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Efficacy Analysis of Simplified Intensity-modulated Radiotherapy with High or Conventional Dose and Concurrent Chemotherapy for Patients with Neck and Upper Thoracic Esophageal Carcinoma

  • Zhu, Wei-Guo;Zhou, Ke;Yu, Chang-Hua;Han, Ji-Hua;Li, Tao;Chen, Xiao-Fei
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.3
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    • pp.803-807
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    • 2012
  • For patients with neck and upper thoracic esophageal carcinoma, it is difficult to control lymph node metastases with conventional dose therapy. In this study, we assessed the feasibility of simplified intensity-modulated radiotherapy (sIMRT) and concurrent chemotherapy for 44 patients and boosted high-dose to metastatic lymph nodes. Three radiation treatment volumes were defined: PGTVnd, with which 68.1Gy was delivered in high dose group (hsIMRT group), and 60Gy in the conventional dose group (csIMRT group); PTV1, featuring 63.9Gy in the hsIMRT group and 60Gy in the csIMRT group; PTV2, with 54Gy given to both groups. The sIMRT plan included 5 equi-angular coplanar beams. All patients received the cisplatin and 5-FU regimen concurrently with radiotherapy. The treatment was completed within six weeks and one case with grade three acute bronchitis was observed in hsIMRT group. For esophageal lesions, 80% complete response (CR) and 20% partial response (PR) rates were found in the hsIMRT group, and 79.2% CR, with 20.8% PR, in the csIMRT group; for lymph node lesions, 75% CR and 25% PR rates were observed in the hsIMRT group, with 45.8% and 37.5% respectively in the csIMRT group (P<0.05). The differences in 1-, 2- and 3-year relapse-free survival rates were all statistically significant (P<0.05). The major toxicity observed in both groups was Grade I~II leucopenia. sIMRT can generate a desirable dose distribution in treatment of neck and upper thoracic esophageal carcinoma with a better short-term efficacy. Boosted high dosing to metastatic lymph nodes can increase the relapse-free survival rate.

Genetic correlations between first parity and accumulated second to last parity reproduction traits as selection aids to improve sow lifetime productivity

  • Noppibool, Udomsak;Elzo, Mauricio A.;Koonawootrittriron, Skorn;Suwanasopee, Thanathip
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.3
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    • pp.320-327
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    • 2017
  • Objective: The objective of this research was to estimate genetic correlations between number of piglets born alive in the first parity (NBA1), litter birth weight in the first parity (LTBW1), number of piglets weaned in the first parity (NPW1), litter weaning weight in the first parity (LTWW1), number of piglets born alive from second to last parity (NBA2+), litter birth weight from second to last parity (LTBW2+), number of piglets weaned from second to last parity (NPW2+) and litter weaning weight from second to last parity (LTWW2+), and to identify the percentages of animals (the top 10%, 25%, and 50%) for first parity and sums of second and later parity traits. Methods: The 9,830 records consisted of 2,124 Landrace (L), 724 Yorkshire (Y), 2,650 LY, and 4,332 YL that had their first farrowing between July 1989 and December 2013. The 8-trait animal model included the fixed effects of first farrowing year-season, additive genetic group, heterosis of the sow and the litter, age at first farrowing, and days to weaning (NPW1, LTWW1, NPW2+, and LTWW2+). Random effects were animal and residual. Results: Heritability estimates ranged from $0.08{\pm}0.02$ (NBA1 and NPW1) to $0.29{\pm}0.02$ (NPW2+). Genetic correlations between reproduction traits in the first parity and from second to last parity ranged from $0.17{\pm}0.08$ (LTBW1 and LTBW2+) to $0.67{\pm}0.06$ (LTWW1 and LTWW2+). Phenotypic correlations between reproduction traits in the first parity and from second to last parity were close to zero. Rank correlations between LTWW1 and LTWW2+ estimated breeding value tended to be higher than for other pairs of traits across all replacement percentages. Conclusion: These rank correlations indicated that selecting boars and sows using genetic predictions for first parity reproduction traits would help improve reproduction traits in the second and later parities as well as lifetime productivity in this swine population.

Effects of Breeds on Body Weight, Age, Body Conformation, Backfat Thickness and Steroid Hormone Concentrations at First Estrus and Mating of Gilts (첫 발정과 종부시 체중, 연령, 체형, 등지방 두께 및 스테로이드 호르몬 농도에 미치는 종빈돈 품종의 영향)

  • 김종상;김홍기;손동수;양창범;이성호;이영주;박창식
    • Korean Journal of Animal Reproduction
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    • v.27 no.2
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    • pp.163-167
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    • 2003
  • This study was carried out to get a fundamental information fur improvement of reproductive performance in gilt. We investigated the effects of breeds on body weight, age, body length, wither's height, girth and backfat thickness, and the serum concentrations of estradiol-17$\beta$, cortisol and progesterone at first estrus and mating of gilts. A total of 47 gilts of Duroc, Landrace and Yorkshire, produced at Livestock Experiment Station, Chungnam Livestock Sanitation Research Institute from 2000 through 2002, were used for this experiment. Body weight, age and girth of Duroc at first estrus and mating were higher than those of Landrace and Yorkshire. There were no differences on body length among the three breeds at first estrus and mating. Wither's height of Duroc and Yorkshire at first estrus and mating was higher than that of Landrace. Backfat thickness of Yorkshire was thinnest among the three breeds at first estrus, but there were no differences on backfat thickness among the three breeds at first mating. Serum estradiol-17$\beta$ concentration of Landrace (45.0 pg/ml) at first estrus was higher than that of Yorkshire (27.4 pg/ml) and Duroc (21.8 pg/ml), but there were no differences on estradiol-17$\beta$ concentration (from 18.5 to 31.9 pg/ml) among the three breeds at first mating. Serum cortisol concentration of Duroc at first estrus and mating was higher than that of Landrace and Yorkshire. There were no differences on serum progesterone concentration among the three breeds at first estrus and mating of gilt.

Comparative study of the prenatal care among Seoul ana Chun Chon areas′clinics (일부 대.중도시의 임신부 병원진찰실태에 관한 비교연구)

  • 강정희
    • Journal of Korean Academy of Nursing
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    • v.4 no.2
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    • pp.121-130
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    • 1974
  • This study was performed with, two groups of 369 pregnant women, which consisted of the first group of 186 pregnant women taking physical examinations for birth at the Korea clinic in Seoul during the months of November and December in 1972, and the second group of 183 pregnant women taking physical examinations for birth at the Kang Won Provincial Hospital for the 12 months from October, 1972 to September 1973, as the results of this study the following concussion was obtained. 1. Age distribution indicated that the group of 25 through 34 age among them fallen 76 percent. 2. The time of the first physical examination by the 76% pregnant women of the second group at Chun Chon was in the initial period of pregnancy, but the time of that by every 33% pregnant women of the first group in Seoul came to the initial, middle and late period of pregnancy, evenly. 3. The 65.6% of the second group had one or two times of physical examination and the 80% of the first group had one to eight times of physical examination. 4. The mean pregnancy times was 1.9 to the first group and 2.8 to the second group, showing high pregnancy rate in Seoul city- 5. The 57.3% of the first group and the 31.3% of the second group did one times of abortion. The 3.2% of the first group and the 10.7% of the second group did more then six times of abortion, this meant big difference between two groups. The 24.1% of the first group had four times of pregnancy and the 18.1% of the second group had three or four times of it. These percentages was the highest of all. 6. Death rate during the period of pregnancy was shown to be 3.2% to the first group and 9.7% to the second group, consequently indicating gre311y high death rate in local city. 7. Many of the first group have three children and some of the second group have seven children. 8. As to totemics of pregnancy, 23.7% of the first group, and 49.7% of the second group were shown to have totemics of pregnancy, consequently with greatly high totemics rate of pregnancy in local city. The 4.0% of the first group and 37.0% of the second group was short of hemoglobin, with remarkable difference between the two groups.

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First Order Difference-Based Error Variance Estimator in Nonparametric Regression with a Single Outlier

  • Park, Chun-Gun
    • Communications for Statistical Applications and Methods
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    • v.19 no.3
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    • pp.333-344
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    • 2012
  • We consider some statistical properties of the first order difference-based error variance estimator in nonparametric regression models with a single outlier. So far under an outlier(s) such difference-based estimators has been rarely discussed. We propose the first order difference-based estimator using the leave-one-out method to detect a single outlier and simulate the outlier detection in a nonparametric regression model with the single outlier. Moreover, the outlier detection works well. The results are promising even in nonparametric regression models with many outliers using some difference based estimators.

THE SOBOLEV REGULARITY OF SOLUTIONS OF FIRST ORDER NONLINEAR EQUATIONS

  • Kang, Seongjoo
    • Journal of the Chungcheong Mathematical Society
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    • v.27 no.1
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    • pp.17-27
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    • 2014
  • In order to study the propagation of singularities for solutions to second order quasilinear strictly hyperbolic equations with boundary, we have to consider the regularity of solutions of first order nonlinear equations satisfied by a characteristic hyper-surface. In this paper, we study the regularity compositions of the form v(${\varphi}$(x), x) with v and ${\varphi}$ assumed to have limited Sobolev regularities and we use it to prove the regularity of solutions of the first order nonlinear equations.

Overuse Capsuloligamentous Injury of the First Metatarsophalangeal Joint: A Case Report

  • Park, Jihong;Grindstaff, Terry L.
    • Journal of Korean Foot and Ankle Society
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    • v.19 no.3
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    • pp.128-131
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    • 2015
  • Capsuloligamentous injury at the first metatarsophalangeal (MTP) joint is a common traumatic injury during physical activity, particularly on artificial turf. Mechanism of injury include excessive flexion, extension, or valgus stress. We report a non-operatively treated capsuloligamentous injury at the first MTP joint, which did not occur traumatically but developed by a stress-related mechanism in a collegiate rower.

The Contents and the Backgrounds on the First Daily Weather Charts in Korea (한국에서 처음 작성된 일기도의 내용과 변경)

  • Byun, Hi-Ryong
    • Atmosphere
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    • v.15 no.2
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    • pp.129-139
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    • 2005
  • The weather charts made at November 1, 1905 that were supposed to be the first daily weather chart in Korea were found and the contents of them were described and investigated. They were consisted of three sheets of paper. The first sheet consists of 2 kinds of weather charts. The second one does 6 kinds, and the third one is a table where 51 stations' records are in it. The diagnosing method and the historical background of the charts were explained. Although it is slim, the possibilities of the other earlier charts than these are explained also.

A NOTE ON THE RETURN TIME OF STURMIAN SEQUENCES

  • Kim, Dong Han
    • Korean Journal of Mathematics
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    • v.16 no.3
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    • pp.301-307
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    • 2008
  • Let $R_n$ be the the first return time to its initial n-word. Then the Ornstein-Weiss first return time theorem implies that log$R_n$ divided by n converges to entropy. We consider the convergence of log$R_n$ for Sturmian sequences which has the lowest complexity. In this case, we normalize the logarithm of the first return time by log n. We show that for any numbers $1{\leq}{\alpha},\;{\beta}{\leq}{\infty}$, there is a Sturmian sequence of which limsup is ${\alpha}$ and liminf is $1/{\beta}$.

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A SYSTEM OF FIRST-ORDER IMPULSIVE FUZZY DIFFERENTIAL EQUATIONS

  • Lan, Heng-You
    • East Asian mathematical journal
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    • v.24 no.1
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    • pp.111-123
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    • 2008
  • In this paper, we introduce a new system of first-order impulsive fuzzy differential equations. By using Banach fixed point theorem, we obtain some new existence and uniqueness theorems of solutions for this system of first-order impulsive fuzzy differential equations in the metric space of normal fuzzy convex sets with distance given by maximum of the Hausdorff distance between level sets.

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