Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Effect of Pentoxifylline on the ICSI Program Undergone in Severe Asthenozoospermia

심한 무력정자증 환자의 ICSI 시행시 Pentoxifylline을 사용한 정자처리법이 임상결과에 미치는 영향

  • Sohn, Jie-Ohn (Infertility Medical Center, CHA General Hospital of Seoul) ;
  • Shin, Ji-Su (Infertility Medical Center, CHA General Hospital of Seoul) ;
  • Jeong, Chang-Jin (Infertility Medical Center, CHA General Hospital of Seoul) ;
  • Cho, Yong-Seon (Infertility Medical Center, CHA General Hospital of Seoul) ;
  • Oum, Ki-Boong (Infertility Medical Center, CHA General Hospital of Seoul) ;
  • Choi, Dong-Hee (Infertility Medical Center, CHA General Hospital of Seoul) ;
  • Kim, Hyun-Joo (Infertility Medical Center, CHA General Hospital of Seoul)
  • 손지온 (차병원 여성의학연구소) ;
  • 신지수 (차병원 여성의학연구소) ;
  • 정창진 (차병원 여성의학연구소) ;
  • 조용선 (차병원 여성의학연구소) ;
  • 엄기붕 (차병원 여성의학연구소) ;
  • 최동희 (차병원 여성의학연구소) ;
  • 김현주 (차병원 여성의학연구소)
  • Published : 2002.06.30
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Abstract

Objective: The aim of this study was to evaluate the effect of pentoxifylline (PF) on the conventional ICSI program undergone in severe asthenozoospermia. Method: Total 348 cycles of ICSI programs undertaken at CHA General Hospital from January, 1996 to September, 2000, were divided into two groups - injected with pentoxifylline-treated sperm (PFT, 204 cycles) or non-treated sperm (NPFT, 144 cycles) and the clinical results of PFT group were compared with those of NPFT. Results: PF-treatment on sperm increased their motility of normozoospermia and severe asthenozoospermia. Fertilization rate of PFT group was higher than those of ICSI programs undertaken using sperm of NPFT (70.6% vs. 62.9%, p<0.01). And, ET and clinical pregnancy rates of PFT were slightly higher than those of NPFT (93.1%, 44.2% vs. 90.3%, 36.2%). Conclusion: These results showed that treatment of pentoxifylline has a beneficial role on selection of viable sperm in severe asthenozoospermia.

Keywords

References

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