• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.12
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• pp.1021-1030
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• 2017

This paper describes the algorithm of computing thermal contact conductance between unmatched grid interfaces for finite element thermal analysis. Because grid interfaces should be coincident with adjacent meshes for finite element method, large amount of man hours and huge computations are required to match interfaces between many numbers of complex subdomains. A novel method that distributes feasibly the conductances to interface nodes is proposed. The aims of the method are described, and details of the nodal conductance distribution algorithm with less dependency on meshes are represented. The algorithm can be applied both the flat and curved interfaces in 3 dimensional space, and proposed method can combined with many finite element application including thermal analysis.

• Journal of Chest Surgery
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• v.43 no.5
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• pp.518-521
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• 2010

A one-day-old baby was transferred for cyanosis and heart murmur. Echocardiographic evaluation revealed that he had severe neonatal Ebstein's anomaly (Carpentier type C), pulmonary atresia, and pulmonary circulation via patent ductus arteriosus. Because the wall of the atrialized right ventricle was very thin, showed decreased contractility, and the small right ventricle showed pulmonary atresia, we decided that a two-ventricular repair was impossible. When the patient was one-month-old, he underwent right atrium reduction-plasty, a right ventricular exclusion procedure (including atrialized right ventricle resection and functional right ventricle plication), and right modified Blalock-Taussig shunt. He was discharged without specific problems. He received a bidirectional cavopulmonary shunt successfully at 4 months later.

• Korean Journal of Microbiology
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• v.45 no.1
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• pp.10-16
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• 2009

A diverse range of stresses such as heat, cold, salt, ethanol, oxygen starvation or nutrient starvation induces same stress-responsive proteins. This general stress response enhances bacterial survival significantly. In Bacillus subtilis and closely related Gram-positive bacteria Listeria monocytogenes, the general stress response is controlled by the alternative transcription factor ${\sigma}^B$. The activity of ${\sigma}^B$ is regulated post-translationally by a signal transduction network that has been extensively studied in B. subtilis, and serve as a model for L. monocytogenes. The proposed model of L. monocytogenes signal transduction network is similar to that of B. subtilis, but the energy stress pathway is missing. More than 150 general stress proteins belong to ${\sigma}^B$ regulon of B. subtilis and L. monocytogenes. In both bacteria, ${\sigma}^B$ function is primarily important for resistance to diverse stresses. In addition, ${\sigma}^B$ function contributes to the control of important virulence genes in food-borne pathogen L. monocytogenes. Therefore, understanding of the general stress response is important not only for bacterial physiology, but also for pathogenicity.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.22 no.6
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• pp.519-525
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• 2009

In this study a cohesive zone model was used to simulate the delamination phenomena which occurs by a successive crack initiation and propagation in composite laminates. The cohesive zone model was incorporated to the classical finite element method via cohesive element formulation and then implemented into the user-subroutine UEL of a commercial finite element program Abaqus. To validate the formulation and implementation of the cohesive element the finite element results were compared with the experimental data of double cantilever beam and end notched flexure tests. The numerical results well agree with the experimental load-displacement curves. Also the effect of the elastic stiffness and the size of the cohesive element on the global load-displacement curves were studied numerically. To minimize the mesh-dependency of the crack propagation path and eliminate the zig-zag patterns in the load-displacement curve, cohesive elements should be refined at the crack-tip.

• Journal of the Korean Geotechnical Society
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• v.40 no.2
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• pp.65-79
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• 2024

This study employs traditional statistical auto-regressive integrated moving average (ARIMA) and deep learning-based long short-term memory (LSTM) models to predict the deformation of earth retaining walls using inclinometer data from excavation sites. It compares the predictive capabilities of both models. The ARIMA model excels in analyzing linear patterns as time progresses, while the LSTM model is adept at handling complex nonlinear patterns and long-term dependencies in the data. This research includes preprocessing of inclinometer measurement data, performance evaluation across various data lengths and input conditions, and demonstrates that the LSTM model provides statistically significant improvements in prediction accuracy over the ARIMA model. The findings suggest that LSTM models can effectively assess the stability of retaining walls at excavation sites. Additionally, this study is expected to contribute to the development of safety monitoring systems at excavation sites and the advancement of time series prediction models.

• Environmental Analysis Health and Toxicology
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• v.21 no.1 s.52
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• pp.13-19
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• 2006

화학적 예방효과가 있는 식물성 에스트로젠은 다양한 환성을 나타내며 여러 세포 수용체와 상호작용한다. Genistein은 isoflavone의 주요물질 중의 하나로 콩류에 존재하며 대표적인 식물성 에스트로젠이다. 본 논문에서는 유방암 세포주인 MCF-7에서 aryl hydrocarbon receptor(AhR)에 의해 매개되는 발암물질 활성화 경로에 대한 genistein의 영향을 살펴보았다. 세포에 genistein을 처리할 경우 cytochrome P450 1A1(CYP1A1) 약물대사효소의 특이적인 효소반응인 7-ethoxyresorufin O-deethylase (EROD) 활성도와 CYP1A1의 유전자 발현이 genistein의 농도 의존적으로 증가하였다. Genistein과 발암물질인 방향족탄화 수소 7, 12-dimethylbenz[a]anthracene(DMBA)를 동시 처리하였을 경우 DMBA에 의해 유도되어 증가된 EROD활성도와 CYP1A1의 유전자 발현이 genistein에 의해 감소하였다. 랫트의 간에서 분리한 세포질을 이용하여 genistein과 AhR의 대표적인 ligand인 2,3,7,8-tetrachlorodibenzo-p-dioxin과 경쟁적 결합에 대한 영향을 조사한 결과 genistein이 AhR에 경쟁적으로 결합함을 알 수 있었다. 이러한 결과들은 genistein이 천연 AhR ligand임을 암시한다. 따라서, 식물성 에스트로젠인 genistein은 AhR경로의 길항제/항진제로 작용할 수 있을 것으로 사료된다.

• Journal of Life Science
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• v.27 no.11
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• pp.1340-1348
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• 2017

Sanguinarine is a benzophenanthridine alkaloid derived from the roots of Sanguinaria canadensis L., which is used for the purpose of treating various diseases. Although studies of anticancer activities have been performed using various cancer cell lines, the phenomenon of inducing apoptosis in cancer cells by using sanguinarine requires more research. Therefore, this study investigated the anti-cancer activities and related mechanisms of sanguinarine used with Hep3B human hepatocellular carcinoma cells in terms of the regulation of apoptosis. Sanguinarine inhibited the proliferation of Hep3B cells in a concentration-dependent manner, which was associated with the induction of apoptosis. Sanguinarine also increased the activity of caspase-3, which is a typical effector caspase, and the activities of caspase-8 and caspase-9, which are key when initiating extrinsic and intrinsic apoptosis pathways, respectively. In addition, sanguinarine increased the expression of death receptor-related genes and pro-apoptotic BAX, which belongs to the Bcl-2 family, while suppressing the expression of anti-apoptotic Bcl-2. Sanguinarine promoted the truncation of Bid and enhanced the release of cytochrome c from the mitochondria to the cytoplasm due to a loss of mitochondrial membrane potential. Furthermore, the reduction of a survival rate that was induced by sanguinarine and the induction of apoptosis disappeared with the inhibition of artificial caspase activity. Therefore, the results of the study indicated that sanguinarine-induced apoptosis in Hep3B cells involves both extrinsic and intrinsic pathways; such apoptosis is a caspase-dependent phenomenon.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.7
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• pp.158-168
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• 1995

연삭숫돌 선택은 공작물제거량, 숫돌의 소모량, 표면정도 및 공작물의 물리적,화학적 특성을 고려하여 설정하는 것을 기본으로 한다. 연삭가공은 구성인자의 상호관계가 복잡하여 이중에서 어느한 요소만을 고려하여 설정하기 어렵고 정량적 기준 또한 정해져있지 않아 현실적으로는 숙련자의 정성적이고 경험적 지식에 따른 주관적 척도에 의존하는 것이 대부분이다. 또한, 연삭숫돌은 작업조건중에서 대량생산을 제외하고는 되도록이면 현장에 구비되어 있는 작업가능한 연삭숫돌 중에서 선택하는 것이 바람직하다. 따라서 본시스템에서는 이와같은 점을 고려하여 최적 연삭숫돌선택을 퍼지이론에 기초한 현장 숙련자의 지식을 활용하므로써 연삭숫돌선택의 효율성을 도모하는 동시에 현장에 연삭숫돌이 구비되지 않은 경우도 고려하여 연삭숫돌설정에 우선순위를 제시하므로써 작업자에 연삭숫돌선택의 유연성을 부여하였다. 또한, 실용성있는 전문가시스템의 구축을 위해 정성적이고 경험적인 지식의 활용을 위한 지식표현으로 설문조사에서 얻은 테이타를 x$^{2}$-분포에 따른 추정신뢰구간을 구해, 이를 토대로한 비대칭 삼각퍼지함수의 결정법을 제시하고, 이를 이용해서 구축한 시스템의 실행결과의 타당성을 비교하고자 한다.

• KDI Journal of Economic Policy
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• v.20 no.1_2
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• pp.3-77
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• 1998

경제위기 극복의 핵심과제는 '시장기구의 원활한 작동에 의존하는 경제의 틀'을 마련하는 것이며, 이를 위해서는 경제적 시장경제체제를 구축해야 한다. 이러한 견지에서 공정거래법 정책의 위상, 역할, 과제, 방향 등을 새로이 정립할 필요가 있다. 공정거래법 정책의 기초개념이 되어온 경제력(집중)과 경쟁의(불)공정성은 지나치게 포괄적이고 주관적이며 이에 대한 분석의 틀이 되는 이론체계도 없어 정책의 개념적 기반이 되기 어렵다. 공정거래법 정책은 독점력과 효율성의 개념 위에서 경제효율 증진이라는 목적을 추구해야만 정책의 일관성과 실효성을 높일 수 있다. 이는 대기업들의 독점력이 경제력집중 및 재벌구조와 형태상 제 문제의 근원(根源)이며, 독점력은 경제이론에 의해 정책방향과 기준이 제시되는 개념이기 때문이다. 공정거래법 정책은 시장구조와 형태를 실질적으로 경쟁화함으로써 경제효율을 극대화하는 데 주력해야 한다. 무엇보다도 경쟁 제한적 법령 제도 관행을 철폐하기 위한 규제개혁을 주도하고 경제구조조정과 재벌개혁의 기본원칙과 방법이 시장기능과 경쟁을 강화하는 방향으로 설정 시행되도록 하는 것이 긴요하다. 특히 대기업간 사업교환이나 인수 합병에 대하여 엄격한 경쟁정책적 검토와 규율을 적용해야 하며, 시장의 독과점화를 방지하면서 구조조정을 촉진하는 방향으로 기업결합 규제기준을 개선해나가야 할 것이다. 가격담합 등에 대한 당연위법 원칙의 확립, 입찰조작의 감시 적발체제 구축 등 카르텔 규제를 강화하고, 유통조직 활동의 효율화를 도모하면서 독점유지 강화행위를 엄격히 금지하여 다양한 유통경로와 업태가 출현 발전하도록 해야 한다. 산업조직적 조사 분석능력을 확충하여 경쟁정책적 시각에서 주요 사건을 선별 조사하고 법집행에 있어 사소(私訴)의 역할을 확대하기 위한 노력도 필요하다.

• Journal of the Korea Concrete Institute
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• v.19 no.6
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• pp.707-715
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• 2007

The vulnerability of concrete to its environment is significantly dependent on the fact that concrete is a porous material. For well-consolidated and well-cured concrete, its service life is a very long and an entrance of aggressive substance might be only pores. However, for cracked concrete, cracks should be preferential channel for the penetration of aggressive substance such as chloride ions. The effect of crack on chloride penetration depends on its size for example, crack width and crack depth. The purpose of this study is examining the effect of crack width and crack depth on chloride penetration. In order to visualize chloride penetration via cracks, RCM (rapid chloride migration) testing is accomplished. Crack width is examined using an optical microscope and CMOD value is used to estimate average crack width. From the examination on the trend of chloride diffusion coefficients of concrete specimens with various crack widths, a critical crack width and a critical crack depth are found out.