Unlike benign tumors, malignant tumors are capable of metastasis, easy to relapse, poor survival, and low quality of life. In Korea, here is a tendency to treat the tumors collectively according to the General Principles of Cancer Chemotherapy(GPCC) of the Health Insurance Review & Assessment Service (HIRA). But recently, companion diagnostics(CDx) is recommended rather than unilateral medication because biomarker-based molecular diagnostics is possible to predict the drug response of patients before drug treatment. Not only domestic but also overseas Food and Drug Administratio (FDA) recommends the development of the CDx system at the stage of drug development to ensure the responsiveness and safety of medicines. In this study, I focused on the necessity of CDx development direction as well as CDx development status through literature review. Furthermore I also discussed CDx types according to the molecular diagnostic technology such as immunohistochemistry (IHC), polymerase chain reaction (PCR), in situ hybridization (ISH), and next-generation sequencing (NGS) not only in the approved CDx but also in the developing one by US FDA. And I suggested the technology issue of CDx development process such as a selection of molecular diagnostics at the time of release, a clear understanding of the CDx mechanism, and a convergence of drug with CDx development. The necessity of social insurance system also was proposed for CDx development.
Journal of the Korea Academia-Industrial cooperation Society
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v.20
no.5
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pp.275-284
/
2019
This study was conducted to evaluate the health promotion behavior level, health beliefs, and self-efficacy of individuals preparing for civil service examinations, as well as the main factors that influence their health promotion behavior. The study subjects were 290 individuals who were preparing for civil service examinations in Noryangjin, where there are a lot of private institutions that provide training for the examinations. Data were collected by questionnaire surveys conducted from December 1 to 19, 2017. With the use of SPSS ver. 23, descriptive statistics, t-tests, one-way ANOVA, correlation analysis, and stepwise multiple regression were conducted. On average, the score for health promotion behavior practice was $2.37{\pm}0.45points$, health beliefs $3.13{\pm}0.45points$, and self-efficacy $3.55{\pm}0.74points$. Health promotion behavior was significantly positively correlated with perceived severity and perceived benefits, which are sub factors of health beliefs (r=.60, p<.001; r=.55, p<.001), while it was significantly negatively correlated with perceived barriers, which are a sub factor of health beliefs (r=.32, p<.001). The factors that influenced health promotion behavior were perceived health condition and perceived barriers, and the explanatory power of health promotion behavior was 25.1% (F=13.58, p<.001). In general, respondents studied for the examinations for a long time and were under severe job pressure; accordingly, they need to have quality meals, regular exercise, and regular medical check-ups to enhance health promotion behavior to control their stress.
One of the current issues in Workers' Compensation Insurance is about the coverage range. Korea uses the definition of worker under the Labor Standards Act in Workers' Compensation Act and solved the problems associated with the coverage range of insurance group by the exceptional clause only for the groups which was raised about the need for the social protection. The purpose of this paper is to draw implications for solving problems which are associated with the coverage range of insurance group by reviewing the German literature. We focus on volunteers and persons in special types of employment. German government supports the activity of volunteers by providing with the protection service against the accidents. This paper shows how the coverage range is extended from the dependent employees in the introduction of the Workers' Compensation Insurance to the people who need social protection focusing on the volunteers. The implications of this research are following. First, German system shows that Workers' Compensation Insurance can be extended to the groups which do not belong to the dependent employee but are worthy of protection. Second, it is necessary to provide volunteers in the social welfare system with the protection service against the accidents and the statutory accident scheme is recommendable to use. Third, volunteers in the social welfare system need to be compulsory insured. Fourth, Korea should find their own way in solving problems associated with persons in special types of employment.
Journal of the Korea Institute of Information Security & Cryptology
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v.18
no.6A
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pp.139-149
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2008
The amount of personal information collected by organizations and government agencies is continuously increasing. When a data collector publishes personal information for research and other purposes, individuals' sensitive information should not be revealed. On the other hand, published data is also required to provide accurate statistical information for analysis. k-Anonymity and ${\iota}$-diversity models are popular approaches for privacy preserving data publication. However, they are limited to static data release. After a dataset is updated with insertions and deletions, a data collector cannot safely release up-to-date information. Recently, the m-invariance model has been proposed to support re-publication of dynamic datasets. However, the m-invariant generalization can cause high information loss. In addition, if the adversary already obtained sensitive values of some individuals before accessing released information, the m-invariance leads to severe privacy disclosure. In this paper, we propose a novel technique for safely releasing dynamic datasets. The proposed technique offers a simple and effective method for handling inserted and deleted records without generalization. It also gives equivalent degree of privacy preservation to the m-invariance model.
Objectives : To identify the relationship between somatization, stress, depression, anxiety, and psychological symptoms risk for nurses working in the intensive care unit. Create clinical evidence of psychosomatic medicine research and complement the meaning of somatization. Methods : Seventy of the mental health checkups conducted by the National Mental Health Center among the nurses using tools including Perceived Stress scale, Fatigue Severity Scale, Patient Health questionnaire-15, Korean Beck Depression Inventory, Korean Beck Anxiety Inventory, and Symptom Checklist-90-Revision. Results : 12.9% of the patients experienced more than moderate somatization. There was no statistical relationship between somatization and psychological stress perception, but feeling of anxiety and decreased self-confidence were related to the level of somatization. The group with severe somatization experienced more depression and anxiety. The group with high physical fatigue also had no statistical relationship with psychological stress perception, but had an effect on the feeling of tension, stress, or decreased control. Physical fatigue level was increased by experience of depression, not by anxiety. For psychological symptoms the higher the level of somatization, the higher the obsession and hostility was explored. In the linear regression model, stress, depression, and anxiety accounted for 39.3% of somatization and 16.1% of physical fatigue symptoms. Conclusions : We can estimate the decrease in stress cognitive symptoms, accompanying depression and anxiety, compulsion and hostility as characteristics of somatization. The causal relationship between somatization and psychological symptoms cannot be confirmed in this study, but the interrelationships are observed, can be referred to mediation strategies.
IoT devices, which are used in various ways in distributed environments, are becoming more important in data transmitted and received from IoT devices as fields of use such as medical, environment, transportation, bio, and public places are diversified. In this paper, as a method to ensure the reliability of IoT data, an autoencoder-based IoT-linked processing technique is proposed to classify and process numerous data by various important attributes. The proposed technique uses correlation indices for each IoT data so that IoT data is grouped and processed by blockchain by characteristics for IoT linkage processing based on autoencoder. The proposed technique expands and operates into a blockchain-based n-layer structure applied to the correlation index to ensure the reliability of IoT data. In addition, the proposed technique can not only select IoT data by applying weights to IoT collection data according to the correlation index of IoT data, but also reduce the cost of verifying the integrity of IoT data in real time. The proposed technique maintains the processing cost of IoT data so that IoT data can be expanded to an n-layer structure.
Journal of the Korean Association of Geographic Information Studies
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v.25
no.1
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pp.77-100
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2022
In the era of low growth, many provincial cities are experiencing population decline and aging. Population decline phenomena such as reduction of productive manpower, reduction of finances, deterioration of quality of life, and collapse of the community base are occurring in a chain and are being pushed to the brink of extinction of the cities. This study aims to propose a methodology to objectively estimate the employment creation centers and setting the basic unit of industrial-centered zoning by applying spatial statistical techniques and GIS for the application of the compact city plan as an efficient spatial management policy in a city with a declining population. In details, based on reviewing previous studies on compact city, 'employment complex index(ECI)' were defined considering the number of workers, the number of settlers, and the area of development land, the employment creation center was estimated by applying the 'Local Moran's I' and 'Getis-Ord's Hot-Spot Analysis'. As a case study, changes in the four years of 2013, 2015, 2017, and 2019 were compared and analyzed for Changwon City. As a result, it was confirmed that the employment creation center is becoming compacted and polycentric, which is a significant result that reflects the actual situation well. This results provide the basic data for functional and institutional territorial governance for the regional revitalization platform, and provide meaningful information necessary for spatial policy decision-making, such as population reduction, regional gross domestic product, and public facility arrangement that can respond to energy savings, transportation plans, and medical and health plans.
The Journal of the Convergence on Culture Technology
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v.8
no.3
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pp.15-23
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2022
This study is a non-equivalent control group quasi-experimental design to test the effectiveness of educational programs on human tissue donation for nursing students to change the perception of human tissue donation. The subjects of the study were 75 nursing students located in U city, 38 in the experimental group and 37 in the control group. The data were analyzed using SPSS/WIN 23.0. The average age was 22.39±0.75 years old, women 84.2% and there was no difference in general characteristics and prior data between the two groups. Knowledge (F=-8.921, p<).001, Attitude (F=-5.414, p<).001, perception of death (F=-3.075, p=).004) showed a significant difference, and the educational intervention of nursing students developed to promote human tissue donation showed a positive effect on human tissue donation. When programs to be applied to educational institutions that train not only medical personnel but also experts in other fields must be developed, the establishment and stability of the human tissue donation culture will be solidified. It is also suggested that health care campaigns and education in public educational institutions should be conducted together.
Journal of Korea Entertainment Industry Association
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v.15
no.8
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pp.423-432
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2021
In this study, we investigated and the following conclusions are presented by identifying the current status and problems in order to expand the future's value of the community care project introduced and implemented to improve the quality and care for the elderly's life. First, the needs analysis of the elderly receiving services is composed of patient-centered rather than investigator-centered, and in particular, medical management through medical staff visits should be strengthened, and specialized service items according to gender, age, disability type, and personal preference should be strengthened. This will have to be gradually strengthened. Second, by analyzing the satisfaction, redundancy, and effectiveness of service items, we save money, and consider the consumer-oriented service item composition and application of items necessary for new services. Third, through the introduction of an integrated schedule management system, it is necessary to specialize in pre-booking and visit schedule management between the elderly and the direct service organizations that provide services. Fourth, as an effort to solve the financial problem, it is necessary to prepare a rational resource sharing system with health and medical finance, long-term care insurance system, and social welfare financial project. and it may consider that putting the medical personnel who are from local public medical college input. Through these proposals, the community care business will be able to complete and have future value as a universal aged care system.
Seo, Jeong-Wook;Park, Jung-Duck;Eom, Sang-Yong;Kwon, Hee-Won;Ock, Minsu;Lee, Jiho
Journal of Environmental Health Sciences
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v.48
no.4
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pp.227-235
/
2022
Background: Abandoned metal mines are classified as vulnerable areas with the highest level of soil contamination among risk regions. People living near abandoned metal mines are at increased risk of exposure to toxic metals. Objectives: This study aimed to evaluate the correlation between soil contamination levels in areas around abandoned metal mine and the blood lead levels of local residents. Moreover, we assess the possibility of using soil contamination levels as a predictive indicator for human exposure level. Methods: Data from the Survey of Residents around Abandoned Metal Mines (2013~2017, n=4,421) and Investigation of Soil Pollution in Abandoned Metal Mines (2000~2011) were used. A random coefficient model was conducted for estimation of the lower level (micro data) of the local resident unit and the upper level (macro data) of the abandoned metal mine unit. Through a fitted model, the variation of blood lead levels among abandoned metal mines was confirmed and the effect of the operationally defined soil contamination level was estimated. Results: Among the total variation in blood lead levels, the variation between abandoned mines was 18.6%, and the variation determined by the upper-level factors such as soil contamination and water contamination was 8.1%, which was statistically significant respectively. There was also a statistically significant difference in the least square mean of blood lead concentration according to the level of soil contamination (p=0.047, low: 2.32 ㎍/dL, middle: 2.38 ㎍/dL, high: 2.59 ㎍/dL). Conclusions: The blood lead concentration of residents living near abandoned metal mines was significantly correlated with the level of soil contamination. Therefore, in biomonitoring for vulnerable areas, operationally defined soil contamination can be used as a predictor for human exposure level to hazardous substances and discrimination of high-risk abandoned metal mines.
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