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Severe SARS-CoV-2 Infection With Multiorgan Involvement Followed by MIS-C in an Adolescent

  • Bomi Lim;Su-Mi Shin;Mi Seon Han
    • Pediatric Infection and Vaccine
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    • v.29 no.3
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    • pp.155-160
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    • 2022
  • Children and adolescents with coronavirus disease 2019 (COVID-19) generally have mild symptoms. Severe infection due to severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) involving multiorgan dysfunction is rare in this population. Herein, we present an unusual case of severe SARS-CoV-2 infection with multiorgan involvement followed by multisystem inflammatory syndrome in children (MIS-C) in a vaccinated 16-year-old boy. The patient was unconscious on initial presentation, and had severe paralytic ileus. On laboratory examination, there was severe metabolic acidosis, lymphocytopenia, thrombocytopenia, elevated inflammatory markers, elevated liver enzymes, and evidence of acute kidney injury with proteinuria and hematuria. His symptoms improved with the administration of remdesivir and dexamethasone. The patient briefly experienced MIS-C 2 weeks after the diagnosis of COVID-19, but the patient was discharged without any complications.

Four-Wheel Tractor Utilization in Korea(II) -Repair and Maintenance- (농용(農用) 트랙터 이용(利用)에 관(關)한 조사연구(調査硏究)(II) -고장(故障) 및 수리실태분석(修理實態分析)-)

  • Park, Ho Seok;Lee, Yong Kook
    • Journal of Biosystems Engineering
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    • v.6 no.2
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    • pp.65-76
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    • 1982
  • This survey was conducted to investigate the status of repair and maintenance of 4 wheel tractor for a basic reference to the improvement of quality and proper utilization of tractors. Thirty two counties from eight provinces, except Jeju, were covered in this study in order to investigate annual break-down and repair of tractor in 1980. The analyzed results are summarized as follows; 1. The average number of break-down of large size tractors(47ps) was 5.0 times in a year and it was about twice of that of small size tractors(19-23ps). The break-down frequency per 100 hours of use was 1.11 times in the large size and 0.65 times in the small size tractors. 2. 75.6 percent of total break-down was occured in main body of tractor and 24.4 percent in attachments. In particular, the break-down of plow and rotavator was more than 80 percent of total break-down of the small size tractor attachments. 3. The large size tractors which were occured more than one times of break-down a year was 75 percent and its rate of the small size tractor was 62 percent. But 9 percent of tractor surveyed had more than ten times of break-down in a year 4. The frequency of break-down had a peak in May, and it was directly proportional to the hours of use. 5. The causes of break-down were poor maintenance and operation by 29.8 precent, old parts by 30.2 percent, poor quality of parts by 20.6 percent, poor field condition by 16.3 percent and others by 3.1 percent. 6. Annual number of repair was 5.5 times and among them 55.6 percent was done by shop and 44.4 percent by operator. 7. Total required repair time was 30.6 hours a year in the large size tractor and 19.9 hours in the small size tractor. Average repair time was 3.62 hours a time. 8. Annual repair cost was 278 thousand won in the large size tractor and 70 thousand won in the small size tractor. The repair cost per hour of use was 621 won in the large size and 198 won in the small size tractor. 9. The repair cost rate of tractor(Y) was regulated with tractor age (X) as follow; Y=0.752X In case of the service life of tractor was 10 years, the total repair cost rate was 64 percent.

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Evaluation of Liver Function Using $^{99m}-Lactosylated$ Serum Albumin Liver Scintigraphy in Rat with Acute Hepatic Injury Induced by Dimethylnitrosamine (Dimethylnitrosamine 유발 급성 간 손상 흰쥐에서 $^{99m}-Lactosylated$ Serum Albumin을 이용한 간 기능의 평가)

  • Jeong, Shin-Young;Seo, Myung-Rang;Yoo, Jeong-Ah;Bae, Jin-Ho;Ahn, Byeong-Cheol;Hwang, Jae-Seok;Jeong, Jae-Min;Ha, Jeong-Hee;Lee, Kyu-Bo;Lee, Jae-Tae
    • The Korean Journal of Nuclear Medicine
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    • v.37 no.6
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    • pp.418-427
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    • 2003
  • Objects: $^{99m}-lactosylated$ human serum albumin (LSA) is a newly synthesized radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically presented on the hepatocyte membrane. Hepatic uptake and blood clearance of LSA were evaluated in rat with acute hepatic injury induced by dimethylnitrosamine (DMN) and results were compared with corresponding findings of liver enzyme profile and these of histologic changes. Materials and Methods: DMN (27 mg/kg) was injected intraperitoneally in Sprague-Dawley rat to induce acute hepatic injury. At 3(DMN-3), 8(DMN-8), and 21 (DMN-21) days after injection of DMN, LSA injected intravenously, and dynamic images of the liver and heart were recorded for 30 minutes. Time-activity curves of the heart and liver were generated from regions of interest drawn over liver and heart area. Degree of hepatic uptake and blood clearance of LSA were evaluated with visual interpretation and semiquantitative analysis using parameters (receptor index : LHL3 and index of blood clearance : HH3), analysis of time-activity curve was also performed with curve fitting using Prism program. Results: Visual assessment of LSA images revealed decreased hepatic uptake in DMN treated rat, compared to control group. In semiquantitative analysis, LHL3 was significantly lower in DMN treated rat group than control rat group (DMN-3: 0.842, DMN-8: 0.898, DMN-21: 0.91, Control: 0.96, p<0.05), whereas HH3 was significantly higher than control rat group (DMN-3: 0.731,.DMN-8: 0.654, DMN-21: 0.604, Control: 0.473, p<0.05). AST and ALT were significantly higher in DMN-3 group than those of control group. Centrilobular necrosis and infiltration of inflammatory cells were most prominent in DMN-3 group, and were decreased over time. Conclusion: The degree of hepatic uptake of LSA was inversely correlated with liver transaminase and degree of histologic liver injury in rat with acute hepatic injury.

A study of the difference of Dongeui-Suse-Bowon and past Oriental-Medicine appeared in the argument of Interior-overheating-sympton of the Tae-Eum-In caused by liver's receiving heat (태음인(太陰人) 간수열(肝受熱) 이열병론(裡熱病論)을 통해 살펴본 과거의학(過去醫學)과 동의수세보원(東醫壽世保元)의 음양관(陰陽觀)의 차이(差異))

  • Kim, Jong-Weon
    • Journal of Sasang Constitutional Medicine
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    • v.9 no.1
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    • pp.127-153
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    • 1997
  • Sasang-Medicine can classify all sympton with more simple classifying system than past Oriental-Medicine, because Sasang Byeon-Zeung(=classifying system of the sympton) separate by four clearly. The merit of this Sasang Byeon-Zeung can be seen more clearly on the part of the pathology of the expiratory-scattering and inspiratory-gathering of the Tae-Eum and Tae-Yang. On this view point, this thesis discussed the following subjects. 1. Investigate the theory of raising-falling and scattering-gathering developed in the Dongeui-Suse-Bowon. 2. Investigate the changes of the recognition of the Yang-Dog sympton and Jo-Yeol sympton argued as Interior-overheating-sympton of the Tae-Eum-In caused by liver's receiving heat. 3. Investigate the Yi-Je-Ma's view on the Eum-Yang in the argument of interior-overheating-sympton of the Tae-Eum-In caused by liver's receiving heat. As a result, the following conclusions were led to. 1. Dongeui-Suse-Bowon considers Spleen-Kidney has the couple motion of the raising Yang and falling Eum, and Liver-Lung has the couple motion of the expiratory-scattering and inspiratory-gathering. This theory of raising-falling and scattering-gathering is same as in the concept with the gathering. This theory of raising-falling and scattering-gathering is same as in the concept with the theory of raising-falling and floating-sinking of past Oriental-Medicine, but more consistently systematized in the pathology and prescription. 2. Dongeui-Suse-Bowon considers the Yang-Dog sympton and Jo-Yeol sympton as the interior-overheating-sympton of the Tae-Eum-In. As following the book, the fire of desire weeken the expiratory-scattering power of the lung, and deepen the shortage of the expiratory-scattering power comparison to the inspiratory-gathering power. Therfore the sympton can be treated by releasing ourselves from the desire and taking medicine strengthening the expiratory-scattering power. 3. In the early stage of the orintal medicine, they used prescriptions composed of So-Yang medicine and Tae-Eum medicine which can cool heat. Galgeun, Mawhang and Seungma were used in the age of Sanghanron, thereafter Jugoing's Jojung-Tang and Gongsin's Galgeunhaegi-Tang were developed as prescriptions of the interior-overheating-sympton of the Tae-Eum-In, and finally Tea-Uem-In Galgeunhaegi-Tang was settled by Yi-Je-Ma.

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Effects of Different Kinds of Salt on the Quality of Wet Noodles (소금종류별에 따른 첨가가 생면의 품질에 미치는 효과)

  • Lee, Jeong-Mi;Kim, So-Young;Park, Kun-Young
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.40 no.12
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    • pp.1776-1780
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    • 2011
  • The effects of different kinds of salt on the qualities of weight, volume, water absorption rate, turbidity, pH, textural characteristics, and sensory evaluation of wet noodles were studied. The salts employed in this study were purified salt (PS), solar salt (SS), solar salt without bittern (SSWB), roasted salt (RS) and bamboo salt (BS, $1{\times}$). The weight, volume, and water absorption rate of the noodles decreased with the 2% addition of different kinds of salts compared to the noodles without any added salt. The turbidity of the noodles decreased when BS (0.484), RS (0.489), or SSWB (0.489) were added to the noodles much more than when PS (0.508) was added. The pH of both wet noodles and cooked noodles was higher when BS, RS, or SS were added than when the others were added. The springiness and cohesiveness of the noodles were both increased with the addition of the salts. BS, RS and SS especially increased the springiness and cohesiveness of the noodles. In sensory evaluations of appearance, taste, texture and overall acceptance, BS received the highest scores. From the results, adding salt to wet noodle preparations is important to increase the quality of the noodles. BS showed the best overall results among the salts employed in this study.

Effects of Salvia plebeia R. Br. on Antioxidative Enzyme Activities and Oxidative Damage in Rats Fed High-Fat and High-Cholesterol Diets (곰보배추섭취가 고지방과 고콜레스테롤 식이 랫드에서의 항산화 효소활성 및 산화적 손상에 미치는 영향)

  • Song, Won-Yeong;Choi, Jeong-Hwa
    • Journal of Food Hygiene and Safety
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    • v.33 no.4
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    • pp.316-323
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    • 2018
  • The purpose of the present study was to investigate the effect of Salvia Plebia R. Br. (SP) powder on the antioxidative defense system and oxidative stress in rats which were fed a high fat high cholesterol diet. Accordingly, the rats were divided into four experimental groups which were composed of a high fat high cholesterol diet group (HF), HF diet with 5% SP powder supplemented group (PA), a HF diet with 10% SP powder supplemented group (PB), and a normal group (N). Consequently, the hepatic catalase activity of the HF group was decreased compared to the normal group (N), but it is recorded that of the PA and PB groups were significantly increased. With this in mind, the PA and PB groups resulted in the case of significantly increased activities of hepatic GSH-px and SOD. The hepatic superoxide radical and hydrogen peroxide contents of the PA and PB groups were significantly decreased, as compared to the HF group. The GOT and GPT activities of the PB group were also significantly decreased when thus compared to the HF group. Notably, the carbonyl values contents of the PA and PB groups were significantly reduced compared to the HF group. The hepatic TBARS values in the liver were significantly reduced as measured in the PA and PB groups. These results suggest that the SP powder may reduce the incidence of oxidative damage, by the activation of an antioxidative enzyme in rats fed with high fat high cholesterol diets.

Changes Quality of Solar Salt According to the Depth of Hea-ju (해주의 깊이에 따른 천일염의 품질 변화)

  • Lee, S.K.;Kim, S.E.;Kim, H.;Kim, W.;Han, J.W.
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2017.04a
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    • pp.97-97
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    • 2017
  • 천일염의 생산공정은 바닷물(나트륨 농도: 2~3%)을 저수지로 유입시킨 바닷물을 농축하는 1차 증발지(난치)와 2차 증발지(누태)로 보내 일반적으로 2주 정도 증발시켜 나트륨 농도 12~15% 소금물을 만든다. 온도가 낮은 겨울철에는 결정지를 거치거나 2차 증발지의 농축시켜 창고(해주)에서 보관 하는 동안 나트륨 농도 25~27%정도로 상승되어 소금 결정을 이루고 채염하여 창고로 운송한다. 보관창고에서 천일염에서 쓴맛을 내는 간수를 제거한 뒤 선별, 건조 및 포장하는 유통하는 단계로 이뤄진다. 천일염의 생산과정 중 해주는 함수를 저장하여 고농도의 함수를 저장하여 불용분 및 이물질을 자연 침전시켜 맑은 함수를 다음 공정으로 이송시켜 천일염 품질향상에 중요한 공정 중에 하나이다. 그러나 일반적인 염전의 해주는 지붕의 복사열로 인하여 저장중인 해수의 대류로 인하여 침전물이 상승되고 이물질이 부유함으로 인하여 품질저하의 원인이 되고 있다. 또한 해주 구조 및 해주 품질에 대한 자료는 전무한 실정이다. 따라서, 본 연구의 목적은 해주의 깊이에 따른 해수의 대류 방지 깊이 및 품질 변화를 측정하여 고품질 천일염 생산공정에 적용하는데 목적이 있다. 해주분석을 위한 염전은 결정지 채염공정을 공유하는 2개지역 3개 염전을 대상으로 하였으며, 무안, 운남 및 만품지역의 3개소를 선정하여 생산방식이 비교적 동일한 염전을 선정하여 조사 및 분석하였다. 해주의 깊이는 1.0, 3.0, 3.5m인 해주의 시료를 채취하여 Calcium, Magnesium, Sulphate, Chloride 의 함량 분석은 Arena 20 XT 자동흡광분석기 (Automated photometric analyzer)을 이용하여 분석을 하였다. 각 염전에서 채취한 해수의 평균 탁도 값은 해주의 깊이가 깊을수록 탁도 값이 낮은 것으로 나타났다. 해수의 색상 "b" 값은 해주 깊이가 깊을수록 낮은 결과를 보였다. Mg 함량은 전반적으로 15,000~40,000 mg/L 범위의 값을 나타냈으며, Sulphate 함량은 약 30,000~65,000 mg/L 범위의 값을 나타났으며, 깊이가 깊을수록 Mg, Sulphate 함량이 낮아지는 결과를 보였으나 Chloride 함량은 뚜렷한 경향을 보이지 않았다. 실험 결과 해주 깊이에 따른 함수의 품질 차이가 발생하는 것을 확인 할 수 있었으며, 해주의 바닥 깊이가 깊을수록 함수의 불용분 침전, 분리에 효율적인 것으로 판단되었다.

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Single Extrahepatic Portosystemic Shunt in 3 Dogs: CT Findings and Progress (3마리의 개에서 발생한 단일 간외성 문맥전신 단락 증례)

  • Lee, Hee-Chun;Ji, Chang-Moo;Moon, Jong-Hyun;Cho, Kyu-Woan;Kim, Young-Ki;Kang, Byeong-Teck;Jung, Dong-In
    • Journal of Veterinary Clinics
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    • v.29 no.6
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    • pp.488-493
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    • 2012
  • Two Maltese (2-year-old, intact female and 4-month-old, intact female) and a Pekingese (10-year-old, intact male) dogs were referred due to vomiting, anorexia, head-pressing and hypersalivation. Physical examinations, complete blood count, serum chemical analysis, radiography, ultrasonography and computed tomography (CT) were evaluated. Laboratory findings in these dogs included high hepatic enzyme, serum bile acid and ammonia concentration. Microhepatia was found on abdominal radiographs in two dogs. The existence of portosystemic shunt was presented in abdominal ultrasonography. The shunt vessel was identified in all dogs by CT imaging. Based on three-dimensional CT reconstruction, the origin and termination of each shunt vessel were defined certainly. In consequence, each dog was diagnosed single extrahepatic portosystemic shunt. After diagnosis, surgical treatment was performed in all dogs. This case report describes clinical finding, imaging characteristics, and three-dimensional CT imaging of single extrahepatic portosystemic shunt cases.

Effect of Dietary Supplementation of Extracts of Mushroom Mycelium on Survival and Growth of juvenile Flounder, Paralichthys olivacceus (버섯균사체 배양액 첨가사료가 넙치 치어의 생존 및 성장에 미치는 영향)

  • Kim, Min-Ju;Kim, Man-Chul;Kim, Taeg;Kim, Ki-Young;Song, Chun-Bok;Jeon, Yu-Jin;Heo, Moon-Soo
    • Journal of Aquaculture
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    • v.19 no.4
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    • pp.231-235
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    • 2006
  • The effects of mycelium cultural extract supplemented diet, hematology and disease resistance against Vibrio anguillarum in juvenile flounder, Paralichthys olivaceus were evaluated. Fish were fed the Phellinus linteus with Coriolus militaris versicolor mixed mycelium cultural extract supplemented diet, Phellinus linteus mycelium cultural extract supplemented diet and Coriolus militaris tmycelium cultural extract supplemented diet a commercial diet for 12 week. The body weight and length gain from the fish fed on daily the phellinus with coriolus versicolor mixed mycelium cultural extract supplemented diet, phellinus linteus mycelium cultural extract supplemented diet and Coriolus versicolor mycelium cultural extract supplemented diet of each mycelium cultural extract were higher than the control and the Glutamic oxalacetic transaminase (GPT) were of lower than the control. The relative precent survival rate (RPS) after an artificial challenge with $7{\times}10^5\;CFU$ of Vibrio anguillarum per fish was higher than the control.

Assessment of the Struvite Crystallization Process for Phosphate Removal and Recovery from a Sludge Treatment System of a Domestic Wastewater Treatment Plant (하수처리장 슬러지처리 계통에서의 인 제거 및 회수를 위한 Struvite 결정화 공정 적용성 평가)

  • Baek, Seung Ryong;Lee, Byung Joon
    • Journal of Korean Society of Environmental Engineers
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    • v.39 no.8
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    • pp.462-469
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    • 2017
  • Eutrophication and shortage of phosphate ore raise the necessity of phosphate removal and recovery from wastewater treatment plants. Especially, a sludge treatment system containing highly concentrated phosphate should be targeted for phosphate removal and recovery. This study thus aimed to evaluate the capability of the struvite crystallization process for phosphate removal and recovery from a sludge treatment system of a wastewater treatment plant. Analysis on phosphate concentrations and masses in the sludge treatment system revealed that digested sludge and centrate have phosphate concentrations and masses, high enough to adopt the struvite crystallization process. Chemical equilibrium modeling indicated that the struvite crystallization reaction substantially occurred with pH higher than 8 and $Mg^{2+}$ concentration 1.2 times higher than its theoretical requirement. A series of batch tests with digested sludge and centrate indicated that the phosphate removal reaction by struvite crystallization followed a first-order kinetics and reached over 80% removal efficiency at equilibrium. Aeration in the batch tests was found to purge $CO_2$ in sludge or centrate and increase pH up to 8.7, without adding NaOH. Thus, we concluded that the struvite crystallization process could be an efficient and economical process for phosphate removal and recovery from a wastewater treatment plant.