Purpose: The purpose of this study was to examine the relationship of the general characteristics of health-related majors to their life expectancy scale, depression scale, health perception scale, subjective wellbeing scale, somatic symptom scale and college life stress scale. And it's also meant to analyze influential factors for their stress about college life. Methods: The subjects in this study were the students who were in the department of dental laboratory technology and the department of dental hygiene at a college located in the region of Iksan, North Jeolla Province. Data were gathered in November and December, 2012. The life expectancy scale, depression scale, health perception scale, subjective wellbeing scale, physical symptom scale, somatic symptom scale and college life stress scale of the general characteristics were analyzed by t-test and one way analyses of variance (ANOVA) and the Duncan's multiple range test at the 95% confidence level to assess the statistical significance. And stepwise multiple regression analysis was conducted to determine what factors would affect the stress of the students about college life. The data were analyzed with the windows ver. 12.0(SPSS GmbH, Germany) statistical software program. Results: Among the general characteristics, there were significant differences according to gender and age in all the variables that were life expectancy scale, depression scale, health perception scale, subjective wellbeing scale, physical symptom scale and college life stress scale. 61.3% of the students responded they slept for six hours or less, and the respondents who slept for six hours or less scored significantly statistically lower in health perception scale, subjective wellbeing scale and physical symptom scale. As for college life stress, the respondents who got depressed more often, whose subjective peace or happiness was lower, whose life expectancy was lower, who had worse physical symptoms, whose living standard was lower and whose academic year was lower were under heavier stress about their college lives. Conclusion: As the worse physical health and worse mental health(life expectancy, depression, health perception, subjective wellbeing and physical symptoms, etc.) of the college students led to heavier stress about college life, how to promote their physical health and mental health should discreetly be considered, and every necessary measure should be taken to improve their physical and mental health.