Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Antifungal Activities of Dimeric Sesquiterpenes, Shizukaols C and F, Isolated from Chloranthus japonicus Sieb.

  • Kang, Tae Hoon (Industrial Bio-materials Research Center, KRIBB) ;
  • Lee, Yun Me (Industrial Bio-materials Research Center, KRIBB) ;
  • Lee, Won Jung (Industrial Bio-materials Research Center, KRIBB) ;
  • Hwang, Eui Il (Technical Research Center, KT&G R&D Headquaters) ;
  • Park, Ki Duk (Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST) ;
  • Choi, Gyung Ja (Center for Eco-friendly New Materials, KRICT) ;
  • Moon, Jae Sun (Industrial Bio-materials Research Center, KRIBB) ;
  • Park, Ho-Yong (Industrial Bio-materials Research Center, KRIBB) ;
  • Kim, Sung Uk (Industrial Bio-materials Research Center, KRIBB)
  • Received : 2017.01.10
  • Accepted : 2017.05.21
  • Published : 2017.07.28
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Abstract

Two dimeric sesquiterpenes were separated from Chloranthus japonicus Sieb. and identified as shizukaols C and F. They exhibited potent antifungal activities ($MICs=4-16{\mu}g/ml$) in vitro against various plant pathogenic fungi (Pythium ultimum, Phytophthora infestans, Botrytis cinerea, Colletotrichum lagenarium, Alternaria kikuchiana, and Magnaporthe grisea). Shizukaol C showed 88% and 91% protective activities in the greenhouse against Puccinia recondita (wheat leaf rust) and Phytophthora infestans (tomato late blight), respectively, at $100{\mu}g/ml$; shizukaol F exhibited 93% antifungal activity against Puccinia recondita at the same concentration. Therefore, these compounds might serve as interesting candidates for effective antifungal agents.

Keywords

References

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