• 교육녹색환경연구
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• 제13권3호
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• pp.15-22
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• 2014

Proceeded with a research with basic data about the qualification standard improvement scheme about the environment school architecture in which a comparison analyze the specialized field of BREEAM system of LEED of the hit environment building qualification standard G-SEED of the domestic and U.S Green Building Counci evaluated with the certification system of the world top class and Building Research Establish, essential item, and mark distribution and weight in this study at this and which I hit with a domestic afterward. The school facility with a hub among the equipment receiving the hit environmental qualification standard, and the range of this research does LEED of the domestic green building certification system February is revised in 2013 G-SEED and which US and BREEAM in UK with a range. The way of the research checked the environment school building certification system and situation hit home and abroad, and a comparison analyze the division of the specialized field of each country qualification standard, essential item, and mark distribution and weight.

• Journal of Communications and Networks
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• 제8권3호
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• pp.330-338
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• 2006

Many web cache systems and policies concerning them have been proposed. These studies, however, consider large objects less useful than small objects in terms of performance, and evict them as soon as possible. Even if this approach increases the hit rate, the byte hit rate decreases and the connections occurring over congested links to outside networks waste more bandwidth in obtaining large objects. This paper puts forth a client-cluster approach for improving the web cache system. The client-cluster is composed of the residual resources of clients and utilizes them as exclusive storage for large objects. This proposed system achieves not only a high hit rate but also a high byte hit rate, while reducing outgoing traffic. The distributed hash table (DHT) based peer-to-peer lookup protocol is utilized to manage the client-cluster. With the natural characteristics of this protocol, the proposed system with the client-cluster is self-organizing, fault-tolerant, well-balanced, and scalable. Additionally, the large objects are managed with an index based allocation method, which balances the loads of all clients well. The performance of the cache system is examined via a trace driven simulation and an effective enhancement of the proxy cache performance is demonstrated.

• 대한조선학회논문집
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• 제59권6호
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• pp.413-422
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• 2022

Blast Hardened Bulkheads (BHB) are used to suppress damage propagation by internal explosions to reduce ships'vulnerability. However, for this reason, the weight of the ship inevitably increased, and other functions such as the ships'mobility were bound to deteriorate. Therefore, it is essential in the initial design of the ship to optimize the dimensions of the bulkhead to minimize the weight while decreasing the vulnerability of the ship. Research on design optimization of BHB has been conducted, but it has not considered explosive load in various hit scenarios. This study proposed an optimal design method for the curtain plate type blast hardened bulkhead, which is currently frequently applied by the Korean Navy in consideration of various hit scenarios. Using genetic algorithms, multiobjective design optimizations that minimize weight increase as well as minimize damage to ships were obtained. By optimizing the dimensions of the BHB considering various hit scenarios, the ship's vulnerability was improved while maintaining its mobility due to weight reduction.

• 한국정보통신학회논문지
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• 제20권5호
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• pp.1040-1048
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• 2016

최근 전투 시스템의 신뢰도를 분석하는 것에 대한 연구가 활발하게 진행되고 있으며, 특히 선행 연구의 한계점을 보완하기 위한 연구와 보다 통합적인 분석에 관한 연구의 필요성이 강조되고 있다. 본 논문에서는 선행 연구에서 분석된 전면과 측면의 피격 확률을 활용하여 시간-효율성을 향상시키기 위한 통합 피격 확률 도출 기법을 제안한다. 또한 도출된 통합 피격 확률을 기반으로 각 구성 요소의 신뢰도를 구하고, 전체 전투 시스템의 기능별 신뢰도를 분석하기 위하여 RBD 기법을 적용하는 방법을 제안한다. 전차 모델에 적용하여 신뢰도 분석을 수행하였으며, 이를 통해 제안하는 방법의 유용성을 검증하였다. 제안하는 방법은 선행 연구에서는 고려되지 않았던 승무원까지도 고려하며, 분석된 기능별 신뢰도는 선행 연구 대비 분석의 정확도 및 시간-효율성을 향상시킬 수 있을 것으로 기대된다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권3호
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• pp.211-216
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• 2014

Endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and mitochondrial biogenesis were assessed following varying intensities of exercise training. The animals were randomly assigned to receive either low- (LIT, n=7) or high intensity training (HIT, n=7), or were assigned to a control group (n=7). Over 5 weeks, the animals in the LIT were exercised on a treadmill with a $10^{\circ}$ incline for 60 min at a speed of 20 m/min group, and in the HIT group at a speed of 34 m/min for 5 days a week. No statistically significant differences were found in the body weight, plasma triglyceride, and total cholesterol levels across the three groups, but fasting glucose and insulin levels were significantly lower in the exercise-trained groups. Additionally, no statistically significant differences were observed in the levels of PERK phosphorylation in skeletal muscles between the three groups. However, compared to the control and LIT groups, the level of BiP was lower in the HIT group. Compared to the control group, the levels of ATF4 in skeletal muscles and CHOP were significantly lower in the HIT group. The HIT group also showed increased PGC-$1{\alpha}$ mRNA expression in comparison with the control group. Furthermore, both of the trained groups showed higher levels of mitochondrial UCP3 than the control group. In summary, we found that a 5-week high-intensity exercise training routine resulted in increased mitochondrial biogenesis and decreased ER stress and apoptotic signaling in the skeletal muscle tissue of rats.

• 대한물리치료과학회지
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• 제21권1호
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• pp.65-77
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• 2014

Purpose : This research is to understand the academic self-efficacy of trainees receiving the 4 category-union education of HIT(Health Integrated Technic) Methods : A self-administered questionnaire survey was conducted in 450 health-related college students in Daegu city from April to July. A statistical analysis was performed using SPSS 17.0 for window version. Results : First, satisfaction to education of HIT was higher in vocational consciousness program than patient care programme educational deepening program. Second, academic self-efficacy to education of HIT was higher in educational deepening program than patient care programme vocational consciousness program. Conclusion : Systemic education is needed to develop vocational consciousness, patient care and educational deepening that suit the characteristics of college students in order to establish an environment for revitalizing satisfaction and academic self-efficacy to 4 category-union education

• 한국식품영양과학회지
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• 제39권1호
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• pp.31-35
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• 2010

본 실험에서는 hamster $\beta$-cell인 HIT-T15 cell을 이용하여 돼지감자추출물의 생리활성 및 기능을 검증하고자 하였다. 돼지감자추출물을 첨가한 NC(0 ${\muL/mL$), HT2(1.1 ${\muL/mL$), HT3(1.5 ${\muL/mL$)군과 inulin을 첨가한 NC(0 ${\muL/mL$), IN2(1.8 ${\muL/mL$), IN3(2.5 ${\muL/mL$)군으로 나누어 실험하였다. 세포 viability 측정한 결과 시료를 첨가하지 않은 군을 100%로 보았을 때 돼지감자추출물을 첨가한 HT3(1.5 ${\muL/mL$)군과 inulin을 첨가한 IN2(1.8 ${\muL/mL$), IN3(2.5 ${\muL/mL$) 군에서 세포생존율이 유의적으로 증가하였다(p<0.05). 시료처리 후 췌장 $\beta$-세포 파괴를 유도하지 않고 HIT-T15 cell의 cell culture supernatant를 이용하여 cytotoxicity를 측정한 결과 시료를 첨가하지 않은 NC(0${\muL/mL$)군에 비해 모든 군에서 cytotoxicity가 낮게 나타났다. Alloxan(4 mM)으로 $\beta$-세포 파괴를 유도하여 HIT-T15 cell에서 세포보호 효과를 측정한 결과 시료를 첨가하지 않은 NC(0 ${\muL/mL$)군에 비해 돼지감자추출물을 첨가한 HT2(1.1 ${\muL/mL$), HT3(1.5 ${\muL/mL$)군에서 세포생존율이 유의적으로 증가하였다(p<0.05). 또한 췌장 $\beta$-세포 파괴를 유도하여 HIT-T15 cell이 분비한 인슐린 분비능 및 세포 내 $NAD^+$/NADH 함량을 측정한 결과 시료를 첨가하지 않은 NC(0 ${\muL/mL$)군에 비해 돼지감자추출물을 첨가한 HT3(1.5 ${\muL/mL$)군에서 인슐린 분비량과 $NAD^+$/NADH 함량이 유의적으로 증가하였다(p<0.05). 이상의 연구 결과 돼지감자추출물은 HIT-T15 cell의 생존율을 높이고, 세포보호 효과를 가짐으로써 인슐린 분비능 정상화 및 $NAD^+$ 함량을 증가시켜 혈당 조절 및 당뇨에 긍정적 효과가 있을 것으로 사료된다.

• 한국통신학회논문지
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• 제25권4B호
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• pp.783-787
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• 2000

현재 사용되고 있는 개인용 컴퓨터의 중앙처리장치로서 주종을 이루고 있는 마이크로프로세서는 256KB, 혹은 512KB의 L2(Second Level) 캐쉬를 Direct Mapping, 32B 라인사이즈, 그리고 Write Allocation을 채택하지 않는 형태로 사용하고 있는데, 이러한 L2 캐쉬에서 Mapping 방식을 8-way Set Associative Mapping Procedure로 바꾸고, 라인사이즈를 늘려서 128B 이상으로 변경하고, 그리고 Write Allocation을 채택하였을 경우 그 적중률(Hit Ratio)이 약간의 하드웨어적 추가 비용만으로 2.5% 정도 개선됨을 확인하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권6호
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• pp.408-411
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• 2013

After radical excision of a tumor in the maxillofacial area, functional and esthetic reconstruction is needed, including flap surgery. Among the many etiologies of flap failure, venous thrombosis is one of the most frequent. Heparin is used routinely in the effort to avoid development of venous thrombosis. In rare cases, heparin-induced thrombocytopenia (HIT) type II occurs due to exposure to heparin. Heparin attached to platelet factor 4 forms a PF4/heparin-immunoglobulin G immune complex on platelet surfaces. This complex activates platelets, which leads to multiple coagulation in venous and arterial blood. We report here on a rare occurrence of HIT type II following fibula free flap surgery.

• 대한의생명과학회지
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• 제15권2호
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• pp.105-112
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• 2009

The screening of the anti-cancer activity of the chemical library provided 2-thio-4-aminopyrimidine as the initial hit. The confirmation of structure and biological effect of hit was performed by synthesis and biological evaluation. The optimization of hit was performed by derivatization of substituents while keeping the core structure. The evaluation of growth inhibitory activity was carried out using SRB assay against 6 human cancer cell lines and human fibroblast. The growth inhibitory activity of compounds showed substituent dependency and more than 5 compounds showed complete growth inhibition of cancer cell lines at 10 ${\mu}M$ concentration. Chemical library screening followed by synthetic modification provided possibility that 2-thio-4-aminopyrimidine can be used as a new scaffold for the development of anti-cancer agent.