• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.2046-2050
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• 2008

현재까지 우리나라에서 주로 사용되고 있는 2차원 흐름 해석 모형은 미연방 도로국(U.S. Federal Highway Administration)과 연계하여 Brigham Young University에서 개발된 SMS(Surface-Water Modeling System)모형이다. SMS모형 중 이송 확산 모형으로는 RMA-4가 포함되나 이 모형은 최신 수치기법을 반영하지 못하는 등의 문제점들로 인해 실제 물리적 현상을 모의에 있어서 한계를 가지고 있다. 따라서 물리적 현상에 대한 적절한 모의를 위해 여러 개선과정을 거쳐 RAM4가 개발되었다. 본 연구를 위해 점적분 유사량 측정기(P-61)와 대하천 유속계를 사용하여 대상구간의 SS자료 및 유속의 2차원적 분포를 취득하였고, SMS의 Pre-processing 기능을 이용하여 유한요소망을 구성하였다. 구성된 유한요소망과 흐름모형인 RMA-2를 사용하여 대상구간의 유속장을 모의하였다. 이때 모의된 유속장과 현장에서 취득한 유속분포를 비교하여 RMA-2를 검증하였고, SS자료와 RAM4로 모의된 농도장을 비교하여 RAM4를 검증하였다. 검증된 두 모형을 바탕으로 대상 구간에서 다량의 점오염원이 투입되는 가상의 시나리오를 선정 및 적용하여 오염물 이송 및 확산 거동에 대해 살펴보았다. 본 연구의 대상 하천은 형산강으로써, 유역 내에 경주시와 포항시가 위치하고 이 두 도시를 잇는 산업도로가 형산강 본류 위를 지나고, 또한 두 도시를 관류하고 있어 다른 국가하천과 마찬가지로 지속적이고 안정적인 수질관리가 필요한 하천이다, 모의구간은 형산강 본류 중 No. 68(안강 수위관측소 상류 약 350 m)에서 No. 48(부조 수위관측소 하류 약 200 m)까지로서, 약 4.3 km 구간을 모의 하였다. 모의구간 시점에서 약 0.35 km 지점에 산업도로의 일부분인 강동대교, 0.98 km 지점에 왕신천 유입, 1.35 km 지점에 수중보, 1.8 km 지점에 국당1교, 3.2 km 지점에 국당2교가 위치하며 구간 내에는 만곡 및 사행, 특히 수중보 전 후로 사주가 발달해있어 2차원 흐름 및 이송확산 모의에 적합하다고 판단되었다.

• Clinical and Experimental Pediatrics
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• v.53 no.4
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• pp.603-606
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• 2010

Paraneoplastic limbic encephalitis, a remote effect of cancer without nervous system metastasis, is rare, especially in childhood. Here, we report a case of paraneoplastic limbic encephalitis associated with an ovarian mature teratoma in an adolescent girl. The 15-year-old girl developed neuropsychiatric symptoms, memory loss, seizures, and unconsciousness. Cerebrospinal fluid analysis and brain magnetic resonance imaging (MRI) findings were normal, while single photon emission computed tomography imaging showed hypoperfusion in both temporal lobes. Ultrasound and MRI of the abdomen revealed a left ovarian cystic mass. The patient experienced a significant recovery of cognitive function after surgical resection of the tumor, which was pathologically identified as a mature ovarian teratoma, and treatment with intravenous immunoglobulin.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.228-228
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• 2018

강변여과는 지하수 인공함양 방식 중 유도함양(induced recharge) 또는 간접함양 방식에 속한다. 이는 하천 및 강변 부근에 집수시설을 설치한 후, 미고결층 대수층(unconsolidated aquifer)의 자연 오염 저감능을 이용하여 지표수를 간접 취수하는 방식으로 수질이 불량한 지표수가 대수층을 관류하면서 희석, 화학적 이온 교환 및 반응, 흡착, 생물막(biofilm; 미생물에 의한 자연저감), 여과 등을 통하여 수질이 개선된다. 강변여과수내의 용존 농도가 높은 철과 망간은 수처리 비용증가, 용수관정 및 시설물의 수명단축을 초래한다. 따라서 강변여과 지역의 미고결 대수층에서 효과적인 철과 망간 동시 제거(vyredox)를 위해 에어서징(air surging)과 블록 서징(block surging)을 실시하기 위해서 실내 물탱크 모델(water tank model)에서 에어서징에 따른 공기 순환 우물시스템을 관찰하였으며, 이를 바탕으로 현장시험(Test bed)에 적용하였다. 미고결 대층수층에서의 철 망간은 음용수 기준치(각각 0.3 mg/L)를 초과하고 있으며, 강변여과 취수 개발 및 이용을 제한하는 요인이 되고 있다. 본 연구에서 사용된 에어서징과 블록서지 기술은 자갈층 및 미고결 대수층에 충진된 슬라임 및 폐색(clogging)을 제거함과 동시에 관정 주변의 대수층의 투수성 개선과 산화환경으로 치환되며, 대수층에 잔존하는 철/망간의 산화물들을 관정내로 빼낼 수 있는 방법이다. 따라서 서징에 따른 폐색 제거효율을 검토한 결과에서 철 망간 이온농도 저감효과와 관정 주변의 수리전도도(hydraulic conductivity) 및 저류계수(coefficient of storage)가 증가한 것으로 나타났다. 이와 같이 강변여과에 의한 폐색은 미고결층내 공기주입 및 블록서지를 통하여 철/망간 이온농도 저감 및 수리특성 개선 효과에 유용한 것으로 평가된다.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.4
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• pp.434-442
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• 2022

Highly toxic chemical warfare agents(CWA) could be used in chemical warfare and terrorism. The protection of skin is crucial for civilians and soldiers, because the primary routes of exposure to CWA are inhalation and skin absorption. Thus, topical skin protectants(TSP) have been studied and developed in many countries to complement protective equipments. In this study, in-vitro test procedure was optimized and established using a flow-through diffusion cell system containing excised hairless mouse skin in an attempt to assess the effectiveness of various TSP formulations against nerve agent simulants. In addition, the test results on the formulations including the ingredients used in SERPACWA(Skin Exposure Reduction Paste Against Chemical Warfare Agent) and IB-1(TSP of Israel) were included, indicating that the formulations with perfluorinated compounds were more effective than the glycerin-based formulations.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.144-144
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• 2020

국내의 하천은 급격한 도시화 및 산업화로 인해 자연하천의 모습은 사라지고 이수와 치수 기능 위주의 하천관리가 이루어졌다. 하천은 치수기능을 강조하여 인공적으로 변화하였을 뿐만 아니라 하천생태환경 내에 서식하는 동식물의 서식 환경에도 교란을 야기하였다. 최근 하천관리의 패러다임이 변화함에 따라서, 하천이 갖는 자연적 특성을 회복하는 환경적 측면을 강조한 생태하천 복원사업에 대한 관심이 높아지고 있으나, 수생생물 서식지 복원과 생태계에 필요한 환경유량에 관한 정량적인 평가를 위한 연구는 부족한 실정이다. 본 연구는 경상북도 김천시와 구미시를 관류하여 낙동강으로 합류되는 감천을 대상으로 하였으며, 댐 건설로 인한 하천 생태계 변화 및 하천유량에 대한 통계적 분석, 수리 모델링, 하천구역의 공간적 분석을 진행하였다. 통계적 분석을 위한 시계열 자료 구축은 감천 하류에 있는 선산관측소의 2002년 ~ 2019년까지 수위, 유량을 사용하였으며, 김천부항댐이 건설 된 2014년 1월 1일을 기점으로 댐 건설 전(2002 ~ 2013)과 댐 건설 후(2014 ~ 2019)로 구분하였다. HEC-EFM(Ecosystem Function Model)을 활용하여 어류를 포함한 수생생물의 성공적인 서식을 위한 환경유량을 산정하였다. 산정된 환경유량을 HEC-GeoRAS(Geographic River Analysis System)와 HEC-GeoEFM(Geographic Ecosystem Function Model)을 적용·연계하여 수생식생 도입이 가능한 하천 구간과 어류 산란 및 성장에 적합한 하천구간을 표현하였으며, 댐 건설 전후의 서식지 면적을 계산하여 수생생물의 성공적인 서식환경이 조성되었는지 확인하였다. 본 연구를 바탕으로 수생생물의 하천 서식지 개선을 위한 명확한 환경유량을 수립하는 데 도움이 될 것으로 판단된다.

• The Korean Journal of Nuclear Medicine
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• v.34 no.5
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• pp.381-392
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• 2000

Purpose: We compared the reproducibility of $^{201}Tl\;and\;^{99m}Tc$-sestamibi (MIBI) gated SPECT measurement of myocardial function using the Germano algorithm Materials and Methods: Gated SPECT acquisition was repeated in the same position in 30 patients who received $^{201}Tl$ and in 26 who received $^{99m}Tc$-MIBI. The quantification of end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) on $^{201}Tl\;and\;^{99m}Tc$-MIBI gated SPECT was processed independently using Cedars quantitative gated SPECT software. The reproducibility of the assessment of myocardial function on $^{201}Tl$ gated SPECT was compared with that of $^{99m}Tc$-MIBI gated SPECT Results: Correlation between the two measurements for volumes and EF was excellent by the repeated gated SPECT studies of $^{201}Tl$ (r=0.928 to 0.986; p<0.05) and $^{99m}Tc$-MIBI (r=0.979 to 0.997; p<0.05). However, Bland Altman analysis revealed the 95% limits of agreement (2 SD) for volumes and EF were tighter by repeated $^{99m}Tc$-MIBI gated SPECT (EDV: 14.1 ml, ESV: 9.4 ml and EF: 5.5%) than by repeated $^{201}Tl$ gated SPECT (EDV: 24.1 ml, ESV: 18.6 ml and EF: 10.3%). The root mean square (RMS) values of the coefficient of variation (CV) for volumes und EFs were smaller by repeated $^{99m}Tc$-MIBI gated SPECT (EDV: 2.1 ml, ESV 2.7 ml and EF: 2.3%) than by repeated $^{201}Tl$ gated SPECT (EDV: 3.2 ml, ESV: 3.5 ml and EF: 5.2%). Conclusion: $^{99m}Tc$-MIBI provides more reproducible volumes and EF than $^{201}Tl$ on repeated acquisition gated SPECT. $^{99m}Tc$-MIBI gated SPECT is the preferable method for the clinical monitoring of myocardial function.

• Tuberculosis and Respiratory Diseases
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• v.39 no.6
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• pp.474-483
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• 1992

Background: Regardless of its causes, acute lung injury is characterized pathophysiologically by increased pulmonary arterial pressure and the protein-rich edema. Many inflammatory mediators are known to be involved in the pathogenesis of acute lung injury, including oxygen free radicals (OFR). But the changes in pulmonary capillary pressure in the OFR-induced acute lung injury is not clear. While the pulmonary edema characterized by the movement of fluid and solutes is dependent on the pressure gradient and the alveolar-capillary permeability, the role of pulmonary capillary pressure in the development of pulmonary edema is also not well understood. Method: Male Sprague-Dawley rats were divided into 5 groups: normal control (n=5), xanthine/xanthine oxidase (X/XO)-treated group (n=7), catalase-pretreated group (n=5), papaverine-pretreated group (n=7), and indomethacin-pretreated group (n=5). In isolated perfused rat lungs, the sequential changes in pulmonary arterial pressure, pulmonary capillary pressure by double occlusion method, and lung weight as a parameter of pulmonary edema were determined. Results: Pulmonary arterial pressure and pulmonary capillary pressure were increased by X/XO. This increase was significantly attenuated by catalase and papaverine, but indomethacin did not prevent the X/XO-induced increase. Lung weight gain was also observed by X/XO perfusion. It was prevented by catalase. Papaverine did not completely block the increase, but significantly delayed the onset. Indomethacin had no effect on the increase in lung weight. Conclusion: These data suggest that increased pulmonary capillary pressure by OFR may aggravate pulmonary edema in the presence of increased alveolar-capillary permeability and this may not be mediated by cyclooxygenase metabolites.

• Journal of Chest Surgery
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• v.38 no.2 s.247
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• pp.101-109
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• 2005

Background: In sudden cardiac arrest, the effective maintenance of coronary artery blood flow is of paramount importance for myocardial preservation as well as cardiac recovery and patient survival. The purpose of this study was to directly compare the effects of pulsatile and non-pulsatile circulation to coronary artery flow and myocardial preservation in cardiac arrest condition. Material and Method: A cardiopulmonary bypass circuit was constructed in a ventricular fibrillation model using fourteen Yorkshire swine weighing $25\~35$ kg each. The animals were randomly assigned to group I (n=7, non-pulsatile centrifugal pump) or group II (n=7, pulsatile T-PLS pump). Extra-corporeal circulation was maintained for two hours at a pump flow of 2 L/min. The left anterior descending coronary artery flow was measured with an ultrasonic coronary artery flow measurement system at baseline (before bypass) and at every 20 minutes after bypass. Serologic parameters were collected simultaneously at baseline, 1 hour, and 2 hours after bypass in the coronary sinus venous blood. The Mann-Whitney U test of STATISTICA 6.0 was used to determine intergroup significances using a p value of < 0.05. Result: The resistance index of the coronary artery was lower in group II and the difference was significant at 40 min, 80 min, 100 min and 120 min (p < 0.05). The mean velocity of the coronary artery was higher in group II throughout the study, and the difference was significant from 20 min after starting the pump (p < 0.05). The coronary artery blood flow was higher in group II throughout the study, and the difference was significant from 40 min to 120 min (p < 0.05) except at 80 min. Serologic parameters showed no differences between the groups at 1 hour and 2 hours after bypass in the coronary sinus blood. Conclusion: In cardiac arrest condition, pulsatile extracorporeal circulation provides more blood flow, higher flow velocity and less resistance to coronary artery than non-pulsatile circulation.

• Journal of the Korean Society of Radiology
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• v.15 no.5
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• pp.591-602
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• 2021

Acute ischemic stroke(AIS) should be diagnosed within a few hours of onset of cerebral infarction symptoms using diagnostic radiology. In this study, we evaluated the clinical usefulness of SVD and the Bayesian algorithm to measure the volume of cerebral infarction using computed tomography perfusion(CTP) imaging and magnetic resonance diffusion-weighted imaging(MR DWI). We retrospectively included 50 patients (male : female = 33 : 17) who visited the emergency department with symptoms of AIS from September 2017 to September 2020. The cerebral infarct volume measured by SVD and the Bayesian algorithm was analyzed using the Wilcoxon signed rank test and expressed as a median value and an interquartile range of 25 - 75 %. The core volume measured by SVD and the Bayesian algorithm using was CTP imaging was 18.07 (7.76 - 33.98) cc and 47.3 (23.76 - 79.11) cc, respectively, while the penumbra volume was 140.24 (117.8 - 176.89) cc and 105.05 (72.52 - 141.98) cc, respectively. The mismatch ratio was 7.56 % (4.36 - 15.26 %) and 2.08 % (1.68 - 2.77 %) for SVD and the Bayesian algorithm, respectively, and all the measured values had statistically significant differences (p < 0.05). Spearman's correlation analysis showed that the correlation coefficient of the cerebral infarct volume measured by the Bayesian algorithm using CTP imaging and MR DWI was higher than that of the cerebral infarct volume measured by SVD using CTP imaging and MR DWI (r = 0.915 vs. r = 0.763 ; p < 0.01). Furthermore, the results of the Bland Altman plot analysis demonstrated that the slope of the scatter plot of the cerebral infarct volume measured by the Bayesian algorithm using CTP imaging and MR DWI was more steady than that of the cerebral infarct volume measured by SVD using CTP imaging and MR DWI (y = -0.065 vs. y = -0.749), indicating that the Bayesian algorithm was more reliable than SVD. In conclusion, the Bayesian algorithm is more accurate than SVD in measuring cerebral infarct volume. Therefore, it can be useful in clinical utility.

• The Journal of the Acoustical Society of Korea
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• v.26 no.7
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• pp.343-352
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• 2007

The present study aims to investigate the design standard for acoustic criteria of Korean traditional music which could be used for the design of Korean traditional music halls. In order to do this, subjective listening tests were undertaken to musicians using auralized sounds which were convolved with the impulse response of traditional instruments recorded in an anechoic chamber. 94 pairs of sound were made which have different value of acoustic parameters including RT, BR, Brilliance, G, C80, ITDG, IACC. A paired comparison method(PCM) was used to analyze the results from the subjective listening tests. The results show that the preference of acoustic criteria for the Korean traditional music is far different from those of western music. As a result, specific range of acoustic criteria were suggested for the appropriate acoustic conditions of Korean traditional music. Also, a guideline of the acoustic design of halls for performing the Korean traditional music was suggested which could be used as a basic reference in the future works.