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http://dx.doi.org/10.4014/jmb.1612.12051

Antifungal Activities of Dimeric Sesquiterpenes, Shizukaols C and F, Isolated from Chloranthus japonicus Sieb.  

Kang, Tae Hoon (Industrial Bio-materials Research Center, KRIBB)
Lee, Yun Me (Industrial Bio-materials Research Center, KRIBB)
Lee, Won Jung (Industrial Bio-materials Research Center, KRIBB)
Hwang, Eui Il (Technical Research Center, KT&G R&D Headquaters)
Park, Ki Duk (Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST)
Choi, Gyung Ja (Center for Eco-friendly New Materials, KRICT)
Moon, Jae Sun (Industrial Bio-materials Research Center, KRIBB)
Park, Ho-Yong (Industrial Bio-materials Research Center, KRIBB)
Kim, Sung Uk (Industrial Bio-materials Research Center, KRIBB)
Publication Information
Journal of Microbiology and Biotechnology / v.27, no.7, 2017 , pp. 1272-1275 More about this Journal
Abstract
Two dimeric sesquiterpenes were separated from Chloranthus japonicus Sieb. and identified as shizukaols C and F. They exhibited potent antifungal activities ($MICs=4-16{\mu}g/ml$) in vitro against various plant pathogenic fungi (Pythium ultimum, Phytophthora infestans, Botrytis cinerea, Colletotrichum lagenarium, Alternaria kikuchiana, and Magnaporthe grisea). Shizukaol C showed 88% and 91% protective activities in the greenhouse against Puccinia recondita (wheat leaf rust) and Phytophthora infestans (tomato late blight), respectively, at $100{\mu}g/ml$; shizukaol F exhibited 93% antifungal activity against Puccinia recondita at the same concentration. Therefore, these compounds might serve as interesting candidates for effective antifungal agents.
Keywords
Chloranthus japonicus Sieb.; shizukaol C; shizukaol F; antifungal activity; Phytophthora infestans; Puccinia recondita;
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