• Journal of Society of Preventive Korean Medicine
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• v.23 no.3
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• pp.1-12
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• 2019

Objectives : Korean national health insurance data is a useful real-world data representing whole medical bills submitted to Health Insurance Review Agency. This study aims to understand recent benefit trend of insurance herbal preparations for treating bronchiectasis(disease code J47) utilizing insurance data. Methods : We reviewed national health insurance claims data from 2013 to 2017 which have main diagnosis or sub diagnosis code of J47 and with the record of prescribing insurance herbal medication. Frequency analysis was performed to analyze the most frequently prescribed prescription. Results & Conclusions : Both the number of claims statement(770 to 1,746cases) and patients(266 to 484) of insurance herbal preparations increased considerably from 2013 to 2017. Top 10 preparations based on the number of claims statement were 'Samso-eum', 'Yeonkyopaedok-san', 'Socheongryong-tang', 'Bojungikgi-tang', 'Hyangsapyungwi-san', 'Yijin-tang', 'Saengmaek-san', 'Jaeumganghwa-tang', 'Ojeok-san' and 'Gungha-tang'. Top 10 preparations based on the number of patients were 'Samso-eum', 'Socheongryong-Tang', 'Saengmaek-san', 'Yeonkyopaedok-san', 'Haengso-tang', 'Hyangsapyungwi-san', Yijin-tang', 'Jaeumganghwa-tang', 'Bojungikgi-tang' and 'Hyeonggaeyeongyo-tang' in respectiv order. Claims of top 10 frequent preparations occupied more than 60% of total claims. We hope this finding to be utilized as basic data for future research of evidence-based bronchiectasis treatment utilizing Korean traditional medicine.

• BMB Reports
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• v.54 no.7
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• pp.386-391
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• 2021

Owing to rapid advancements in NGS (next generation sequencing), genomic alteration is now considered an essential predictive biomarkers that impact the treatment decision in many cases of cancer. Among the various predictive biomarkers, tumor mutation burden (TMB) was identified by NGS and was considered to be useful in predicting a clinical response in cancer cases treated by immunotherapy. In this study, we directly compared the lab-developed-test (LDT) results by target sequencing panel, K-MASTER panel v3.0 and whole-exome sequencing (WES) to evaluate the concordance of TMB. As an initial step, the reference materials (n = 3) with known TMB status were used as an exploratory test. To validate and evaluate TMB, we used one hundred samples that were acquired from surgically resected tissues of non-small cell lung cancer (NSCLC) patients. The TMB of each sample was tested by using both LDT and WES methods, which extracted the DNA from samples at the same time. In addition, we evaluated the impact of capture region, which might lead to different values of TMB; the evaluation of capture region was based on the size of NGS and target sequencing panels. In this pilot study, TMB was evaluated by LDT and WES by using duplicated reference samples; the results of TMB showed high concordance rate (R² = 0.887). This was also reflected in clinical samples (n = 100), which showed R² of 0.71. The difference between the coding sequence ratio (3.49%) and the ratio of mutations (4.8%) indicated that the LDT panel identified a relatively higher number of mutations. It was feasible to calculate TMB with LDT panel, which can be useful in clinical practice. Furthermore, a customized approach must be developed for calculating TMB, which differs according to cancer types and specific clinical settings.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.7C
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• pp.641-652
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• 2002

We introduce a new ultra-large capacity time- and wavelength-division hybrid optical switching system, called ESCIMONET(Easily SCalable Interconnected Multiwavelength Optical NETwork). We describe its architecture, principle of operation, and performance characteristics. ESCIMONET is very effective system in terms of its handling capacity versus number of wavelength needed. It can handle n$^3$number of channels using only n number of different wavelengths. The insertion loss of the whole system is less than conventional optical switching system so that the number of optical amplifiers in the system can be minimized. We analyzed the performance of the system by investigation the characteristics of the buffer used in the system such as throughput and average waiting time of the signal in a buffer.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.49 no.1
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• pp.29-39
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• 2013

Fishing vessels have been causing more than 70% of marine casualty in Korea. As a view of the occurring number of marine casualty, it is obvious for fishing vessel to account for the absolute high portion of that in comparison with the non-fishing vessels. That is a natural outcome because fishing vessels have occupied more than 90% of all registered Korean vessels. If we consider it not occurring number, but occurring ratio, we could find out that fishing vessels accounted for 5 times lower than non-fishing vessels in marine casualties. Nevertheless, fishing vessels have not immunity from responsibility for marine casualties at all, because the tendency of it in fishing vessel has been dominating the whole marine casualties in Korea. So for reduction of them, it is indispensable to decrease the casualties of fishing vessel. In this study, the authors tried to carry out many items of them to compare the occurring number with the occurring ratio, and dealt with the casualties of collision and machine damage in detail, because those have not only been occurring most frequently in casualties in Korea, but also led to the death and injury of lives. To reduce the collision and the machine damage, the operator have to keep the watch more strictly and check and keep the machine in good order. And it is necessary for the operator to take more education and training intended to decrease those systematically and continuously, especially for the crews of fishing vessels.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.6
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• pp.530-537
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• 2006

Recently isolated, Pseudomonas putida SN1 grows on styrene as its sole carbon and energy source through successive oxidation of styrene by styrene monooxygenase (SMO), styrene oxide isomerase (SOI), and phenylacetaldehyde dehydrogenase. For the production of (S)-styrene oxide, two knockout mutants of SN1 were constructed, one lacking SOI and another lacking both SMO and SOI. These mutants were developed into whole-cell biocatalysts by transformation with a multicopy plasmid vector containing SMO genes (styAB) of the SN1. Neither of these self-cloned recombinants could grow on styrene, but both converted styrene into an enantiopure (S)-styrene oxide (e.e. > 99%). Whole-cell SMO activity was higher in the recombinant constructed from the SOI-deleted mutant (130 U/g cdw) than in the other one (35 U/g cdw). However, the SMO activity of the former was about the same as that of the SOI-deleted SN1 possessing a single copy of the styAB gene that was used as host. This indicates that the copy number of styAB genes is not rate-limiting on SMO catalysis by whole-cell SN1.

• Korean Journal of Pharmacognosy
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• v.49 no.1
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• pp.47-54
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• 2018

Astilbe rubra (AR) is a perennial, belongs to the Saxifragaceae family, it contains tannin and triterpene. AR has been used in republic korea to improve toxication, fever, pain and convulsion. Recently, number of natural products have been analyzed for potential pharmacological activities including anti-cancer, anti-obesity and anti-diabetic medication. Consequently, we investigated the growth inhibition effect of Astilbe rubra water extract (WAC), ethanol extract (EAC) and bergenin on Hela cell (human adenocarcinoma cell). From whole plant of A. rubra, bergenin was isolated by column chromatography and its structures were identified by $^1H$, $^{13}C$ NMR and IT TOF-ESI MS. High extraction efficiency of bergenin was shown at 0.95% under 60 min reflux extraction with 50% MeOH. The MTS assay showed that EAC (ethanol extract) treatment increased cell death in a dose-dependent manner. Moreover, EAC treatment on Hela cell increased apoptotic cell death and caspase-3 activity. Results suggest that EAC has growth inhibition effect on Hela cells, but not WAC and bergenin. $500{\mu}g/mL$ EAC treatment inhibited Hela cell at $60.2{\pm}1.5%$.

• Journal of Community Nutrition
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• v.5 no.4
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• pp.209-217
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• 2003

The food and nutrition system is a network of processes linking agriculture, food, eating, nutrition, and health. The system includes a series of nine stages (production, processing, distribution, acquisition, preparation, consumption, digestion, transport, and utilization) and two types of contexts (biophysical and sociocultural). Analysis of whole food and nutrition systems provides information about the structure and processes involved in the complete scope of food and nutrition, assisting in the identification of ″upstream″ influences and ″downstream″ consequences in the system. The current analysis gathered existing data about the food and nutrition system in South Korea from public sources and professional publications, and interpreted that information to consider how different elements of the system contribute to health. The findings revealed that South Korea has substantial domestic food production and processing supplemented by imports, widespread food distribution in markets and a growing number of Korean and Western restaurants, a relatively low percentage of household income spent on food, growing use of new food preparation methods such as microwave ovens, a rice/vegetable/fish based three-meal consumption pattern, few recorded digestive problems, increasing calorie storage as body fat, and a relatively low chronic disease prevalence compared to other developed societies. Examination of the full scope of the food and nutrition system provides a broad perspective using whole system thinking that can identify potential strategies for future research and intervention.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.39 no.4
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• pp.388-398
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• 2002

Video representation through representative frames (key frames) has been addressed frequently as an efficient way of preserving the whole temporal information of sequence with a considerably smaller amount of data. Such compact video representation is suitable for the purpose of video browsing in limited storage or transmission bandwidth environments. In a case like this, the controllability of the total key frame number (i.e. key frame rate) depending on the storage or bandwidth capacity is an important requirement of a key frame selection method. In this paper, we present a sequential key frame selection method when the number of key frames is given as a constraint. It first selects the desired number of initial key frames and determines non-overlapping initial time intervals that are represented by each key frame. Then, it adjusts the positions of key frames and time intervals by iteration, which minimizes the distortion. Experimental result demonstrates the improved performance of our algorithm over the existing approaches.

• International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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• v.26 no.1
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• pp.59-73
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• 1998

Sediment samples from five stations at the Shihwa Lake sewage outfall, west cost of Korea, were collected to evaluate the effect of the outfall on benthic foraminifers. Heavy metal (Cu and Zn) polluted the eastern part of the Shihwa Lake, adjacent to the Shihwa-Banwol Industrial Complexes, shows barren or nearly barren of benthic foraminifers, and the lowest number of species both at the core top and downcore. Excepting for the barren zone, pyritized benthic foraminifers abundantly occur both at the surface and downcore sediments in the western part of the Shihwa Lake, suggesting that foraminiferal disease by anoxic bacteria. Recent intrusion of pollutants form the Shihwa-Banwol Industrial Complexes and adjacent six major streams severely polluted the Shihwa Lake as shown by the low abundance (number/10 g) of benthic foraminifers, low number of Ammonia beccarii, low species diversity, and absence of both Elphidium spp. and ostracodes at the surface sediments compared of both downcore. Except the barren zone, both pyritized and non-pyritized Ammonia beccarii occur dominantly in the surface sediments and downcore. Elphidium spp. (either pyritized or non-phyritized) do not occur in the surface sediments of whole stations. However, they occur from the entire downcore sediments except in the eastern part of Shihwa Lake. Arenaceous foraminifers do not inhabit in the heavily polluted areas as evidenced by the occurrence of relatively deep core depth (11-15 cm). Ostracodes occur at the downcore sediments, but they do not occur at the surface sediments. Ostracodes also do not occur at the heavily polluted areas in the eastern part of the Shihwa Lake both at the surface and downcore sediments, indicating that the abundance of ostracodes also can be used for a pollution indicator.

• Journal of Korean Society for Quality Management
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• v.39 no.4
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• pp.527-542
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• 2011

The importance of service industry in national economy is getting increasing due to current trend of aging society and increasingly desire for better quality of life. However, the level of labor productivity in domestic service industry is lower than Japan and Germany that are typically strong in manufacturing industry. Difficulty of process control and measurement in accordance with variability and intangibility which are features of service industry, is considered as the cause of this poor labor productivity in Korea. This study aims to present managerial implications by calculating sigma levels on branch bank service quality and suggesting the quality dimensions of banks can be checked through a gap comparison between the sigma level on service quality in the whole banks and service quality in each bank. Quality level presented by the KS-SQI is applied to the measurement method that Yoo Han Joo and Song Kwang Seok suggested in 2006. Spss18.0 is used as an analysis tool. As a result of factorial analysis, 7 dimensions of service quality in KS-SQI can be divided into new 3 dimensions of service quality. This study also suggests that width and number of questions in previous questionnaire shall be extended. The whole of the bank service quality level is evaluated 3 sigma. The research help banks to figure out their service quality level through gap comparison objectively.