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Development and Assessment Individual Maximum Permissible Dose Method of I-131 Therapy in High Risk Patients with Differentiated Papillary Thyroid Cancer (물리학 선량법을 이용한 갑상선암의 개인별 최대안전용량 I-131 치료법 개발과 유용성 평가)

  • Kim, Jeong-Chul;Yoon, Jung-Han;Bom, Hee-Seung;JaeGal, Young-Jong;Song, Ho-Chun;Min, Jung-Joon;Jeong, Heong;Kim, Seong-Min;Heo, Young-Jun;Li, Ming-Hao;Park, Young-Kyu;Chung, June-Key
    • The Korean Journal of Nuclear Medicine
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    • v.37 no.2
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    • pp.110-119
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    • 2003
  • Purpose: Radioiodine (I-131) therapy is an effective modality to reduce both recurrence and mortality rates in differentiated thyroid cancer. Whether higher doses shows higher therapeutic responses was still debatable. The purpose of this study was to validate curve-fitting (CF) method measuring maximum permissible dose (MPD) by a biological dosimetry using metaphase analysis of peripheral blood lymphocytes. Materials and Methods: Therapeutic effects of MPD was evaluated in 58 patients (49 females and 9 males, mean age $50{\pm}11$ years) of papillary thyroid cancer. Among them 43 patients were treated with ${\Leq}7.4GBq$, while 15 patients with ${\geq}9.25GBq$. The former was defined as low-dose group, and the latter high-dose group. Therapeutic response was defined as complete response when complete disappearance of lesions on follow-up I-131 scan and undetectable serum thyroglobulin levels were found. Statistical comparison between groups were done using chi-square test. P value less than 0.05 was regarded as statistically significant. Results: MPD measured by CF method using tracer and therapeutic doses were $13.3{\pm}1.9\;and\;13.8{\pm}2.1GBq$, respectively (p=0.20). They showed a significant correlation (r=0.8, p<0.0001). Exposed doses to blood measured by CF and biological methods were $1.54{\pm}0.03\;and\;1.78{\pm}0.03Gy$ (p=0.01). They also showed a significant correlation (r=0.86, p=0.01). High-dose group showed a significantly higher rate of complete response (12/15, 80%) as compared to the low-dose group (22/43, 51.2%) (p=0.05). While occurrence of side effects was not different between two groups (40% vs. 30.2%, p=0.46). Conclusion: Measurement of MPD using CF method is reliable, and the high-dose I-131 therapy using MPD gains significantly higher therapeutic effects as compared with low-dose therapy.

Analysis of the Structural Characteristics of the Chungnam Display Industry (충남 디스플레이 산업의 구조적 특성 분석)

  • Kim, Dae-Jung;Ko, Kyoung-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.3
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    • pp.620-626
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    • 2021
  • The purpose of this study is to examine the characteristics and industrial structure and to present a future vision through analysis of industrial agglomeration, growth, and industrial efficiency targeting the Chungnam display industry nurtured by regional industrial policies since 2002. The industrial scale and aggregate status were analyzed through the business scale quotient and location quotient, and the growth and pace of structural change in the industry were analyzed through the industrial growth rate and change of industrial structure. Analysis results found the display industry shows its solid status based on industrial agglomeration. The RLQ, added value ratio, and employment coefficient have a relatively high comparative advantage. However, the growth rate has declined, and the pace of structural change has become lower. The regional competitiveness has been deteriorating. It is necessary to develop strategies to help the industry evolve into a convergence display industry to secure competitiveness by forming value chains. The regional industrial policy 'Regional Innovation Growth Plan' should be utilized to foster local industries that consider the regional characteristics and development directions and to promote the shared growth of related subsidiary industries through fostering specialized complexes for materials, parts, and equipment.

An Empirical Study on Factors Affecting the Survival of Social Enterprises Using Non-Financial Information (비재무정보를 이용한 사회적기업의 생존에 영향을 미치는 요인에 관한 실증연구)

  • Hyeok Kim;Dong Myung Lee;Gi Jung Nam
    • Journal of Industrial Convergence
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    • v.21 no.1
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    • pp.111-122
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    • 2023
  • The purpose of this study is to verify the factors affecting survival time by estimating survival rate and survival time using non-financial information of social enterprises using credit guarantee in credit guarantee institutions, and provide information to stakeholders to improve survival rate and employ to contribute to maintaining and expanding the As a research method, survival analysis was performed using a non-parametric analysis method, Kaplan-Meier Analysis. As a sample, 621 companies (577 normal companies, 44 insolvent companies) established between 2009 and 2018 were selected as the target companies. As a result of examining the factors affecting survival time by classifying social enterprise representative information and corporate information, representative credit rating, representative home ownership, credit transaction period, and corporate credit rating were derived as significant variables affecting survival time. In the future, financial institutions will be able to induce corporate soundness by reflecting factors that affect survival when examining loans for social enterprises, contributing to job retention and reduction of social costs. Supporting organizations such as the government and private organizations will be able to use it in various ways, such as policy establishment and education and training for the growth and sustainability of social enterprises. With this study as an opportunity, I hope that research will continue with more interest in the factors influencing social enterprise performance as well as corporate insolvency.

The Effectiveness of the Early Reemployment Bonus: the Role of the Policy Change in 2010 (조기재취업수당 제도의 효과: 2010년 제도 변화를 중심으로)

  • Ahn, Taehyun
    • Journal of Labour Economics
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    • v.37 no.4
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    • pp.1-24
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    • 2014
  • This paper examines the changes in early reemployment bonus system in Korea and investigates its effects on job finding rates of the unemployed and on their reemployment outcomes. The analysis on the characteristics of the recipients reveals that, after the policy change, the probability of receiving the bonus increases among female, older, and less educated job seekers. This paper also shows that exit hazard from unemployment has not changed significantly while the stability of the subsequent jobs has been substantially improved.

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Problems and Improvement of Provincial Rotation Hunting System in Korea (우리나라 도별(道別) 순환수렵제도(循環狩獵制度)의 문제점(問題點)과 개선방향(改善方向))

  • Lee, Jung-Joo;Lee, Woo-Shin;Rhim, Shin-Jae
    • Journal of Korean Society of Forest Science
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    • v.90 no.3
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    • pp.346-354
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    • 2001
  • This study was conducted to investigate the status and problems, and suggest the proper improvement of provincial rotation hunting system in Korea. There were many problems in recently provincial rotation hunting system, such as, difficulty of budget interiority, low participation rate of hunters, low specialization degree of officers on their job, and extremity of illegal capture of wildlife by the absence of wildlife manager. The municipal hunting system, which have many merits, such as, increase of hunters' participation and income of municipality, creation of engagement, and prohibit of illegal capture of wildlife would be suggest for the improvement of hunting system.

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Determinants of Regional Poverty in Korea (지역 빈곤의 격차와 요인에 관한 연구)

  • Kim, Kyo-Seong;Noh, Hye-Jin
    • Korean Journal of Social Welfare
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    • v.61 no.2
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    • pp.85-106
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    • 2009
  • The main purpose of this paper is to examine the structural determinants of regional variations of poverty in Korea. Poverty rates and independent variables in Seoul, 6 other metropolitan areas, and 8 provinces except Jejudo from the year of 1998 through 2006 were pooled as unit of analysis. The pooled cross-sectional time-series regression(TSCSREG) using SAS program was adapted for the analysis. As a result of the analysis, absolute poverty and relative poverty of Gangwondo and Chungcheongnamdo were relatively higher, and that of Seoul and Ulsan metropolitan area were lower than other areas. And, the increase of financial self-reliance, social welfare expenditure, rate of standard workers, and rate of workers in manufacturing sector were associated with lower poverty rates. Therefore, place-based policies should be considered as another poverty-fighting tool in conjunction with people-based policies.

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Estimating the Socioeconomic Costs of Child Poverty (아동 빈곤의 사회경제적 비용 추계)

  • Kim, Soo Jung;Chung, Ick-Joong
    • Korean Journal of Social Welfare
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    • v.69 no.3
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    • pp.9-33
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    • 2017
  • This study estimated the socioeconomic costs of child poverty. Based on previous studies, the present study organized component categories for direct and indirect costs of child poverty, and estimated the cost of each category in 2015 through the collection of existing data and Delphi survey techniques among experts. The total socioeconomic costs of child poverty were compared to Korea's GDP. The results of this study were as follows. First, the socioeconomic costs of child poverty in Korea in 2015 ranged from 55 trillion KW(3.5% of GDP) to 99 trillion KW(6.5% of GDP). Second, the indirect socioeconomic costs of child poverty are much higher than the direct costs. Third, among the total cost categories, costs related to productivity loss and unemployment accounted for the largest portion of both the socioeconomic costs based upon absolute poverty and relative poverty. Crime costs are the second largest. Based on these results, we discussed the importance of early intervention for children in poverty; implementation of two-generation program that intervenes simultaneously with parents and children; and long-term, continuous and integrated intervention for high-risk groups such as poor children.

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Doping Effects with $GeO_{2}$ and $SnO_{2}$ in Mn-Zn Ferrites (Mn-Zn 훼라이트의 $GeO_{2}$$SnO_{2}$ 첨가효과)

  • 최용석;유병두;김종오
    • Journal of the Korean Magnetics Society
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    • v.2 no.2
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    • pp.99-104
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    • 1992
  • The permeability vs. temperature curve, the loss factor and the microstructure of a commercial Mn-Zn ferrites were investigated by X-ray diffractometer, SEM and LCR meter, where the additives, such as $SnO_{2}$ and $GeO_{2}$, were added to the main composition. Their wt% were 0.05, 0.3 and 1.0, respectively. When the content of additives increased, the SPM (Secondary Peak Maximum) of the permeability moved from $80^{\circ}C$ to below the room temperature. This movement, without the significant change of the microstructure, is because Sn and Ge, having the different ionic radius, were soluble in the matrix. There was no variation of the permeability with the frequency up to 100 kHz. And the loss factor showed the maximum value at 10 kHz.

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Outcome of patients with neuroblastoma aged less than 1 year at diagnosis (진단 시 1세 이하인 신경모세포종 환자의 치료성적)

  • Suh, Jung Min;Lee, Sang Goo;Yoo, Keon Hee;Sung, Ki Woong;Koo, Hong Hoe;Kim, Ju Youn;Cho, Eun Joo;Lee, Suk Koo;Kim, Jhingook;Lim, Do Hoon
    • Clinical and Experimental Pediatrics
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    • v.52 no.1
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    • pp.93-98
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    • 2009
  • Purpose : The purpose of this study was to evaluate the clinical characteristics and outcomes of patients with neuroblastoma aged less than 1 year. Methods : From January 1997 to December 2007, 41 patients aged less than 1 year were diagnosed with neuroblastoma. Patients were divided into 3 risk groups according to the stage of the disease and N-myc amplification. Low-risk patients underwent surgery with (stage 2) or without (stage 1) short-term chemotherapy. Intermediate-risk patients underwent chemotherapy and surgery with or without local radiation therapy. High-risk patients underwent chemotherapy, surgery, radiation therapy, and high-dose chemotherapy/autologous stem cell rescue (HDCT/ASCR). Results : While tumor relapse occurred in only 1 patient, 7 patients died of treatment-related toxicities. Causes of treatment- related death included infection during conventional chemotherapy in 5 patients and acute myocarditis during HDCT/ASCR in 2 patients. The overall 5-year survival (${\pm}$ standard error) and 5-year event-free survival (EFS) rates after diagnosis for all 41 patients were $82.8{\pm}5.9%$ and $80.0{\pm}$6.3%$, respectively, with a median follow-up of 58 (9-137) months. The 5-year EFS rates for low-risk, intermediate-risk, and high-risk patients were 100%, $68.4{\pm}10.8%$, and $66.7{\pm}19.3%$, respectively. Conclusion : Increased efforts to reduce infection-associated toxicity deaths during conventional chemotherapy are needed to further improve the survival of patients with neuroblastoma aged less than 1 year.

Comparative Analysis of Job Satisfaction Factors between Permanently and Temporarily Employed School Foodservice Dietitians in Gyeongsangnam-do (경상남도 일부지역 학교급식 영양사의 직무만족 요인 분석 - 정규직과 비정규직의 비교를 중심으로 -)

  • Sung, Ki-Hyun;Kim, Hyun-Ah;Jung, Hyun-Young
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.5
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    • pp.808-817
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    • 2013
  • This study was conducted to compare job satisfaction and factors related to job satisfaction between permanently and temporarily employed dietitians in school foodservices in the Gyeongsangnam-do area. A total of 204 questionnaires were used in the final analysis. The average age, length of employment, and monthly wage of temporarily employed dietitians was significantly lower than those of permanently employed dietitians. However, there was no significant difference of overall job satisfaction between permanently and temporarily employed dietitians, although the average pay, welfare benefits, and promotion factors for permanently employed dietitians was significantly higher. Work and pay factors had significant effects on the overall job satisfaction of permanently employed dietitians, while work factors and work atmosphere had significant effects on the overall job satisfaction of temporarily employed dietitians. In conclusion, there was a significant difference in overall factors related to job satisfaction between permanently employed dietitian and temporarily employed dietitians. The pay, welfare benefits, and promotion condition of temporarily employed dietitians should be improved to ensure the efficient management of the school foodservice workforce in the future.