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http://dx.doi.org/10.9766/KIMST.2022.25.4.434

In-vitro Tests of Topical Skin Protectants using a Flow-Through Diffusion Cell System Containing Excised Hairless Mouse Skin  

Lee, Eun Young (Drug Delivery Research Team, Cellgentek Co, LTD.)
Choi, Hoo Kyun (Drug Delivery Research Team, Cellgentek Co, LTD.)
Kim, Sang Woong (Research and Development Center, Hanso Inc.)
Seo, Dong Sung (Research and Development Center, Hanso Inc.)
Joe, Hae Eun (Chem-Bio Technology Center, Agency for Defense Development)
Yu, Chi Ho (Chem-Bio Technology Center, Agency for Defense Development)
Kim, Chang Hwan (Chem-Bio Technology Center, Agency for Defense Development)
Cho, Young (Research and Development Center, Hanso Inc.)
Publication Information
Journal of the Korea Institute of Military Science and Technology / v.25, no.4, 2022 , pp. 434-442 More about this Journal
Abstract
Highly toxic chemical warfare agents(CWA) could be used in chemical warfare and terrorism. The protection of skin is crucial for civilians and soldiers, because the primary routes of exposure to CWA are inhalation and skin absorption. Thus, topical skin protectants(TSP) have been studied and developed in many countries to complement protective equipments. In this study, in-vitro test procedure was optimized and established using a flow-through diffusion cell system containing excised hairless mouse skin in an attempt to assess the effectiveness of various TSP formulations against nerve agent simulants. In addition, the test results on the formulations including the ingredients used in SERPACWA(Skin Exposure Reduction Paste Against Chemical Warfare Agent) and IB-1(TSP of Israel) were included, indicating that the formulations with perfluorinated compounds were more effective than the glycerin-based formulations.
Keywords
Flow-through Diffusion Cell; Topical Skin Protectant; Chemical Warfare Agents; Perfluorinated Polyether; Polytetrafluoroethylene; Glycerin;
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Times Cited By KSCI : 1  (Citation Analysis)
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