Journal of Pharmaceutical Investigation
- Volume 26 Issue 1
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- Pages.13-22
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- 1996
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Preparation and Characterization of Poly(D,L-lactic acid) Microspheres Containing Alprazolam
Alprazolam함유 poly(D,L-lactic acid) Microsphere의 제조 및 평가
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Yong, Chul-Soon
(College of Pharmacy, Yeungnam University)
;
- Kwon, Mi-Ra (College of Pharmacy, Yeungnam University) ;
- Park, Sae-Hae (College of Pharmacy, Yeungnam University) ;
- Oh, Doo-Man (College of Pharmacy, Taegue Hyosung Catholic University)
- Published : 1996.03.20
Abstract
Poly(D,L-lactic acid) (PLA) microspheres containing alprazolam(APZ) were prepared by a solvent-emulsion evaporation method and their release patterns were investigated in vitro. Various batches of microspheres with different size and drug content were obtained by changing the ratio of APZ to PLA, PLA concentration in the dispersed phase and stirring rate. Rod-like APZ crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decrease in the molecular weight of PLA. The release rate of APZ for long-acting injectable delivery system in vitro, which would aid in predicting in vitro release profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres.