• Title/Summary/Keyword: $K^{+}$ channels

Search Result 4,177, Processing Time 0.035 seconds

LIGHT-REGULATED LEAF MOVEMENT AND SIGNAL TRANSDUCTION IN NYCTINASTIC PLANTS

  • Kim, Hak-Yong
    • Journal of Photoscience
    • /
    • v.4 no.1
    • /
    • pp.23-30
    • /
    • 1997
  • Leaf movements in nyctinastic plants are produced by changes in the turgor of extensor and flexor cells, collectively called motor cells, in opposing regions of the leaf movement organ, the pulvinus. In Samanea saman, a tropical tree of the legume family, extensor cells shrink and flexor cells swell to bend the pulvinus and fold the leaf at night, whereas extensor cells swell and flexor cells shrink to straighten the pulvinus and extend the leaf in the daytime. These changes are caused by ion fluxes primarily of potassium and chloride, across the plasma membrane of the motor cells. These ion fluxes are regulated by exogenous light signals and an endogenous biolgical clock. Inward-directed K$^+$ channels are closed in extensor and open in flexor cells in the dark period, while these channels are open in extensor and closed in flexor cells in the light period. Blue light opens the closed K$^+$ channels in extensor and closes the open them in flexor cells during darkness. Illumination of red light followed by darkness induces to open the closed K$^+$ channels in flexor and to close the open K$^+$ channels in extensor cells in the light. The dynamics of K$^+$ channels in motor cells that are controlled by light signals are consistent with the behavior of the pulvini in intact plants. Therefore, these cell types are an attractive model system to elucidate regulations of ion transports and their signal transduction pathways in plants. This review is focused on light-controlled ion movements and regulatory mechanisms involved in phosphoinositide signaling in leaf movements in nyctinastic plants.

  • PDF

Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance $Ca^{2+}$-activated $K^+$ channel in Aplysia neuron R15

  • Lee, Yong;Han, Jin-Hee;Lim, Chae-Seok;Chang, Deok-Jin;Lee, Yong-Seok;Heun Soh;Park, Chul-Seung;Kaang, Bong-Kiun
    • Proceedings of the Korean Biophysical Society Conference
    • /
    • 2003.06a
    • /
    • pp.38-38
    • /
    • 2003
  • The electrical properties of neurons are produced by the coordinated activity of ion channels (Hille, 1992). $K^{+}$ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance $Ca^{2+}$-activated $K^{+}$ (S $K_{Ca}$ ) channels are involved in modulating the slow component of afterhyperpolarization (AHP) (Kohler et al., 1996). Here we examine whether rat type 2 S $K_{Ca}$ (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intraburst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15, Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic S $K_{Ca}$ channels play an important role in regulating the filing pattern and the shape of the action potential.ntial.

  • PDF

Rate Bounds for MIMO Relay Channels

  • Lo, Caleb K.;Vishwanath, Sriram;Heath, Jr., Robert W.
    • Journal of Communications and Networks
    • /
    • v.10 no.2
    • /
    • pp.194-203
    • /
    • 2008
  • This paper considers the multi-input multi-output (MIMO) relay channel where multiple antennas are employed by each terminal. Compared to single-input single-output (SISO) relay channels, MIMO relay channels introduce additional degrees of freedom, making the design and analysis of optimal cooperative strategies more complex. In this paper, a partial cooperation strategy that combines transmit-side message splitting and block-Markov encoding is presented. Lower bounds on capacity that improve on a previously proposed non-cooperative lower bound are derived for Gaussian MIMO relay channels.

Characterization of Voltage-Sensitive Calcium Channels and Insulin Secretion and the effect of 4,4'-Dichlorobiphenyl in RINm5f cells

  • Lee, Ihn-Soon;Hur, Eun-Mi;Sungkwon Chung;Kim, Kyong-Tai
    • Proceedings of the Korean Biophysical Society Conference
    • /
    • 2001.06a
    • /
    • pp.47-47
    • /
    • 2001
  • Opening of $Ca^{2+}$ -channels represents the final common pathway for insulin secretion in pancreatic beta-cells and related cell lines. We investigated voltage-sensitive calcium channels (VSCCs) and insulin secretion in RINm5F, an insulinoma cell line derived from rat pancreatic beta-cells. Several types of VSCCs were identified in RINm5f cells: dihydropyridine-sensitive L-type, $\omega$-conotoxin GVIA-sensitive N-type, $\omega$-agatoxin IVA-sensitive P-type channels, and $\omega$-conotoxin MVIIC sensitive Q-type channels.(omitted)

  • PDF

Manufacturing of Rapid Tooling for Thick-Wall Plastic Lens Mold with Conformal Cooling Channel (균일 냉각을 고려한 Thick-Wall 형상의 플라스틱 렌즈 쾌속 금형 제작)

  • Park, Hyung-Pil;Cha, Baeg-soon;Lee, Sang-Yong;Choi, Jae-Hyuk;Lee, Byung-Ok
    • Design & Manufacturing
    • /
    • v.1 no.1
    • /
    • pp.27-32
    • /
    • 2007
  • In the optical application demand for high quality lens is increasing. Plastics lenses are demanded more than glass lenses for large size lenses as well as micro-size lenses. It is difficult to apply typical straight cooling channels of injection mold to lens molding due to its non-uniform temperature distribution. In this study, we manufactured molds for plastic lenses with the conventional cooling channels and conformal cooling channels produced by the DMLS process. We evaluated cooling performance for the 2 molds by injection molding experiment. Also, uniformity of the temperature distribution was tested by infrared camera and temperature monitoring. We confirmed that the cooling performance and temperature uniformity with the conformal cooling channels is much improved from the ones with the conventional. The cooling time with the conformal cooling channels was reduced 30% compared with the conventional cooling channels.

  • PDF

Numerical study of laminar flow and friction characteristics in narrow channels under rolling conditions using MPS method

  • Basit, Muhammad Abdul;Tian, Wenxi;Chen, Ronghua;Qiu, Suizheng;Su, Guanghui
    • Nuclear Engineering and Technology
    • /
    • v.51 no.8
    • /
    • pp.1886-1896
    • /
    • 2019
  • Modern small modular nuclear reactors can be built on a barge in ocean, therefore, their flow characteristics depend upon the ocean motions. In the present research, effect of rolling motion on flow and friction characteristics of laminar flow through vertical and horizontal narrow channels has been studied. A computer code has been developed using MPS method for two-dimensional Navier-Stokes equations with rolling motion force incorporated. Numerical results have been validated with the literature and have been found in good agreement. It has been found that the impact of rolling motions on flow characteristics weakens with increase in flow rate and fluid viscosity. For vertical narrow channels, the time averaged friction coefficient for vertical channels differed from steady friction coefficient. Furthermore, increasing the horizontal distance from rolling pivot enhanced the flow fluctuations but these stayed relatively unaffected by change in vertical distance of channel from the rolling axis. For horizontal narrow channels, the flow fluctuations were found to be sinusoidal in nature and their magnitude was found to be dependent mainly upon gravity fluctuations caused by rolling.

Ginseng and ion channels: Are ginsenosides, active component of Panax ginseng, differential modulator of ion channels?

  • Jeong, Sang-Min;Nah, Seung-Yeol
    • Journal of Ginseng Research
    • /
    • v.29 no.1
    • /
    • pp.19-26
    • /
    • 2005
  • The last two decades have shown a marked expansion in publications of diverse effects of Panax ginseng. Ginsenosides, as active ingredients of Panax ginseng, are saponins found in only ginseng. Recently, a line of evidences shows that ginsenosides regulate various types of ion channel activity such as $Ca^{2+},\;K^+,\;Na^+,\;Cl^-$, or ligand gated ion channels (i.e. $5-HT_3$, nicotinic acetylcholine, or NMDA receptor) in neuronal, non-neuronal cells, and heterologously expressed cells. Ginsenosides inhibit voltage-dependent $Ca^{2+},\;K^+,\;and\;Na^+$ channels, whereas ginsenosides activate $Ca^{2+}-activated\;Cl^-\;and\;Ca^{2+}-activated\;K^+$ channels. Ginsenosides also inhibit excitatory ligand-gated ion channels such as $5-HT_3$, nicotinic acetylcholine, and NMDA receptors. This review will introduce recent findings on the ginsenoside-induced differential regulations of ion channel activities and will further expand the possibilities how these ginsenoside-induced ion channel regulations are coupled to biological effects of Panax ginseng.

Bibliographic Study on the Interrelation between Dong Shi' Acupuncture and Twelve Regular Channels (동씨침법(董氏針法)과 십이정경(十二正經)의 상관성(相關性)에 관(觀)한 연구(硏究))

  • Jang Jin-Yo;Kim Kyung-Sik;Sohn In-Chul
    • Korean Journal of Acupuncture
    • /
    • v.19 no.1
    • /
    • pp.107-130
    • /
    • 2002
  • In the clinics of traditional medicine, various acupuncture methods, that is Sa-Am' acupuncture, scalp acupuncture, auricular acupuncture and Dong-Shi' acupuncture, have been introduced and increased gradually to treat the diseases. In this bibliographic study, we examined the interrelation between the Dong Shi' acupuncture and 12 regular channels. The theoretical origination of Dong Shi' acupuncture and 12 regular channels was applied from Yin and Yang, Five Element, State of Viscera and so on. As the treatment using by 12 regular channels have used to 'regulating Qi and Treating Shin (調氣治神)', Dong Shi' acupuncture have used to the itself defense mechanism and relative balance of human beings. Also, these methods have the same rules that was selected to the opposing needling (巨刺) of remote point selection, however, Ah-Shi' points (阿是穴) were not used for the selection. Of Dong-Shi' acu-points, there were many ones which have the same location as the acupoints of regular channels. However, these one was renamed according to the new characteristics and therapeutics found by Dong Shi. Dong Shi' acupuncture has divided human body to the 12 areas but not considered to the concept of a mutual connection of human being body. The needling manipulation methods were vary at the regular channels, but Dong Shi' acupuncture did not use the traditional manipulation method except for supplementary Dong-Qi acupuncture, To-Ma acupuncture and To-In acupuncture. From these study, we found that the Dong-Shi' acupuncture have something in common with 12 regular channels, although the Dong-Shi' acupuncture was not based on the theory of 12 regular channels.

  • PDF

Thermal managing effects by cooling channels on performance of a PEMFC (냉각채널 열관리에 따른 고분자연료전지의 성능영향 연구)

  • Sohn, Young-Jun;Kim, Min-Jin;Park, Gu-Gon;Kim, Kyoung-Youn;Lee, Won-Yong
    • 한국신재생에너지학회:학술대회논문집
    • /
    • 2009.06a
    • /
    • pp.373-373
    • /
    • 2009
  • Relative humidity, membrane conductivity and water activity are critical parameters of polymer electrolyte membrane fuel cells (PEMFC) for high performance and reliability. These parameters are closely related with temperature. Moreover, the ideal values of these parameters are not always identical along the channels. Therefore, the cooling channel design and its operating condition should be well optimized along the all location of the channels. In the present study, we have performed a numerical investigation on the effects of cooling channels on performance of a PEMFC. Three-dimensional Navier-Stokes equations are solved with the energy equation including heat generated by the electrochemical reactions in the fuel cell. The present numerical model includes the gas diffusion layers (GDL) and serpentine channels for both anode and cathode gas flows, as well as cooling channels. To accurately predict the water transport across the membrane, the distribution of water content in the membrane is calculated by solving a nonlinear differential equation with a nonlinear coefficient, i.e., the water diffusivity which is a function of water content as well as temperature. Main emphasis is placed on the heat transfer between the solid bipolar plate and coolant flow. The present results show that local current density is affected by cooling channels due to the change of the oxygen concentration and the membrane conductivity as well as the water content. It is also found that the relative humidity is influenced by the generated water and the gas temperature and thus it affects the distribution of fuel concentration and the conductivity of the membrane, ultimately fuel cell performance. Unit-cell experiments are also carried out to validate the numerical models. The performance curves between the models and experiments show reasonable results.

  • PDF