• 한국환경과학회지
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• 제31권8호
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• pp.715-725
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• 2022

Lactic Acid Bacteria (LAB) are among the representative probiotics that have been used for a long time in fermented food. Although there are many studies on detecting the radical scavenging activity of LAB, few studies have been conducted on the environmental factors that improve scavenging activity. This study investigated the environmental factors affecting the DPPH radical scavenging and various antioxidant activities of Kimchi-derived Lactobacillus plantarum K-21 with antihypertensive and radical scavenging activities. The optimal conditions for scavenging DPPH radicals were glucose 2%, bactopeptone 0.5%, Tween 80 0.05%, L-cysteine 0.05%, and an initial pH 6.5 at 35℃. Under optimal conditions, the DPPH radical scavenging activity was 94.8±2.2%, which was 1.5 times higher than that of the basic medium. In addition, L. plantarum K-21 had other antioxidant activities; ABTS radical scavenging (93.6±1.5%), hydroxyl radical scavenging (8.5±0.9%), metal chelating (65.9±0.5%), NO scavenging (53.1±19%), SOD-like (25.1±1.5%), and reducing power (11.7±1.4%) activities were detected. Therefore, L. plantarum K-21 may act not only as a starter for lactic acid-fermented foods with improved functionality but also as a drug for various diseases caused by oxidative stress.

• 한국발생생물학회지:발생과생식
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• 제23권2호
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• pp.129-138
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• 2019

In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. $NAD^+$-dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseases. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity.

• 한국융합학회논문지
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• 제10권1호
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• pp.239-244
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• 2019

본 연구의 목적은 우리나라 30세이상 성인의 혈청지질분포와 치주질환간의 관련성을 파악하고자 하였다. 본 연구자료는 2013년, 2014년 국민건강영양조사 자료를 병합하여 이용하였으며, 최종분석대상자는 8,854명이었다. 치주질환은 지역사회치주지수를 이용하였으며, 혈청지질분포와 치주질환간의 관련성을 파악하기 위해 로지스틱회귀분석을 이용하였다. 연구결과 HDL 이 ${\leq}40mg/dL$ 인 경우에서 치주질환 교차비가 1.39배(95% CI=1.16-1.66)증가하였으며, Triglyceride가 ${\geq}200mg/dL$ 인 경우에서 치주질환 교차비가 1.14배(95% CI=1.02-1.27) 유의하게 증가하였다. HDL과 Triglyceride가 치주질환과 유의한 관련성이 있음을 확인하였다. 따라서, 향후 연구에서는 혈청지질분포와 치주질환간의 실질적 관련성을 파악하고 인과관계와 직접적인 연관성을 파악해야 할 것이다.

• Journal of the Korean Statistical Society
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• 제24권2호
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• pp.273-280
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• 1995

This paper gives a generalization of an $L_1$-convergence theorem for dependent processes due to Andrews (1988) and also a probability convergence theorem.

• Reproductive and Developmental Biology
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• 제41권1호
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• pp.1-6
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• 2017

In all mammalian species, progesterone is essential to both the preparation for, and maintenance of, pregnancy. The $20{\alpha}$-hydroxysteroid dehydrogenase ($20{\alpha}$-HSD) enzyme predominantly converts progesterone into its biologically inactive form $20{\alpha}$-hydroxyprogesterone, thereby regulating its activity. Thus, to directly assess sexual maturation in the MediKinetics $micropig^{(R)}$, we analyzed the concentration of the steroid hormones progesterone and estradiol during the estrous cycle. Our results show that the progesterone level exhibited by the analyzed $micorpig^{(R)}$ was low at the beginning of the estrous cycle, and then abruptly increased to $30.32{\pm}10.0ng/mL$ and $46.37{\pm}11.0ng/mL$ by days 9 and 11 of the cycle, respectively. It reached the highest level $55.87{\pm}3.5ng/mL$ on day 13 of the estrous cycle, before decreasing to $46.58{\pm}13.1ng/mL$ and $10.0{\pm}7.6ng/mL$ by days 15 and 17 of the cycle, respectively. In contrast, the estradiol level was shown to be highest ($27.13{\pm}11.2ng/mL$) at the initiation of the estrous cycle, after which point it decreased to $13.29{\pm}6.5ng/mL$ and $10.94{\pm}5.9ng/mL$ by days 4 and 5 of the estrous cycle, respectively. By day 17 of the estrous cycle, the estradiol level decreased to $4.13{\pm}7.6ng/mL$. We anticipate that these results will provide useful information to enable the study of human ovulation and reproductive physiology using the MediKinetics $micoripig^{(R)}$ as a model system. We recommend further investigation to elucidate the functional mechanisms underlying the regulation of sexual maturation in the MediKinetics $micropig^{(R)}$.

• 정보통신설비학회논문지
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• 제9권1호
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• pp.29-34
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• 2010

In this study, we realized the broadband home gateway system of dual mode based upon EDR 2~3Mbps transmission speed and 300Mbps of 802.11n, In broadcasting and telecommunication convergence networks to deliver multimedia services, high-quality home. The bluetooth module is designed to use general low rate data speed service and the 802.11n module also is designed to use high rate speed service at various home network situation. The dual mode home gateway system, bluetooth and 802.l1n module, is well realized for many specification such as emission power, spurious power, impedance matching, frequency channel test.

• 한국항공우주학회지
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• 제36권6호
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• pp.558-564
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• 2008

적응제어신호를 저역필터에 통과시켜 점근적 추종과 과도구간 성능을 동시에 보장하는 적응제어 기법과 비선형 시스템을 선형 시불변 형태로 변환하는 피드백 선형화 기법을 결합하여 적응제어 기법의 적용가능 범위를 확대하였다. Barbalat의 보조정리를 이용하여 추종오차가 0으로 수렴함을 증명하고 과도구간의 추종오차도 원하는 크기로 감소시킬 수 있음을 보였다.

• 한국환경과학회지
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• 제30권3호
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• pp.235-243
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• 2021

This study was conducted to investigate the growth of Dendranthema zawadskii in damaged soils when they are treated with improvement agents. The treatments consisted of a control (unamended field soil) and the application of a loess ball of 1 cm to the field soil. According to the degree of damage the de-icing agent had caused, the soils were divided into 3 areas (based on the yellowing of Pinus densiflora for. multicaulis in soil surveys): H (high saline), M (medium saline), and L (low saline). A total of six treatments were performed: D. zawadskiia plant without soil amendment (H; high saline soil, M; medium saline soil, L; low saline soil), and a D. zawadskiia plant with loess ball on the soil surface (H.L; high saline soil with loess ball, M.L; medium saline soil with loess ball, L.L; low saline soil with loess ball). The results showed that D. zawadskiia growth went from highest to lowest in the order: M.L > L.L > M > L > H.L > H. Plant growth results showed that soils treated with soil amendments (loess ball) were better for D. zawadskii growth than untreated soils.

• Journal of applied mathematics & informatics
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• 제4권1호
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• pp.17-30
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• 1997

In this work we approximate the solution of initialboun-dary value problem using a Galerkin-finite element method for the spatial discretization and Implicit Runge-Kutta method for the spatial discretization and implicit Runge-Kutta methods for the time stepping. To deal with the nonlinear term f(x, t, u), we introduce the well-known extrapolation sheme which was used widely to prove the convergence in $L_2$-norm. We present computational results showing that the optimal order of convergence arising under $L_2$-norm will be preserved in $L_{\infty}$-norm.

• Journal of Plant Biotechnology
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• 제49권1호
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• pp.3-14
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• 2022

Leonotis nepetifolia (L.) R. Br, commonly called dagga, klip dagga, or lion's ear, has been used to effectively treat various diseases and other health problems for a long time because of its antimicrobial, anti-inflammatory, antioxidant, and analgesic activities. Several studies have attributed these biological activities to L. nepetifolia's constituent secondary metabolites, such as alkaloids, phenolics, flavonoids, tannins, steroids, glycosides, coumarins, anthocyanins, and saponins. This review aims to examine the evidence-based ethnopharmacological uses of L. nepetifolia in the treatment of bronchial asthma, diarrhea, skin diseases, malaria, burns, cancer, diabetes mellitus, and rheumatism. However, although L. nepetifolia has great potential to treat these diseases, further isolation and identification of its therapeutic phytochemical constituents are required. In addition, the performance of its extracts and phytochemicals should be thoroughly tested in preclinical and clinical trials in order to ascertain their safety and efficacy, which will prove valuable in developing new medicines.