• The Korean Journal of Food And Nutrition
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• v.15 no.1
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• pp.36-41
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• 2002

The aim of this study was to assess the antitoxic compounds, flavanones(Leachianone A=LA and Sophoraflavanone G=SFG), from Sophora flavescens(S. flavescens). We investigated the possibility of antitoxicity of LA and SFG against NIH 3T3 fibroblasts cell lines using calorimetric MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl -2H-tetra-azolium bromide] assay. The results were as follows : After cadmium was treated against NIH 3T3 cell lines, we determined IC$\_$50/. Accordingly we have examined the detoxification effects of S. flavescens, LA and SFG under cadmium IC$\_$50/=12.5$\mu$M and was carried out to observe morphological changes by the light microscopic study In NIH 3T3 cells, Sophora flavescens, LA, SFG and LA + SFG showed inhibitory effects on the cytotoxicity of cadmium and these detoxication effects increased in proportion to the concentration of these drugs. These results suggest that LA and SFG from S. flavescens retain a potential antitoxic activity.

• Journal of Haehwa Medicine
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• v.1 no.1
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• pp.47-55
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• 1992

청열조습(淸熱燥濕), 거풍살충(祛風殺蟲)의 효능이 있는 고삼(苦蔘)의 체내 면역활성에 미치는 영향에 대해 실험한 결과 아래와 같은 지견을 얻었다. ICR 생쥐에 고삼(苦蔘) 수침액을 투여한 결과 백혈구수 및 면역장기 변화는 없었다. in vitro실험에서 IgM PFCs에 유의성 있는 영향을 주지 못했고, BSA를 주사한 생쥐에서의 Arthus 반응에도 영향이 없었다. 그러나 지연형 과민반응을 억제하였으며, 비특이적 면역에 관여하는 macrophage의 탐식능을 약간 저하시켰다. 이상의 결과 고삼(苦蔘) 수침액(水浸液)은 세포성 면역을 억제하는 것으로 사료된다.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.6
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• pp.1656-1664
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• 2015

The effects of lightyellow sophora, Sophora flavescens extract were tested on non-specific immune response and a disease resistance of olive flounder, Paralichthys olivaceus. For feeding trial, weight gain of fish fed different treated groups were not significant differences. Serum analysis of treated and control group did not demonstrated any differences. Lysozyme activity in the kidney and spleen of the 0.05% treated group on $4^{th}$ and $8^{th}$ week showed significant increase, respectively. In addition, phagocytic activity of the 0.05% treated group on $4^{th}$ and 8th week showed significant increase compared to the control group. Histopathology of the liver and kidney tissue of the administrated group for $4^{th}$, $8^{th}$ and $12^{th}$ week showed no particular signs of tissue degeneration. The treated group was higher than control group by analyzing the relative percent survival (RPS) of the experimental challenge of Edwardsiella tarda. Therefore, the lightyellow sophora showed effective in preventing fish-pathogenic edwardsiellosis for a certain period of time.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.5
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• pp.1344-1348
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• 2008

Anti-microbial activities of Scutellariae Radix Extracts and Sophora flavecens Extracts was tested by formulation, such as skinsoftener, emulsion for 4 weeks. Control contained no preservative, test group contained 1.00% Scutellariae Radix extracts and 1.00% Sophora flavecens extracts and positive control contained parabens and imidazolidinyl urea. To determine the anti-microbial activity of these extract, the 4 germs such as Escherichia coil, Pseudomonas aeruginosa, Staphylococcus aures, Canida albicans were used. The test groups showed significant anti-microbial activities against the 4 germs at 2 and 3 weeks as compared with control. Anti-microbial activities of these extracts were similar to positive control. Considering that the Scutellariae Radix Extracts and the Sophora flavecens Extracts have a significant anti-microbial activities against 4 germs, it is possible as natural preservative in cosmetics.

• Microbiology and Biotechnology Letters
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• v.30 no.4
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• pp.420-424
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• 2002

The purpose of this study is to investigate anticariotic activity of the ethyl acetate soluble extract of Sophora flavescens Ait. for the prevention of dental caries and glucosyltransferase activity caused by Streptococcus mutans. The fraction 5-4-3 showed strong growth inhibition activity against Streptococcus mutans (MIC, 3.13 $\mu\textrm{g}$/ml). The glucosyltransferase activity of the active fraction 5-4-3 inhibited the formation of glucan and showed 77% of the antiproliferative effect at 100 $\mu\textrm{g}$/ml (P<0.05). Two flavanones, (2S)-2'-methoxy kurarinone (1) and (+)-kurarinone (2), were isolated from the active fraction 5-4-3 of the ethyl acetate soluble extract of S. flavescens Ait. Their structures were elucidated using spectroscopic methods.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.2
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• pp.384-389
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• 2012

As part of our screening of anticariogenic agents from medicinal plants, the ethanol extracts of 25 herbs widely used in the fork medicine were tested for the antimicrobial activity against a cariogenic bacterium Streptococcus mutans ATCC 25175. The ethanol extracts of Coptis chinensis, Sophora flavescens, Glycyrrhiza uralensis, Mentha arvensis, and Saururus chinensis showed antimicrobial activities against S. mutans. The extracts of Coptis chinensis and Sophora flavescens among these medicinal plants showed significant antomicrobial activity against S. mutans. These results suggested that the extracts of Coptis chinensis and Sophora flavescens could be the potential source of antimicrobial agent against S. mutans ATCC 25175.

• The Korean Journal of Food And Nutrition
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• v.13 no.6
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• pp.539-546
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• 2000

The purpose of this study is to investigate antibacterial activities of Sophora flavescens Ait. extracts for the prevention of dental caries caused by Streptococcus mutans. The fraction 5-4-3 of the ethyl acetate soluble extract of Sophora flavescens Ait. Showed strong growth inhibition activity against Streptococcus mutans (MIC, 3.13 ${\mu}$g/ml). The glucosyltransferase activity inhibited the formation of glucan by the fraction 5-4-3 and showed 77% of the antiproliferative effect at 100 ${\mu}$g/ml. This showed a significant activity (p<0.05). These results suggest that the fraction 5-4-3 of the ethyl acetate soluble extract of Sophora flavescens Ait. may be a valuable material as the prevention of dental caries.

• Korean Journal of Organic Agriculture
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• v.22 no.2
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• pp.269-280
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• 2014

This study was performed to test the insecticidal and antimicrobial activity of plant extracts from clove, Sophora flavescens Aiton and neem. As the result of antimicrobial activity test, clove extract showed the strongest activity against Botrytis cinerea. In insecticidal activity test, the extract of Sophora flavescens Aiton was the highest against Nilaparvata lugens. The pyroligneous liquor (10%) and emulsified spreader (10%) were added to the extracts of clove and Sophora, respectively, to apply the environment-friendly rice field. In the field treated clove extract, disease damage occurred 49.1% and insect damage occurred 29.5% compared to control plot (100%). In the field treated Sophora extract, disease damage was 56.7% and insect damage was 21.0% compared to control plot (100%). In conclusion, plant extracts from Sophora and clove could control about 50% of disease and about 70% of insect damage that they could be used as environment-friendly resources to control disease and insect in rice farming.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.4
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• pp.361-369
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• 2020

Atopic dermatitis (AD) is a common and multifactorial inflammatory skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. AD has a complex etiology that includes genetic, immunological, and environmental factors that cause skin barrier abnormalities and immune dysfunctions. Sophora flavescens (SF) has been used in traditional Chinese medicine, but little research has been conducted on its anti-AD efficacy. In this study, we evaluated the effect of SF extract (SFE) on improving skin barrier function and immune abnormalities, which are the main symptoms of AD. SFE has the capacity to enhance the formation of cornified envelope (CE) that plays an important role in the skin barrier function. In addition, it was confirmed that SFE increased the expression of hyaluronic acid related to skin moisture. The effect of SFE against Staphylococcus aureus (S. aureus), which increases specifically in AD lesions, confirmed that SFE inhibited the production of pro-inflammatory cytokines induced by S. aureus. Furthermore, SFE was shown to inhibit the expression of pro-inflammatory cytokines induced by substance P (SP), the cause of skin neurogenic inflammation. These results demonstrate that SFE could be one of potential candidate agent for the treatment of AD by improving the skin barrier function and immune responses.

• Journal of the Korean Applied Science and Technology
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• v.37 no.2
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• pp.279-286
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• 2020

Natural extracts were isolated from 20 kinds of medicinal plants that have been traditionally widely used in Korea to develop treatments for dental caries. Medicinal plants showing antibacterial activity against a cariogenic bacterium, Streptococcus sobrinus KCOM 1157 were investigated. The natural extracts of Glycyrrhiza uralensis, Sophora flavescens, Coptis Chinensis, Mentha arvensis, Pinus densiflora, Spirodela polyrhiza showed antimicrobial activities against S. sobrinus KCOM 1157. The extracts of Pinus densiflora, Sophora flavescens, Coptis Chinensis among these medical herbs showed significant antimicrobial activity. These results suggested that the natural products of Pinus densiflora, Sophora flavescens, Coptis Chinensis could be the potential source of anticariogenic agent against dental pathogens including S. sobrinus.