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피크노제놀 성분이 한국 10~20대 여드름 피부에 미치는 영향

The effect pycnogenol has on the acne skin of Koreans in their 10s and 20s

  • 김경연 (동명대학교 뷰티케어학과)
  • 투고 : 2022.01.07
  • 심사 : 2022.03.20
  • 발행 : 2022.03.28

초록

프랑스 해송 껍질추출물인 피크노제놀은 항염, 항혈전, 혈압조절 효과, 면역조절 효과 등의 다양한 의학적 연구결과를 바탕으로 건강식품 소재로 활용되고 있으며 최근 화장품 소재로도 활용되고 있지만 피부 유효성에 관한 임상연구는 미미한 실정이다. 본 연구는 피크노제놀 성분을 화장품에 적용하여 10~20대 여드름 피부에 미치는 효과를 피부임상학적으로 접근하여 그 유효성을 연구하고자 하였으며, 피크노제놀 0.2% 첨가 화장품과 무첨가 화장품을 각 그룹별 11명의 임상자가 참여하여 6주 동안 사용하게 한 후 여드름 피부 상태변화를 살펴보았다. 피크노제놀을 함유한 화장품을 사용한 그룹에서 여드름 균(P-Acnes)의 대사산물인 포비린 지수가 감소하였으며 홍조와 색소침착 지수가 감소하는 효과가 있었다. 본 연구를 통하여 피크노제놀 성분이 여드름 균을 감소시키고 여드름 피부에 나타나는 홍조와 색소침착 증상을 완화하는 효과가 있는 화장품 소재인 것을 확인하였다.

Pycnogenol is used as a dietary supplement based on various medical research studies suggesting health benefits. In recent years, it has also been used in cosmetic products, but the clinical research on its dermatologic effects has been insufficient. This study was designed to determine the effectiveness of pycnogenol topically applied to skin of individuals with acne in their teens and twenties. Cosmetics containing 0.2% pycnogenol were applied to a group of 11 clinical subjects for 6 weeks and their skin conditions were assessed. The group that used cosmetics with pycnogenol showed decrease in P-Acnes, acne causing bacteria, phorphyrin index, a metabolite, and the pigmentation and redness index. This study confirms that pycnogenol extract is effective dermatologically in decreasing acne bacteria and reducing redness and pigmentation of skin affected by acne.

키워드

참고문헌

  1. L. Rehn, E. Meririnne, J. H.-Nikanne, E. Isometsa & M. Henriksson. (2008). Depressive symptoms, suicidal ideation and acne: a study of male Finnish conscripts. Journal of the European Academy of Dermatology and Venereology, 22(5), 561-567. DOI : 10.1111/j.1468-3083.2007.02514.x
  2. M. S. Na, E. H. Ju & M. H. Kim. (2009). A Study on Pimple Breakout and Influencing Factors in Middle School Students. Korean journal of aesthetics and cosmetics society, 7(3), 153-164. DOI : G704-SER000010442.2009.7.3.014
  3. L. W. Fu & R. B. Vender. (2011). Newer approaches in topical combination therapy for acne. Skin Therapy Letter, 16(9), 3-6. DOI : europepmc.org/article/med/22089505
  4. J. Bensouilah. (2002). Aetiology and management of acne vulgaris. International journal of aromatherapy, 12(2), 99-104. DOI : 10.1016/S0962-4562(02)00034-6
  5. P. P. Michael. (2003). Defensins and acne. Molecular Immunology, 40, 457-462. DOI : 10.1016/S0161-5890(03)00154-8
  6. J. K. Lalla, S. Y. Nandedkar, M. H. Paranjape & N. B. Talreja. (2001). Clinical trials of ayurvedic formulations in the treatment of acne vulgaris. Journal of Ethnopharmacology 78, 99-102. DOI : 0.1016/S0378-8741(01)00323-3 https://doi.org/10.1016/S0378-8741(01)00323-3
  7. A. Koreck, A. Pivarcsi, A. Dobozy & L. Kemeny. (2003). The role of innate immunity in the pathogenesis of acne. Dermatology, 206, 96-105. DOI : 10.1159/000068476
  8. J. James. (2003). A review of the use of combination therapies for the treatment of acne vulgaris. Journal of the American Academy of Dermatology, 49(3), 200-210. DOI : 10.1067/S0190-9622(03)01154-X
  9. M. Witold & K. Aleksander. (2003). Preliminary assessment of alginic acid as a factor buffering triethanol amine interacting with artificial skin sebum. European Journal of Pharmaceutics and Biopharmaceutics, 55, 237-240. DOI : 10.1016/S0939-6411(02)00195-9
  10. N. Kim, Y. H. Lim, S. W. Park & E. S. Nam. (2009). Antimicrobial activities of the anti-acne compounds from natural sources. Microbiology and Biotechnology Letters, 37(1), 80-84. DOI : 1234420090370010080
  11. B. J. Kim & S. J. Lee. (2009). Aesthetic dermathlogy. Seoul : Yeomungak publishing.
  12. J. H. Suh, M. Y. Hyun, S. E. Jang, S. Y. Choi, M. N. Kim & B. J. Kim. (2016). Efficacy and safety of topical application of epidermal growth factor (EGF) for Korean acne patient. Journal of the Society of Cosmetic Scientists of Korea, 42, 111-118. DOI : 10.15230/SCSK.2016.42.2.111
  13. J. Y. Lee & H. J. Son. (2018). Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments. Asian J Beauty Cosmetol, 16(3), 449-463. DOI : 10.20402/ajbc.2017.0199
  14. G. Y. Chan & H. J. Kim. (2011). Antimicrobial effects of extracts of Taraxacum officinale H. on acnes strains. Intentional Journal of Complementary, Integrative and Alternative Medicine, 7, 3-16. DOI : I410-ECN-0102-2012-510-003019450
  15. S. H. Han, N. Y. Woo, S. D. Lee & M. H. Kang. (2006). Antioxidaitve and antibacterial activities of endemic plants extracts in Korea. Korean Journal of Medicinal Crop Science, 14, 49-55. DOI : G704-000251.2006.14.1.006
  16. H. S. Kim, H. Y. Lee, J. N. Lee, C. G. Joo & T. B. Choi. (2011). The effects of antimicrobial properties of manuka oil and improvement of acne. Journal of the Korean Society of Cosmetology 17, 245-256. DOI : G704-001852.2011.17.2.013
  17. H. S. Kim. (2007). Beauty science, Seoul : Chung Gu Publisher.
  18. M. Y. Choi, E. J. Choi, E Lee, T. J. Rhim, B. C. Cha & H. J. Park. (1997). Antimicrobial Activities of Pine Needle Extract. Korean Journal of Microbiology and Biotechnology, 25(3), 293-297. DOI : G704-000674.2010.20.4.022
  19. J. H. Kuk, S. J. Ma & K. H. Park. (1997). Isolation and Characterization of Benzoic Acidwith Antimicrobial Activity from Needle of Pinus densiflora. Korean J, Food. Sci. Technol, 29(2), 204-210.
  20. V. Fabio, H. Kobuchi & P. Lester. (1998). Procyanidins Extracted From Pinus maritima(Pycnogenol): Scavengers of Free Radical Species and Modulators of Nitrogen Monoxide Metabolism in Activated Murine RAW 264.7 Macrophages. Free Radical Biology and Medicine, 24, 1120-1129. DOI : 10.1016/S0891-5849(97)00430-9
  21. J. H. Kim. (2002). Phenolic compounds from needles of Pinus densiflora Siebold et Zuccarini and COX-2, iNOS inhibitory effect. Master's thesis Chung-Ang University, Seoul.
  22. B. Erben, H. Benjamin & S. Lau. (2000). Pycnogenol Inhibits generation of Inflammatory mediators in macrophage. Nutrition Research, 20, 249-259. DOI : 10.1016/S0271-5317(99)00157-8
  23. K. J. Cho et al. (2000). Effects of Bio-flavonoids Extracted from the bark of Pinus maritima on Proinflammatory Cytokine Interlukin-1 Production in Lipopoly saccharide-Stimulated-38-RAW254.7. Toxicology and Applied Pharmacology, 168, 64-71. DOI : 10.1006/taap.2000.9001
  24. Amber. R, Buz'Zard, Q. Peng, Benjamin H & S. Lau. (2002). Kyolic and Pycnogenol increase human growth hormone secretion in genetically-engineered keratinocytes. Growth Hormone & IGF Research, 12, 34-40. DOI : 10.1054/ghir.2002.0260
  25. M. Araghi-Niknam, S. Hosseini, D. Larson, P. Rohdewald & R. Watson. (2000). Pine bark extract reduces platelet aggregation. Integrative Medicine, 2, 73-77. DOI : 10.1016/S1096-2190(00)00002-0
  26. M. Putter et al. (1999). Inhibition of Smoking-Induced Platelet Aggregation by Aspirin and Pycnogenol. Thrombosis Research, 95, 155-161. DOI : 10.1016/S0049-3848(99)00030-4
  27. S. Hosseini, J. Lee, R. Sepulveda, P. Rohdewald & R. Watson. (2001). A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol in modifying blood pressure inmildly hypertensive patients. Nutrition Research, 21, 1251-1260. DOI : 10.1016/S0271-5317(01)00342-6
  28. J. Cheshier et al. (1995). Immunomodulation by pycnogenol inretrovirus-infected or ethanol-fed mice. Life Sciences, 58, PL87-PL96. DOI : 10.1016/0024-3205(95)02303-8
  29. E. J. Kim, S. W. Jung, K. P. Choi & S. S. Ham. (1998). Cytotoxic Effect of the Pine-39-needle extracts. Korean J. Food Sci. Technol, 30, 213-217.
  30. J. H. Moon, Y. B. Han & J. S. Kim. (1993). Studies on antitumor effects of pine needles, Pinus densiflora Steb. et. Zucc. Korean Vet Res, 33, 701-710.
  31. Ministry of Food and Drug Safety. (2018). Test method guidelines for cosmetic labeling and advertising verification, Seoul : Ministry of Food and Drug Safety.
  32. D. J. JUNG et al. (2015). Dermatological esthetic science, Seoul : Korea med books.
  33. R. M. Szeimies, P. G. Calzavara-Pinton, S. Karrer, B. Ortel, M. Landthaler. (1996). Topicalphotodynamic therapy in dermatology. J Photochem Photobiol, 36, 213-219. DOI: 10.1016/S1011-1344(96)07375-7