• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.6
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• pp.50-59
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• 2014

In this paper, Reinforced concrete (R/C) and R/C+steel plate concrete slab was carried out by SAP2000 software program in order to compare the stability of the multi-functional fishway, that is Bonggok fishway, built at Bonggok river recently in Gumi city, when the size of underground passage is $1m{\times}0.2m$, $1m{\times}0.4m$, $1m{\times}0.6m$ and the velocity is 0.8m/s, 1.2m/s, 1.6m/s respectively for the S2 (R/C+S/C). The analysis shows the maximum stress of S2 decreases less 26~50% than that of Bonggok, bending moment of sidewall decreases less 28~54%, maximum stress of side wall decreases less 17~31%, bending moment of upper slab decreases less 24~47%, maximum stress of upper slab decreases less 4~20%, and bending moment decreases less 10~27% than that of Bonggok. The complementation is required as much as the following percent; 27% and 25% for the maximum stress and bending moment of underground passage, 15% and 24% for the side wall maximum stress and bending moment, and 10% and 14% for the upper slab maximum stress and bending moment, respectively. This result shows that the S2 is greatly superior to that of the Bonggok fishway, and underground passage size of $1m{\times}0.4m$ is superior to that of $1m{\times}0.2m$ or $1m{\times}0.6m$, and R/C+S/C slab is superior to that of R/C slab. This result is expected to be the basic data for the construction and design of the multi-functional fishway.

• Toxicological Research
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• v.13 no.4
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• pp.339-347
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• 1997

Disulfiram (DSF) and diethyldithiocarbamate (DDC), a reduced form of DSF, protect the liver against toxicant-induced injury through inhibition of cytochrome P450 2E1. The effect of DSF and DDC on the levels of major hepatic microsomal epoxide hydrolase (mEH) and glutathione S-transferase (GST) expression was comparatively studied, given the view that these enzymes are involved in terminal detoxification events for high energy intermediates of xenobiotics. Treatment of rats with a single dose of DSF (20-200 mg/kg, po) resulted in 2- to 15-fold increases in the mEH mRNA level at 24 hr with the ED$_{50}$ value being noted as 60 mg/kg. The mEH mRNA level was elevated ~15-fold at 24 hr after treatment at the dose of 100 mg/kg, whereas the hepatic mRNA level was rather decreased from the maximum at the dose of 200 mg/kg, indicating that DSF might cause cytotoxicity at the dose. In contrast to the effect of DSF, DDC only minimally elevated the mEH mRNA level at the doses employed. DSF moderately increased the major GST mRNA levels in the liver as a function of dose, resulting in rGSTA2, rGSTA3/5 or rGSTM1 mRNA levels being elevated 3- to 4-fold at 24 hr post-treatment, whereas the rGSTM2 mRNA level was not altered. DDC, however, failed to stimulate the mRNA levels for major GST subunits, indicating that the reduced form of DSF was ineffective in stimulating the GST the expression. The effect of other organosulfides including aldrithiol, 2, 2'-dithiobis(benzothiazole) (DTB), tetramethylthiouram disulfide (TMTD) and allyl disulfide (ADS) on the hepatic mEH and GST mRNA expression was assessed in rats in order to further confirm the increase in the gene expression by other disulfides. Treatment of rats with aldrithiol (100 mg/kg, po) resulted in a 16-fold increase in the mEH mRNA level at 24 hr post-treatment. DTB, TMTD and ADS also caused 5-, 9- and 12-fold increases in the rnRNA level, respectively, as compared to control. Thus, all of the disulfides examined were active in stimulating the mEH gene in the liver. The organosulfides significantly increased the rGSTA2, rGSTA3, rGSTA5 and rGSTM1 mRNA levels at 24 hr after administration. In particular, aldrithiol was very efficient in stimulating the rGSTA and rGSTM genes among the disulfides examined. These results provide evidence that DSF and other sulfides effectively stimulate the mEH and major GST gene expression at early times in the liver and that DDC, a reduced form of DSF, was ineffective in stimulating the expression of the genes, supporting the conclusion that reduced form(s) of organosulfur compound(s) might be less effective in inducing the mEH and GST genes through the antioxidant responsive element(s).

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.7-13
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• 2004

As a novel anti-wrinkle agent, 3,9-diferuloyl-6-oxopterocarpen (Tensolin-F$^{(R)}$) has been synthesized and its anti-aging effects have been investigated. In the present study, to investigate the relationship between aging and Tensolin-F$^{(R)}$, we examined its effect on scavenging activities of radicals and reactive oxygen species (ROS), in vitro inhibition activity of matrix-metalloproteinase (MMP) and expression of UVA-induced MMPs in human dermal fibroblasts (HDF). Tensolin-F$^{(R)}$ was found to show activities of scavenging radicals and ROS with the $IC_{50}$/ values of 0.2 mM and 0.95 mM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and superoxide radicals, respectively, in the xanthine/xanthine oxidase system. Fluorometric assays for the proteolytic activities of MMP-l (collagenase) were performed using fluorescent collagen substrates. Tensolin-F$^{(R)}$ inhibited the activities of MMP-l in a dose-dependent manner and the $IC_{50}$/ values calculated from semi-log plots were 0.025 mM. Also, UVA induced MMP-1 expression was reduced 85％ by treatment with Tensolin-F$^{(R)}$ at 0.8 uM, which was reduced dose-dependent manner. The results of clinical study showed that 4.8 mM Tensolin-F$^{(R)}$ treated group reduced wrinkle significantly compared with placebo treated group (P 〈 0.05). Taken together, these result suggest that Tensolin-F$^{(R)}$ act as an anti-wrinkle agent by taking effects to antioxidation and reducing UVA-induced MMP-l production.-l production.

• Journal of the Korean Mathematical Society
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• v.34 no.1
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• pp.159-165
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• 1997

In this paper, k will denote an arbitrary field. If m, n are natural numbers, then $M_{m \times n}(k)$ will denote the set of all $m \times n$ matrices with entries in k. Every k-algebras will be assumed to contain a (multiplicative) identity $1 \neq 0$. A k-subspace $R_0$ of a k-algebra R will be called a k-subalgebra of R if $R_0$ is closed under multiplication from R and $R_0$ contains the identity of R. We will assume all k-algebra homomorphisms take the identity to identity.

• Journal of KIISE:Databases
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• v.30 no.6
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• pp.593-605
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• 2003

Since spatial join processing consumes much time, several algorithms have been proposed to improve spatial join performance. The M-way R-tree join (MRJ) is a join algorithm which synchronously traverses M R-trees in the M-way spatial join. In this paper, we introduce indirect predicates which do not directly come from the multi-way join conditions but are indirectly derived from them. By applying the concept of indirect predicates to MRJ, we improve the performance of MRJ. We call such a multi-way R-tree join algorithm using indirect predicates indirect predicate filtering (IPF). Through experiments using synthetic data and real data, we show that IPF significantly

• Journal of the Korean Mathematical Society
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• v.52 no.6
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• pp.1253-1270
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• 2015

Let (R, m) be a commutative Noetherian local domain, M a non-zero finitely generated R-module of dimension n > 0 and I be an ideal of R. In this paper it is shown that if $x_1,{\ldots },x_t$ ($1{\leq}t{\leq}n$) be a sub-set of a system of parameters for M, then the R-module $H^t_{(x_1,{\ldots },x_t)}$(R) is faithful, i.e., Ann $H^t_{(x_1,{\ldots },x_t)}$(R) = 0. Also, it is shown that, if $H^i_I$ (R) = 0 for all i > dim R - dim R/I, then the R-module $H^{dimR-dimR/I}_I(R)$ is faithful. These results provide some partially affirmative answers to the Lynch's conjecture in [10]. Moreover, for an ideal I of an arbitrary Noetherian ring R, we calculate the annihilator of the top local cohomology module $H^1_I(M)$, when $H^i_I(M)=0$ for all integers i > 1. Also, for such ideals we show that the finitely generated R-algebra $D_I(R)$ is a flat R-algebra.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.5
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• pp.237-243
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• 2008

Intraplantar injection of melittin has been known to induce sustained decrease of mechanical threshold and increase of spontaneous flinchings. The present study was undertaken to investigate how the melittin-induced nociceptive responses were modulated by changes of metabotropic glutamate receptor (mGluR) activity. Changes in paw withdrawal threshold (PWT), number of flinchings and paw thickness were measured at a given time point after injection of melittin ($10{\mu}g$/paw) into the mid-plantar area of rat hindpaw. To observe the effects of mGluRs on the melittin-induced nociceptions, group I mGluR (AIDA, $100{\mu}g$ and $200{\mu}g$), $mGluR_1$ (LY367385, $50{\mu}g$ and $100{\mu}g$) and $mGluR_5$ (MPEP, $200{\mu}g$ and $300{\mu}g$) antagonists, group II (APDC, $100{\mu}g$ and $200{\mu}g$) and III (L-SOP, $100{\mu}g$ and $200{\mu}g$) agonists were intrathecally administered 20 min before melittin injection. Intraplantar injection of melittin induced a sustained decrease of mechanical threshold, spontaneous flinchings and edema. The effects of melittin to reduce mechanical threshold and to induce spontaneous flinchings were significantly suppressed following intrathecal pre-administration of group I mGluR, $mGluR_1$ and $mGluR_5$ antagonists, group II and III mGluR agonists. Group I mGluR antagonists and group II and III mGluR agonists had no significant effect on melittin-induced edema. These experimental findings indicate that multiple spinal mGluRs are involved in the modulation of melittin-induced nociceptive responses.

• East Asian mathematical journal
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• v.36 no.3
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• pp.389-415
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• 2020

Let M be a semi-invariant submanifold of codimension 3 with almost contact metric structure (𝜙, ξ, η, g) in a complex space form M_n+1(c), c ≠ 0. We denote by R_ξ and R'_X be the structure Jacobi operator with respect to the structure vector ξ and be R'_X = (∇_XR)(·, X)X for any unit vector field X on M, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a scalar 𝜃(≠ 2c) and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_ξ𝜙 = 𝜙R_ξ and at the same time R'_ξ = 0, then M is a Hopf real hypersurfaces of type (A), provided that the scalar curvature ${\bar{r}}$ of M holds ${\bar{r}}-2(n-1)c{\leq}0$.

• Journal of the Korean Statistical Society
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• v.35 no.4
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• pp.343-353
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• 2006

The two-way balanced one-level rotation design, $r_1^m-r_2^{m-1}$, and the three-way balanced multi-level rotation design, $r_1^m(\iota)-r_1^{m-1}$, were discussed (Park et al., 2001, 2003). Although these rotation designs enjoy balancing properties, they have a restriction of $r_2=c{\cdot}r_1$ (c should be a integer value) which interferes with applying these designs freely to various situations. To overcome this difficulty, we extend the $r_1^m(\iota)-r_1^{m-1}$ design to new one under the most general rotation system. The new multi-level rotation design also satisfies tree-way balancing which is done on interview time, rotation group and recall time. We present the rule and rotation algorithm which guarantee the three-way balancing. In particular, we specify the necessary condition for the extended three-way balanced multi-level rotation sampling design.

• Journal of the Chungcheong Mathematical Society
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• v.26 no.4
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• pp.799-809
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• 2013

An ideal I of a local ring (R, m, k) is said to be m-full if there exists an element $x{\in}m$ such that Im : x = I. An ideal I of a local ring R is said to have the Rees property if ${\mu}$(I) > ${\mu}$(J) for any ideal J containing I. We study properties of m-full ideals and we characterize m-primary m-full ideals in terms of the minimal number of generators of the ideals. In particular, for a m-primary ideal I of a 2-dimensional regular local ring (R, m, k), we will show that the following conditions are equivalent. 1. I is m-full 2. I has the Rees property 3. ${\mu}$(I)=o(I)+1 In this paper, let (R, m, k) be a commutative Noetherian local ring with infinite residue field k = R/m.