Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Clinical Implications of EEG and ERP as Biological Markers for Alzheimer's Disease and Mild Cognitive Impairment

경도인지장애와 알츠하이머병 치매의 생물학적 표지자로서 뇌파와 사건유발전위의 임상적 의미

  • Kim, Chang Gyu (Clinical Emotion and Cognition Research Laboratory (CEC Lab), Inje University) ;
  • Kim, Hyun-Taek (Department of Psychology, Korea University) ;
  • Lee, Seung-Hwan (Clinical Emotion and Cognition Research Laboratory (CEC Lab), Inje University)
  • 김창규 (인제대학교 임상감정인지기능연구소) ;
  • 김현택 (고려대학교 심리학과) ;
  • 이승환 (인제대학교 임상감정인지기능연구소)
  • Received : 2013.08.08
  • Accepted : 2013.09.30
  • Published : 2013.11.30
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Abstract

Objectives Memory impairment is a very important mental health issue for elderly and adults. Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Early detection of the prodromal stage of patients with AD is an important topic of interest for both mental health clinicians and policy makers. Methods Electroencephalograpgy (EEG) has been used as a possible biological marker for patients with MCI, and AD. In this review, we will summarize the clinical implications of EEG and ERP as a biological marker for AD and MCI. Results EEG power density, functional coupling, spectral coherence, synchronization, and connectivity were analyzed and proved their clinical efficacy in patients with the prodromal stage of AD. Serial studies on late event-related potentials (ERPs) were also conducted in MCI patients as well as healthy elders. Even though these EEG and ERP studies have some limitations for their design and method, their clinical implications are increasing rapidly. Conclusion EEG and ERP can be used as biological markers of AD and MCI. Also they can be used as useful tools for early detection of AD and MCI patients. They are useful and sensitive research tools for AD and MCI patients. However, some problems remain to be solved until they can be practical measures in clinical setting.

Keywords

References

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