• Biomolecules & Therapeutics
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• 제6권2호
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• pp.219-224
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• 1998

The bioequivalence of two clarithromvcin products was evaluated with 16 normal male volunteers (age 23-28 yr, body weight 57.5-75.517g) following single oral dose. Test product was ReYon Clarithromycin tablets (ReYon Pharm. Corp., Korea) and reference product was Klarici $d_{R}$ tablets (Abbott Korea). Both products contain 250 mg of clarithromucin. One tablet of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study (2$\times$2 Latin square method). The determination of clarithromycin was accomplished using a modified agar well diffusion bioassay. As a result of the assay validation, the quantification of clarithromycin in human serum by this technique was possible down to 0.03$\mu$g/ml using 100$\mu$l of serum. The coefficient of variation (C.V.) was less than 10%. Average drug concentrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products P>0.05); the area under the curve to last sampling time (24 hr) (AU $Co_{24hr}$ (8.10$\pm$ 1.26 vs 8.22$\pm$ 1.627g . hr/ml), AUC from time zero to infinite (AU $Co_{\infty}$) (8.61 $\pm$ 1.28 vs 8.84$\pm$ 1.71 $\mu$g . hr/ml), maximum plasma concentration ( $C_{msx}$) (0.87$\pm$0.22 vs 0.88$\pm$0.19 $\mu$g/ml) and time to maximum plasma concentration ( $T_{max}$) (2.69 $\pm$0.48 vs 2.56$\pm$ 0.51 hr). The differences of mean AU $Co_{24h}$, $C_{msx}$ and $T_{msx}$ between the two products (1.44, 1.39, and 4.65%, respectively) were less than 20%. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $Co_{24hr}$, and $C_{max}$ were more than 0.8 and less than 0.2, respectivly. Although the power for $T_{max}$ was under 0.8, $T_{max}$. of the two products was not significantly different each other (p>0.05). These results suggest that the bioavailability of ReYon Clarithromycin tablets is not significantly different from that of Klarici $d_{R}$ tablets. Therefore, two products are bioequivalent based on the current results. results.sults.sults.s.s.s.s.s.s.s.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.403-406
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• 1997

Electrogastrogaphy(EGG) is the technique by which gastric myoelectrical activity is recorded noninvasively, from electrodes on the abdominal skin. Despite many attempts made over the decades, the clinical application of the EGG signal has not improved to the identification of waveform characteristics using comparison of EGG signal to be detected other EGG system. Cutaneous measurements of EGG are yet to be standardized in methods of detection and analysis. This may be responsible in part for some of the variability in the results. Thus, we develope EGG system composed of amplifiers, analysis methods, patient database or standardization. we introduce configurations of EGG system and their functions. Several important EGG parameters are introduced, including the dominant frequency and power of the EGG, the relative, period EGG-dominant frequency and power, the instability coefficient of EGG-dominant frequency and power, standard deviation, the percentage of running spectrum activity of gastric slow waves.

• 대한전자공학회논문지SD
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• 제39권10호
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• pp.35-42
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• 2002

Modulation frequency dependences of the pyroelectric properties of PLT (P $b_{1-x}$ L $a_{x}$ $Ti_{1-x}$ 4/ $O_3$) thin films with La concentrations of 5, 10 and 15㏖% have been investigated by using the dynamic method. The PLT thin film with 10㏖% of the La concentration (PLT(10) thin film) shows the most excellent pyroelectric properties among the films. For PLT(10) thin film, the pyroelectric coefficient shows the maximum value of 6.6$\times$10$^{-9}$ C/$\textrm{cm}^2$ㆍK without frequency dependence. The figure of merits for the voltage responsivity and specific detectivity are 1.03$\times$10$^{-11}$ Cㆍcm/J and 1.46$\times$10$^{-9}$ Cㆍcm/J, respectively. Voltage responsivity corresponding to the pyroelectric voltage is almost constant at low modulation frequency and decreases in proportional to frequency at high modulation frequency. Voltage responsivity is 5.15 V/W at 8Hz. Noise equivalent power (NEP) and specific detectivity ( $D^{*}$) of the PLT(10) thin film are 9.93$\times$10$^{-8}$ W/H $z^{1}$2/ and 1.81$\times$10$^{6}$ cmH $z^{1}$2/W at the frequency of 100Hz, respectively. The results indicate that PLT(10) thin film is very suitable for pyroelectric IR sensors.s.s.

• Ocean Systems Engineering
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• 제9권2호
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• pp.111-133
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• 2019

Flow through a scaled horizontal axis marine current turbine was numerically simulated after validation and the turbine design was optimized. The computational fluid dynamics (CFD) code Ansys-CFX 16.1 for numerical modeling, an in-house blade element momentum (BEM) code for analytical modeling and an in-house surrogate-based optimization (SBO) code were used to find an optimal turbine design. The blade-pitch angle (${\theta}$) and the number of rotor blades (NR) were taken as design variables. A single objective optimization approach was utilized in the present work. The defined objective function was the turbine's power coefficient ($C_P$). A $3{\times}3$ full-factorial sampling technique was used to define the sample space. This sampling technique gave different turbine designs, which were further evaluated for the objective function by solving the Reynolds-Averaged Navier-Stokes equations (RANS). Finally, the SBO technique with search algorithm produced an optimal design. It is found that the optimal design has improved the objective function by 26.5%. This article presents the solution approach, analysis of the turbine flow field and the predictability of various surrogate based techniques.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집 Vol.14 No.1
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• pp.104-107
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• 2001

The fabricated La-modified lead titanate (PLT) thin flim without paling treatment was investigated for modulation frequency dependence of pyroelectric properties by the dynamic method. $Pb_{1-x}La_{x}Ti_{1-x/4}O_{3}$ PLT (x=0.1) thin film having 10 mol% La content was deposited on a $Pt/TiO_{x}/SiO_{2}/Si$ substrate by sol-gel method. The PLT(10) thin film exhibits a relatively excellent dielectric property. The pyroelectric coefficient (p) of the PLT(10) thin film is $6.6{\times}10^{-9}C/cm_{2}\cdot K$ without frequency dependence. The figure of merits for the voltage responsivity and specific detectivity are $1.03{\times}10^{-11}C\cdot cm/J$ and $1.46\times 10^{-9}C\cdot cm/J$, respectively. The PLT(10) thin film has voltage responsivity (Rv) of 5.15 V/W at 8 Hz. Noise equivalent power (NEP) and specific detectivity (D*) of the PLT(10) thin film are$9.93{\times}10^{-8}W/Hz^{1/2}$ and $1.81\times 10^{6}cmHz^{1/2}/W$ at the same frequency of 100 Hz, respectively. The results means that PLT thin film having 10 mol % La content is suitable for the sensing materials of pyroelectric IR sensors.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 추계학술대회 논문집
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• pp.104-107
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• 2001

The fabricated La-modified lead titanate (PLT) thin flirt without poling treatment was investigated for modulation frequency dependence of pyroelectric properties by the dynamic method. $Pb_{1-x}La_{x}Ti_{1-x/4}O_3$PLT (x=0.1) thin film having 10 mol% La content was deposited on a Pt/$TiO_{x}$/$SiO_2$/Si substrate by sol-gel method. The PLT(10) thin film exhibits a relatively excellent dielectric property. The pyroelectric coefficient (p) of the PLT(10) thin film is 6.6 x $10^{-9}$C/$\textrm{cm}^2$.K without frequency dependence. The figure of merits for the voltage responsivity and specific detectivity are 1.03${\times}$$10^{-11}$/C.cm/J and 1.46 x $10^{-9}$C.cm/J, respectively. The PLT(10) thin film has voltage responsivity ($R_{V}$) of 5.15 V/W at 8 Hz. Noise equivalent power (NEP) and specific detectivity (D＊) of the PLT(10) thin film are 9.93 x $10^{-8}$W/Hz$^{1/2}$ and 1.81 x $10^{6}$ cmHz$^{1/2}$/W at the same frequency of 100 Hz, respectively. The results means that PLT thin film having 10 mol % La content is suitable for the sensing materials of pyroelectric IR sensors.

• 한국응용과학기술학회지
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• 제37권4호
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• pp.688-698
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• 2020

본 연구는 병원간호사의 간호조직문화, 조직커뮤니케이션만족, 직무착근도의 관계를 확인하고, 직무착근도에 미치는 영향요인을 파악하기 위함이다. C시 소재한 대학병원에 근무하고 있는 간호사 238명을 대상으로 2017년 8월 1일~8월 10일까지 자료수집 하였다. 자료는 SPSS WIN 22.0 통계 프로그램을 이용하여, 기술통계, t-test, ANOVA, Pearson's correlation coefficient, Stepwise Multiple Linear Regression으로 확인하였다. 본 연구결과 간호조직문화는 5점 만점에 평균 3.32±0.33점 이었고, 조직커뮤니케이션만족은 5점 만점에 평균 3.19±0.37점 이었으며, 직무착근도는 5점 만점에 평균 3.19±0.44점이었다. 일반적 특성에 따른 직무착근도의 차이는 연령(F=9.00, p<.001), 학력(F=13.24, p<.001), 직위(t=-5.42, p<.001), 결혼(t=-3.11, p=.002), 근무경력(F=10.55, p<.001), 근무형태(F=10.99, p<.001)에서 유의한 차이가 있었다. 직무착근도와 간호조직문화(r=.502, p<.001), 조직커뮤니케이션만족(r=.673, p<.001)은 양의 상관관계가 있었다. 직무착근도에 영향을 미치는 요인으로 조직커뮤니케이션만족(β=.575 p=.000), 근무경력 '10년 이상'(β=.342 p=.000), 간호조직문화(β=.203 p=.000), 근무경력 '5년 이상~10년 미만'(β=.121 p=.000)의 순이었고, 모형의 설명력은 57.4%이었다. 이상의 결과에 따라 병원간호사의 간호직무에 착근도를 높이기 위하여 조직커뮤니케이션만족도를 수시로 파악하고, 근무경력, 간호조직문화 등을 고려한 간호실무 및 교육중재 프로그램 개발이 필요하다.

• 문화기술의 융합
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• 제6권2호
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• pp.223-230
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• 2020

본 연구는 간호대학생을 대상으로 자아탄력성, 성인애착, 대인관계유능성이 학업스트레스에 미치는 영향을 확인하여 학업스트레스를 조절하기 위한 기초자료를 제공하고자 시도되었다. 연구참여자는 B와 Y시의 간호대학생 287명을 대상으로 하였다. 자료분석은 SPSS 22.0 프로그램을 이용하여 실수, 백분율, 평균, 표준편차, t-test, ANOVA, 피어슨 상관계수, 다중회귀분석으로 분석하였다. 대상자의 학업스트레스는 2.28±.46점이었고, 일반적 특성에 따른 학업스트레스의 차이를 분석한 결과 학년(F=16.342, p<.001), 경제상태(F=3.331, p=.037), 음주 횟수(F=3.393, p=.035), 학과만족도(F=40.539, p<.001), 대학생활만족도(F=67.304, p<.001)에서 유의한 차이를 나타냈다. 연구대상자의 학업스트레스는 성인애착(r=.557, p<.001)과는 정적상관관계, 자아탄력성(r=-.379, p<.001), 대인관계유능성(r=-.423, p<.001)과는 부적상관관계를 나타냈다. 학업스트레스에 영향을 미치는 요인은 자아탄력성, 성인애착으로 나타났고, 설명력은 34%로 확인되었다. 본 연구결과를 통하여 간호대학생을 대상으로 학업스트레스에 영향을 미치는 요인을 확인하기 위한 반복연구가 필요하다.

• 대한전자공학회논문지SD
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• 제39권12호
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• pp.1008-1015
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• 2002

분극처리 없이 제작한 lanthanum-modified lead titanate (PLT) 박막의 초전특성에 대한 변조 주파수 의존성을 dynamic method를 이용하여 조사하였다. La이 10mo1% 첨가된 Pb/sub l-x/La/sub x/Ti/sub l-x/4/O₃ (h=0.1) (PLT(10)) 박막을 Pt/TiO/sub x//SiO₂/Si 기판위에 acetate 계 precursor 을 이용한 sol-gel 법으로 제작하였다. 제작된 PLT(10) 박막은 비교적 우수한 유전특성을 보였다. 초전계수 (p) 는 주파수 의존성이 없이 6.6×10/sup -9/ C/㎠·K 을 나타내었다. 이를 이용하여 구한 전압감도와 비검출능을 위한 재료평가지수는 각각 1.03×10/sup -11/ C·㎝/J 과 1.46×10/sup -9/C·㎝/J 로 나타났다. 제작된 PLT(10) 박막 초전형 적외선 센서는 주파수 8Hz 에서 5.15v/w 의 전압감도 (Rv)를 가지며, 잡음등가전력 (NEP) 과 비검출능 (D/sup */) 은 동일한 주파수 100Hz 에서 각각 9.93×10/sup -8/W/Hz/sup 1/2/와 1.81×10/sup 6/cm·Hz/sup 1/2//W 의 최소값과 최대값을 나타내었다. 이와 같은 특성들은 PLT(10) 박막이 초전형 적외선 센서의 감지물질로 매우 적합함을 나타낸 것이다.

• 한국재료학회지
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• 제15권2호
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• pp.89-92
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• 2005

The induction melting was employed to prepare Nb-doped $CoSb_3$ skutterudites and their thermoelectric properties were investigated. Single phase $\delta-CoSb_3$ was successfully obtained by induction melting and subsequent annealing at $400^{\circ}C$ for 2 hrs in vacuum. The positive signs of Seebeck coefficients for all the specimens revealed that Nb atoms acted as p-type dopants by substituting Co atoms. Electrical conductivity decreased and then increased with increasing temperature, indicating mixed conduction behavior. Electrical conductivity increased by Nb doping, and it was saturated at high temperature. Maximum value of the thermoelectric power factor was shifted to higher temperature with increasing the amount of Nb doping, mainly originated from the high Seebeck coefficient around mixed conduction temperature and high electrical conductivity.