• BMB Reports
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• v.51 no.2
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• pp.57-58
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• 2018

An accurate diagnostic marker for detecting early-stage hepatocellular carcinoma (eHCC) is clinically important, since early detection of HCC remarkably improves patient survival. From the integrative analysis of the transcriptome and clinicopathologic data of human multi-stage HCC tissues, we were able to identify barrier-to-autointegration factor 1 (BANF1), procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) and splicing factor 3b subunit 4 (SF3B4) as early HCC biomarkers which could be detected in precancerous lesions of HCC, with superior capabilities to diagnose eHCC compared to the currently popular HCC diagnostic biomarkers: GPC3, GS, and HSP70. We then showed that SF3B4 knockdown caused G1/S cell cycle arrest by recovering $p27^{kip1}$ and simultaneously suppressing cyclins, and CDKs in liver cancer cells. Notably, we demonstrated that aberrant SF3B4 overexpression altered the progress of splicing progress of the tumor suppressor gene, kruppel like factor 4 (KLF4), and resulted in non-functional skipped exon transcripts. This contributes to liver tumorigenesis via transcriptional inactivation of $p27^{kip1}$ and simultaneous activation of Slug genes. Our results suggest that SF3B4 indicates early-stage HCC in precancerous lesions, and also functions as an early-stage driver in the development of liver cancer.

• International Journal of Concrete Structures and Materials
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• v.18 no.3E
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• pp.191-198
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• 2006

The objective of this study is to examine fracture characteristics of concrete at early ages, i.g. critical stress intensity factor, critical crack-tip opening displacement, fracture energy, and bilinear softening curve based on the concepts of effective-elastic crack model and cohesive crack model. A wedge splitting test for Mode I was performed on cubic wedge specimens with a notch at the edge. By experimenting with various strengths and ages, load-crack mouth opening curves were obtained, and the results were analyzed by linear elastic fracture mechanics and FEM(finite element method). The results from the test and analysis showed that critical stress intensity factor and facture energy increased while critical crack-tip opening displacement decreased with concrete aging from 1 day to 28 days. Four parameters of bilinear softening curve from 1 day to 28 days were obtained from a numerical analysis. The obtained fracture parameters and bilinear softening curves at early ages from this study are to be used as a fracture criterion and an input data for the finite element analysis of concrete at early ages.

• Journal of the Korean Home Economics Association
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• v.48 no.2
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• pp.113-120
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• 2010

Quality characteristics effects of adding four different amounts (0%, 1%, 2%, 3%) of Ulleung-Maesil (Prunus mume fruit) powder cookie doughs were examined. pH, water content & bulk density of dough, spread factor, color value, hardness and consumer acceptability of maesil cookies were measured. The pH and water content of freezedried Ulleung-Maesil powder were 2.01 and 6.26%, respectively, while the L, a, b values were 76.14, -1.66 and 28.65, respectively. Although bulk density of the 3% powder group of cookie dough was the highest, its pH value was the lowest compared to the other groups (p < 0.05). Spread factor of the 3% group showed the lowest value among all groups (p < 0.05). Hardness of the control group (i.e, 0%) was significantly higher than the 1%, 2%, 3% groups (p < 0.05), which showed no significant difference among themselves. The ${\Delta}E$ value of cookies increased significantly with increasing Maesil powder content (p < 0.05). The consumer acceptability scores for control and 1% Maesil cookie groups ranked significantly higher than the 2% and 3% groups in overall acceptability, taste, flavor and texture (p < 0.05). In conclusion, our study suggests that small amounts of Ulleung-maesil can add positive attributes to cookies.

• 한국경영정보학회:학술대회논문집
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• 2008.06a
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• pp.371-376
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• 2008

As the e-business developed fast and more firms embrace CRM as a core e-business strategy, it is getting more important to assess the firms. The CRM is approaching customer-centric. This approach focuses on the long-term relationship with the customers by providing the benefits of the customer rather than based on what the company wants to sell. How to establish the overall efficiency and effectiveness of a global enterprise becomes more and more important to the E-business. The study investigates the cross-national psychometric prosperities of the establishment in the E-business. Using a cross-national survey of customers from Korea and China to compare the Korean customers' acceptance of e-business with the Chinese customers', and compare the development of e-business in Korea with the development in China it will be found that Korea and China samples shared a somewhat similar factor structure. And there are also some differences between Korea and China. These findings suggest that the way to establish the e-business strategy is influenced by the cultural effects. So focusing on the cultural differences among the countries becomes more and more important, this study will help to analysis how to use the different cultural dimension to establish the better CRM system in the e-business field.

• Parasites, Hosts and Diseases
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• v.48 no.2
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• pp.121-126
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• 2010

To know the prevalence of Enterobius vermicularis infection and what are the most important risk factors, we evaluated the incidence and risk factors of enterobiasis among children attended in kindergartens in Busan metropolitan city, Republic of Korea. A total of 1,674 children from 21 kindergartens in 11 of 16 autonomous districts of Busan were evaluated for E. vermicularis infection by the cellotape anal swab technique. The overall egg-positive rate for E. vermicularis was 10.7% (179/1,674), and the prevalence of enterobiasis in each kindergarten ranged between 0% and 32.4%. There was an increasing tendency of the egg positive rate according to the population density; the higher the population density communities had, the higher egg-positive rate for E. vermicularis was detected (P = 0.001). Among personal hygiene factors involving children, thumb-sucking (P = 0.036) and fingernail-trimming (P = 0.024) were highly associated with enterobiasis. In addition, taking anthelmintic medications against E. vermicularis infection was strongly associated with enterobiasis (P = 0.014). Moreover, parents' knowledge of enterobiasis was correlated significantly with the incidence of enterobiasis of their children (P = 0.006). In conclusion, we need to consider not only personal hygiene but also parents' knowledge about enterobiasis as a factor in order to develop new strategies for elimination or to complete reduction of enterobiasis in Korea.

• Solar Energy
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• v.17 no.2
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• pp.75-89
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• 1997

In this paper, the operating thermal characterictics of liquid-ice was expeimentally investigated in an adiabatic and a non-adiabatic direct contact liquid-ice heat exchanger. Experiments were carried out varing inlet temperature, Ice Packing Factor, and the flow rate of heat transfer fluid. The higher inlet temperature and the more much inlet flow rate, thermal stratification in liquid-ice heat exchanger was established faster. In the case of adiabatic ice storage tank, temperature distribution was a little higher at all conditions than that of non-adiabatic one. The ratio of latent energy to total discharge energy($E_{\lambda}/E_[tot}$) was about 80%, and the discharge of latent heat energy was appeared rapidly as inlet temperature and flow rate were higher.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.989-997
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• 2014

AMFR, autocrine motility factor receptor, also called gp78, is a cell surface cytokine receptor which has a dual role as an E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. AMFR expression is associated with tumor malignancy. We here investigated the clinical significance of AMFR and its role in metastasis and prognosis in gastric cancer. Expression of AMFR, E-cadherin and N-cadherin in cancer tissues and matched adjacent normal tissues from 122 gastric cancer (GC) patients undergoing surgical resection was assessed by immunohistochemistry. Levels of these molecules in 17 cases selected randomly were also analysed by Western blotting. AMFR expression was significantly increased in gastric cancer tissues, and associated with invasion depth and lymph node metastasis. Kaplan-Meier analysis showed AMFR expression correlated with poor overall survival and an increased risk of recurrence in the GC cases. Cox regression analysis suggested AMFR to be an independent predictor for overall and recurrence-free survival. E-cadherin expression was decreased in gastric cancer tissues; conversely, N-cadherin was increased. Expression of AMFR negatively correlated with E-cadherin expression, whereas N-cadherin expression showed a significant positive correlation with AMFR expression. AMFR might be involved in the regulation of epithelial-mesenchymal transition, with aberrant expression correlating with a poor prognosis and promoting invasion and metastasis in GCs.

• Journal of Soil and Groundwater Environment
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• v.25 no.3
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• pp.65-73
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• 2020

Exposure assessment methodology for outdoor air inhalation pathways (i.e., inhalation of volatile compounds and fugitive dust in outdoor air) was investigated. Default values of several parameters currently used in Korea (e.g., Q/C; inverse value of concentration per unit flux, and frs; soil fraction in PM10) may not be suitable and lack site-specificity, as they have been adopted from the risk assessment guidance of the United States or the Netherlands. Such limitation can be addressed to a certain degree by incorporating the volatilization factor (VF) and the particulate emission factor (PEF) with Box model. This approach was applied to an exposure assessment of a site contaminated with petroleum hydrocarbons in Korea. The result indicated that the suggested methodology led to more accurate site-specific exposure assessment for outdoor inhalation pathways. Further work to establish methodology to determine site-specific Q/C values in Korea needs to be done to secure the reliability of the exposure assessment for outdoor air inhalation pathways.

• Journal of Korean Society for Atmospheric Environment
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• v.23 no.2
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• pp.158-168
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• 2007

The cement industry is one of the energy intensive industries such as petrochemical and steel industry. The energy efficiency of cement industry is high comparing to oversea's cement industries due to the enforcement of energy conservation policies. The purpose of this study is estimate emission factors for greenhouse gas ($CO_{2}$) in cement industry. The results of field study, quicklime contained quantity of five factories were $0.64{\sim}0.65$. Measurement emission (15,382 ton/day) is 40% higher than process emission (8,929 ton/day) on the IPCC Guidelines (1996). Add to combustion emission on the lines of IPCC Guidelines (1996) is similar to the emission of this study. The emission factor of greenhouse gas ($CO_{2}$) were as follows the emission factor between $9.01E-01{\sim}2.15E-01\;ton/ton$ for $CO_{2}$. The result of this study is higher than emission factor of IPCC (0.51) but it is similar to U.S. EPA's (0.952).

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.103-107
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• 2005

It has been known that the novel diterphenoids, hericenone and erinacine isolated from the fruiting body and cultured mycelia of Hericium erinaceus showed potent stimulating activity of nerve growth factor (NGF)-synthesis. To investigate the biological activities of extracts from fruiting body, cultured mycelium and cell-free broth of H. erinaceus, the activity experiments of antioxidation and AChE inhibition were carried out. Sephadex G-10 gel filtration followed by HPLC on a ${\mu}Bondapak$ $C_{18}$ column of EtOAc extract from cultured mycelium showed a biological activity.