• Food Science of Animal Resources
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• v.23 no.1
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• pp.86-95
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• 2003

Potential mechanisms by which vitamin E improves oxidative stability of myoglobin are documented. The basis by which this lipid-soluble antioxidant, ${\alpha}$-tocopherol, protects water-soluble oxymyoglobin is beginning to be understood. Recent evidence suggests that ${\alpha}$-tocopherol delays the release of prooxidative products of lipid oxidation from biomembranes, which in turn delays oxymyoglobin oxidation and the concomitant loss of desirable beef color. ${\alpha}$, ${\beta}$-Unsaturated aldehydes are one class of lipid oxidation products that enhance oxymyoglobin oxidation in vitro and appear to act by covalently binding to the protein. If ${\alpha}$-tocopherol delays the formation of these reactive aldehydes, then this could inhibit the prooxidative effect of these oxidation products toward oxymyoglobin. Additionally, ${\alpha}$-tocopherol may exert part of its color-stabilizing effect in beef by enhancing the metmyoglobin reduction.

• Honam Mathematical Journal
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• v.31 no.4
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• pp.505-513
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• 2009

Let {$X_k;k{\in}N^d$} be centered and identically distributed random field which is asymptotically negative dependent in a certain case. In this note we prove that for $p{\alpha}$ > 1 and ${\alpha}$ > ${\frac{1}{2}}$ $E{\mid}X_1{\mid}^p(log^+{\mid}X_1{\mid}^{d-1})$ < ${\infty}$ if and only if ${\sum}_n{\mid}n{\mid}^{p{\alpha}-2}P$($max_{1{\leq}k{\leq}n{\mid}S_k{\mid}}$ > ${\epsilon}{\mid}n{\mid}$) < ${\infty}$ for all ${\epsilon}$ > 0, where log$^+$x = max{1,log x}.

• Journal of Nutrition and Health
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• v.52 no.2
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• pp.176-184
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• 2019

Purpose: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The effect of emodin against palmitic acid (PA) - induced ER stress in HepG2 cells was investigated. Methods: HepG2 cells were treated with varying concentrations of palmitic acid to determine the working concentration that induced ER stress. ER stress associated genes such as ATF4, XBP1s, CHOP and GRP78 were checked using RT- PCR. In addition, the expression levels of unfolded protein response (UPR) associated proteins such as $IRE1{\alpha}$, $eIF2{\alpha}$ and CHOP were checked using immunoblotting to confirm the induction of ER stress. The effect of emodin on ER stress was analyzed by treating HepG2 cells with $750{\mu}M$ palmitic acid and varying concentrations of emodin, then analyzing the expression of UPR associated genes. Results: It was evident from the mRNA and protein expression results that palmitic acid significantly increased the expression of UPR associated genes and thereby induced ER stress. Subsequent treatment with emodin reduced the mRNA expression of ATF4, GRP78, and XBP1s. Furthermore, the protein levels of $p-IRE1{\alpha}$, $p-eIF2{\alpha}$ and CHOP were also reduced by the treatment of emodin. Analysis of sirtuin mRNA expression showed that emodin increased the levels of SIRT4 and SIRT7, indicating a possible role in decreasing the expression of UPR-related genes. Conclusion: Altogether, the results suggest that emodin could exert a protective effect against fatty acid-induced ER stress and could be an agent for the management of various ER stress related diseases.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.6
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• pp.345-351
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• 2011

High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), inositol requiring enzyme alpha (IRE-$1{\alpha}$) and phosphoreukaryotic initiation factor alpha (p-eIF-$2{\alpha}$) was activated in the presence of high glucose. Activating transcription factor 4 (ATF-4), a downstream protein of p-eIF-$2{\alpha}$ as well as a transcription factor for collagen, was also phosphorylated and translocalized into the nucleus. The chemical chaperone 4-PBA inhibited the ER stress response and ATF-4 phosphorylation as well as nuclear translocation. Our results suggest that high concentrations of glucose-induced collagen are linked to ER stress and the associated phosphorylation and nuclear translocation of ATF-4.

• Molecules and Cells
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• v.40 no.1
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• pp.66-72
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• 2017

Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to maladaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit $(p-eIF2)-{\alpha}$, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal ($0.5mg{\cdot}kg^{-1}{\cdot}day^{-1}$) alleviated cardiac hypertrophy and tissue fibrosis. Salubrinal also alleviated hypertrophic growth in endothelin 1 (ET1)-treated NRVMs. Therefore, the present results suggest that salubrinal may be a potentially efficacious drug for treating pathological cardiac remodeling.

• Kyungpook Mathematical Journal
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• v.63 no.2
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• pp.155-166
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• 2023

In 2018, Andrews introduced the partition functions ${\mathfrak{EO}}$(n) and ${\bar{\mathfrak{EO}}}$(n). The first of these denotes the number of partitions of n in which every even part is less than each odd part, and the second counts the number of partitions enumerated by the first in which only the largest even part appears an odd number of times. In 2021, Pore and Fathima introduced a new partition function ${\mathfrak{EO}}_e$(n) which counts the number of partitions of n which are enumerated by ${\bar{\mathfrak{EO}}}$(n) together with the partitions enumerated by ${\bar{\mathfrak{EO}}}$(n) where all parts are odd and the number of parts is even. They also proved some particular congruences for ${\bar{\mathfrak{EO}}}$(n) and ${\mathfrak{EO}}_e$(n). In this paper, we establish infinitely many families of congruences modulo 2, 4, 5 and 8 for ${\bar{\mathfrak{EO}}}$(n) and modulo 4 for ${\mathfrak{EO}}_e$(n). For example, if p ≥ 5 is a prime with Legendre symbol $({\frac{-3}{p}})=-1$, then for all integers n ≥ 0 and α ≥ 0, we have ${\bar{\mathfrak{EO}}}(8{\cdot}p^{2{\alpha}+1}(pn+j)+{\frac{19{\cdot}p^{2{\alpha}+2}-1}{3}}){\equiv}0$ (mod 8); 1 ≤ j ≤ (p - 1).

• Economic and Environmental Geology
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• v.28 no.6
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• pp.559-569
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• 1995

Paleomagnetic data have been obtained from the Upper Carboniferous-Permian Komok and Cheolam Groups which are exposed in the E-W trending Baekunsan syncline comprising the Pyongan Supergroup in eastern Korea. Two ancient components of magnetization are recovered in these groups by detailed thermal demagnetization: a post-folding component and a pre-folding component. The post-folding component $(D/I=54.0/54.6^{\circ},\;{\alpha}_{95}=14.6^{\circ})$ is a magnetic signature of the Oaebo Orogeny and appears to have been confined mainly to Cretaceous Normal Superchron. It has been rotated clockwise since this magnetization has been acquired. The pre-folding components ($D/I=341/-9.2^{\circ},\;{\alpha}_{95}=7.2^{\circ})$, paleopole at $335.7^{\circ}E$, $44.6^{\circ}N$ for Upper Carboniferous; $D/I=358.3/11.5^{\circ},\;{\alpha}_{95}=6.3^{\circ})$, paleopole at $311.9^{\circ}E$, $58.7^{\circ}N$ for Permian) pass fold and reversal tests. These paleopoles correspond only with the contemporaneous poles from the North China Block: they are removed from the poles from the South China Block. If the results of this study are corrected for the clockwise rotation deduced from the prefolding component, the enhanced agreement with North China Block can be achieved. Therefore, a first-order correlation between the Korean Peninsula and North China at least since Upper Paleozoic times is identified in this study.

• Journal of the Korean Mathematical Society
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• v.46 no.1
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• pp.151-170
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• 2009

Let m be a positive integer. We show that for any given real number ${\alpha}\;{\in}\;[0,\;1]$ and complex number $\mu$ with $|\mu|{\leq}1$ which satisfy $e^{2{\pi}i{\alpha}}{\mu}^m\;{\neq}\;1$, there exists a Blaschke product B of degree 2m + 1 which has a fixed point of multiplier ${\mu}^m$ at the point at infinity such that the restriction of the Blaschke product B on the unit circle is a critical circle map with rotation number $\alpha$. Moreover if the given real number $\alpha$ is irrational of bounded type, then a modified Blaschke product of B is quasiconformally conjugate to some rational function of degree m + 1 which has a fixed point of multiplier ${\mu}^m$ at the point at infinity and a Siegel disk whose boundary is a quasicircle containing its critical point.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.4
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• pp.373-378
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• 2012

The objective of this research is to examine the probabilistic approach to evaluating turbine ejection frequency considering common-cause failure. This paper identifies basic turbine ejection mechanisms under high and low speeds and presents a detailed probabilistic methodology (fault tree) for assessing ejection frequency. The alpha factor methodology is applied to common-cause failure evaluations. The frequencies under different test schemes are compared and the propagation of uncertainty through the fault tree model is evaluated. The following conclusions were reached: (1) the turbine blade ejection frequency due to ductile failure under high speed is around 8.005E-7/yr; (2) if common-cause failure is considered, the frequency will be increased by 11% and 33% depending on the test scheme; and (3) if the parameter uncertainties are considered, the frequency is estimated to be in the range of 9.35E-7 to 1.13E 6, with 90% confidence.

• Bulletin of the Korean Mathematical Society
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• v.55 no.5
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• pp.1523-1528
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• 2018

For $r{\geq}2$, let ${\mathcal{H}}$ be an r-uniform hypergraph with n vertices and m hyperedges. Let R be a random vertex set obtained by choosing each vertex of ${\mathcal{H}}$ independently with probability p. Let ${\mathcal{H}}[R]$ be the subhypergraph of ${\mathcal{H}}$ induced on R. We obtain an upper bound on the matching number ${\nu}({\mathcal{H}}[R])$ and a lower bound on the independence number ${\alpha}({\mathcal{H}}[R])$ of ${\mathcal{H}}[R]$. First, we show that if $mp^r{\geq}{\log}\;n$, then ${\nu}(H[R]){\leq}2e^{\ell}mp^r$ with probability at least $1-1/n^{\ell}$ for each positive integer ${\ell}$. It is best possible up to a constant factor depending only on ${\ell}$ if $m{\leq}n/r$. Next, we show that if $mp^r{\geq}{\log}\;n$, then ${\alpha}({\mathcal{H}}[R]){\geq}np-{\sqrt{3{\ell}np\;{\log}\;n}-2re^{\ell}mp^r$ with probability at least $1-3/n^{\ell}$.