taiwanese, from more to less. Multiple regression analyses showed that experiences of traditional medical treatment, knowledge of traditional medicine, and expectations for traditional medicine were associated with the intention to use traditional medicine in the future in Korean and Taiwanese, but not in Chinese. Only the expectations for traditional medicine were associated with the future intentions to use traditional medical treatment in Chinese. Conclusions: These findings suggest that Korean and Taiwanese may need to improve their knowledge of traditional medicine whereas Chinese need to link their knowledge of traditional medicine with the intention to use it in the future. Understanding the characteristics of traditional medicine would probably contribute to enhancing the intentions to use it more.

• Journal of Acupuncture Research
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• 제32권3호
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• pp.127-133
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• 2015

Objectives : Previous studies have shown that the amount of melittin, the main active ingredient in bee venom pharmacopuncture, tends to decrease substantially with time during pharmacopuncture manufacture. This study aimed to assess whether the stability of bee venom pharmacopuncture improved with pharmacopuncture additives. Methods : Components were measured using high performance liquid chromatography. Acute toxicity and antigenicity tests by subcutaneous and venous routes were conducted at Korea Pharmaceutical Test & Research Institute and mortality, adverse reactions, and body weight changes were assessed. Results : Stability tests using additives revealed that bee venom without additives was most stable. Bee venom pharmacopuncture without additives was further tested for toxicity in subcutaneous and venous administration in mice and no changes pertaining to toxicity were found over the testing period. Conclusions : Bee venom pharmacopuncture without additives was found to be most stable, and further, it did not show toxicity or antigenicity in subcutaneous and venous administration in mice.