• 대한화장품학회지
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• 제42권4호
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• pp.393-401
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• 2016

자외선은 피부 노화를 가속화하여 피부 광노화를 유발하고, 일광 화상, 피부암 등을 유발한다. 자외선 차단제를 사용하더라도 일부 자외선에 의하여 피부 손상은 유발될 수 있기 때문에 자외선에 대한 피부 자체의 방어력을 올려주는 것이 필요하다. 최근, 식물에서 자외선 보호 기능을 하는 것으로 알려진 COP1이 사람의 피부에서도 자외선에 대한 반응들을 조절한다고 새롭게 밝혀졌다. 본 연구에서는, COP1과 그의 결합 단백질 DET1이 사람 피부의 각질형성세포에서 자외선에 대한 시그날 조절 물질인 c-Jun 단백질 양을 조절하는 것을 확인하였다. 자외선에 노출 시 COP1과 DET1 발현이 감소하였고, 그 영향으로 c-Jun 단백질이 증가하였다. 반대로 COP1과 DET1을 발현하는 DNA를 transfection 시켜줄 경우 c-Jun 단백질 양이 감소하였다. 피부 각질형성 세포에서 COP1과 DET1의 발현을 조절할 수 있는 물질을 탐색한 결과, 초피나무 열매 추출물이 COP1과 DET1의 발현을 증가시켜 주었다. 초피나무 열매 추출물은 c-Jun 시그날에 의해서도 조절되는 MMP1이 자외선에 의해 유도되는 것을 억제하였다. 뿐만 아니라, 초피나무 열매 추출물 PPAR-${\alpha}$ 활성이 있어 장벽강화를 통한 피부 보호 효과가 있는데, 자외선에 의하여 염증 유발 물질인 IL-6와 IL-8의 발현이 증가하는 것도 억제하였다. 사람의 팔에 자외선을 쪼여 준 경우에도 초피나무 열매 추출물이 홍반이 생기는 것을 억제하고 홍반에 의한 색소침착도 억제하였다. 종합적으로, 초피나무 열매 추출물은 다양한 메카니즘을 통하여 자외선으로부터 피부를 보호해 줄 것으로 기대된다.

• 대한한의학회지
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• 제40권2호
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• pp.17-34
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• 2019

Objectives: This study was carried out to observe and compare the effects of Pinellia ternata, Zingiber officinale and Sobanhatang on the reflux esophagitis induced by gastric fundus and pylorus ligation in mice with esomeprazole. Methods: Antioxidant effects were measured by DPPH radical scavenging activity at four different concentration of 0.125, 0.25, 0.5 and $1.0mg/102{\mu}{\ell}$. Zingiber officinale water extract(ZE), Pinellia ternata water extract(PE) and Sobanhatang water extract(SBE) and esomeprazole were treated orally for 14 days before gatric fundus and pylorus ligation. In the histochemistry, changes in suface mucous cells, muscle tissue and connective tissue in gastro esophageal junction(GEJ) and mast cell on the esophageal mucosa were observed. The change of Hemo oxygenase(HO)-1, ghrelin, gastrin and substance P in gastric body tissue were measured by immunohistochemistry. Results: DPPH radical scavenging activity exhibited concentration dependently increases in ZE, PE, SBE. ZE was significantly higher at all concentrations than PE. The gastric surface mucous cells were more in the treated group than in the reflux esophagitis elicited group(GE) in the order of PE, SBE, ZE and esomeprazole treateded group(PT, SBT, ZT, ET). Lower esophageal sphincter muscle damage and intercellular space in the GEJ were less in the treated group than GE. In the esophageal mucosa, the mast cell distribution and the migration of inflammatory cells were lower in the treateded troup than GE in order to ZT, SBT, PT and ET. The antioxidative enzyme, HO-1 was more in the order of ZT, SBT, control group, PT, ET than in GE. ZT was significantly higher than the other groups and SBT was significantly higher than ET. Ghrelin was found to be higher in ZT, ET, SBT and PT than in GE, and ZT was significantly higher than all other groups except ET. Gastrin showed the highest positivity in GE, and was lower in the order of ET, ZT, SBT, PT, and control group. Substance P was the highest in GE, and was lower in the order of ET, ZT, SBT, PT and control group, and PT were significantly lower than ET. Conclusion: ZT, PT and SBT showed superior antioxidative, anti-inflammatory and mucosal protective effects on mouse reflux esophagitis as compared with ET. In particular, ZE was more effective in antioxidant and gastric motility enhancement, while PE was more effective in mucosal protection and anti-inflammatory effects. Sobanhatang is expected to be effective treatment because it has advantages of both drugs and reduces toxicity.

• 문화기술의 융합
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• 제8권1호
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• pp.277-284
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• 2022

본 연구에서는 실제 청년 모택동(毛泽东)이 1917년 『신청년(新靑年)』잡지에 직접 작성 투고한 「체육지연구(體育之硏究)」라는 문장을 직접 해석하고 분석하여, 이후 그의 이 체육에 대한 사유가 이후 그의 체육사상 형성과 현대 중국의 체육 발전에 미친 직간접적 영향이 무엇이었는지를 정리하고자 하였다. 구체적 연구 방법으로는 원문 「체육지연구(體育之硏究)」중 청년모택동의 특이한 체육에 대한 생각이 담겨있는 서론과 본론 2조항과 6조항을 주로 인용 발췌하였다. 그는 이 문장에서 첫째, 그는 체육교육의 목적이 구국에 있음을 밝히고 당시 체육교육의 폐해를 일부 언급하며, 실질적인 체육교육이 되어야 함을 이야기하였다. 두 번째, 그는 심신일원론적인 체육사상을 제시하였다. 세 번째, 그의 체육사상에 따른 실천은 예외적으로 소박하고 실질적이었다. 대표적으로 「체육지연구(體育之硏究)」에서 제시하는 모택동이 고안한 6가지 체력운동실천방법이 중요한 예시가 된다. 결론적으로 이 문장에서 모택동(毛泽东)은 체육을 통해 덕육과 지육의 부족한 부분을 극복할 수 있으며, 적극적인 체육활동은 개인의 자아실현을 앞당기는 것이라고 주장하였다. 모택동(毛泽东)은 중화인민공화국 수립이후 근 30년간 중국 최고 통치자로서 본인이 직접 '장강 수영' 등 체육활동의 적극적인 실천을 강조하였고, 중국 전역에 체육교육과 신체 활동의 중요성을 강조하였다. 그리고 이러한 체육사상은 1960년대 이후 중국의 엘리트 체육이 급속히 성장하고 중국 전역에 사회체육의 기초가 다져지는 기반이 되었다.

• 호남수학학술지
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• 제16권1호
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• pp.41-45
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• 1994

• 대학교육
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• 통권134호
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• pp.32-37
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• 2005

• 대한치과의사협회지
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• 제34권10호통권329호
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• pp.695-698
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• 1996

• 한국표면공학회지
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• 제31권6호
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• pp.389-392
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• 1998

We have investigated the crystal properties of the Cd0.96Zn0.04Te(CZT) films evaporated on the Si(100) substrates by Elecctron Beam Evaporator(EBE) techique. The compositions of the As-preared films were different about 4% of atomic ratio, The films stucture was observad to be polycrystalline in cubic phase. Diffraction peaks were notable at the substrate temperature of $300^{\circ}C$. The reflectance measurements yield $E_1$=3.25~3.29 eV $E_1$+${\Delta}_1$=3.76~3.83 eV and $E_2$=5.08 eV,showing that the films wear in cubic phase. For the film evaporated at the substrate temperature of $150^{\circ}C$, the peaks of photocurrent are at 720nm and 980nm.

• Industrial Engineering and Management Systems
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• 제10권1호
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• pp.15-23
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• 2011

This research considers scheduling problems with jobs which can be divided into sub-jobs and do not required to be processed immediately following one another. Heuristic algorithms considering how to divide jobs are proposed in an attempt to find near-optimal solutions within reasonable run time. The algorithms contain two phases which are executed recursively. Phase 1 of the algorithm determines how jobs should be divided while phase 2 solves the scheduling problem given the sub-jobs established in phase 1. Simulated annealing and genetic algorithms are applied for the two phases and four heuristic algorithms are established. Numerical experiment is conducted to determine the best parameter values for the heuristic algorithms. Examples with different sizes and levels of complexity are generated. Performance of the proposed algorithms is evaluated. It is shown that the proposed algorithms are able to efficiently and effectively solve the considered problems.

• Industrial Engineering and Management Systems
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• 제8권3호
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• pp.148-154
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• 2009

In recent days, large-sized flat-panel display (FPD) has been increasingly applied to computer monitors and TVs. Mura defects, appearing as low contrast or non-uniform brightness region, sometimes occur in manufacturing of the Thin-Film Transistor Liquid-Crystal Displays (TFT-LCD). Implementation of automatic Mura inspection methods is necessary for TFT-LCD production. Various existing Mura detection methods based on regression diagnostics, surface fitting and data transformation have been presented with good performance. This paper proposes an efficient Mura detection method that is based on a regression diagnostics using studentized residuals for automatic Mura inspection of FPD. The input image is estimated by a linear model and then the studentized residuals are calculated for filtering Mura regions. After image dilation, the proposed threshold is determined for detecting the non-uniform brightness region in TFT-LCD by means of monitoring the every pixel in the image. The experimental results obtained from several test images are used to illustrate the effectiveness and efficiency of the proposed method for Mura detection.

• International Journal of Quality Innovation
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• 제2권1호
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• pp.69-86
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• 2001

The economic design of control charts has been researched for over four decades since Duncan proposed the concept in 1956. Few studies, however, have focused attention on the economic design of a moving average (MA) control chart. An MA control chart is more effective than the Shewhart chart in detecting small process shifts [9]. This paper provides an economic model for determining the optimal parameters of an MA control chart with multiple assignable causes and two failures in the production process. These parameters consist of the sample size, the spread of the control limit and the sampling interval. A numerical example is shown and the sensitivity analysis shows that the magnitude of shift, rate of occurrence of assignable causes and increasing cost when the process is out of control have a more significant effect on the loss cost, meaning that one should more carefully estimate these values when conducting an economic analysis.