BMB Reports
- Volume 51 Issue 2
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- Pages.57-58
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- 2018
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- 1976-670X(eISSN)
DOI QR Code
SF3B4 as an early-stage diagnostic marker and driver of hepatocellular carcinoma
- Shen, Qingyu (Department of Pathology, College of Medicine, The Catholic University of Korea) ;
- Nam, Suk Woo (Department of Pathology, College of Medicine, The Catholic University of Korea)
- Received : 2018.01.17
- Published : 2018.02.28
Abstract
An accurate diagnostic marker for detecting early-stage hepatocellular carcinoma (eHCC) is clinically important, since early detection of HCC remarkably improves patient survival. From the integrative analysis of the transcriptome and clinicopathologic data of human multi-stage HCC tissues, we were able to identify barrier-to-autointegration factor 1 (BANF1), procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) and splicing factor 3b subunit 4 (SF3B4) as early HCC biomarkers which could be detected in precancerous lesions of HCC, with superior capabilities to diagnose eHCC compared to the currently popular HCC diagnostic biomarkers: GPC3, GS, and HSP70. We then showed that SF3B4 knockdown caused G1/S cell cycle arrest by recovering