• Archives of Pharmacal Research
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• 제27권9호
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• pp.973-977
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• 2004

Carvedilol is administered as a racemic mixture of the R(＋)- and S(-)-enantiomers, although they exhibit different pharmacological effects. To investigate the stereoselective pharmacoki-netics, the enantiomeric separation of carvedilol in human plasma was undertaken using capil-lary electrophoresis (CE). Resolution of the enantiomers was achieved using 2-hydoxypropyl-$\beta$-cyclodextrin as the chiral selector. Phosphate buffer (50 mM, pH 4.0) containing 10 mM of 2-hydoxypropropyl-$\beta$-cyclodextrin was used as electrolytic buffer. Achiral separation was carried out with the same electrolytic buffer without chiral selector. Following a single oral administra-tion of 25-mg carvedilol to 11 healthy, male volunteers, stereoselective pharmacokinetic analy-sis was undertaken. The maximum plasma concentrations ( $C_{max}$) were 48.9 and 21.6 ng/mL for (R)-carvedilol and (S)-carvedilol, respectively, determined by the chiral method. The profiles of the plasma concentration of (RS)-carvedilol showed $C_{max}$ of 71.5, 72.2, and 73.5 ng/mL, as determined by the CE, HPLC/FD methods and calculations from the data of the chiral method, respectively.y.y.

• 대한전자공학회논문지SD
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• 제42권3호
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• pp.1-8
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• 2005

본 논문에서는 $0.1\;{\mu}m$ 이하의 게이트 길이를 갖는 MHEMT의 DC 및 RF 특성을 상용 시뮬레이터인 ISE-TCAD tool을 이용하여 결과를 고찰하였다. 이후 MHEMT의 게이트 길이와, 소스-드레인 간격 및 채널 두께를 변화시켜 가면서 소자의 수평, 수직 Scaling효과가 소자 특성에 미치는 영향을 비교하였으며, 게이트 길이 $(L_g)$가 $0.1\;{\mu}m$ 이하로 감소함에 따라 $g_{m,max}$가 같이 감소하는 현상에 대해서 논의해 보았다. 또한 이 현상을 가지고 소자의 횡적, 종적 파라미터의 scaling 효과에 대한 모델을 제시 했다.

• 대한기계학회논문집B
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• 제22권3호
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• pp.267-279
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• 1998

A numerical study was made of flow behind a circular cylinder in a uniform flow, where the cylinder was rotationally oscillated in time. The temporal behavior of vortex formation was scrutinized over broad ranges of the two externally specified parameters, i.e., the dimensionless rotary oscillating frequency (.110.leq. $S_{f}$.leq..220) and the maximum angular amplitude of rotation (.theta.$_{max}$=15 deg., 30 deg. and 60 deg.). The Reynolds number (Re= $U_{{\inf}D}$.nu.) was fixed at Re=110. A fractional-step method was utilized to solve the Navier-Stokes equations with a generalized coordinate system. The main emphasis was placed on the initial vortex formations by varying $S_{f}$ and .theta.$_{max}$. Instantaneous streamlines and pressure distributions were displayed to show the vortex formation patterns. The vortex formation modes and relevant phase changes were characterized by measuring the lift coefficient ( $C_{L}$) and the time of negative maximum $C_{L}$( $t_{-C}$$_{Lmax}$) with variable forcing conditions.s.tions.s.s.s.

• Preventive Nutrition and Food Science
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• 제2권1호
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• pp.66-70
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• 1997

A mixed-culture of Gluconobacter suboxydans IFO 3172 and Saccharomyces uvarum IFO 0751 was per-formed in a synthetic medium. the optimal inculum ratio of G. suboydans and S. uvarum for mixed-culture fermentation was 150:1. The optimum pH, incubation temperature and aeration rate for mixed-culture fer- mentation were 5.0, 3$0^{\circ}C$ and 2.25vvm, reapectively. As a result of batch pure-and mixed-culture fer-mentation, specific growth rate in pure-culture of both strain was lower than that in mixed-culture. The yield of cell mass from S. uvarum exclusively decreased. The growth rate of the mixed-culture was very similar to the pure-culture in the begining of culture, but it has been decreased after 16hrs. In the mean time, S. uvarum in mixed-culture fermentation could grow due to fructose converted, but it could not row in pure-culture fermentation. Thus, the relationship was a sort of commensalism. The kinetic parameters cal-culated through steady-state results during continuous fermentations are as follows :{TEX}$$\mu$_{max1}${/TEX}=0.118({TEX}$h^{-1}${/TEX}), {TEX}$Ks_{1}${/TEX}=0.330(g/L),:{TEX}$$\mu$_{max2}${/TEX}=0.162({TEX}$h^{-1}${/TEX}), {TEX}$Ks_{2}${/TEX}=0.038(g/L). The yield of bacterial cell mass relatively constant, but yield of yest cell mass was gradually decreased.

• 한국전자통신학회논문지
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• 제13권4호
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• pp.685-694
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• 2018

본 논문에서는 Ku대역 추적레이더의 핵심부품인 고주파 헤드 내 주파수 믹서(혼합기)의 설계 및 제작 결과에 대해서 다룬다. 단일종단(Single-Ended) 및 단일평형(Single-Balanced) 믹서의 단점을 보완하기 위해서, Fine-Line 구조의 평형(Balanced) 믹서를 설계하여 낮은 변환손실 특성을 가지도록 하였으며, Ku대역 RF신호를 입력받아 L밴드 IF신호를 생성하도록 하였다. 제작된 믹서에 대해서 Ku밴드 5개 샘플주파수를 대상으로 실험한 결과, 최대 잡음지수(Noise Figure Max) 6.823dB, 이득(Gain) 4.159dB ~ 4.676dB, 통과대역(Band Pass) 61MHz의 값을 확인하였다.

• Journal of Crop Science and Biotechnology
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• 제11권3호
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• pp.171-176
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• 2008

The agronomic traits, such as days to flowering and maturity, plant height, 100-seed weight and seed filling period, are quantitatively inherited and important characters in soybean(Glycine max L. Merr.). A total of 126 $F_5$ recombinant inbred lines(RILs) developed from the cross of PI 171451$\times$Hwaeomputkong were used to identify quantitative trait loci(QTLs) for days to flowering(FD), days to maturity(MD), plant height(PH), 100-seed weight(SW), number of branches(NB) and seed filling period(FP). A total of 136 simple sequence repeat(SSR) markers segregated in a RIL population were distributed over 20 linkage groups(LGs), covering 1073.9 cM of the soybean genome with the average distance between adjacent markers of 7.9 cM. Five independent QTLs were identified for FD, three for MD, two for PH, three for SW, one for NB and one for FP. Of these, three QTLs were related to more than two traits of FD, MD, PH, NB and FP and mapped near the same positions on LGs H and O. Thus, these traits could be correlated with biologically controlled major QTLs in this soybean RIL population.

• 한국작물학회지
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• 제63권4호
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• pp.360-377
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• 2018

The levels of 12 isoflavones were measured in soybean (Glycine max (L.) Merrill) sprouts of 68 genetic varieties from three countries (China, Japan, and Korea). The isoflavone profile differences were analyzed using data mining methods. A principal component analysis (PCA) revealed that the CSRV021 variety was separated from the others by the first two principal components. This variety appears to be most suited for functional food production due to its high isoflavone levels. Partial least squares discriminant analysis (PLS-DA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA) showed that there are meaningful isoflavone compositional differences in samples that have different countries of origin. Hierarchical clustering analysis (HCA) of these phytochemicals resulted in clusters derived from closely related biochemical pathways. These results indicate the usefulness of metabolite profiling combined with chemometrics as a tool for assessing the quality of foods and identifying metabolic links in biological systems.

• 상하수도학회지
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• 제20권3호
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• pp.329-338
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• 2006

The research aims to provide the basic data for practical applications by correlating the bio-kinetic coefficients with the load of recalcitrant organic matter in box-mill wastewater. The activated sludge process was employed to a Wastewater disposal plant in an industrial setting, increase of consequently leading to the organic load. The parameter values derived by Monod-kinetic analysis were as follows:specific substrate removal rate $K_{max}=0.17day^{-1}$, half saturation constants $K_s=60.37mg/l$, decay coefficient $K_d=0.142day^{-1}$, microbial yield coefficient y = 0.388mg/mg, and max specific growth rate ${\mu}_{max}=0.006day^{-1}$. In view of biodegradability, the $TCOD_{Mn}/TBOD_5$ ratios of inflow and outflow were 1.07 and 1.41, and the $SCOD_{Mn}/SBOD_5$ ratios of inflow and outflow were 1.10 and 1.50, respectively. The higher $TCOD_{Mn}/TBOD_5$ ratio of outflow indicated that metabolites of a microorganism have accumulated in the cells.

• Biomolecules & Therapeutics
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• 제8권3호
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• pp.269-275
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• 2000

Silibinin(silybin) is the active component of silymarin from Silybum marianum and has hepato-protective effect. It is water-insoluble and has low bioavailability. To improve its bioavailability, self-micro-emulsifying drug delivery system (SMEDDS) has been developed by Hanmi Pharmaceutical Company (Silyma $n^{R}$ 140 soft capsule). In this study, the pharmacokinetic profiles of Silyma $n^{R}$ were examined and compared it with a reference preparation, L Caps140 of B Pharmaceutical Company. This study was approved by Yonsei University Severance Hospital IRB(approval No. CR0004) and followed the bioequivalence test guideline of Korean FDA. Eighteen healthy adult volunteers were allocated based on 2$\times$2 Latin square cross-over design. They were given 2 capsules (each contains silymarin 140 mg (60 mg as silibinin)) of either drug at each period and crossed over after a week of drug-free washout period. Blood concentration of silibinin was measured by HPLC. The $C_{max}$ and AUC of the Silyma $n^{R}$ were 1542.0 $\pm$ 402.7 ng/ml and 3323.3 $\pm$ 824.7 ng.h/ml, respectively, and were significantly higher than those of reference preparation. The Tmax was 0.8 $\pm$ 0.3 h and significantly shorter than reference preparation. The $K_{e}$ and $T_{1}$2/ of both drugs were comparable. Percent differences in means against reference preparation were +88.3% for AUC, +222.6% for $C_{max}$, and -61.1% for $T_{max}$./.>././.>./.

• PNF and Movement
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• 제12권1호
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• pp.13-17
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• 2014

Purpose: To determine the normative data for the correlation of spinal, pelvic parameters with foot pressure in the young subjects. Methods: The subjects of this study were 39 patients in healthy adults. The Formetric-III was used to measure of spinal alignment. The pedoscan was used to measure of foot pressure. The correlation of trunk imbalance, trunk inclination, lateral deviation with foot pressure. The foot pressure measurement was consisted of maximal/mean pressure, weight contribution. Result: There was a negative correlation of trunk inclination with Max_R. There was a negative correlation of trunk inclination with Max_R. There was a positive correlation of trunk imbalance with Max_L. There was a positive correlation of lumbar lordosis with Mean_R_front, Lt. posterior weight distribution. There was a negative correlation of lumbar lordosis with Lt., Rt. in distribution There was a negative correlation of pelvic tilt with Mean_R_front, Lt. posterior weight distribution. There was a positive correlation of pelvic tilting with Rt. weight distribution, Lt. posterior weight distribution. There was a negative correlation of pelvic torsion with Lt. weight distribution, Rt. posterior weight distribution. There was a negative correlation of pelvic rotation with Lt. weight distribution, Lt. posterior weight distribution. Conclusion: The data obtained from the study may be used for future studies related to correlation of the spinal, pelvic deviation with foot pressure.