The Brazos River is one of the longest rivers contained entirely in the state of Texas, flowing over 700 miles from northwest Texas to the Gulf of Mexico. Today, the Brazos River Authority and Texas Commission on Environmental Quality interest in drought protection plan, waterpower project, and allowing the appropriation of water system-wide and water right within the Brazos River Basin to meet water needs of customers like farmers and local civilians in the future. Especially, this purpose of this paper primarily intended to provide the data for the engineering guidelines and make easily geological mapping tool. In the Brazos River basin, many stream-flow gage station sites are not working, and they can not provide stream-flow data sets enough for development of the Probable Maximum Flood (PMF) for use in the evaluation of proposed and existing dams and other impounding structures. Integrated GIS-Spatial Interpolation (GIS-SI) tool are composed of two parts; (1) extended GIS technique (new making interface for hydrological regionalization parameters plus classical GIS mapping skills), (2) Spatial Interpolation technique using weighting factors from kriging method. They are obtained from the relationship among location and elevation of geological watershed and existing stream-flow datasets. GIS-SI technique is easily used to compute parameters which get drainage areas, mean daily/monthly/annual precipitation, and weighted values. Also, they are independent variables of multiple linear regressions for simulation at un gaged stream-flow sites. In this study, GIS-SI technique is applied to the Brazos river basin in Texas. By assuming the ungaged flow at the sites of Palo Pinto, Bryan and Needville, the simulated daily/monthly/annual time series are compared with observed time series. The simulated daily/monthly/annual time series are highly correlated with and well fitted to the observed times series.