• Childhood Kidney Diseases
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• v.5 no.2
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• pp.117-124
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• 2001

Purpose : Since Mendoza(1990)'s report that long term methylprednisolone pulse therapy by Mendoza protocol (MP therapy) is a good treatment option in focal segmental glomerulosclerosis(FSGS), there have been reports of the effects of this therapy in steroid-resistant nephrotic syndrome. However, no studies have been performed on the effects of MP therapy in steroid- dependent nephrotic syndrome and secondary nephrotic syndrome. In this study, we investigated the effects of long term MP therapy in primary and secondary nephrotic syndrome in which previous treatment options were not effective. Methods : We chose 10 children who were diagnosed with steroid-dependent minimal change nephrotic syndrome(SD-MCNS), who had shown frequent relapse during the immunocompromised or cytotoxic therapy Period, and 6 children with FSGS and 5 children with secondary nephrotic syndrome children, who had shown no response during the previous therapy period. We treated these patients according to Mendoza protocol involving infusions of high doses of methylprednisolone, often in combination with oral cyclophosphamide for 82 weeks. Results : In all the 10 children with SD-MCNS, complete remission was visible on average of $18{\pm}9$ days after MP therapy was started. However, all these children relapsed during or after MP therapy. In these children, the mean relapse rate prior to MP therapy was $2.1{\pm}1.0$ relpases/year, which was reduced to $1.4{\pm}0.9$ relapses/year during MP therapy(P>0.05) and rose to $2.7{\pm}1.0$ relapse/year after MP therapy. Of the 6 children with FSGS, 4 children($67\%$) showed complete remission, of whom 3 children($50\%$) remained in the remission status during the follow up period, $1.2{\pm}0.7$ years, after the end of MP therapy. 2 children($33\%$) showed no response. All of the 5 children with secondary nephrotic syndrome showed remission and remained in the remissiom status during the follow up period, $1.7{\pm}0.6$ years The only side effect of MP therapy was transient hypertension in 10 children of ail subjects during the intravenous infusion of methylprednisolone. Conclusion : We conclude that although long term MP therapy is not effective in the treatment of SD-MCNS, it is an effective therapy against intractable FSGS and secondary nephrotic syndrome. (J Korean Soc Pediatr Nephrol 2001 ; 5 : 117-24)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.3
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• pp.267-271
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• 2006

Lymphangiomas are benign tumors of the lymphatic system characterized by congenital lymphatic malformation such as anastomosis or obstruction of the lymphatic channels. They are most frequently diagnosed in children younger than 2 years, and the lymphangiomas in head and neck represent about 50-75% of all lymphangiomas. Spontaneous regression is rare, and rapid enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequence such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosing agents. Problems associated with surgical excision include the risk of scarring, damage to surrounding vital structure and the high risk of incomplete excision. The sclerosing agents previously used have numerous local and systemic side effects as their problems. We present a case of lymphangioma occured in tongue that was treated by surgical excision and sclerotherapy with OK-432.

• Korean Journal of Head & Neck Oncology
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• v.26 no.1
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• pp.41-44
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• 2010

Hemangiomas are the most common benign tumors or tumor-like malformations of blood vessels or blood filled cavernous spaces. Hemangiomas of the oral cavity represents 14% of all hemangiomas. Most hemangiomas are detected by one year of age and most commonly occurred in the lips, tongue, buccal mucosa and palate. But hemangiomas are sometimes reported in adults. We report one case of extensive hemangioma of the tongue in adult. Our case is a 48-year-old male who presented with a hemangioma occupying entirely two-third of the tongue. Treating those lesions pose a challenge to the surgeon. This paper discusses one case of extensive tongue hemangiomas treated with alcoholic sclerotherapy with satisfactory results supporting this particular approach in the management of these lesion.

• Korean Journal of Head & Neck Oncology
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• v.39 no.1
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• pp.15-18
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• 2023

A plunging ranula is a pseudocyst caused by mucus secreted from the sublingual glands, and it is mainly observed on the mouth floor. Nowadays, sclerotherapy using picibanil has been performed instead of invasive surgical treatment, and studies are reporting safe and effective outcomes. In our study, more than 92% of the 25 patients had marked response after picibanil sclerotherapy, and no serious complications were observed. Picibanil sclerotheraphy can be considered as the primary treatment of plunging ranula for patients who refuse surgery under general anaesthesia.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.3
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• pp.350-354
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• 2008

Mandibular chronic osteomyelitis with diffuse osteosclerosis is recognized as an intractable infectious disease. We emplyed decortication and intraarterial infusion of antibiotics in 6 cases. Decortication on the affected mandible was performed with retrocatherization to the superficial temporal artery of affected side under general anesthesia. Antibiotics, IPM/CS or FOMX was used through the artery for 4-11 days. In addition, we administered FOMX, PIPC intravenously for 8-17 days. CT and MRI were taken postoperatively. The postoperative follow-up period ranged from 1 year and 6 months to 2 years and 5 months. Postoperative MR showed that bone marrow signal was recovered to approximately normal in 4 cases. High signal area of bone marrow and osteosclerosis image remained in 2 cases, but showed improvement. The results were satisfactory without recurrence in all of 6 cases.

• Clinical and Experimental Pediatrics
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• v.48 no.2
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• pp.212-215
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• 2005

Renal artery stenosis is a major cause of renovascular hypertension and the most common cause of treatable secondary hypertension. There are several methods to treat renal artery stenosis, including surgery, percutaneous transluminal renal angioplasty(PTRA), and renal artery stenting(RAS). But, renal artery embolization can be tried in atherosclerotic stenosis, multiple stenosis, microaneurysm, and stenosis difficult to try PTRA or RAS. We report a case of renovascular hypertension in a 14-year-old female who had multiple segmental renal artery stenosis. Hypertension was controlled by renal ablation therapy with renal artery embolization.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.23 no.3
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• pp.281-288
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• 2001

Lymphangiomas are relatively rare benign tumors of the lymphatic system, characterized by congenital lymphatic malformation such as anastomosis or obstuction of the lymphatic channels. There are most frequently diagnosed in children younger than 3years. In contrast to that of the hemangioma, the sex distribution of the lymphangioma is nearly evenly divided. The head and neck lymphangioma represents about $70{\sim}75%$ of all lymphangiomas, and they are difficult to manage. Spontaneous regression is rare, and rapid intermittent enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequelae such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosants. Problems associated with surgical excision include the risk of cosmetically unacceptable scarring and the risk of damage to surrounding vital stricture and the high risk of incomplete excision. The sclerosants previously used have numerous other local and systemic side effects. This report describes a case that was successfully treated using OK-432 as a new sclerosant drug and secondary surgical excision for congential cavenous lymphangioma extensively enlarged to tongue, mouth floor and submandibular region.

• Industry Promotion Research
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• v.6 no.4
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• pp.47-58
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• 2021

The purpose of this study is to analyze the effect of reminiscence-based collective art therapy on the depression, interpersonal relationships, and the subjective sense of happiness among the elderly with dementia. The study was conducted on 30 volunteers with dementia aged 65 or older attending the S Weekly Care Center located in S-gun as subjects during the period between November 7, 2020 and January 2, 2021 with one session week for a total of 12 sessions. The SPSS 24.0 statistics program has been used for various data analyses, including confidence verification, cross tabulation analysis, independent sample T-test, 3×2 multi-variant analysis. The study findings are as follows. First, the collective art therapy based on reminiscence therapy is effective in reducing the depression among the elderly with dementia. Second, the collective art therapy based on reminiscence therapy is effective in promoting interpersonal relationships among the elderly with dementia. Third, the collective art therapy based on reminiscence therapy is effective in improving the subjective sense of happiness among the elderly with dementia. Therefore, the reminiscence-based collective art therapy is found to serve as an effective means to relieve depression, improve interpersonal relationships and to promote a subjective sense of happiness among elderly people witn dementia.

• Korean Journal of Bronchoesophagology
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• v.13 no.1
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• pp.33-38
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• 2007

Background and Objectives: A plunging ranula represents a mucus escape reaction occuring because of the disruption of the sublingual salivary gland. It is commonly a condition of young adults, although the reported age range is 6-43 years. There is said to be a slightly female preponderance of about 1.9:1(F:M). Surgical incision has been considered the definite treatment, but sometimes complete excision is very difficult. Non-surgical treatment of these lesions has been attempted, but the results have not been satisfactory. In this study, we present our experiences with picibanil (OK-432) sclerotherapy for a plunging ranula. Materials and Methods: We retrospectively reviewed 41 patients who have undergone sclerotherapy with picibanil for plunging ranula. Information was collected on age, sex, a number of injection, post-sclerotherapy side effect and outcome of treatment. Results: 17 patients (41.5%) showed a complete response, and 20 patients (48.7%) showed inter-mediate response. No response was seen in 4 patients (9.8%). As a side effect of intracystic OK-432 injection therapy, fever (26.8%) and pain(39.0%) were observed. However, fever and pain disappeared after several days in all cases. Conclusion: The results are showing that OK-432 injection is an effective and safe treatment for plunging ranula.

• Industry Promotion Research
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• v.6 no.4
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• pp.59-68
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• 2021

This study has identified the effect of reminiscence-based collective art therapy on the depression, interpersonal relationships, and the subjective sense of happiness among the elderly with dementia. The study was conducted on 30 volunteers with dementia aged 65 or older attending the S Weekly Care Center located in S-gun as subjects during the period between November 7, 2020 and January 2, 2021 with one session week for a total of 12 sessions. The SPSS 24.0 statistics program has been used for various data analyses, including confidence verification, cross tabulation analysis independent sample T-test, 3×2 multi-variant analysis, and the intergroup independent sample T-test between the groups. The study findings are as follows, First, the collective art therapy based on reminiscence therapy is effective in reducing the depression among the elderly with dementia. Second, the collective art therapy based on reminiscence therapy is effective in promoting interpersonal relationships among the elderly with dementia. Third, the collective art therapy based on reminiscence therapy is effective in improving the subjective sense of happiness among the elderly with dementia. These study findings are meaningful in that they have provided an informative basic data on the reminiscence-based collective art therapy.