• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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• pp.36-36
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• 2001

Small conductance $Ca^{2＋}$-activated $K^{+}$ channels (or S $K_{Ca}$ channels) are a group of $K^{＋}$-selective ion channels activated by sub-micromolar concentrations of intracellular $Ca^{2＋}$ independent of membrane voltage. We expressed a cloned S $K_{Ca}$ channel, rSK2, in Xenopus oocytes and investigated the monovalent cation selectivity of the channels. We have used site-directed mutagenesis and macro-channel recordings to identify amino acid residues influencing the ion selectivity.(omitted)d)

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권11호
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• pp.3026-3045
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• 2012

In this paper, diversity-multiplexing tradeoff (DMT) of three-user wireless multiple-antenna cooperative systems is investigated in general fading channels when half-duplex and decode-and-forward relay is employed. Three protocols, i.e., adaptive protocol, receive diversity protocol, and dual-hop relaying protocol, are considered. The general fading channels may include transmit and/or receive correlation and nonzero channel means, and are extensions of independent and identically distributed Rayleigh or Rician fading channels. Firstly, simple DMT expressions are derived for general fading channels with zero channel means and no correlation when users employ arbitrary number of antennas. Explicit DMT expressions are also obtained when all users employ the same number of antennas and the channels between any two users are of the same fading statistics. Finally, the impact of nonzero channel means and/or correlation on DMT is evaluated. It is revealed theoretically that the DMTs depend on the number of antennas at each user, channel means (except for Rayleigh and Rician fading statistics), transmit and/or receive correlation, and the polynomial behavior near zero of the channel gain probability density function. Examples are also provided to illustrate the analysis and results.

• 한국수정란이식학회지
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• 제24권3호
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• pp.189-197
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• 2009

Two-pore domain 칼륨($K_{2P}$) 통로는 흥분세포 및 비흥분세포의 안정막 전압을 일정하게 유지하는데 관여한다. 그러나 생식세포 및 생식기관에서 발현되는 $K_{2P}$ 통로의 분포영역 및 그 기능에 대해서는 연구자들에 의해 아직 정리되지 못하였다. 본 종설에서는 $K_{2P}$ 통로의 생식세포 및 생식기관에서 발현, 분포 및 생리학적 의의를 논하였다. $K_{2P}$ 통로는 인간 영양막세포, 자궁근층, 태반혈관계, 자궁평활근조직, 태반융모조직 및 임신자궁조직에서 발현되어 임신에 있어서 관련성을 제시되었다. 또한, $K_{2P}$ 통로는 마우스 전핵배, 원숭이 정자 및 한우의 난소, 정소, 난자, 정자 및 수정란에서 발현 변화를 보였다. 특히, $K_{2P}$ 통로는 체외배양 시 변화되는 온도, 산소분압과 같은 배양조건에 의해 조절되는 특징을 보임으로써 수정 및 배 발달에 영향을 줄 수 있는 인자로 제시되었다. 그리고 $K_{2P}$ 통로는 과산화수소에 의해 유도된 마우스 전핵배의 세포 사멸에 있어서 칼륨 이온의 유출에 관여함이 확인되었다. $K_{2P}$ 통로의 생식세포 및 생식기관 내 발현 형태와 생리학적 특징은 생식생리학에 있어서 이온 통로 관련 기능들을 이해하는데 도움이 될 것이다.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.44-44
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• 2003

$BK_{Ca}$ channels were suggested to contain one or more domains of the ‘regulator of K+ conductance’(RCK) in their cytosolic carboxyl termini (Jiang et al.2001). It was also shown that the RCK domain in mammalian $BK_{Ca}$ channels might sense the intracellular $Ca^{2+}$ with a low affinity (Xia et al. 2002). We aligned the amino acid sequence of the $\alpha$-subunit of rat $BK_{Ca}$ channels (rSlo) with known RCK domains and identified a second region exhibiting about 50％ homology. This putative domain, RCK2, contains the characteristic amino acids conserved in other RCK domains. We wondered whether this second domain is involved in the domain-domain interaction and the gating response to intracellular $Ca^{2+}$ for rSlo channel, as revealed in the structure of RCK domain of E. coli channel (Jiang et al.2001). In order to examine the possibility, site-directed mutations were introduced into the RCK2 domain of rSlo channel and the mutant channels were expressed in Xenopus oocytes for functional studies. One of such mutation, G772D, in the putative nucleotide-binding domain resulted in the enhanced $Ca^{2+}$ sensitivity and the channel gating of rSlo channel. These results suggest that this region of $BK_{Ca}$ channels is important for the channel gating and may form an independent domain in the cytosolic region of $BK_{Ca}$ channels. In order to obtain the mechanistic insights of these results, G772 residue was randomly mutagenized by site-directed mutagenesis and total 17 different mutant channels were constructed. We are currently investigating these mutant channels by electrophysiological techniques.ical techniques.

• The Korean Journal of Physiology and Pharmacology
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• 제10권2호
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• pp.65-69
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• 2006

The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic or parasympathetic nerves to the submandibular gland. One week later, the expression of Na,K-ATPase, epithelial sodium channels (ENaC), and aquaporins (AQP) was examined in the denervated and contralateral glands. The sympathetic denervation slightly but significantly decreased the expression of ${\alpha}1$ subunit of Na,K-ATPase, whereas the parasympathetic denervation increased it. The expression of ${\alpha}$-subunit of ENaC was significantly increased in both the denervated and contralateral glands either by the sympathetic or parasympathetic denervation. The sympathetic denervation significantly increased the expression of AQP5 in both the denervated and contralateral glands, whereas the parasympathetic denervation decreased it. It is suggested that the autonomic nerves have a tonic effect on the regulation of sodium transporters and AQP water channels in the salivary gland.

• Korean Journal of Acupuncture
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• 제28권3호
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• pp.85-98
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• 2011

Objectives : The aim of this thesis is to examine the effect of acupuncture treatment at the GB37 on normal humans by using the power spectral analysis of the EEG. Methods : EEG (Electroencephalogram) power spectrum exhibits site-specific and state-related differences in specific frequency bands. In this thesis, the power spectrum was measured by the complexity. the 32 channels EEG study was carried out in the 13 subjects (12 males ; age=22.58 years old, 1 females ; 22 years old). Results : In the ${\alpha}$ (alpha) band, the power values at F7, F3, F4, F8, FTC2, C4, T4, CP1, CP2, TCP2, TT2, Pz, P4, Po1, Po2, O1, Oz, O2 channels (p<0.05) during the GB37-acupoint treatment were significantly changed. And in many channels were decreased. In the ${\beta}$ (beta) band, the power values at Cz, C4, T4, Tcp1, T6, Po1, O1, Oz, O2 channels (p<0.05) during the GB37-acupoint treatment were significantly changed. And in many channels were decreased. In the ${\delta}$(delta) band, the power values at Fp1, TT2 channels (p<0.05) during the GB37-acupoint treatment were significantly changed. And in many channels were decreased. In the $\theta$ (theta) band, the power values at Fp1, F8, FTC2, Pz channels (p<0.05) during the GB37-acupoint treatment were significantly changed. And in many channels were decreased. Conclusions : This results suggest that the acupuncture treatment at the GB37 significantly mostly change the power spectrum value on the alpha (18 channels), beta (9 channels) bands.

• 한국전산유체공학회지
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• 제17권3호
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• pp.93-98
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• 2012

The injection molding process is suitable for manufacturing complicated plastic products. As the customer request higher quality products increase, realization of the precise dimensional and shape controls is getting more important. For this purpose it is important to obtain uniform cooling procedure over the whole surface of the high temperature molded plastic. Failure to this may lead to different shrinkage speed, internal stresses and unwanted shape deformations. It is necessary to distribute coolant flow rates to the main channel and to the sub-channels properly to insure uniform cooling process when there are parallel cooling channels. In this study, three-dimensional turbulent flow simulations for representative parallel cooling channels were performed. To insure the intended flow rate to each sub-channels, various shape designs for the channel system were investigated. The results show that as the Reynolds number increases the effect of shape design is more profound. Through the proper flow distribution, uniform cooling effects would be expected.

• Journal of information and communication convergence engineering
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• 제9권2호
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• pp.183-186
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• 2011

In this work, we consider imperfectness of feedback channels in the adaptive transmission scheme which was previously studied with an assumption of error-free feedback channels. New method of mapping the modulation index into the feedback channel symbols and quantifying feedback error over fading channels are proposed. The presented method and results are expected to offer valuable tools for the system designer to efficiently implement adaptive diversity schemes to compensate for the performance degradation due to feedback error.

• Nuclear Engineering and Technology
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• 제34권5호
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• pp.502-516
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• 2002

Wolsong NPP are CANDU6 type reactors and there are 4 CANDU6 type reactors in commercial operation. CANDU type reactors require on-power refuelling by two remote controlled F/Ms (Fuelling Machines). Most of channels, fuel bundles are float by channel coolant flow and move toward downstream, however in about 30% of channels the coolant flow are not sufficient enough to carry fuel bundles to downstream. For those channels a special device, FARE (Flow Assist Ram Extension) device, is used to create additional force to push fuel bundles. It has been showing that during fuelling operation of some channels the channel coolant flow rate is reduced below specified limit (80% of normal), and consequently trip alarm signal turns on. This phenomenon occurs on selected channels that are instrumented for the channel flow and required to use the FARE device for refuelling. Hence it is believed that the FARE device causes the problem. It is also suspected that other channels that do not use the FARE device for refuelling might also go into channel flow low state. The analysis revealed that the channel How low occurs as the FARE device is introduced into the core and disappears as the FARE device is removed from the core. This paper presented the FARE device behavior, detailed fuelling operation sequence with the FARE device and effect on channel flow low phenomena. The FARE device components design changes are also suggested, such as increasing the number or now holes in the tube and flow slots in the ring orifice.

• Journal of Information Processing Systems
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• 제8권1호
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• pp.1-20
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• 2012

The most important criterion for achieving the maximum performance in a wireless mesh network (WMN) is to limit the interference within the network. For this purpose, especially in a multi-radio network, the best option is to use non-overlapping channels among different radios within the same interference range. Previous works that have considered non-overlapping channels in IEEE 802.11a as the basis for performance optimization, have considered the link quality across all channels to be uniform. In this paper, we present a measurement-based study of link quality across all channels in an IEEE 802.11a-based indoor WMN test bed. Our results show that the generalized assumption of uniform performance across all channels does not hold good in practice for an indoor environment and signal quality depends on the geometry around the mesh routers.