• BMB Reports
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• v.45 no.11
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• pp.595-603
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• 2012

Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy.

• Molecules and Cells
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• v.39 no.2
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• pp.136-140
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• 2016

Eph receptors and their ligands, ephrins, mediate cell-to-cell contacts in a specific brain region and their bidirectional signaling is implicated in the regulation of apoptosis during early brain development. In this report, we used the alpha(${\alpha}$)-Cre transgenic line to induce ephrin-A5 over-expression in the distal region of the neural retina. Using this double transgenic embryo, we show that the over-expression of ephrin-A5 was responsible for inducing massive apoptosis in both the nasal and temporal retinas. In addition, the number of differentiated retinal neurons with the exception of the bipolar neuron was significantly reduced, whereas the laminar organization of the mature retina remained intact. Consistent with this finding, an analysis of the mature retina revealed that the size of the whole retina-particularly the nasal and temporal regions-is markedly reduced. These results strongly suggest that the level of ephrin-A5 expression plays a role in the regulation of the size of the retinal progenitor pool in the neural retina.

• Genomics & Informatics
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• v.9 no.4
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• pp.173-180
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• 2011

Recent trends in generating multiple, large-scale datasets provide new challenges to manipulating the relationship of different types of components, such as gene expression and drug response data. Integrative analysis of compound response and gene expression datasets generates an opportunity to capture the possible mechanism of compounds by using signature genes on diverse types of cancer cell lines. Here, we integrated datasets of compound response and gene expression profiles on NCI60 cell lines and constructed a network, revealing the relationship for 801 compounds and 341 gene probes. As examples, obtusol, which shows an exclusive sensitivity on a small number of colon cell lines, is related to a set of gene probes that have unique overexpression in colon cell lines. We also found that the SLC7A11 gene, a direct target of miR-26b, might be a key element in understanding the action of many diverse classes of anticancer compounds. We demonstrated that this network might be useful for studying the mechanisms of varied compound response on diverse cancer cell lines.

• Genomics & Informatics
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• v.2 no.1
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• pp.19-29
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• 2004

Gene expression profiles may offer more information than morphology and provide an alternative to morphology- based tumor classification systems. Informative gene selection is finding gene subsets that are able to discriminate between tumor types, and may have clear biological interpretation. Gene selection is a fundamental issue in gene expression based tumor classification. In this report, techniques for selecting informative genes are illustrated and supervised shaving introduced as a gene selection method in the place of a clustering algorithm. The supervised shaving method showed good performance in gene selection and classification, even though it is a clustering algorithm. Almost selected genes are related to leukemia disease. The expression profiles of 3051 genes were analyzed in 27 acute lymphoblastic leukemia and 11 myeloid leukemia samples. Through these examples, the supervised shaving method has been shown to produce biologically significant genes of more than $94\%$ accuracy of classification. In this report, SVM has also been shown to be a practicable method for gene expression-based classification.

• Proceedings of the Korea Information Processing Society Conference
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• 2013.05a
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• pp.898-899
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• 2013

There are numerous approaches to improve the performances of database systems. The most efficient ones are considered to be implementing an effective database indexing technique. This must guarantee the balance between the memory, storage resources and processor of the database server according to the type, structure, the physical organization and the cardinality of data, the type of queries and the number of competing transactions. The challenge is to find an appropriate index type that would suite these requirements. In this paper, we provide an overview of the most used database indexing techniques such as B-tree index and Bitmap index, present an analysis of these techniques and discuss their limitations.

• Journal of the Korean Data and Information Science Society
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• v.27 no.5
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• pp.1337-1347
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• 2016

This study investigates factors affecting the number of insurance solicitor's turnovers of life insurance companies based on questionnaire about them. Since the response variable which is the number of insurance solicitor's turnovers is count data, it is analyzed by Poisson regression which is one of generalized regression. When work year in current company, which is direct influential factor on the number of insurance solicitor's turnovers, is controlled, affiliated corporation has been found to be the most influential factor. In addition, age, motivation to work as financial planner, monthly income, a number of average new contract per month, and final education have been identified to be important factors. If insurance solicitor's occupant organization is large company, the number of turnovers becomes small, but if the organization is general agent(GA), it becomes larger. When insurance solicitor's age is high, the number of insurance solicitor's turnovers are reduced. If the motivation to become a financial planner is due to acquaintance such as family and relatives, the number of turnovers becomes small.

• Journal of Korean Academy of Nursing Administration
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• v.6 no.3
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• pp.421-429
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• 2000

Two nurses' assications were organized in Korea during Japanese colonial period One was Choseon Ganhoboohoi(朝餘看護續會, the Korean Nurses' Association)started in 1923 and the other was Choseon Ganhoboohoiphoi started in 1924. Two nursing associations were very different in their members and activities. Choseon Ganhoboohoi was organized and lead by Western missionary nurses in Korea and their Korean pupil nurses. The aim of Choseon Ganhoboohoi was to become a member of ICN. Choseon Ganhoboohoi united with the Western Graduate nurses' Association in Korea, tried to raise the standard of nursing education, and became a branch of Japan Imperial Nurses' Association. All was to become a member of ICN. It continued 15 years and was quite active. But after the half of 1930s Japan's ruling policy became more and more suppressive and western missionaries were expelled from Korea so it could not but discontinue it's activities. Choseon Ganhoboohoiphoi(朝鮮觸護續協會) was organized and lead by Korean nurses. The aim of it was to do the role of nurses by social activities. So it tried health education for the public, It continued only about 2 years, But the leaders of Choseon Ganhoboohoiphoi moved to women's liberation movement and Korean liberation movement and tried to solve the problems of colonized women. The organizations and activities of Choseon Ganhoboohoi and Choseon Ganhoboohoi were two trends to develop Korean nursing during Japaneses Colonial period. The former asked for international cognizance by the raise of nursing standard, and the latter asked for national cognizance by social activities. Although two nurses' associations were different in their ways but quite same in the aspect that both tried for the development of nursing in Korea. But the colonial situation prevented them from continuing their activities. This means that the colonial situation of national level influenced deeply on the development of nursing profession.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.209-218
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• 2020

This study examined the sexual function, sexual distress, and quality of life of middle-aged women with osteoarthritis, as well as the factors influencing the quality of life. The participants were 121 middle-aged women who have been suffering osteoarthritis. Data collection was conducted from September 1 to October 31, 2019. The instruments were the Female Sexual Distress Scale (FSDS), the Female Sexual Function Index (FSFI), and the World Health Organization Quality of Life Assessment Instrument (WHOQLO) -BREF scale. Data were collected with structured questionnaires and analyzed using a t-test, ANOVA, Pearson's correlation analysis, and multiple regression analysis. A positive correlation was observed between sexual function and quality of life, whereas sexual distress had a negative correlation between sexual function and the quality of life. Factors affecting the quality of life of middle-aged women with osteoarthritis were sexual function, sexual distress, which explained 16.1%. Sexual distress, sexual function, and quality of life showed a correlation. Therefore, it is important to develop a nursing intervention that can improve the sexual function and reduce the sexual distress of middle-aged women with osteoarthritis to improve their quality of life.

• Journal of Korean Academy of Nursing Administration
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• v.11 no.1
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• pp.59-66
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• 2005

Purpose: The purpose of this study was to identify the effects images about medical organizations and the quality of service on customer satisfaction of obs and gyn patients. Method: The subjects of this study were selected conveniently 220 women among obstetrics and gynecology outpatients( who visited H- doctor's office of the first medical organ, P- hospital of the second medical organization, Chospital of the third medical organization). The data were collected from August, 20th 2004 using structured questionaires which included modified form of SERVPERF and customer's satisfaction scale by oliver & swan(1989), and modified form of image scale by kang(1997). Results: Image of hospital(45.3%), visiting frequencies(9.3%), service provider (3.9%) and convenient use(1.2%) of the quality of medical service were significant predictors to explain customer's satisfaction. Conclusion: To increase customer's satisfaction of obs and gyn patients, it is required to developed strategies that improve image of hospital and the quality of service to service provider and convenient use of hospital.

• Journal of Agricultural Extension & Community Development
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• v.2 no.2
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• pp.95-108
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• 1995

Localization trends in Korea and trade liberalization in the world are the important challenges to agricultural extension services in Korea, and strategic directions in terms of system, organization, programs and conciousness would be necessary for adapting to the new circunstances. Some of the measures to improve and activate agricultural extension services in Korea should include the following: 1) Modification of extension personnel appointment regulations to secure specialized extension agents by the provincial administrators and county directors at the provincial and county level rural extension services. 2) Flexible organization and operation of county level rural guidance offices to meet the specific needs of local areas. 3) Strenghening the central government's financial support for effective local extension services in terms of facility and manpower. 4) Expansion of agricultural extension programs for women and urban people and quality inservice training for extension personnel.