한국응용곤충학회지 (Korean journal of applied entomology)

  • 제61권1호
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  • Pages.211-219
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  • 2022
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  • 1225-0171(pISSN)
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  • 2287-545X(eISSN)
한국응용곤충학회 (Korean Society of Applied Entomology)
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Double-stranded RNA(dsRNA)를 이용한 해충방제의 현황과 미래

Current and Future of dsRNA-mediated Pest Management

  • 윤준선 (전북대학교 농축산식품융합학과) ;
  • 지창윤 (제놀루션 R&D Center) ;
  • 성건묵 (충남대학교 응용생물학과) ;
  • 최만연 (미농무부 농업연구청)
  • Yoon, June-sun (Department of Agricultural Convergence Technology, Jeonbuk National University) ;
  • Ji, Chang Yoon (R&D Center, Genolution Inc.) ;
  • Seong, Keon Mook (Department of Applied Biology, College of Agriculture and Life Sciences, Chungnam National University) ;
  • Choi, Man-yeon (USDA-ARS Horticultural Crops Research Unit)
  • 투고 : 2022.01.28
  • 심사 : 2022.02.22
  • 발행 : 2022.03.01
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초록

지난 10년 동안, 이중 가닥 RNA (double-stranded RNA, dsRNA)를 이용한 특정 유전자 발현 간섭(RNA interference, RNAi) 기술은 의약품 개발뿐만 아니라 작물보호 분야에 해충방제부터 익충보호까지 다양하게 그 기술이 사용되어 왔다. 그동안 학계 및 산업체에서 활발히 연구되어 온 RNAi기술을 이용한 작물 및 익충보호제는 상용화를 눈앞에 두고 있다. 미래 농업 시장에서 해충방제제와 익충보호제로써의 개발을 위한 RNAi의 기술적 응용은 상당한 잠재력을 가지고 있지만, 현장에 직접 사용되기에는 아직 여러 가지 한계점이나 극복해야 할 과제가 남아있다. 본 리뷰에서는 최근에 활발히 진행되고 있는 작물보호제 및 익충보호제(protection of crops and beneficial insects)로써의 dsRNA의 다양한 활용과 그 잠재성(potential)을 소개하고자 한다.

Over the past decade, double-stranded RNA (dsRNA)-mediated gene silencing technology has progressed significantly for pest management in agriculture and for protecting beneficial insects from pathogens. Recently, breakthroughs in RNA interference (RNAi) applications for insect pest management by academia and commercial entities have provided RNAi products as commercial biopesticides. Although RNAi technology has vast potential and advantages for pest control, challenges, and limitations remain in practical applications. This review explores current challenges in the development of dsRNAs as a pest management tool and considers new approaches to overcome biological and environmental obstacles, such as poor stability and resistance.

키워드

과제정보

This work was funded by a grant (PJ015763) from the Rural Development Administration of Korea.

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