• Title/Summary/Keyword: 김윤구

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Human Immunodeficiency Virus-Infected T Cells Are Selectively Killed by Monoclonal Anti-gp120 Antibody Coupled to Pokeweed Antiviral Protein (섬자리공 유래 항바이러스 단백질과 항체 복합체를 이용한 HIV-1 감염세포의 선택적 제거)

  • Kang, Mi-Ran;Kim, Yoon-Kyu;Hong, Hyo-Jeong;Cho, Myung-Hwan;Shin, Hyung-Sik;Kim, Sun-Young
    • The Journal of Korean Society of Virology
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    • v.28 no.4
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    • pp.383-391
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    • 1998
  • A murine monoclonal antibody (mAb) specific for the envelope glycoprotein gp120 of human immunodeficiency virus type-I (HIV -1) was chemically coupled to pokeweed antiviral protein (PAP) from Phytolacca americana. The immunotoxin was purified by FPLC using S200 colum. The purified immunotoxin efficiently bound to HIV-infected T cells as evidenced by fluorescenceactivated cell sorter analysis. The immunotoxin selectively killed human T lymphoid lines infected with $HIV-1_{IIIB}$ at less than 250 pM of the immunotoxin cells, while PAP or mAb alone did not have any significant effect on infected cells. The uninfected control T cell lines were not affected. Human cells infected with HIV-2 or other HIV-1 strains were not killed, suggesting that the killing depends completely on the antibody used for coupling. These in vitro results suggest that the PAP-mAb conjugate may be used to selectively remove cells expressing viral antigens from individuals infected with HIV.

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A Case of Cytomegalovirus Colitis in Chronic Adult T-Cell Leukemia/Lymphoma (만성 성인T세포백혈병/림프종 환자에서 병발한 거대세포바이러스 장염 1예)

  • Park, Han-Seung;Kim, Dae-Young;Kim, Ji-Beom;Kim, Yun-Ku;Cho, Min-Soo;Ok, Tae-Jin;Jang, Sun-Joo;Lee, Kyoo-Hyung
    • Journal of Yeungnam Medical Science
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    • v.28 no.2
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    • pp.187-191
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    • 2011
  • Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of mature T-cells caused by the human T-cell lymphotrophic virus type I (HTLV-D. HTLV-I is endemic in some areas in Japan, the Caribbean basin, and Africa but has low prevalence in South Korea. Patients with ATLL are susceptible to opportunistic infections such as cytomegalovirus (CMV) infection, but CMV infection in chronic ATLL is uncommon. Reported herein is a case involving a 44-year-old woman with chronic ATLL who presented the symptoms of fever and diarrhea. She was suspected to have acute-type ATLL but was later diagnosed with CMV colitis.

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Low Power Design of Filter Based Face Detection Hardware (필터방식 얼굴검출 하드웨어의 저전력 설계)

  • Kim, Yoon-Gu;Jeong, Yong-Jin
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.45 no.6
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    • pp.89-95
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    • 2008
  • In this paper, we designed a low power face detection hardware and analysed its power consumption. The face detection hardware was fabricated using Samsung 0.18um CMOS technology and it can detect multiple face locations from a 2-D image. The hardware is composed of 6 functional modules and 11 internal memories. We introduced two operating modes(SLEEP and ACTIVE) to save power and a clock gating technique was used at two different levels: modules and registers. In additional, we divided an internal memory into several pieces to reduce the energy consumed when accessing memories, and fully utilized low power design option provided in Synopsis Design Compiler. As a result, we could obtain 68% power reduction in ACTIVE mode compared to the original design in which none of the above low power techniques were used.

Dynamic analysis of wind turbine wake (풍력 발전 터빈 후류의 동적 분석)

  • Um, Young Han;Kim, Yun Gu;Park, Sung Goon
    • Journal of the Korean Society of Visualization
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    • v.18 no.2
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    • pp.59-65
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    • 2020
  • Vertical axis wind energy systems including 3 and 4 blades are numerically investigated in a two-dimensional (2D) computational domain. The power coefficient (Cp) is adopted to measure the efficiency of the system and the effect of the rotating velocity on the power coefficient is analyzed for the two different systems. The rotating velocity varies from 30 rad/s to 90 rad/s, which corresponds to the tip speed ratio (T.S.R) of 0.5 to 1.5. The torque exerted on the blades is mainly determined by the aerodynamic force in the x-direction and maximized when the blade is positioned at around θ = 186°. The efficiency of the 4-blade system is higher than that of the 3-blade system within the tip speed ratio range between 0.5 and 0.67, besides where the 3-blade system shows a better performance. For the 3-blade system, the maximum efficiency is reached to 0.082 at the tip speed ratio of 1.083. The maximum efficiency of the 4-blade system is 0.071 at T.S.R. = 0.92. The velocity fields in the x-direction, pressure fields, and the vorticity magnitude are analyzed in detail for the optimal cases of the 3- and 4-blades systems, respectively.

The design of coffer dam utilized P.R.D. method (P.R.D. 공법을 활용한 가물막이 설계)

  • Park, Chal-Sook;Lee, Kyu-Tak;Yum, Kyung-Taek;Kim, Yoon-Ku;Kang, Bong-Gwon;Lee, Jae-Weon;Lim, Seok-San;Jeong, Ji-Yearl
    • Proceedings of the Korean Geotechical Society Conference
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    • 2008.10a
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    • pp.869-887
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    • 2008
  • Coffer dam for tunnel type spillway in inflow section of Dae-am dam was originally planned as 2 lines sheet piles with Water Zet method. But, the result of pilot test was caused of some problems that vibration during installation of pile could pollute water and water leakage could the lower part. So, sheet piles was not satisfactory for faculty of coffer dam. Structural instability of sheet pile system need to reinforcement. Characteristic of Dae-am dam was small reservoir capacity but wide drainage area, of which it was judgment that security of leakage and stability was difficult during excavation of inlet part. So, we consider that water curtain method utilized with in site pouring concrete pile method was designed at weir part of spillway. We were known about basement rock that geological boring was carried out in weir part. After taking a deep consideration, PRD method was accepted as a new method. Concrete pile by PRD was installed to below country rock. CJM method was carried out with PRD. After making concrete wall using Top-down method, earth anchors were installed for supporting it. According to the result of numerical analysis, as water level rises, wall is stable.

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Face detect hardware implementation for embedded system (임베디드 시스템 적용을 위한 얼굴검출 하드웨어 설계)

  • Kim, Yoon-Gu;Jeong, Yong-Jin
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.44 no.9
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    • pp.40-47
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    • 2007
  • For image processing hardware, including a face detecting engine, efficient constitution of external and internal memories is a consequential point because huge memory is required to store various signal processing filters and incoming images. In this paper, we modified a face detect algerian of a general filter method for efficient hardware design. In the hardware, several memory design techniques are presented for efficient handling of image data : re-accessing avoidance with minimized internal memory usage, residing frequently accessed memory and sequence memory accessing. The hardware which can process 25 frame image data per one second with 40KB internal memory was verified by using ARM(S3C2440A) and Virtex4 FPGA and it is being fabricated as a ASIC chip using Samsung CMOS 0.18um technology.

A Case of Acute Eosinophilic Pneumonia after Hematopoietic Stem Cell Transplantation (혈연간 동종 조혈모세포 이식 후 이식편대숙주질환과 함께 발생한 급성 호산구성 폐렴 1예)

  • Park, Hwan-Sung;Ok, Tae-Jin;Kim, You-Jae;Kim, Guang-Un;Park, So-Eun;An, Ji-Hyun;Kim, Yun-Ku;Jeong, Jae-Ho;Kim, Su-Jeong;Lee, Yu-Mi;Lee, Ho-Su;Kang, Bo-Hyoung;Kim, Ga-Hee;Kim, Dae-Young;Kim, Woo-Sung;Kim, Dong-Soon;Song, Jin-Woo
    • Tuberculosis and Respiratory Diseases
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    • v.71 no.6
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    • pp.459-463
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    • 2011
  • Pulmonary complications occur in 40~60% of patients who receive hematopoietic stem cell transplantation (HSCT) and are a source of substantial morbidity and mortality. Acute eosinophilic pneumonia (AEP) is an uncommon, non-infectious pulmonary complication occurring in HSCT recipients. We now report the case of a 52-year-old man with AEP who was treated with allogenic HSCT due to acute myeloid leukemia. He complained of fever, cough and dyspnea 390 days after allogenic HSCT. He also had skin and hepatic graft versus host disease (GVHD). Hypoxemia, diffuse pulmonary infiltrates on a chest x-ray and eosinophilia in bronchoalveolar lavage fluid were also noted in several tests. His symptoms, pulmonary infiltrates, hepatic dysfunction and skin lesions rapidly improved after treatment with corticosteroid therapy. Our case supports the idea that AEP is a late phase non-infectious pulmonary complication and one of the manifestations of chronic GVHD.

Real-time Environmental Radiation Monitoring System with Automatic Restoration of Backup Data in Site Detector via Communication using Radio Frequency (현장검출기에 저장된 백업데이터를 무선통신방식으로 자동 복원하는 실시간 환경선량 감시 시스템)

  • Lee, Wan-No;Kim, Eun-Han;Chung, Kun-Ho;Cho, Young-Hyun;Choi, Geun-Sik;Lee, Chang-Woo;Park, Ki-Hyun;Kim, Yun-Goo
    • Journal of Radiation Protection and Research
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    • v.28 no.3
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    • pp.255-261
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    • 2003
  • An environmental radiation monitoring system based on high pressurized ionization chamber has been used for on-line gamma monitoring surrounding the KAERI (Korea Atomic Energy Research Institute), which transmits the dose data measured from ion chamber on the site via radio frequency to a central processing computer and stores the transmitted real-time data. Although communication using radio frequency has several advantages such as effective and economical transmission, storage, and data process, there is one main disadvantage that data loss during transmission often happens because of unexpected communication problems. It is possible to restore the loss data by off-line such as floppy disk but the simultaneous process and display of current data as well as the backup data are very difficult in the present on-line system. In this work, a new electronic circuit board and the operation software applicable to the conventional environmental radiation monitoring system are developed and the automatical synchronization of the ion chamber unit and the central processing computer is carried out every day. This system is automatically able to restore the backup data within 34 hours without additional equipments and also display together the current data as well as the transmitted backup data after checking time flag.

An Adaptive USB(Universal Serial Bus) Protocol for Improving the Performance to Transmit/Receive Data (USB(Universal Serial Bus)의 데이터 송수신 성능향상을 위한 적응성 통신방식)

  • Kim, Yoon-Gu;Lee, Ki-Dong
    • Proceedings of the Korea Contents Association Conference
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    • 2004.11a
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    • pp.327-332
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    • 2004
  • USB(Universal Serial Bus) is one of the most popular communication interfaces. When USB is used in an extended range, especially configurating In-home network by connecting multiple digital devices each other, USB interface uses the bandwidth in the way of TDM(Time Division Multiplexing) so that the bottleneck of bus bandwidth can be brought. In this paper, the more effective usage of bus bandwidth to overcome this situation is introduced. Basically, in order to realize the system for transferring realtime moving picture data among digital information devices, we analyze USB transfer types and Descriptors and introduce the method to upgrade detailed performance of Isochronous transfer that is one of USB transfer types. In the case that Configuration descriptor of a device has Interface descriptor that has two AlternateSetting, if Isochronous transfers are not processed smoothly due to excessive bus traffic, the application of the device changes AlternateSetting of the Interface descriptor and requires a new configuration by SetInterface() request. As a result of this adaptive configuration, the least data frame rate is guaranteed to a device that the sufficient bandwidth is not alloted. And if the bus traffic is normal, the algorithm to return to the original AlteranteSetting is introduced. this introduced method resolve the bottleneck of moving picture transfer that can occur in home network connected by multiple digital devices.

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The Moderating Effect of Union Instrumentality in the Relationship between Job satisfaction and Union Participation (직무만족과 노조참여 관계에서 노조수단성의 조절효과)

  • Bae, Seung-Hyun;Kim, Seung-Ho;Kim, Yun-Gu
    • Management & Information Systems Review
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    • v.32 no.2
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    • pp.165-191
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    • 2013
  • A long debate has been made about whether job satisfaction facilitates or impedes union participation. This study analyzed the moderating effect of union instrumentality in the relationship between job satisfaction and union participation. The data collected from 826 employees of 22 workplaces were empirically evaluated. The result of the research revealed that both positive effect and negative effect were observed in the relationship between job satisfaction and union participation. The positive effect was noticed in the direct influence of job satisfaction on the union participation. However, given the interaction between job satisfaction and union instrumentality, the job satisfaction showed the negative effect on the union participation. Based on this result, we can conclude that the direct influence of job satisfaction on the union participation supports dissonance theory about the union participation and the interaction effect between job satisfaction and union instrumentality confirms the utility theory. The present study indicates that the effect of union participation is more reinforced when job satisfaction and union instrumentality are closely connected than when job satisfaction independently affects union participation. Thus, the result implicates that for the revitalization of the labor union, the organization needs to offer a variety of services to satisfy the expectation of whole union members in practical terms instead of concentrating on the labor movement for the political struggle. This point says a lot for a new direction of labor movement.

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