Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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The effect of swimming plus hypolipidemic agent on obesity

비만에 대한 고지혈증 치료제와 수영운동의 병합처방의 효과

  • Jeong, Sun-Hyo (Division of Biomedical Engineering & Health, Science Management, Mokwon University)
  • 정선효 (목원대학교 의생명.보건학부)
  • Received : 2019.01.23
  • Accepted : 2019.03.26
  • Published : 2019.03.31
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Abstract

Obesity is frequently associated with metabolic disease. This study showed whether fenofibrate, a hypolipidemic agent, swimming and swimming combined with fenofibrate (: combination) regulate obesity, and whether combination is more effective than fenofibrate on regulation of obesity in high-fat diet-fed mice for 8 weeks. Both fenofibrate and swimming decreased obesity-associated factors such as body weight, adipose tissue mass, serum lipid levels and adipoctye size, compared with control mice. When mice were concomitantly treated with fenofibrate and swimming, combination reduced further the inhibitory effects on obesity-associated factors, compared with fenofibrate. Both fenofibrate, swimming and combination decreased serum glucose levels, compared with control mice. The evidence is presented herein that combination were effective to control obesity and serum glucose levels, suggesting that swimming combined with fenofibrate might contribute to inhibition of high-fat diet fed-induced metabolic syndrome.

비만은 대사증후군과 밀접한 관련이 있다. 본 연구는 8주간 고지방식이를 섭취한 쥐에서 고지혈증 치료제인 피노피브레이트(fenofibrate) 단독처방, 수영운동 단독처방 및 fenofibrate와 수영운동의 병합처방이 비만을 조절하는지를 조사하고, fenofibrate와 수영운동의 병합처방이 fenofibrate 단독처방에 비해 효과적으로 비만을 조절하는지를 분석하였다. Fenofibrate 단독처방과 수영운동 단독처방 모두 대조군에 비해 비만과 관련된 요소들인 몸무게, 지방무게, 혈청 지질성분 및 지방세포 크기를 감소시켰다. 쥐는 fenofibrate와 수영운동의 병합처방 되었을 경우 fenofibrate 단독처방 되었을 경우에 비해 비만과 관련된 요소들이 더 효과적으로 감소되었다. 대조군에 비해 fenofibrate 단독처방, 수영운동 단독처방 및 fenofibrate와 수영운동의 병합처방 모두 혈청 포도당 수치를 감소시켰다. 본 연구는 fenofibrate와 수영운동의 병합처방이 비만과 혈당을 효과적으로 조절함으로써 고지방식이 섭취로 인해 발생되는 대사증후군의 억제에 공헌할 것임을 제시하고 있다.

Keywords

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Fig. 1. The chemical structure of fenofibrate.

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Fig. 2. Effects of fenofibrate and swimming on the body weight in high-fat diet-fed mice.

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Fig. 3. Effects of fenofibrate and swimming on the adipose tissue mass in high-fat diet-fed mice.

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Fig. 4. Effects of fenofibrate and swimming on adipocyte size in high-fat diet-fed mice.

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Fig. 5. Effects of fenofibrate and swimming on serum lipid levels in high-fat diet-fed mice.

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Fig. 6. Effects of fenofibrate and swimming on glucose tolerance test in high-fat diet-fed mice.

Table 1. Effects of fenofibrate and swimming on body weight in high-fat diet-fed mice

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Table 2. Effects of fenofibrate and swimming on the adipose tissue mass in high-fat diet-fed mice.

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Table 3. Effects of fenofibrate and swimming on serum lipid levels in high-fat diet-fed mice

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Table 4. Effects of fenofibrate and swimming on serum glucose control in high-fat diet-fed mice

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Table 5. Effects of fenofibrate and swimming on glucose tolerance test in high-fat diet-fed mice

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