To strengthen the R&D capability and the competitiveness of the Korean oriental medicine industry, an adequate supply of qualified R&D personnel including medical doctors of Korean oriental medicine is an important precondition. This study analyze current and future R&D manpower requirements including medical doctors in the Korean oriental medicine research area. Our analyses can be utilized for developing the government R&D manpower planning including the adequate supply of medical doctors for the Korean oriental medicine research. For the study, we conducted and analyzed a delphi survey of the experts, the principal investigators, with expertise in Korean oriental medicine research areas. The results of this study can be summarized as follows; First, in 2007 the Korean oriental medicine R&D personnel is currently under-supplied as many as 302 people including 111 medical doctors of Korean oriental medicine. The rate of under-supplied is 28.2%. Second, in 2017 the forecast shows that the R&D personnel in this area will be more severely under-supplied as many as 539 people including 185 medical doctor of Korean oriental medicine. The rate of under-supplied will be 32.6%. As a result, the confrontation of demand and supply forecasts shows that, in general, severe shortages of R&D manpower in the areas of Korean oriental medicine will result if there are not adequate manpower policy adjustment.

This study aimed to validate neuroprotective effect of Chungpaesagan-tang on the early stage of cerebral ischemic damage. Cerebral ischemic damage was induced by the middle cerebral artery occlusion (MCAO) for 2 hours in the Sprague-Dawley rats. Water extract of Chungpaesagan-tang(8.7g/kg) was administered orally twice at 1 and 4 hours after the MCAO. Neurological score was tested at 3 and 24 hours after the MCAO and Chungpaesagan-tang administration. At 24 hours after the MCAO, infarct volume and edema ratio was evaluated with the TTC staining. Apoptotic cell death in cerebral cortex and caudate putamen was observed with cresyl violet staining and TUNEL labeling. Bax expression in the MCAO rat brain was stained with immunohistochemistry. Chungpaesagan-tang improved neurological and behavioral impairment of the MCAO rats and reduced infarct area, infarct volume and brain edema formation. Chungpaesagan-tang attenuated cell death percentage in cortex penumbra and reduced TUNEL positive cells in cortex penumbra and in caudate putamen of the MCAO rats. Chungpaesagan-tang reduced Bax positive neurons in caudate putamen and reduced c-Fos positive neurons in cortex penumbra of the MCAO rats. Chungpaesagan-tang intensified neuronal HSP72 expression in cortex penumbra of the MCAO rats. In results, Chunpaesagan-tang reduces infarct volume and edema formation through anti-apoptotic effect. This result suggests that Chunapaesagan-tang has an adequate neuroprotective effect on the early stage of cerebral ischemic damage.

The demand of research for the development of pulse meter and analyzer by the examination questionnaire made from repeated preliminary investigations. Which was presented in the exhibition KIMES 2008, it's has been proved to be practical. 159 people(oriental medical doctor) sent in the question papers and selected the double answers in the relevant question. At the time of the development of the pulse meter and analyzer, we put the investigation for oriental medical doctor's demands in practice and found the following results. The development of the pulse analyzer is getting more important for modernization of oriental medicine. The purpose of this study was to find out the research needs for the pulse analyzer considering the practical use in the oriental medical clinics. A survey was conducted at the KIMES 2008 exhibition with a set of questionnaires. We collected the data from 159 oriental medical doctors who attended the exhibition, and we found following results. The more oriental doctors did not think the diagnostic devices were important in their clinical practices. Most responders preferred to use the Chon-Kwan-Cheok pulse diagnosis. To find out the mechanism of the pulse diagnosis and to standardize it, the clinical data base containing the results of the pulse diagnosis and the patten discrimination of each patient should be established. In conclusion, the researches on the standardization of Chon-Kwan-Chuk pulse diagnosis including the measurement techniques and the pulse-pattern correlations are very important for developing the pulse analyzer.

Objectives: The purpose of this study was to investigate the effects of Hyolbuchukeo-tang extracts on the hyperlipidemia rats induced by high fat diet. Methods and Materials: In vitro; The extracts prepared for Hyolbuchukeo-tang by hot water extraction (HH), fermentation(HF) and UMPM extraction(HU) method. The extracts were examined for levels of polyphenol compounds, antioxidant activities, and inhibitory potencies for HMG-CoA reductase. In vivo; Sprague-Dawley male rats of weighing $150{\pm}5g$ were randomly divided into six groups ; normal control diet(NC), and high fat diet(HC), high fat diet with treated lovastatin of 10mg/kg(PC), high fat diet with Hyolbuchukeo-tang extracts; HH, HF and HU treated extracts of 300mg/kg, respectively. Also, we compared the effects of the extracts of HH, HF and HU on rats fed high fat diet for four weeks. Results: 1. The content of polyphenol compounds and electron donating abilities(EDAs) was the HF higher than HH and HU. The superoxide dismutase(SOD)-like activities were proportionate in consistency and they appeared highly from all extracts. The HMG-CoA reductase inhibition activities was highest activities in the HU. 2. The activities of serum GOT and GPT were significantly lower in the HH and HF groups. The level of serum triglyceride was significantly decreased in the HF group. HH and HU groups were significantly decreased in the atherogenic index(AI). The total cholesterol concentration in liver was significantly decreased in the HF group, and HU showed more significantly decreased in the triglyceride than of the lovastatin. Also, photomicrographs of liver tissue showed higher fat accumulation in the HC group than in the HH, HF and HU groups. Conclusions: These result suggest that the hyper-lipidemia caused by a high fat diet was effectively inhibited the administration of HF and HU.

Objectives : This research aimed to evaluate the effects of Rubus coreanus $M_{IQ}$. Methods: These extracts from fresh R. coreanus $M_{IQ}$. were investigated with radical scavenging activity, the content of total phenolics, ferric thiocyanate method and flavonoid contents Results: These results revealed that the ethyl acetate extract from fresh R. coreanus $M_{IQ}$. possesses remarkable radical scavenging activity. The content of total phenolics of the ethanol extract from dried R. coreanus $M_{IQ}$. ($IC_{50}$=155.87${\pm}$8.8${\mu}$g/mL) is the highest among all of the samples. The stronger radical-scavenging activity ($IC_{50}$=77.72${\pm}$2.1${\mu}$g/mL) of ethyl acetate extract from dried R. coreanus $M_{IQ}$. should be related to its phenolic content as measured by gallic acid test. Conclusion: These results suggest that dried R. coreanus $M_{IQ}$. may act as a potential antioxidant agent.

The purpose of this study was to investigate the effect of garlic(Allium sativum L.) extracts with extraction conditions on hyperlipidemia prevention. The extracts prepared for garlic by hot temperature extraction(HG), low temperature extraction(LG), UMPM extraction(UG), fermentation(FG) and black garlic hot temperature(BG) method. To evaluate of hypolipidemia effect in vivo, we examined serum and liver lipid profiles of Triton WR-1339 induced hyperlipidemia rats. Serum triglyceride and total cholesterol levels in UG group were significantly higher than control group. Liver total cholesterol content in LG group and liver triglyceride in UG group was significantly lower than control group.

Objective : This study was designed to the effect of moxibustion therapy on the pain decrease and joint recovery with degenerative knee arthritis Methods : The research was administered from January to March 2008. The study subjects are menopause female 20 person and over 50 years old with degenerative knee arthritis patients, The Research were conducted with 10 moxibustion group and to 10 hot pack group during 4 Weeks. Results : 1. There is no significant difference of LSS of pre-treatment between hot pack group and moxibustion group(p<0.05). 2. There is no significant difference of LSS of post-treatment between hot pack group and moxibustion group(p<0.05). 3. There is no significant difference of LSS between pretreatment and post-treatment in hot pack group and moxibustion group(p<0.05). 4. There is no significant difference of VAS of pre-treatment between hot pack group and moxibustion group(p<0.05). Conclusion : This study suggests that hot pack used usually in physical therapy can decrease pain but the there is no significantly different between these two methods.

Evidences from various countries suggest that toxic heavy metals in herbal medicine may constitute a serious health problem. In order to evaluate whether the toxic heavy metals caused by herbal medicine intake, blood samples collected from 222 patients taking herbal medicine were analyzed. In average levels of analyzed metals, $0.4{\sim}33.9%$ of total samples for 8 metals such as Cd, Co, Cu, Hg, Mn, Ni, Pb and Zn except Cr and Fe exceeded the upper limit for WHO reference value. In analysis of regression coefficients indicating the levels of metals increased or decreased after taking herbal medicine for one month, however, there were different aspects by intake types for herbal medicine. For example, the metals increased by taking decoction in blood samples were as follows; Cd and Pb whether Mn, Ni and Pb as increased metals were identified in the group taking pill and decoction(combined intake group). The odds ratio showing values higher than 1 indicating that people who take herbal medicine would have possibility higher for metal accumulation in blood than that from people who do not take herbal medicine. The metals showing the odds ratio higher than 1 were Hg and Ni in decoction group, and Cd and Hg in combined intake group. However, eight of the total, 10 metals showed the odds ratios lower than 1 by taking herbal medicine. Thus, this may explain the possible role of herbal medicine as a chelator for heavy metals in body.

Background: The resource-based relative value scale has been applied to Korean medicine services as part of the National Health Insurance, yet the proper scoring method for physician's work needs to be developed. Objectives: To measure physician's work for Korean medicine services using Analytical Hierarchy Process(AHP) and to compare results abstracted by AHP with those by Magnitude Estimation method. Methods: We developed the AHP questionnaires for Korean Medicine services and administered it to 12 Korean medicine insurance experts. Weighted scores were calculated and were converted into physician's work scores. Results: In AHP measurement, the physician's work scores for acupuncture activities, especially special acupunctures, far increased, while those for diagnosis and basic consultations decreased. Variations in the scores enlarged. Conclusions: As an alternative, AHP method can be considered for measuring the physician's work for Korean medicine services with careful management of scoring variation.

This study was attempted to suggest fundamental data to take health care plan in terms of oriental medicine by evaluating the health-related quality of life according to the Sasang constitutional medicine (SCM) of factory workers. General characteristics, living habits, and health-related quality of life were investigated through self-administration questionnaire in the course of oriental health examination for 1,870 male workers at a manufacturing company located in the Jeollabuk-do region, and the Sasang constitution of each worker was identified and analyzed through questionnaires and oriental doctor's medical examination. For Sasang constitutional medicine, So-eum person(少陰人) was found to be the most, and then So-yang preson(少陽人), Tai-eum preson(太陰人), and Tai-yang preson(太陽人) in order; for lifestyle, smokers were most found in So-yang person workers, non-smokers in Tai-yang person workers, drinkers in Tai-yang person workers, and non-drinkers in So-eum person workers. For the general health score by the Sasang constitutions, Tai-yang person workers were found to be 42.73 in general health area, Tai-eum preson workers 41.69, So-yang person workers 40.87, and So-eum person workers 40.42; in the vitality area, Tai-eum person workers were found to be 45.14, So-yang person workers 44.16, So-eum person workers 43.02, and Tai-yang person workers 41.34. Specially, it was found that regular exercise improved physical health factors, drinking adversely affected mental health factors, and the mental health factors of Tai-eum person workers who have regularly exercised showed the highest values, while those of Tai-yang person workers who have not exercised showed the lowest values. There was difference in lifestyle by Sasang constitutions, and accordingly, the quality of life might be different Therefore it is deemed that health care plan is required to be taken by Sasang constitutions and lifestyle for health promotion and care of blue-collar workers in the future.