The purpose of this study was to investigate perceptions of the self-efficacy of youth (self-confidence, self-regulatory efficacy, and task difficulty preference) and the subjective quality of life. The participants in this research were 697 university students 314 males and 383 females. All respondents submitted their answers on a self-report questionnaire. The data were analyzed with descriptive statistics, t-tests, Pearson's correlations, and multiple regression analyses. The major results of this study were as follows: (a) Young males exhibited higher levels of self-efficacy perception compared to young females. Regarding the subjective quality of life, gender was not a significant factor. (b) The subjective quality of life was highly correlated with the self-efficacy of youth (self-confidence, self-regulatory efficacy, and task difficulty preference). (c) Self-satisfaction, self-confidence regarding one's career, satisfaction with one's friends, satisfaction with one's parental relationship, quantity of reading, and the amount of study-time all had significant influences on the self-efficacy of youth, whereas the family's socioeconomic status and campus life satisfaction were not significant factors. (d) Self-efficacy had the strongest influence on the youth subjective quality of life. Self-satisfaction, campus life satisfaction, and satisfaction with friends all had significant influences on the youth subjective quality of life, whereas the quantity of reading, the amount of study-time, self-confidence with one's career, the family's socioeconomic status, and satisfaction with one's parental relationship were not significant factors. However, self-confidence with one's career, satisfaction with one's parental relationship, the family's socioeconomic status, and quantity of reading all had different levels of influence on the subjective quality of life for young males and females.