• Korean Journal of Mathematics
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• v.13 no.1
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• pp.1-11
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• 2005

The purpose of the present paper is to introduce a new concept of the E($^*{\kappa}$)-connection ${\Gamma}^{\nu}_{{\lambda}{\mu}}$, which is both Einstein and ($^*{\kappa}$)-connection, and to obtain a necessary and sufficient condition for the existence of the unique E($^*{\kappa}$)-connection in $n-^*g$-UFT. Next, under this condition, we shall obtain a surveyable tensorial representation of the unique E($^*{\kappa}$)-connection in $n-^*g$-UFT.

• Molecules and Cells
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• v.37 no.3
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• pp.189-195
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• 2014

The NF-${\kappa}B$ pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-${\kappa}B$ in cancer cells, recent findings postulate that NF-${\kappa}B$ participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-${\kappa}B$. In this review, we discuss implications of the NF-${\kappa}B$ signaling pathway in cancer. Particularly, we emphasize the connection of NF-${\kappa}B$ with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-${\kappa}B$ produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.

• Bulletin of the Korean Mathematical Society
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• v.37 no.2
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• pp.401-409
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• 2000

In this paper, we determine the structure of ${\kappa}-potent$ elements and regular elements of the semigroup ${\Omega}_n$of doubly stochastic matrices of order n. In connection with this, we find the structure of the matrices X satisfying the equation AXA = A. From these, we determine a condition of a doubly stochastic matrix A whose Moore-Penrose generalized is also a doubly stochastic matrix.

• Earthquakes and Structures
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• v.11 no.3
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• pp.505-516
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• 2016

This paper evaluates the scaling of ground motions recorded from nine intermediate-depth earthquakes produced in the Vrancea seismic zone in Romania. The considered ground motion database consists of 363 horizontal recordings obtained on soil classes B and C (according to Eurocode 8). An analysis of the inter- and intra-event spectral accelerations is performed in order to gain information regarding the magnitude and distance scaling of the Vrancea ground motions. The analyses reveal a significant influence of the earthquake magnitude and focal depth on the distance scaling and different magnitude and distance scaling for the two soil classes. A linear magnitude and distance scaling is inferred from the results for the range of magnitudes $5.2{\leq}M_W{\leq}7.1$. The results obtained are checked through stochastic simulations and the influence of the stress drop and kappa values on the ground motion levels is assessed. In addition, five ground motion models which were tested in other studies using recordings from Vrancea earthquakes are analyzed in order to evaluate their corresponding host stress drop and kappa. The results show generally a direct connection between the host kappa values and the host stress drop values. Moreover, all the ground motion models depict magnitude dependent host kappa and stress drop levels.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.3
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• pp.651-656
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• 2006

Activation of $NF-{\kappa}B$ is known to be a trigger of various cellular disorders including inflammatory and autoimmune diseases such as rheumatoid arthritis. Numerous approaches are ongoing within laboratories to identify potential therapeutic agents which inhibit the $NF-{\kappa}B$ activation. In this study, we have tested the inhibitory effects of five traditional medicines on the activation of $NF-{\kappa}B$ by NIK. Among three medicines which exhibited inhibitory effect on the expression of $NF-{\kappa}B$ repoter plasmid, we investigated further the inhibitory mechanism of Dichroa febrifuga in connection with IKKY activity. Wild type $IKK{\gamma}$ inhibited the $NF-{\kappa}B$ activation by NIK but the C-terminal deletion mutant of IKKY did not show the inhibitory effect, indicating that the C-terminal leucine zipper domain of $NF-{\kappa}B$ is important for the inhibition of $NF-{\kappa}B$ activation. The water extract of Dichroa febrifuga(DFE) also strongly inhibited the $NF-{\kappa}B$ activation by NIK. The inhibitory activity of DFE appeared to be independent of the expression of $IKK{\gamma}$, suggesting that the pathways of inhibition by Dichroa febrifuga and $IKK{\gamma}$ are different. Our results suggest that Dichroa febrifuga can be used as a medicine for inhibition of the $NF-{\kappa}B$ activation in a wide range of cells without relation to the expression of $IKK{\gamma}$.

• Honam Mathematical Journal
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• v.43 no.4
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• pp.655-665
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• 2021

In the present paper, we study the geometric properties of the invariant submanifold of an almost Kenmotsu structure whose Riemannian curvature tensor has (𝜅, 𝜇, 𝜈)-nullity distribution. In this connection, the necessary and sufficient conditions are investigated for an invariant submanifold of an almost Kenmotsu (𝜅, 𝜇, 𝜈)-space to be totally geodesic under the behavior of functions 𝜅, 𝜇, and 𝜈.

• Toxicological Research
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• v.34 no.4
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• pp.333-341
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• 2018

Ferulate is a phenolic compound abundant in wheat germ and bran and has been investigated for its beneficial activities. The aim of the present study is to evaluate the efficacy of ferulate against the oxidative stress-induced imbalance of protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs), and serine/threonine protein phosphatase 2A (PP2A), in connection with our previous finding that oxidative stress-induced imbalance of PTKs and PTPs is linked with proinflammatory nuclear factor-kappa B $(NF-{\kappa}B)$ activation. To test the effects of ferulate on this process, we utilized two oxidative stress-induced inflammatory models. First, YPEN-1 cells were pretreated with ferulate for 1 hr prior to the administration of 2,2'-Azobis(2-methylpropionamidine) dihydrochloride (AAPH). Second, 20-month-old Sprague-Dawley rats were fed ferulate for 10 days. After ferulate treatment, the activities of PTKs, PTPs, and PP2A were measured because these proteins either directly or indirectly promote $NF-{\kappa}B$ activation. Our results revealed that in YPEN-1 cells, ferulate effectively suppressed AAPH-induced increases in reactive oxygen species (ROS) and $NF-{\kappa}B$ activity, as well as AAPH-induced PTK activation. Furthermore, ferulate also inhibited AAPH-induced PTP and PP2A inactivation. In the aged kidney model, ferulate suppressed aging-induced activation of PTKs and ameliorated aging-induced inactivation of PTPs and PP2A. Thus, herein we demonstrated that ferulate could modulate PTK/PTP balance against oxidative stress-induced inactivation of PTPs and PP2A, which is closely linked with $NF-{\kappa}B$ activation. Based on these results, the ability of ferulate to modulate oxidative stress-related inflammatory processes is established, which suggests that this compound could act as a novel therapeutic agent.

• Communications of the Korean Mathematical Society
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• v.35 no.4
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• pp.1269-1281
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• 2020

In this article, we show that a pseudo-Hermitian magnetic curve in a normal almost contact metric 3-manifold equipped with the canonical affine connection ${\hat{\nabla}}^t$ is a slant helix with pseudo-Hermitian curvature ${\hat{\kappa}}={\mid}q{\mid}\;sin\;{\theta}$ and pseudo-Hermitian torsion ${\hat{\tau}}=q\;cos\;{\theta}$. Moreover, we prove that every pseudo-Hermitian magnetic curve in normal almost contact metric 3-manifolds except quasi-Sasakian 3-manifolds is a slant helix as a Riemannian geometric sense. On the other hand we will show that a pseudo-Hermitian magnetic curve γ in a quasi-Sasakian 3-manifold M is a slant curve with curvature κ = |(t - α) cos θ + q| sin θ and torsion τ = α + {(t - α) cos θ + q} cos θ. These curves are not helices, in general. Note that if the ambient space M is an α-Sasakian 3-manifold, then γ is a slant helix.

• The Journal of Korean Medicine
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• v.39 no.2
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• pp.92-105
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• 2018

Objectives: This aim of this study is to compare the reflux esophagitis improvement effects of Sepiae Os, Arcae Concha, Ostreae Concha, and Proton Pump Inhibitor(esomeprazole) through rat experiments. Methods: NO production inhibitory effect was measured by NO production amount and iNOS mRNA expression level in cell lines. iNOS, $TNF-{\alpha}$ and $p-I{\kappa}B$, and serotonin were compared using immunohistochemistry at the rat reflux esophagitis. Reflux esophagitis connection external form, lower esophageal sphincter, and gap were observed and an esophageal inflammatory indicator, IL-6 activity was also evaluated by immunohistochemistry. Results: NO production and iNOS mRNA expression was showed concentration dependent decrease in cell lines treated with Sepiae OS, Arcae Concha, and Ostreae Concha at the experiments of cell lines. In the suppression of iNOS and $p-I{\kappa}B$ at the rat reflux esophagitis, Sepiae Os treat group(SOT) and Ostreae Concha treat group(OCT) were more effective. In the increase of serotonin at the rat reflux esophagitis, ACT, MT and OCT were more effective. Damage of lower esophageal sphincter, and gap between esophageal keratin and mucosa were observed less at the SOT, ACT, OCT. In the suppression of IL-6 at the rat reflux esophagitis, SOT and OCT were more effective than GE and, SOT was more effective than MT significantly. Conclusions: The anti-inflammatory effect was the best in the SOT and lower esophageal sphincter muscle contraction was the best in the ACT at the rat reflux esophagitis. Sepiae OS was more effective than esomeprazole in the suppression of iNOS, $TNF-{\alpha}$, and IL-6.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.2
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• pp.98-112
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• 2020

There is a strong connection between the diet rich in antioxidants and the decreased incidence of inflammatory bowel disease and cancerous diseases. Diets that are rich in anti-oxidants particularly include fruits and vegetables containing the high amounts of vitamin A-E, carotenoids, and minerals. The supercritical heat-treated radish extracts of the research result had an inhibitory effect on the development of aberrant crypt foci (ACF), namely, preneoplastic lesions having a potential to become cancer cells and reduced the number of the aberrant crypt foci (ACF) consisting of four or more aberrant crypts (AC) having high risk to become tumors by about half. The supercritical heat-treated radish extracts can reduce the incidence of preneoplastic lesions having a high risk of developing cancer by about 28 %. DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. Supercritical heat-treated radish extracts, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, supercritical heat-treated radish extracts treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-kB) signaling pathways, and prevented the apoptosis of colon. Moreover, supercritical heat-treated radish extracts administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase.