• Journal of the Korean Data and Information Science Society
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• 제21권3호
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• pp.471-480
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• 2010

군집방법은 탐색적 통계기법에서 매우 유용한 방법이나 최종 의사결정을 지지할 검정 통계량이 없는 것이 단점이다. 자료구조에서 살펴보면 군의 성격을 파악하는 변수가 있느냐 없느냐가 군집분석과 판별분석의 차이이다. 군집분석이 가장 이상적으로 이루어졌다면 그 프로파일의 분석결과가 판별분석과 같을 것이다. 이 점에 근거하여 비계층 분석의 대표적인 K-평균법 방법과 자기 조직화지도 군집분석의 유효성을 2009년 여자프로골프 선수들의 프로파일 분석을 통하여 비교 연구하였다.

• 대한간호학회지
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• 제33권8호
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• pp.1111-1118
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• 2003

Background. A midwife is a medical professional who has a nursing license, and is also licensed as a midwife with one additional year of education. In this globalization era, a midwife's role is increasing in importance for women and children's health care worldwide. Purpose. The primary purpose was to analyze midwifery education programs in Korea and other nations. The secondary purpose was to define strategies to improve midwifery education and practice, and to extend the role of a midwife women and children's health care in Korea. Methods & Results. 1) The definition of a midwife and midwifery practice recognized internationally by World Health Organization (WHO) and International Council of Nurse Midwives (ICNM) was identified. 2) Midwifery education programs of Korea, U.S.A., Sweden, Australia, and Japan, were investigated and discussed. 3) Core competencies for the basic midwifery practice suggested by ACNM of the U.S.A. were reviewed as standard of midwifery practice. 4) As for the midwifery education system, a Masters degree program in a college of nursing is suggested. 5) The role of a midwife includes not only health care of childbirth women and newborn babies, but also a lifelong health care of women as well as her family and children. Conclusion. An effort to extend the midwife's role and to improve service is imperative. The Laws/Acts related to midwives should be revised in regard to education, and practices, and the national examination for midwifery licensure needs revision to qualify for international approval. Also, midwifery curriculum and standards of practice need to be evaluated periodically, and an effective system needs to be established to renew midwife licenses.

• Genomics & Informatics
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• 제11권4호
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• pp.224-229
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• 2013

Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein, amyloid-${\beta}$-protein, Mac-1, and phosphatidylserine. Its interaction is engaged in critical cellular processes, such as inflammation, proliferation, apoptosis, autophagy, and migration, and dysregulation of RAGE and its ligands leads to the development of numerous human diseases. In this review, we summarize the signaling pathways regulated by RAGE and its ligands identified up to date and demonstrate the effects of hyper-activation of RAGE signals on human diseases, focused mainly on renal disorders. Finally, we propose that RAGE and its ligands are the potential targets for the diagnosis, monitoring, and treatment of numerous renal diseases.

• 한국보건간호학회지
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• 제3권1호
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• pp.101-119
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• 1989

In the present, since a five-year plan for economic development which was started in the early 60's has been successfully promoted for a quarter century, with consolidation in a department of social welfare in our country the participation. in economic society for women is more required than any other times. As a professional occupation for women is incereaing through a high-standard specialization, I think the upbringing for productive woman expert who has a strong motive of accomplishment as a developed person as well as a technical and skilful capacity which can be contributed to the growth of organization is very important. So in this study, I am evaluating the technical disposition of character of professional nurses working with hospital and also trying to supply the basic data being served to th extension of a skillful ability as a nurse, understanding the important factor related to it. The research method applied here is that we used 527 of formed questionnaires which were distributed to 7 University and General Hospitals, somewhat large in a scale, located in Seoul as an analytical material. It was performed between October 11, 1988 and October 18, 1988. An implement which was invented by Cho Moo-Sung is used after being amended and supplemented, which can measure the disposition of professional character. The formation of questionnaires of the disposition of character is 26 totally, 10 for Open-disposition, 11 for Active-disposition, 5 for wise-disposition, and it was measured. 'Ye', or 'No' through an one-half-standard and the environment of hospital organization is composed 12 questions from one point of 'Very Good' to 5 points of 'Very Bad.' Collected materials were analysed through an electronic calculation into the average value, the standard deflection, percentage, person correlative number, $X^2-test, m$ stepwise multiple regression. Summarizing the result from this research is as follows; 1. The average age of the subjective person of this investigation is 28.6 and the average career as a nurse is 6.0 years. 2. The Open-disposition that technical nurses showed is mostly half and half. 3. The Active-disposition of professional nurses was discovered affirmative largely and what they said in their questionnaires describes that they are very active answering $88.2\%$ for the disposition of self-control, $87.3\%$ for the people who think the training more seriously. 4. It was found out that the wise·disposition of technical nurse showed $90.7\%$ of 'Yes' about a new alternative of inquisitive question and we can see a progressive and profound aspect here. 5. As technical character of nurses, mutual relations between Active-disposition, Active-disposition, and wise­disposition were very profitably revealed as 0.42 in justice relations and also suggested that relations between Open-disposition, Active-disposition, and wise-disposition are 0.27 and 0.20 respectively. 6. What nurses recognize about the environment of hospital organization is reasonably acceptable while they feel very bad about rewards and punishments showing average 3.1 comparing to average 2.2 about time­control each other. Considering the prosperity of Active-disposition upon the result what I mentioned above, th possibility which is contributed to the productive improvement of hospital organization is very great and I think it can be more developed as a professional woman who has a strong motive of accomplishment, in advance.

• 응용통계연구
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• 제35권4호
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• pp.527-541
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• 2022

회사는 영리 등의 공동 목표를 달성하는 조직으로, 더 나은 성과를 도출해내기 위해 함께 노력하는 수많은 개인으로 구성된 사회 집단이다. 이에 따라 개인의 의사소통 능력을 비롯한 구성원 간의 네트워크 형성이 중요해지고 있다. 이러한 배경으로부터 본 연구는 직원 간 조언 관계 형성에 어떠한 요인이 영향을 미치는지 알아보고자 수행되었다. 이를 위해 미국과 유럽에 지사를 둔 컨설팅 회사 내 직원 44명의 네트워크 데이터를 ERGM(Exponential Random Graph Model) 방법으로 분석하였다. 분석 결과로 첫째, 연결을 비롯해 네트워크의 구조와 관련한 변수들이 유의하였다. 둘째, 서로 조언을 구할 확률에 성별 속성이 가장 큰 주효과로 나타났다. 셋째, 지역별 동질성은 성별 주효과보다 더 큰 연결 확률을 유도하였다. 이러한 결과로부터 직장 내 네트워크가 조금 더 효율적으로 활발하게 이루어질 수 있는 방법을 제시하였다.

• 한국산업보건학회지
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• 제26권3호
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• pp.377-387
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• 2016

Objectives: The objective of this study was to describe the emotional labor experiences of ward nurses in Korea. Methods: The data were collected through focus group interviews with seven ward nurses. The phenomenological analytic method suggested by Colaizzi was used to analyze the data. Results: Four theme clusters and eleven themes emerged from the analysis. The first theme cluster, 'Terrible working environment' includes changes in the health environment and realities of nursing organization. The second theme cluster, 'Suppressed feelings' includes institutionalized power trip, patient-centered emotion management and burning. The third theme cluster, 'Tired body and mind' includes withdrawal, wounded self-esteem, burnout and turnover desicion. The fourth theme cluster, 'Want to be comforted' includes emotional control and wishing to live as a nurse. Conclusions: The findings of this study provide an understanding of the emotional labor experiences of ward nurses to explain their perceptions and language. The essence of the emotional labor of ward nurses is a negative working environment created by increased competition in the healthcare industry and the nature of nursing organization, and as a result their quality of life has fallen.

• 한국임상약학회지
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• 제21권3호
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• pp.237-242
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• 2011

This study measures seriousness of adverse drug reactions (ADRs) among Korean physicians and pharmacists using two times surveys based on Delphi technique. Each participant scored 20 ADR terms on a scale of one to ten (10 being the most serious). We repeated the exercise for the 49 first survey respondents and 32 re-evaluated score. We compared the results of our survey with those of WHO CIOMS (Council for International Organization of Medical Sciences) working groups members conducted in 1995. The overall mean ADR seriousness score was 6.49 for Koreans and 5.12 for WHO CIOMS members, presenting Korean experts perceived more seriously for each ADR. Mean score changes for the same respondents showed similar trends regardless of access to the first survey results. There were no statistically significant score differences between the physicians and the pharmacists. The high consensus of seriousness for each ADR between the Korean experts and the WHO CIOMS members implies that the similar results are reproducible, suggesting the possibility of developing standardized tools for measuring the seriousness of individual ADRs in the future.

• Toxicological Research
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• 제32권4호
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• pp.311-316
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• 2016

Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDerm$^{TM}$ skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time according to the test guidelines. Cell viabilities of EpiDerm$^{TM}$ skins were measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide based method. FeNPs, AlNPs, TNPs, and AgNPs were non-corrosive because the viability was more than 50% after 3 min exposure and more than 15% after 60 min exposure, which are the non-corrosive criteria. All NPs were also non-irritants, based on viability exceeding 50% after 60 min exposure and 42 hr post-incubation. Release of interleukin 1-alpha and histopathological analysis supported the cell viability results. These findings suggest that FeNPs, AlNPs, TNPs, and AgNPs are 'non-corrosive' and 'non-irritant' to human skin by a globally harmonized classification system.

• 한국기록관리학회지
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• 제14권1호
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• pp.7-24
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• 2014

본 연구의 목적은 한국 근대 여성 구술기록물의 효율적인 주제 접근을 위한 시소러스를 개발하는 것이다. 이를 위해 문헌 연구와 국내외 시소러스 사례 분석을 수행하였고, 구술기록물에 입력된 색인어를 중심으로 시소러스를 구축하였다. 구축 과정은 총 5단계로 1단계는 한국 근대를 산 53명의 여성 구술자의 구술기록물에 입력된 한글 색인어 총 1,784개 추출하여 용어의 특성을 분석하였다. 2단계에서는 수차례에 걸쳐 해당 분야 전문가 회의를 거쳐 시소러스 대상 용어를 선정하였고, 3단계에서는 용어에 대한 등위 계층 연관 관계를 설정하였다. 4단계에서는 웹기반 시소러스 관리시스템을 개발한 후, 용어 및 관계 정보를 입력하였고, 5단계에서는 입력된 용어의 정보와 관계를 전문가 집단이 재검토하였다. 구축된 시소러스는 일반 주제어를 비롯한 지명, 장소명, 인명, 단체명 등 고유명사가 포함된 39개 대주제 영역의 1,076개의 용어로 구성되었으며 추후 추가적인 구술기록물을 바탕으로 확장될 것이다.

• Journal of Microbiology and Biotechnology
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• 제13권6호
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• pp.949-954
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• 2003

The argG gene of Corynebacterium glutamicum encoding argininosuccinate synthetase (EC6345) was cloned and sequenced. The gene was cloned by heterologous complementation of an Escherichia coli arginine auxotrophic mutant (argG/sup -/). The cloned DNA fragment also complements E. coli argD, argF, and argH mutants, suggesting a clustered organization of the genes in the chromosome. The coding region of the argG gene is 1,206 nucleotides long with a deduced molecular weight of about 44 kDa, comparable with the predicted size of the expressed protein on the SDS-PAGE. Computer analysis revealed that the amino acid sequence of the argG gene product had a high similarity to that of Mycobacterium tuberculosis and Streptomyces clavuligerus. Two conserved sequence motifs within the ArgG appear to be ATP-binding sites which correspond to 2 of the 3 conserved regions found in sequences of all known argininosuccinate synthetases.