Journal of the Korea Institute of Military Science and Technology (한국군사과학기술학회지)

The Korea Institute of Military Science and Technology (한국군사과학기술학회)
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In-vitro Tests of Topical Skin Protectants using a Flow-Through Diffusion Cell System Containing Excised Hairless Mouse Skin

생체 피부조직을 이용한 피부보호제 in-vitro 시험평가

  • Lee, Eun Young (Drug Delivery Research Team, Cellgentek Co, LTD.) ;
  • Choi, Hoo Kyun (Drug Delivery Research Team, Cellgentek Co, LTD.) ;
  • Kim, Sang Woong (Research and Development Center, Hanso Inc.) ;
  • Seo, Dong Sung (Research and Development Center, Hanso Inc.) ;
  • Joe, Hae Eun (Chem-Bio Technology Center, Agency for Defense Development) ;
  • Yu, Chi Ho (Chem-Bio Technology Center, Agency for Defense Development) ;
  • Kim, Chang Hwan (Chem-Bio Technology Center, Agency for Defense Development) ;
  • Cho, Young (Research and Development Center, Hanso Inc.)
  • 이은영 ((주)셀젠텍 약물전달기술연구팀) ;
  • 최후균 ((주)셀젠텍 약물전달기술연구팀) ;
  • 김상웅 (한소주식회사 부설연구소) ;
  • 서동성 (한소주식회사 부설연구소) ;
  • 조혜은 (국방과학연구소 Chem-Bio기술센터) ;
  • 유치호 (국방과학연구소 Chem-Bio기술센터) ;
  • 김창환 (국방과학연구소 Chem-Bio기술센터) ;
  • 조영 (한소주식회사 부설연구소)
  • Received : 2022.03.08
  • Accepted : 2022.07.22
  • Published : 2022.08.05
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Abstract

Highly toxic chemical warfare agents(CWA) could be used in chemical warfare and terrorism. The protection of skin is crucial for civilians and soldiers, because the primary routes of exposure to CWA are inhalation and skin absorption. Thus, topical skin protectants(TSP) have been studied and developed in many countries to complement protective equipments. In this study, in-vitro test procedure was optimized and established using a flow-through diffusion cell system containing excised hairless mouse skin in an attempt to assess the effectiveness of various TSP formulations against nerve agent simulants. In addition, the test results on the formulations including the ingredients used in SERPACWA(Skin Exposure Reduction Paste Against Chemical Warfare Agent) and IB-1(TSP of Israel) were included, indicating that the formulations with perfluorinated compounds were more effective than the glycerin-based formulations.

Keywords

Acknowledgement

본 연구는 국방과학연구소의 연구비(과제명: rTSP제재 피부 보호 및 제독제 개발) 지원을 받아 수행되었으며 기술적으로 도와주신 국방과학연구소 Chem-Bio 기술센터에 감사 드립니다.

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