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Hepatoprotective Effects of White and Red Ginseng Extracts on Acetaminophen-induced Hepatotoxicity in Mice (Acetaminophen 유도 간독성에 대한 백삼과 홍삼 추출물의 간보호 효과)

  • Seong, Geum-Su;Chun, Seung-Gi;Chang, Che-Chul
    • Journal of Ginseng Research
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    • v.29 no.3
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    • pp.131-137
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    • 2005
  • Acetaminophen(APAP) is one of the most extensively used analgesics and antipyreics worldwide. In order to investigate preventive effects of white and red ginseng extracts, male ICR mice pretreated with white or red ginseng extracts(50 or 250 mg/kg/day, for 5 days, orally) before treatment with acetaminophen(800mg/kg, i.p, single dose). In an attempt to elucidate the possible mechanism of hepatoprotective effect, superoxide dismutase(SOD), catalase(CAT), hydroperoxide, malondialdehyde(MDA) contents were studied. In pretreatment with red ginseng extract(250 mg/kg), the activities of SOD, CAT were generally highest and the hydrogen peroxide content was lowest. The levels of MDA were significantly lower in white and red ginseng extract groups than those in the APAP groups. By treatment with ginseng extract, high content of hydrogen peroxide and increased lipid peroxidatiion level caused by APAP could be lowered. Also, ginseng extracts were found to increase antioxidative enzyme activity. Finally, the results suggest that the antioxidant effects of (white and red) ginseng extracts prevent oxidative damage by direct antioxidant effects involving SOD, CAT and increasing the ability to synthesize endogenous antioxidants. It was concluded that ginseng can protect against APAP intoxication through its antioxidant properties.

Simulation and Evaluation of the KOMPSAT/OSMI Radiance Imagery (다목적 실용위성 해색센서 (OSMI)의 복사영상에 대한 모의 및 평가)

  • 반덕로;김용승
    • Korean Journal of Remote Sensing
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    • v.15 no.2
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    • pp.131-146
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    • 1999
  • The satellite visible data have been successfully applied to study the ocean color. Another ocean color sensor, the Ocean Scanning Multi-spectral Imager (OSMI) on the Korea Multi-Purpose Satellite (KOMPSAT) will be launched in 1999. In order to understand the characteristics of future OSMI images, we have first discussed the simulation models and procedures in detail, and produced typical patterns of radiances at visible bands by using radiative transfer models. The various simulated images of full satellite passes and Korean local areas for different seasons, water types, and the satellite crossing equator time (CET) are presented to illustrate the distribution of each component of radiance (i.e., aerosol scattering, Rayleigh scattering, sun glitter, water-leaving radiance, and total radiance). A method to evaluate the image quality and availability is then developed by using the characteristics of image defined as the Complex Signal Noise Ratio (CSNR). Meanwhile, a series of CSNR images are generated from the simulated radiance components for different cases, which can be used to evaluate the quality and availability of OSMI images before the KOMPSAT will be placed in orbit. Finally, the quality and availability of OSMI images are quantitatively analyzed by the simulated CSNR image. It is hoped that the results would be useful to all scientists who are in charge of OSMI mission and to those who plan to use the data from OSMI.

The Origin of Thinking Mind (우리는 왜 생각하는 존재가 되었는가?)

  • Park, Man-joon
    • Journal of Korean Philosophical Society
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    • v.131
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    • pp.131-163
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    • 2014
  • This Paper aims to elaborate on the origin of thinking mind. And this is a cooperative project between philosophy and neuroscience and brain science. I have written this paper in admiration for the achievements of twentieth century neuroscience and brain science, and out of desire to assist the subject in future. Much of the history of modern philosophy, from Descartes and Kant forward, consists of failed models of brain. As Edward O. Wilson precisely said, the shortcoming is not the fault of the philosophers, who have doggedly pushed their methods to the limit, but a straightforward consequence of the biological evolution of the brain. Guiding that investigation down pathways that will illuminate brain research is a task of neuroscience and brain science. Investigating logical relations among concepts is a philosophical task. If we are to understand the neural structures and dynamics that make perception, thought, intentional behaviour possible, clarity about these concepts and categories and their relations is essential. Hence our joint venture of philosophy and science. Sure, it is human beings that perceives, not parts of its brain. And it is human beings that who think and reason, not their brain. But the brain and its activities make it possible for human beings-not for it-to perceive and think, to feel emotions, and to form and pursue projects. Thus We try to investigate and reveal the origin of thinking mind as follow: 1) The difference between chimpanzee and human beings 2) brain and mind 3) the origin of thinking 4) the wisdom of nature.

Magnetism and Half-metallicity of Co2TiSn(001) Surfaces: A First-principles Study (Co2TiSn(001) 표면의 자성 및 반쪽금속성에 대한 제일원리연구)

  • Jin, Y.J.;Lee, J.I.
    • Journal of the Korean Magnetics Society
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    • v.18 no.4
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    • pp.131-135
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    • 2008
  • The electronic structures, magnetism, and half-metallicity of the full-Heusler $Co_2TiSn$(001) surfaces have been investigated by using the all-electron full-potential linearized augmented plane wave method within the generalized gradient approximation. We have considered both of the Co atoms terminated(Co-term) and the TiSn atoms terminated(TiSn-term) surfaces. From the calculated density of states, we found that the half-metallicity was destroyed at the surface of the Co-term, while the half-metallicity was retained at the TiSn-term. For the surface of the Co-term, due to the reduced coordination number the occupied minority d-states were shifted to high energy regions and that cross the Fermi level, thus destroy the surface half-metallicity. On the other hand the surface states at the surface of the TiSn-term were located just below the Fermi level, which reduces the minority spin-gap with respect to that of the center layer. The calculated magnetic moment of the surface Co atom for the Co-term was increased by 10 % to 1.16 ${\mu}_B$ with respect to that of the inner-layers, while the magnetic moment of the subsurface Co atom in the TiSn-term has almost same value of the innerlayers(1.03 ${\mu}_B$).

Floristic Characteristics of Vascular Plants in the Dong-gang River Basin Ecological and Scenery Conservation Area (동강유역 생태·경관보전지역의 관속식물)

  • Chae, Hyun-Hee;Kim, Young-Chul;Lee, Kyu-Song;Nam, Gi-Heum;Lee, Sae-Rom;Lee, Yoon-Joong;Lee, Yoon-Kyeong
    • Korean Journal of Environment and Ecology
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    • v.33 no.2
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    • pp.131-167
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    • 2019
  • Securing reference information (inventory) is essential for proper conservation and management of protected areas. Moreover, the investigation results should be available for comparison and evaluation. For this study, we established seven investigational lattices and carried out the field examinations to obtain comparable data in the Donggang river basin ecological and scenery conservation area, We conducted a total of 16 field surveys and identified a total of 830 taxa that is composed of 127 families, 408 genera, 716 species, 10 subspecies, 88 varieties, and 16 forms. We identified a total of 487 taxa in the 6th investigational lattice and 457 taxa in the 4th. We observed 6 species (grade II) designated by the Ministry of Environment as the endangered plants, one "species to monitor" designated by the Ministry of Environment, and 23 taxa designated as endemic species. Regarding the floristic characteristics plants, 15 taxa of grade V, 27 taxa of grade IV, 38 taxa of grade III, 31 taxa of grade II, and 19 taxa of grade I were identified. The 6th investigational lattice showed the largest number of taxa at 70. A total of 58 taxa were identified as the naturalized plant, and the 6th investigational lattice showed the most at 35 taxa. The Donggang river basin ecological and scenery conservation area was assessed to be an extremely important area to conserve and maintain plants species diversity not only in the regional scale but also national scale.

Development And Applying Detailed Competencies For Elementary School Students' Data Collection, Analysis, and Representation (초등학생의 데이터 수집, 분석, 표현 수업을 위한 세부역량 개발 및 적용)

  • Suh, Woong;Ahn, Seongjin
    • Journal of The Korean Association of Information Education
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    • v.23 no.2
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    • pp.131-139
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    • 2019
  • From 2019, software education has become a required subject for all elementary school students. However, many teachers are still unfamiliar with how the classes should be instructed. So this paper presented the meaning, detailed competencies and achievement standard in order to help in the collection, analysis and representation of data among the computational thinking that are key to software education. And it also suggested the applicability of the classes. The full course of the paper is summarized as follows. First, existing studies have summarized the meaning, detail and achievement standard of data related competencies. Based on this, a preliminary investigation was instructed. Pilot study carried out both FGI and closed questions at the same time. This was done in response to the survey's questionnaire reflecting the opinions of experts. Second, the results of the questionnaire generated as a result of the above were verified for validity, stability, and reliability among the PhD, PhD courses, software education teachers, and software education workers. Third, I developed and applied the five lessons as a class objective as 'Choosing collection method-Select the collection method according to the problem situation.', 'Searching for meaning of data-Understand what the analyzed data mean..', 'Using various expression methods-Use a variety of expression tools.' using the backward design model to integrate education, class, and assessment. As a result, the detailed competencies of data collection, analysis, and representation and achievement standard were presented. This may help in setting specific and specific criteria for what direction classes are recommended when planning data-related classes in elementary schools.

A Study for Generation of Artificial Lunar Topography Image Dataset Using a Deep Learning Based Style Transfer Technique (딥러닝 기반 스타일 변환 기법을 활용한 인공 달 지형 영상 데이터 생성 방안에 관한 연구)

  • Na, Jong-Ho;Lee, Su-Deuk;Shin, Hyu-Soung
    • Tunnel and Underground Space
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    • v.32 no.2
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    • pp.131-143
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    • 2022
  • The lunar exploration autonomous vehicle operates based on the lunar topography information obtained from real-time image characterization. For highly accurate topography characterization, a large number of training images with various background conditions are required. Since the real lunar topography images are difficult to obtain, it should be helpful to be able to generate mimic lunar image data artificially on the basis of the planetary analogs site images and real lunar images available. In this study, we aim to artificially create lunar topography images by using the location information-based style transfer algorithm known as Wavelet Correct Transform (WCT2). We conducted comparative experiments using lunar analog site images and real lunar topography images taken during China's and America's lunar-exploring projects (i.e., Chang'e and Apollo) to assess the efficacy of our suggested approach. The results show that the proposed techniques can create realistic images, which preserve the topography information of the analog site image while still showing the same condition as an image taken on lunar surface. The proposed algorithm also outperforms a conventional algorithm, Deep Photo Style Transfer (DPST) in terms of temporal and visual aspects. For future work, we intend to use the generated styled image data in combination with real image data for training lunar topography objects to be applied for topographic detection and segmentation. It is expected that this approach can significantly improve the performance of detection and segmentation models on real lunar topography images.

Effect of Ginsenoside Rg3 on COX-2 Expression in Brain Tissue of Lipopolysaccharide-Treated Mice (Ginsenoside Rg3이 Lipopolysaccharide에 의한 생쥐 뇌조직의 Cyclooxygenase-2 발현에 미치는 영향)

  • Choi, Wonik;Cho, Yong-Deok;Lee, Joon-Seok;Shin, Jung-Won;Kim, Seong-Joon;Sohn, Nak-Won
    • The Korea Journal of Herbology
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    • v.27 no.6
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    • pp.131-137
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    • 2012
  • Objectives : Cyclooxygenase (COX) plays a central role in the inflammatory cascade by converting arachidonic acid into prostaglandin. COX-2 is typically induced by inflammatory stimuli in the majority of tissues, it is responsible for propagating the inflammatory response and thus, considered as the best target for anti-inflammatory drugs. The present study investigated the modulatory effect of ginsenoside Rg3, a principle active ingredient in Panax ginseng, on COX-2 expression in the brain tissue induced by systemic lipopolysaccharide (LPS) treatment in C57BL/6 mice. Methods : Because systemic LPS treatment induces COX-2 expression immediately in the brain, ginsenoside Rg3 was treated orally with doses of 10, 20, and 30 mg/kg at 1 hour before the LPS (3 mg/kg, i.p.) injection. At 4 hours after the LPS injection, COX-2 mRNA was measured by real-time polymerase chain reaction method, COX-2 protein levels were measured by Western blotting. In addition, COX-2 expressions in brain tissue were observed with immunohistochemistry and double immunofluoresence labeling. Results : Ginsenoside Rg3 (20 and 30 mg/kg) significantly attenuates up-regulation of COX-2 mRNA and protein expression in brain tissue at 4 hours after the LPS injection. Moreover, ginsenoside Rg3 (20 mg/kg) significantly reduced the number of COX-2 positive neurons in the cerebral cortex and amygdala. Conclusion : These results indicate that ginsenoside Rg3 plays a modulatory role in neuroinflammation through the inhibition of COX-2 expression in the brain and suggest that ginsenoside Rg3 and ginseng may be effective on neurodegenerative diseases caused by neuroinflammation.

A Proposal of Jeungsan Pilgrimage Way (증산 순례길 제언)

  • Kim, Jin-young
    • Journal of the Daesoon Academy of Sciences
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    • v.31
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    • pp.131-163
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    • 2018
  • The concept of pilgrimage is a phenomenon that appears in almost every major religion. It is traditionally defined as religious travel to a sacred external place for spiritual purposes and introspection. However, there are many different relationships between pilgrimages and religious customs, including excursions through abstract dimensions and regular journeys such as annual holidays. Because modern pilgrimages are taken for a variety of reasons, they are not limited to faith-based historical locations. Thus, many scholars also perceive pilgrimages as an increasing part of the general industry of tourism. These journeys are now studied in a diverse range of fields (e.g., ethnography and tourism). In this way, pilgrimages have created a new market from an industrial perspective. This economic analysis has resulted in secular interest. Pilgrimages can now be taken by gil (walkways), which have gained tremendous popularity. Thus, religiosity and humanity as they are embraced through pilgrimages are now receiving outside influences. This study therefore is aimed at generating suggestions for developing the pilgrimage routes related to Kang Jeungsan (i.e., the Supreme God of Daesoon Jinrihoe). These proposed Jeungsan routes are not simply restricted to religious activities or nostalgia, nor are they exclusively concerned with encountering holiness. To realize this idea, it is necessary to reconsider the concept of a sacred space.

Effect of Social Relation on Digital Device Usage: A Social Capital Perspective (개인의 사회적 관계가 디지털 기기 활용에 미치는 영향에 대한 연구: 사회적 자본 관점)

  • Yunmo Koo;Joohyun Oh
    • Information Systems Review
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    • v.21 no.3
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    • pp.131-149
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    • 2019
  • As smart phones, tablets, and other digital devices become more pervasive, theoretical arguments around digital divide, which has previously focused on "access," is now expanding to effectively "utilize," actively "produce" and "share" information. Such discussion is significant because the impact on inter-personal and social networks depends on how digital divides are used, which can then recreate or exacerbate social inequality structures. This study examines the effect of individual's social relations and two types of social capital (i.e., bonding and bridging) on economic and socio-participatory usage of digital devices. An empirical analysis of dataset from 740 surveys reveals that the more horizontal the social relations of the individual, the more both bonding and bridging social capital increase. However, rather than the social relationship of the individual directly influencing the two types of digital device usage, it has an indirect effect on both economic and socio-participatory usage of digital devices. In particular, mediating effects of both bonding and bridging social capital exist in the case of economic usage of digital devices, whereas bonding social capital only has mediating effects on economic usage of digital devices. We discuss the role of social capital on digital devices usage and present the theoretical and practical implications.