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Adiponectin gene SNP 276G${\rightarrow}$T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients

  • Yu, So-Young;Ryu, Han-Kyoung;Park, Hee-Jung;Choi, Young-Ju;Huh, Kap-Bum;Kim, Wha-Young
    • Nutrition Research and Practice
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    • v.1 no.4
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    • pp.363-370
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    • 2007
  • Single nucleotide polymorphism (SNP) in adiponectin gene has been associated with insulin resistance, diabetes, and cardiovascular disease (CVD). This study was performed to investigate the association of SNP 276G${\rightarrow}$T at adiponectin gene with CVD risk factors in Korean type 2 diabetes mellitus (DM) patients. The subjects were 351 type 2 DM patients visited a DM clinic in Seoul, and the patients with known CVD were excluded. The adiponectin SNP 276G${\rightarrow}$T was analyzed and dietary intakes were assessed by a Food Frequency Questionnaire. The prevalence of G/G, G/T, and T/T genotype was 47.6%, 43.3%, and 9.1%, respectively. Male subjects with T/T genotype showed significantly lower level of adiponectin and HDL-cholesterol and significantly higher C-reactive protein (CRP) level compared to G/G and G/T genotypes. In G/G genotype, protein intake was negatively correlated to body weight, BMI, and waist circumference, and there were positive correlation between carbohydrate intake and BMI, waist-hip ratio, and ApoB/apoA-1 ratio in G/T genotype. However, in T/T genotype, there was no significant association between macronutrient intakes and anthropometric and hematological values. In conclusion, CVD risk would be high in type 2 DM patients with T/T genotype, and the association of macronutrient intakes with anthropometric and hematologic factors was different among the three adiponectin genotypes. These results may imply the need for different dietary management regime according to adiponectin genotype to lower CVD complications in Korean type 2 DM patients.

Effects of Chinae Rhizoma Extracts on the Growth of the Dermatophytes (토복령알코홀추출물의 항진균작용)

  • Lee, Jong-Hwa;Song, Byung-Sook;Lee, Sun-Hee;Kim, Chung-Il
    • The Korean Journal of Pharmacology
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    • v.9 no.2
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    • pp.39-45
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    • 1973
  • The majority of drugs used in the treatment of superficial fungal infections has limited values due to its low efficacy or development of resistance. For the purpose of searching efficacious agent on the superficial fungal infections induced by dermatophytes which is regarded as the most malicious one, authors examined whether Chinae Rhizoma Extracts have significant on it. Extracts from Smilax china Linne used for the study are water extract (CRWE), ethanol extract (CREE) and methanol extract (CRME). In in vitro studies, the spores of the dermatophytes were inoculated on Sabouraud's glucose agar media which contained three extracts of Chinae Rhizoma in each concentration of $500\;{\mu}g/ml$, $1,000\;{\mu}g/ml$ and $5,000\;{\mu}g/ml$ respectively, and also $1,000\;{\mu}g/ml$ of salicylic acid and undecylenic acid $1,000\;{\mu}g/ml$ as comparable drugs. The growth of the dermatophytes were observed for 3 weeks. The species of the dermatophytes used in this experiment were Epidermophyton floccosum, Microsporum canis, Microsporum cookei, Microsporum gypseum, Microsporum nanum, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans and Trichophyton verrucosum distributed from The Institute of Tropical Medicine in Belgium. The results of the studies were as follows: 1. The growth of M. canis, M. nanum, T. mentagrophytes, T. rubrum & T. tonsurans were slightly inhibited in CRWE $1,000\;{\mu}g/ml$ and CRWE $5,000\;{\mu}g/ml$, and only slight inhibition on the growth of E. floccosum, M. canis and M. gypseum were observed in CRWE $5,000\;{\mu}g/ml$. 2. Complete inhibition of T. rubrum, moderate inhibition of M. nanum & T. tonsurans, and slight inhibition of E. floccosunl, M. canis, M. cookei & T. mentagrophytes in growth were observed in concentration of CREE $500\;{\mu}g/ml$. The growth of M. gypseum was slightly inhibited, moderate inhibition on the growth of M. canis, M. cookei & T. mentagrophytes, and complete inhibition of E. floccosum, M. nanum, T. rubrum & T. tonsurans in growth were observeed by CREE $1,000\;{\mu}g/ml$. With $5,000\;{\mu}g/ml$ of CREE, the growth of E. floccosum, M. canis, M. cookei, M. gypseum, T. mentagrophytes, T. rubrum & T. tonsurans were completely inhibited except T. verrucosum being showed slight inhibition. 3. In CRME $500\;{\mu}g/ml$, slight inhibition of T. verrucosum, moderate inhibition of M. gypseum and complete inhibition of E. floccosum, M. canis, M. cookei, T. mentagrophytes, T. rubrum & T. tonsurans in growth were observed. The growth of E. floccosum, M. canis, M. cookei, M. gypseum, M. nanum, T. mentagrophytes, T. rubrum & T. tonsurans were completely inhibited except T. verrucosum being showed moderate inhibition in both CRME $1,000\;{\mu}g/ml$ and CRME $5,000\;{\mu}g/ml$. 4. In $1,000\;{\mu}g/ml$ of undecylenic acid, slight inhibition of T. verrucosum and complete inhibition of E, floccosum, M. canis, M. cookei, M. gypseum, M. nanum, T. mentagrophytes, T. rubrum & T. tonsurans in growth were observed. From the above results, it was found that Chinas Rhizoma Alcoholic Extracts(CREE & CRME) exerted significant antifungal activity, and their effects were probably derived from the pharmacological actions of triterpenoidal saponin and steroidal saponin.

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EFFECT OF SOIL mOISTURE CONDITiON ON THE GROWTH AND EVAPOTRANSPIRATION OF THE TOBACCO PLANT (토양수분의 과, 부족이 연초의 생장과 증발산량에 미치는 영향)

  • 홍순달;이윤환;김재정;조성진
    • Journal of the Korean Society of Tobacco Science
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    • v.7 no.1
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    • pp.15-23
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    • 1985
  • Growth response and evapotranspiration of tobacco as to each soil moisture condition treated with different height of ground water table such as 30cm, 100cm, 170cm, and 230cm were investigated. The results obtained were as follows; 1. Soil water potential in the rhizosphere (25cm depth from surface) treated with ground water table (G.W.T) of 230 cm was less than -6.5 bar at 60 days after transplanting. 2. Dry weight of leaves per plant was the highest in the pot treated with 100 cm G.W.T and was the lowest in the pot treated with 230 cm G.W.T.. Leaves/Stem ratio of dry weight was the lowest in the pot treated with 230 cm G.W.T. This would show that extension of leaves as compared with elongation of stem was suppressed. .3. In the roster stress condition of 230 cm G.W.T., extension of leaves was continued until the latter growth stage, Relative growth rate of leaf area per plant of the pot with 30 cm G.W.T. was the highest through all growth period after fixation of G.W.7., but owing to lower density of leaf, the dry weight of leaves per plant was less rather than that of the pot with 170 cm G.W.T. at 64 days after transplanting. 4. The highest evapotranspiration per plant per day was shown at the 45th day after transplanting in the pots with 30cm and 100cm G.W.T. and at 60 days in the pots with 170cm and 230cm G.W.T respectively. 5. In the soil moisture conditions with 30cm and 100cm G.W.T., evapotranspiration per plant per hour was much higher in the daytime that at night as well as in clear day than in rain-cloudy day owing to loner relative humidity , but in the water stress condition with 230 cm G.W.T., that was much lower. 6. Total evapotranspiration per plant during the whole growing period of 64 days was in order of 30cm > 100 cm > 170 cm > 230 cm G.W.T.. Total evapotranspiration for 34 days after fixation of G.W.T was much higher at night than in the daytime in case of water stress conditions i.e 170cm and 230cm G.W.T. but in normal condition of the pots with 30cm and 100cm G.W.T. that was much higher in the daytime than at night. 7. Leaf water potential of the 3rd and 6th leaf from top at 64 days after transplanting was in order of 100cm > 30 cm > 170cm > 230cm G.W.T. The reason why leaf water potential in the pot with 30cm was less than that in the pot with 100cm G.W.T. would be the abnormal turgidity with low density of cell substrates by the excess water absorption in the pot with 30cm G.W.T..

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On the Gauss Map of Tubular Surfaces in Pseudo Galilean 3-Space

  • Tuncer, Yilmaz;Karacan, Murat Kemal;Yoon, Dae Won
    • Kyungpook Mathematical Journal
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    • v.62 no.3
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    • pp.497-507
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    • 2022
  • In this study, we define tubular surfaces in Pseudo Galilean 3-space as type-1 or type-2. Using the X(s, t) position vectors of the surfaces and G(s, t) Gaussian transformations, we obtain equations for the two types of tubular surfaces that satisfy the conditions ∆X(s, t) = 0, ∆X(s, t) = AX(s, t), ∆X(s, t) = λX(s, t), ∆X(s, t) = ∆G(s, t), ∆G(s, t) = 0, ∆G(s, t) = AG(s, t) and ∆G(s, t) = λG(s, t).

A role of carboxy-terminal region of Toxoplasma gondii-heat shock protein 70 in enhancement of T. gondii infection in mice

  • Mun, Hye-Seong;Norose, Kazumi;Aosai, Fumie;Chen, Mei;Yano, Akihiko
    • Parasites, Hosts and Diseases
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    • v.38 no.2
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    • pp.107-110
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    • 2000
  • We investigated the role of recombinant Toxoplasma gondii heat shock protein (rT.g.HSP) 70-full length, rT.g. HSP70-NH2-terminal region, or rT.g. HSP70-carboxy-terminal region in prophylactic immunity in C57BL/6 mice perorally infected with Fukaya cysts of T. gondii. At 3, 4, 5, and 6 weeks after infection, the number of T gondii in the brain tissue of each mouse was measured by quantitative competitive-polymerase chain reaction (QC-PCR) targeting the surface antigen (SAG) 1 gene. Immunization with rT.g.HSP70-full length or rT.g.HSP70-carboxy-terminal region increased the number of T. gondii in the brain tissue after T. gondii infection, whereas immunization with rT.g.HSP70-NHa-terminal region did not. These results suggest that T.g. HSP70-carboxy-terminal region as well as T.g.HSP70-full length may induce deleterious effects on the protective immunity of mice infected with a cyst-forming T. gondii strain, Fukaya.

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[r, s, t; f]-COLORING OF GRAPHS

  • Yu, Yong;Liu, Guizhen
    • Journal of the Korean Mathematical Society
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    • v.48 no.1
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    • pp.105-115
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    • 2011
  • Let f be a function which assigns a positive integer f(v) to each vertex v $\in$ V (G), let r, s and t be non-negative integers. An f-coloring of G is an edge-coloring of G such that each vertex v $\in$ V (G) has at most f(v) incident edges colored with the same color. The minimum number of colors needed to f-color G is called the f-chromatic index of G and denoted by ${\chi}'_f$(G). An [r, s, t; f]-coloring of a graph G is a mapping c from V(G) $\bigcup$ E(G) to the color set C = {0, 1, $\ldots$; k - 1} such that |c($v_i$) - c($v_j$ )| $\geq$ r for every two adjacent vertices $v_i$ and $v_j$, |c($e_i$ - c($e_j$)| $\geq$ s and ${\alpha}(v_i)$ $\leq$ f($v_i$) for all $v_i$ $\in$ V (G), ${\alpha}$ $\in$ C where ${\alpha}(v_i)$ denotes the number of ${\alpha}$-edges incident with the vertex $v_i$ and $e_i$, $e_j$ are edges which are incident with $v_i$ but colored with different colors, |c($e_i$)-c($v_j$)| $\geq$ t for all pairs of incident vertices and edges. The minimum k such that G has an [r, s, t; f]-coloring with k colors is defined as the [r, s, t; f]-chromatic number and denoted by ${\chi}_{r,s,t;f}$ (G). In this paper, we present some general bounds for [r, s, t; f]-coloring firstly. After that, we obtain some important properties under the restriction min{r, s, t} = 0 or min{r, s, t} = 1. Finally, we present some problems for further research.

SOLVABILITY FOR SECOND-ORDER BOUNDARY VALUE PROBLEM WITH INTEGRAL BOUNDARY CONDITIONS ON AN UNBOUNDED DOMAIN AT RESONANCE

  • Yang, Ai-Jun;Wang, Lisheng;Ge, Weigao
    • The Pure and Applied Mathematics
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    • v.17 no.1
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    • pp.39-49
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    • 2010
  • This paper deals with the second-order differential equation (p(t)x'(t))' + g(t)f(t, x(t), x'(t)) = 0, a.e. in (0, $\infty$) with the boundary conditions $$x(0)={\int}^{\infty}_0g(s)x(s)ds,\;{lim}\limits_{t{\rightarrow}{\infty}}p(t)x'(t)=0,$$ where $g\;{\in}\;L^1[0,{\infty})$ with g(t) > 0 on [0, $\infty$) and ${\int}^{\infty}_0g(s)ds\;=\;1$, f is a g-Carath$\acute{e}$odory function. By applying the coincidence degree theory, the existence of at least one solution is obtained.

Effect of the Cultivation Method and Cutting Time on the Growth Characteristics, Dry Matter Yield and Voluntary Intake in Sorghum X Sudangrass Hybrid (재배방식과 예취시기가 수수 X 수단그라스 교잡종의 생육특성, 건물수량 및 사일리지 채식성에 미치는 영향)

  • Lee Sang Moo
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.25 no.1
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    • pp.7-16
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    • 2005
  • This experiments were carried out to determine growth characteristics, dry matter yield and voluntary intake of silage according to growth stage of Sorghum$\times$sudangrass(SSH) hybrid in mono-cropping and inter-cropping(C; com, T1; cutting of SSH at milk stage. T2; cutting of SSH at dough stage, T3; cutting of SSH at yellow ripe stage, T4; cutting of SSH and soybean at milk stage, T5; cutting of SSH and soybean at dough stage, T6: cutting of SSH and soybean at yellow ripe stage). Results obtained from these experiments are as follows; Plant length and leaf length of SSH(T2, T3, T4. T5 and T6)) were higher than C. T1 treatment was lower than it. C showed $2.3\~2.9$ times higher stem diameter as 29.5mm compare to SSH(T1, T2, T3, T4, T5 and T6). soybean(T4, T5 and T6) was lower in $4.3\~5.4$ times. But SSH of inter-cropping treatment(T4, T5 and T6) showed highly comparing with mono-cropping(T1, T2 and T3) at the same maturity. Leaf rate and stem hardness of SSH(T1, T2, T3, T4, T5 and T6) were lower than C. The fresh yield was high line with T2(72,320kg/ha), T1(69,103kg/ha), T3(68,333kg/ha) and C(57,988kg/ha), dry matter yield was high in line with T3(22.413kg/ha), T2(21,479kg/ha), C(19,252kg/ha) and T6(18,175kg/ha), (P<0.05). Protein dry matter yield was higher in T3(1,434kg/ha), C(1,386kg/ha)T5 and T6(1,345kg/ha) it was lower in T1(872kg/ha), (P<0.05). Crude protein of silage of T4 and T5 was higher than C, T2 and T3 were lower than it(P<0.05), while NDF content was not different. ADF content of T6 was higher than those of the other treatment. The highest hemi-cellulose among treatments was shown in T1 whereas T6 showed the lowest. Fresh intake of silge was 160.4, 155.8, 168.7, 172.9, 132.9, 158.7 and 185.2 g/BW for C, T1, T2, T3, T4, T5 and T6, respectively. Dry matter intake was high in line with T6(60.3g), C(153.8g), T3(53.6g), T5(47.8g), T2(46.8g), T4(35.2g) and T1(34.48g/BW), (P<0.05). Crude protein intake was high in line with T6(3.9g), T5(3.4g), C(3.4g), T2(2.9g), T3(2.9g), T4(2.6g) and T1(2.3g/BW), (P<0.05). As mentioned above the results, mono-cropping(T3) and inter-cropping(T5 and T6) could be recommended as increasing method of sorghum $\times$ sudangrass hybrid silage utilization when silage intake of dry matter and crude protein were considered.

STABILITY OF HAHN DIFFERENCE EQUATIONS IN BANACH ALGEBRAS

  • Abdelkhaliq, Marwa M.;Hamza, Alaa E.
    • Communications of the Korean Mathematical Society
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    • v.33 no.4
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    • pp.1141-1158
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    • 2018
  • Hahn difference operator $D_{q,{\omega}}$ which is defined by $$D_{q,{\omega}}g(t)=\{{\frac{g(gt+{\omega})-g(t)}{t(g-1)+{\omega}}},{\hfill{20}}\text{if }t{\neq}{\theta}:={\frac{\omega}{1-q}},\\g^{\prime}({\theta}),{\hfill{83}}\text{if }t={\theta}$$ received a lot of interest from many researchers due to its applications in constructing families of orthogonal polynomials and in some approximation problems. In this paper, we investigate sufficient conditions for stability of the abstract linear Hahn difference equations of the form $$D_{q,{\omega}}x(t)=A(t)x(t)+f(t),\;t{\in}I$$, and $$D^2{q,{\omega}}x(t)+A(t)D_{q,{\omega}}x(t)+R(t)x(t)=f(t),\;t{\in}I$$, where $A,R:I{\rightarrow}{\mathbb{X}}$, and $f:I{\rightarrow}{\mathbb{X}}$. Here ${\mathbb{X}}$ is a Banach algebra with a unit element e and I is an interval of ${\mathbb{R}}$ containing ${\theta}$.

Effect of Ionic Copper Toxicity on the Growth of Green Alga, Selenastrum capricornutum

  • Kim, Mi-Kyung;Ralph E. H. Smith
    • Journal of Microbiology and Biotechnology
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    • v.11 no.2
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    • pp.211-216
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    • 2001
  • The growth of Selenastrum capricornutum in culture was investigated as a function of ionic copper concentrations to verify the toxicity and physiological variation. In a $Cu^{++}$ excess culture (E: $Cu^{++}$ of $130{\mu}g/l$), the growth rate (K)(0.32) was lower than that of the control culture (C: $Cu^{++}$ of $0.065{\mu}g/l$) (0.61) after 8 days and the exponential growth rate ($R_E$) was also found to be lower in culture E (1.1) than culture C (2.9). On the contrary, the K of S. capricornutum in trace $Cu^{++}$ culture ($T_1$ and $T_2$, 0.72) after 6 days tended to be more increased than culture C (0.68). From 8 to 14 days of culture, the amounts of chlorophyllls a and b were increased in culture C (chlorophyll a, $106->126{\mu}g/g$ dry wt; chlorophyll b, $158->208{\mu}g/g$ dry wt; chlorophyll b were decreased in culture E (chlorophyll a, $309->235{\mu}g/g$ dry wt; chlorophyll b, $405->352{\mu}g/g$ dry wt). The amounts of chlorophylls in ionic copper trace culture ($T_1$ and $T_2$) [(chl a/b) of $T_1$: $384/620\;{\mu}g/g$ dry wt; (chl a/b) of $T^2$:$320/467{\mu}g/g$ dry wt] were increased more than the culture C($260/387{\mu}g/g$ dry wt). Howeveer, when photosynthetic rates were normalized to the dry weight of algae, the control culture continued to showed higher values than the treated culture ($T_1$). An appropriate amount of ionic copper ($T_1:\;26\;{\mu}g/l$) stimulated the grwoth of S. capricornutum than the ionic copper content of $13\;{\mu}g/l$ ($T_2$), while the excess amount of ionic copper ($130\;{\mu}g/l$) resulted in the highest toxicity to the growth of S. capricornutum.

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