• Journal of Information Science Theory and Practice
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• 제4권4호
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• pp.49-63
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• 2016

The emergence of the World Wide Web (WWW) has changed the scholarly publishing system. Today, Open Access (OA) scholarly publishing offers free access and wide dissemination for research findings anytime and anywhere as an additional value for scholarly content. Despite the potentials of OA publishing, its adoption and use is still low.This paper determines factors influencing the adoption and use of OA publishing by academic staff in universities in Nigeria using an adapted Unified Theory of Acceptance and Use Technology (UTAUT). The study applies methodological triangulation by combining quantitative and qualitative approaches. The empirical data were collected from 317 academic staff in universities in southwest Nigeria. The questionnaire forms were analyzed using the Statistical Package for Social Sciences (IBM-SPSS) 19.0 version to generate descriptive statistics, Analysis of Variance, and Hierarchical Multiple Regression. Thematically, analysis also applies to the interviews. The results show that awareness, attitude, performance expectancy, Internet self-efficacy, and facilitating conditions significantly influenced the adoption and use of OA publishing. The study also reveals that due to lack of OA policy, most of the respondents did not know about OA. The findings further establish that all predictors and moderating variables jointly contributed 64.4% total variance towards the adoption and use of OA publishing. One of the implications of this study is that there is a need for adequate facilities to support adoption and use of OA publishing. The findings inform the proposed framework for improving and evaluating the adoption and use of OA publishing. The findings also have theoretical, societal, and methodological significance to all stakeholders.

• 미생물학회지
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• 제47권3호
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• pp.218-224
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• 2011

케피어그레인을 이용하여 제조한 요쿠르트로부터 젖산균 OA18을 분리하여 그 특성을 조사하였다. 분리된 균주는 그람양성, 구균이었으며, 혐기적 조건에서 이산화탄소를 생성하였다. 균주는 MRS 배지에서 $30-37^{\circ}C$ 온도 범위와 pH 7.0-9.0범위에서 잘 자랐으며, 성장을 위한 최적 온도와 pH는 각각 $37^{\circ}C$와 pH 7.0이었다. 분리된 젖산균은 리보오스, D-글루코오스, cellobiose, D-trehalose 등을 분해하여 산을 생성하였고, L-xylose, D-melibiose, inositol은 분해하지 못하였다. 16S rRNA gene 염기서열 분석을 통해 OA18 균주는 유전자은행(NCBI)에 등재되어 있는 Enterococcus faecalis (AB012212)의 염기서열과 99.8% 동질성이 있음을 확인하였다. 이와 같은 생화학적 특성과 염기서열 분석 결과를 토대로 분리된 균주를 Enterococcus faecalis OA18로 명명하였다. E. faecalis OA18균주는 오르니틴 생성능력과 Streptomyces coelicolor subsp. Flavus, S. coeruleorubidus, S. coeruleoaurantiacus, S. coelicolor, S. coeruleoprunus 대한 항균 활성을 보유하고 있었으며, 0-7% NaCl을 함유하는 MRS 배지에서 증식이 가능한 것으로 조사되었다.

• 한국식품과학회지
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• 제31권3호
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• pp.831-837
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• 1999

곰팡이 독소인 ochratoxin A (OA)는 동물과 사람에게 간 및 신장의 손상을 일으키는 것으로 알려져 있다. 본 연구는 산화적 손상과 관련이 있는 OA-유발 지질과산화에 대한 항산화 비타민의 완화작용에 대하여 조사하였다. 수컷 ICR 마우스에 비타민 C (10 mg/kg)와 비타민 E (63.8 mg/kg)를 복강 투여하고, 한 시간 후에 0.1M $NaHCO_3$에 녹인 OA를 4 mg/kg/day의 용량이 되게 복강 투여하였다. 4일간 반복투여 한 후 간과 신장의 microsome 내의 superoxide dismutase (SOD) 및 catalase 활성과 malondialdehyde (MDA) 생성을 측정하였다. 아울러 comet assay에 의해 세포의 손상과 항산화 비타민의 완화 작용에 대한 관련성을 알아보았다. 결과들은 간과 신장에서 모두 i) OA투여에 의해 SOD, catalase 활성 및 MDA 수치가 유의성(p<0.05) 있게 증가하였고, ii)항산화 비타민 혼합 투여에 의해 OA에 의한 SOD, catalase 활성 및 MDA 형성이 유의성 있게 저하되었으며. iii) OA-유발 지질과산화와 관련이 있는 혈구세포의 손상도 항산화 비타민에 의해 완화되었다. 이러한 결과들은 항산화 비타민이 OA중독에 의한 간과 신장의 손상의 예방에 사용될 수 있을 것으로 사료된다.

• Journal of Plant Biotechnology
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• 제31권2호
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• pp.103-108
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• 2004

본 연구는 나리의 종간잡종 육성체계를 확립하기 위한 기초자료를 얻고자 Oriental과 Asiatic 잡종 (OA-hybrid) 의 후대 획득에 필요한 실험을 수행하여 얻은 결과이다. 체세포 배수화를 통한 이질 4배체 OA-hybrid 3계통으로 화분발아 실험을 수행한 결과, 0-80% 범위로 계통간 차이가 현저하였다. 이질 4배체 OA-hybrid를 자방친 또는 화분친으로 사용하고 Asiatic 또는 Oriental hybrid와 교배시 후대 획득수에 차이가 있었는데 4배체 OA-hybrid를 화분친으로 이용하였을 때, 그리고 상대친을 Asiatic hybrid로 교배하였을 때 후대획득이 현저히 용이하였다. 그러나, 이질 4배체 F$_1$ OA-hybrid를 자방친으로 사용하거나 Oriental hybrid와 교배하면 후대 획득률이 현저히 저하되거나 또는 전혀 후대생산이 이루어지지 않았다. 이질 4배체 F$_1$ OA-hybrid와 교배시 상대친의 ploidy level은 4배체 보다는 2배체가 유리하였다.

• 복식문화연구
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• 제22권1호
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• pp.112-125
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• 2014

The purpose of this study was to compare the effects of internet fashion advertisement (Ad) formats according to university students' online lifestyle. Static banner, rich media, floating, shopping, and target advertisement were selected as stimuli and a self-administered questionnaire was used for data collection. SPSS PC (Ver. 16.0) was used for factor analysis, ANOVA, and Chi-square test. Factors of online lifestyle were economy, early adaption, cyberspace activity, sociability, innovation, and entertainment, and subjects were segmented into online activity (OA) retard group, OA mania group, hedonic early adapter group, and OA intermediate group. OA retard group was positive to a static banner Ad with intimacy, and OA mania group and OA intermediate group were positive to a static banner Ad with confidence, attention, and intimacy and rich media Ad and floating Ad with confidence and attention. Hedonic early adapter group was positive to a target Ad with attention and intimacy. Internet shopping mall managers should select internet Ad format after segmenting their customers according to OA lifestyle.

• 근관절건강학회지
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• 제17권2호
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• pp.183-191
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• 2010

Purpose: The purpose of this study was to test the validity and reliability of the Diabetes Self-Care Barriers Assessment Scaler for Older Adults (DSCB-OA) in Korean older adults with type 2 diabetes. Method: To develop Korean version DSCB-OA used translation and back-translation method. Then, Korean version DSCB-OA was analyzed using data of 278 older adults with type 2 diabetes. Cronbach's alpha coefficient, item to total correlation and test-retest reliability was used for the reliability test, and factor analysis was used for the construct validity. Results: Cronabach's alpha of the DSCB-OA was.77, and item to total correlation coefficient ranged from -.13 to.56. The results of factor analysis showed DSCB-OA consisted of four factors(diet, exercise, blood sugar test, treatment) which explained 62.8% of total variance. Conclusion: The Diabetes Self-Care Barriers Assessment Scaler for Older Adults (DSCB-OA) was confirmed helpful tool for Korean older adults with type 2 diabetes.

• Molecules and Cells
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• 제25권1호
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• pp.1-6
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• 2008

Osteoarthritis (OA), one of the most common skeletal disorders characterized by cartilage degradation and osteophyte formation in joints, is induced by accumulated mechanical stress; however, little is known about the underlying molecular mechanism. Several experimental OA models in mice by producing instability in the knee joints have been developed to apply approaches from mouse genetics. Although proteinases like matrix metalloproteinases and aggrecanases have now been proven to be the principal initiators of OA progression, clinical trials of proteinase inhibitors have not been successful for the treatment, turning the interest of researchers to the upstream signals of proteinase induction. These signals include undegraded and fragmented matrix proteins like type II collagen or fibronection that affects chondrocytes through distinct receptors. Another signal is proinflammatory factors that are produced by chondrocytes and synovial cells; however, recent studies that used mouse OA models in knockout mice did not support that these factors have a role in the central contribution to OA development. Our mouse genetic approaches found that the induction of a transcriptional activator Runx2 in chondrocytes under mechanical stress contributes to the pathogenesis of OA through chondrocyte hypertrophy. In addition, chondrocyte apoptosis has recently been identified as being involved in OA progression. We hereby propose that these endochondral ossification signals may be important for the OA progression, suggesting that the related molecules can clinically be therapeutic targets of this disease.

• Journal of Microbiology and Biotechnology
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• 제22권5호
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• pp.654-658
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• 2012

Osteoarthritis (OA) is the most common rheumatic pathology. One of the major objectives of OA research is the development of early diagnostic strategies such as those using proteomic technology. Synovial fluid (SF) in OA patients is a potential source of biomarkers for OA. The efficient and reliable preparation of SF proteomes is a critical step towards biomarker discovery. In this study, we have optimized a pretreatment method for twodimensional gel electrophoresis (2DE) separation of the SF proteome, by enriching low-abundance proteins and simultaneously removing hyaluronic acid, albumin, and IgG. SF samples pretreated using this optimized method were then evaluated by 1DE and 2DE separation followed by immunodetection of cartilage oligomeric matrix protein (COMP), a known OA biomarker, and by the identification of 3 proteins (apolipoprotein, haptoglobin precursor, and fibrinogen D fragment) that are related to joint diseases.

• 한국균학회지
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• 제19권2호
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• pp.148-155
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• 1991

한국내에서 재래적인 방법에 의하여, 생산, 시판되고 있는 전통 발효식품인 메주 (12종), 된장 (28종) 및 간장 (28종)을 전국에서 수거하였다. 이들로부터 OA 생성하는 fungi를 분리하였다. 분리된 균으로 다시 Ochratoxin A 생성 유무를 관찰하였으며, 개괄적인 균 동정도 시도하였다. 1. Ochratoxin A를 정량조사(定量調査)한 표준곡선의 작성결과(作成結果), 감도 (Sensitivity)는 20 pg/tube 수준 이었다. 2. 본 실험에서 이용한 OA 의 분석 방법에서 OA 의 회수율(回收率)은 90% 이상 이었다. 3. 각 시료(試料)에서 분리(分離)해낸 222 fungi 중 Ochratoxin A를 생성하는 것은 39 isolates로 나타났으며, 이 중 대부분이 Aspergillus 속, Penicillium 속 그리고 Pae-cilomyces 속 이었다. 4. 전통 발효식품인 메주,된장,간장내의 곰팡이중 Ochratoxin A 생성곰팡이의 생성률은 각각 19.27%, 18.30%, 14.70%으로 나타났으며 0.2g / 2 petridish 이상의 OA 생성률은 20.5% (8/39)로 나타났다. 또한 Ochratoxin A 생성에 대한 몇가지 추론도 함께 하였다.

• Imaging Science in Dentistry
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• 제50권3호
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• pp.245-253
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• 2020

Purpose: This study investigated the prevalence of temporomandibular joint osteoarthritis (TMJ-OA) using the Research Diagnostic Criteria for Temporomandibular Disorders image analysis criteria, assessed the severity of incidental osteoarthritic changes affecting the TMJ, and evaluated the correlations of sex and age with the prevalence and severity of TMJ-OA. Materials and Methods: This retrospective study assessed 145 randomly selected cone-beam computed tomography scans (261 TMJs) from the authors' institutional maxillofacial radiology archive following the application of inclusion and exclusion criteria. The criteria described by Ahmad et al. were used to determine whether each TMJ was affected by OA, and the severity of the osteoarthritic changes was scored for each joint based on the method described by Alexiou et al. The chi-square, McNemar, Bhapkar chi-square, and Stuart-Maxwell chi-square tests were applied to evaluate the significance of the relationships between variables(age and sex). Results: Sixteen TMJs (6.1%) had no OA, 74 (28.6%) were indeterminate for OA, and 171 (65.5%) had OA. Flattening and sclerosis were observed in 86.6% and 12.3% of cases, respectively, while resorption was observed in 7.3% of the joints. Only 21 (8.1%) of the examined TMJs had subchondral cysts. Erosion of the articular eminence was observed in 58 (22.1%) cases, while sclerosis and resorption were found in 68 (25.9%) and 16 (6.1%) TMJs, respectively. Conclusion: Female patients had a higher prevalence and severity of TMJ-OA than male patients. The prevalence and severity of TMJ-OA increased with age, with peaks in the fifth and seventh decades of life.