Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지

Enhancement of Dissolution Properties through Formulations of Insoluble Drug Biphenyl Dimethyl Dicarboxylate

난용성약물 Biphenyl Dimethyl Dicarboxylate의 제제화를 통한 용출증대

  • Lee, Soon-Ah (Ilhwa Co., Ltd.) ;
  • Song, Kyung (College of Pharmacy, Institute of Pharmaceutical Research and Development, and Medicimal Resources Center, Wonkwang University) ;
  • Park, Eun-Jin (College of Pharmacy, Institute of Pharmaceutical Research and Development, and Medicimal Resources Center, Wonkwang University) ;
  • Sohn, Dong-Hwan (College of Pharmacy, Institute of Pharmaceutical Research and Development, and Medicimal Resources Center, Wonkwang University) ;
  • Go, Geon-Il (College of Pharmacy, Institute of Pharmaceutical Research and Development, and Medicimal Resources Center, Wonkwang University) ;
  • Kim, Jae-Baek (College of Pharmacy, Institute of Pharmaceutical Research and Development, and Medicimal Resources Center, Wonkwang University)
  • 이순아 ((주)일화) ;
  • 송경 (원광대학교 약학대학, 약품연구소, 의약자원연구센타) ;
  • 박은진 (원광대학교 약학대학, 약품연구소, 의역자원연구센타) ;
  • 손동환 (원광대학교 약학대학, 약품연구소, 의역자원연구센타) ;
  • 고건일 (원광대학교 약학대학, 약품연구소, 의역자원연구센타) ;
  • 김재백 (원광대학교 약학대학, 약품연구소, 의역자원연구센타)
  • Published : 1996.03.20
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Abstract

The dissolution characteristics of DDB were markedly enhanced by preparing solid dispersions of drug with polyethylene glycol 6000. Solid dispersions of various weight fraction were formed by a melting method. And various tablets$(A{\sim}E)$ were prepared from these solid dispersions with excipients (lactose, com starch, Avicel and PVP) by wet granulation method. There were no significant differences in dissolution rates between physical mixture and DDB alone. But dissolution rates of solid dispersions were $1.4{\sim}2.0$ times greater than that of DDB alone and $1.2{\sim}1.8$ times greater than those of a commercial tablet.

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