• Korean Journal of Food Science and Technology
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• v.46 no.1
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• pp.61-67
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• 2014

This study aimed to investigate the anti-inflammatory activities of raw (P) and roasted (RP) Perilla frutescens Britton (perilla) seeds in RAW 264.7 macrophages and an ulcerative colitis mouse model. In lipopolysaccharide-treated RAW 264.7 cells, treatment with ethanol extract of P at the concentrations of 75 and $150{\mu}g/mL$ decreased nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) levels to 48-85% of the control (p<0.01). Treatment with RP extract exhibited similar effects on NO, IL-6, and TNF-${\alpha}$, decreasing those levels to 51-84% of the control (p<0.01). In dextran sulfate sodium-treated ulcerative colitis mice, dietary treatment with 1% RP for 7 days decreased the colonic levels of prostaglandin $E_2$ and leukotriene $B_4$ to 34% and 58% of the control, respectively (p<0.05). Dietary P treatment, however, did not decrease those levels significantly. These results indicate that roasted perilla seed exerts anti-inflammatory activity both in vitro and in vivo.

• Journal of Oral Medicine and Pain
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• v.37 no.1
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• pp.19-25
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• 2012

Personality characteristics of recurrent aphthous ulcer patients was analyzed psychologically by means of the SCL-90-R. The patients, 20 recurrent aphthous ulcer(RAU) patients, 33 oral lichen planus patients who visited Department of Oral Medicine, in Pusan National University Dental Hospital from 2010 to 2011. 59 control were collected from students of School of Dentistry, in Pusan National University. The obtained results were as follows. 1. Mean values of T-scores on 9 basic scales in RAU patients group, oral lichen planus patients group and control group were within normal range. 2. The T-score of SOM in RAU patients group were significantly higher than that in the control group. 3. The T-score of SOM, DEP, HOS in RAU female patients group were remarkably higher than that in the female control group. 4. The T-score of HOS in RAU patients group were significantly higher than that in the oral lichen planus patients group.

• Journal of Korean Society of Forest Science
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• v.95 no.1
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• pp.139-144
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• 2006

Chestnut trees have been severely damaged by the various cankers in Korea. Field surveys for elucidating the relationships between disease occurrence and environmental factors, i.e., tree age, temperature, rainfall precipitation, direction, degree of slope, chemical properties of soils, and so on, were carried out in the chestnut tree plantations located at Gyeongnam, Jeonnam, Chungnam, and Gyeonggi-Do Province. Totally, one thousand and one hundred thirty seven trees from 36 experiment plots were investigated. Trees infected by at least one of the canker fungi were estimated up to 66%. The most severely infested area was Sunchon in Jeonnam Province with the rate of 80%, while the most lightly infested area was Kongju in Chungnam Province with 39%. Disease occurrence was found to be highly correlated with tree age. The disease occurred most frequently on trees ranged from 7 to 12 years old, while it was relatively low on trees below 5 years old or above 25 years old. Canker positions on the tree formed by the pathogenic fungi were most often at 1.6-2.0m above the ground. Over five hundreds bark samples from the canker area on the tree were collected and the pathogenic fungi were isolated. The most commonly isolated fungus was identified as Cryphonectria parasitica, the chestnut blight fungus.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.2
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• pp.177-182
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• 2009

Purpose: Colitis is a condition associated with a spectrum of altered morphologic changes and cellular adhesion. E-cadherin plays a key role in the establishment and maintenance of epithelial tissue structure and cell-cell adhesion. The purpose of this study is to evaluate E-cadherin expression in colonic epithelium of various colitis in children. Methods: The expressions of E-cadherin were examined in 39 cases of colonic mucosal biopsy specimen using immunohistochemical staining. When more than 50 percent of cells exhibited uniformly the same intensity and pattern of immunostaining as the adjacent normal mucosa, the antigen expression was considered normal. Abnormal expression was defined when less than 50 percent of cells stained, when cells showed a heterogeneously weak or altered distribution, or when complete absence of staining was observed. Results: Fifteen cases with non-specific colitis (38.5%), 7 cases of with Crohn's disease (17.9%), 5 cases of infectious colitis and milk protein sensitive proctocolitis (12.8%), 3 cases of ulcerative colitis (7.7%), 2 cases of Henoch-Schonlein purpura colitis (5.1%), one case of Behcet's disease and ischemic colitis (2.6%) were included in this study. E-cadherin expression was decreased in all kinds of colitis. Reduced expression of E-cadherin was observed in 77 percent of cases. E-cadherin was weaker or no expression in reparative epithelium and "ulcer associated cell lineage". Conclusion: Altered expression of E-cadherin occurs during mucosal inflammation in any kinds of colitis. These changes may be involved in promoting cell migration during epithelial restitution of the gastrointestinal mucosa.

• Journal of Veterinary Clinics
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• v.30 no.3
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• pp.210-213
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• 2013

We herein describe a feline case of facial dermatitis whose histopathological features resembled to those of FHV-associated ulcerative dermatitis. A 3-year-old, intact male domestic short-haired cat was presented with 2-years history of pruritic dermatitis that initially appeared on periocular area and extended toward the entire face. The cat had ocular discharge and conjunctivitis from 2-month of age. Clinically, skin lesions were characterized as erythema, erosions and ulcers covered with crusts on the facial and perianal area. Histopathologically, the facial lesion was characterized as interface dermatitis with hydropic degeneration at the basal layer, and single cell necrosis of keratinocytes. In addition, the epidermal and dermal necrosis infiltrated with eosinophils, and intranuclear inclusion bodies in keratinocytes were also recognized. Moreover, feline herpesvirus-1 gene was detected by a PCR analysis using a swab obtained from the crusted lesions. Based upon these findings, the present case was considered as having FHV-associated ulcerative dermatitis. Therapy including oral acyclovir and topical recombinant feline interferon omega resulted in marked improvement of the skin and mucosal lesions.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.317-326
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• 2019

The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both MAPK) and nuclear factor-kappa B (NF-${\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazin.

• Korean Journal of Agricultural and Forest Meteorology
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• v.24 no.4
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• pp.305-317
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• 2022

To investigate the blossom infection risk of fire blight on pears, the program Maryblyt has been executed from 2018 to 2022 based on meteorological data from central-Korean cities where fire blight has occurred as well as from southern Korean cities where the disease has not yet occurred. In the past five years, years with the highest risk of pear blossom blight were 2022 and 2019. To identify the optimal time for spraying, we studied the spray mode according to the Maryblyt model and recommend spraying streptomycin on the day after a "High" warning and then one day before forecasted precipitation during the blossom period. Maryblyt also recommends to initiate surgical controls from mid-May for canker blight symptoms on pear trees owing to over-wintering canker in Korea. Web-cam pictures from pear orchards at Cheonan, Icheon, Sangju, and Naju during the flowering period of pear trees were used for comparing real data and constructing a phenological model. The actual starting dates of flowering at southern cities such as Sangju and Naju were consistently earlier than those calculated by the model. It is thus necessary to improve the forecasting model to include field risks by recording the actual flowering period and the first day of the fire blight symptoms, according to the farmers, as well as mist or dew-fall, which are not easily identifiable from meteorological records.

• Journal of the Korea Society of Computer and Information
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• v.27 no.9
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• pp.1-12
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• 2022

Traditional methods of measuring corneal ulcers were difficult to present objective basis for diagnosis because of the subjective judgment of the medical staff through photographs taken with special equipment. In this paper, we propose a method to detect the ulcer area on a pixel basis in corneal ulcer images using a semantic segmentation model. In order to solve this problem, we performed the experiment to detect the ulcer area based on the DeepLab model which has the highest performance in semantic segmentation model. For the experiment, the training and test data were selected and the backbone network of DeepLab model which set as Xception and ResNet, respectively were evaluated and compared the performances. We used Dice similarity coefficient and IoU value as an indicator to evaluate the performances. Experimental results show that when 'crop & resized' images are added to the dataset, it segment the ulcer area with an average accuracy about 93% of Dice similarity coefficient on the DeepLab model with ResNet101 as the backbone network. This study shows that the semantic segmentation model used for object detection also has an ability to make significant results when classifying objects with irregular shapes such as corneal ulcers. Ultimately, we will perform the extension of datasets and experiment with adaptive learning methods through future studies so that they can be implemented in real medical diagnosis environment.

• The Monthly Diabetes
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• s.289
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• pp.37-41
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• 2013

당뇨 족은 하지 절단의 비외상성 원인의 가장 많은 부분을 차지한다고 합니다. 당뇨 환자에서는 하지를 절단할 가능성이 당뇨가 없는 환자보다 최저 15배에서 최고 46배까지 높다는 보고가 있습니다. 더욱이 당뇨족에 의한 합병증은 당뇨 환자의 입원 이유 중 25%에 이른다는 보고도 있습니다. 대부분의 당뇨 족 환자에서 합병증은 피부 궤양에서 시작되는데 일찍 발견하여 적절히 치료하는 것이 하지 절단을 피하는 것에 있어 매우 중요합니다. 이를 방치하였을 때 하지 절단으로 이어질 수 있는 당뇨 족의 원인 예방, 진단 및 치료에 대해 알아보도록 하겠습니다.

• The Monthly Diabetes
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• s.289
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• pp.42-47
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• 2013

당뇨병이 증가함에 따라 당뇨환자의 발에 궤양(당뇨발)이 생겨 발을 절단하는 경우가 증가하고 있다. 이는 당뇨환자에게 심리적 문제나 경제적 비용뿐만 아니라 육체적 장애 및 사망의 주요 원인이 되고 있다. 그러나 당뇨환자의 건강한 발관리가 중요하다는 인식은 아직 미미한 상태이다. 당뇨발이 발생하는 원인을 잘 알고 미리 발 관리를 시행하는 것은 중요하다. 또한 당뇨발 증상을 조기 인식하는 것만이 발을 절단할 가능성을 줄일 수 있는 방법이다. 이 쳅터에서는 당뇨발 발생 위험요인에 대해 알아보고 당뇨발을 예방하기 위한 발 관리법은 무엇인지 살펴보도록 하겠다.