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Effect of Pentoxifylline on the ICSI Program Undergone in Severe Asthenozoospermia  

Sohn, Jie-Ohn (Infertility Medical Center, CHA General Hospital of Seoul)
Shin, Ji-Su (Infertility Medical Center, CHA General Hospital of Seoul)
Jeong, Chang-Jin (Infertility Medical Center, CHA General Hospital of Seoul)
Cho, Yong-Seon (Infertility Medical Center, CHA General Hospital of Seoul)
Oum, Ki-Boong (Infertility Medical Center, CHA General Hospital of Seoul)
Choi, Dong-Hee (Infertility Medical Center, CHA General Hospital of Seoul)
Kim, Hyun-Joo (Infertility Medical Center, CHA General Hospital of Seoul)
Publication Information
Clinical and Experimental Reproductive Medicine / v.29, no.2, 2002 , pp. 97-103 More about this Journal
Abstract
Objective: The aim of this study was to evaluate the effect of pentoxifylline (PF) on the conventional ICSI program undergone in severe asthenozoospermia. Method: Total 348 cycles of ICSI programs undertaken at CHA General Hospital from January, 1996 to September, 2000, were divided into two groups - injected with pentoxifylline-treated sperm (PFT, 204 cycles) or non-treated sperm (NPFT, 144 cycles) and the clinical results of PFT group were compared with those of NPFT. Results: PF-treatment on sperm increased their motility of normozoospermia and severe asthenozoospermia. Fertilization rate of PFT group was higher than those of ICSI programs undertaken using sperm of NPFT (70.6% vs. 62.9%, p<0.01). And, ET and clinical pregnancy rates of PFT were slightly higher than those of NPFT (93.1%, 44.2% vs. 90.3%, 36.2%). Conclusion: These results showed that treatment of pentoxifylline has a beneficial role on selection of viable sperm in severe asthenozoospermia.
Keywords
Pentoxifylline; Asthenozoospermia; ICSI;
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