• Journal of Haehwa Medicine
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• v.8 no.1
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• pp.593-623
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• 1999

This experimental study was designed to verify the anti-aging efficacy of Eukmigihwangtang (EMGHT) and Rehmannia Radix, and determine the specific role and actions of Rehmannia Radix. Normal rat (2 months old), aging rat (8 months old), and pathologically induced rat (2 months old, injected 30mg/kg of streptozotocin) are observed to study the aging eliciting factors such as peroxide contents and enzyme activities. The following results were obtained in this study: 1. For the body weight changes, normal group given Rehmannia Radix showed decrease in the body weight compared to the control group, aging group given EMGHT and Rehmannia Radix showed significant decrease in the body weight, and STZ injected group showed suppression to the body weight loss when given EMGHT and Rehmannia Radix. 2. For the content changes in serum lipid peroxide, normal group showed increasing level as the rat gets older. Aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the lipid peroxide level compared to the control group. Decrease was more prominant in the group given EMGHT. 3. For the changes in serum hydroxyl radical, normal group did not show significant changes, but aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the hydroxyl radical level compared to the control group. Decrease was more prominant in the group given EMGHT. 4. For the changes in serum superoxide dismutase (SOD) activity, normal group did not show significant changes, but aging group given EMGHT and Rehmannia Radix showed significant increase in the SOD activity compared to the control group. STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the SOD activity compared to the control group. 5. For the content changes in hepatic lipid peroxide, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the lipid peroxide level compared to the control group. 6. For the changes in hepatic cytochrome P-450 activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease compared to the control group. Cytochrome b5 activity was significantly decreased only in the STZ injected group given EMGHT and Rehmannia Radix. 7. For the changes in hepatic aminopyrine demethylase and aniline hydroxylase activity, aging group given EMGHT and Rehmannia Radix showed significant decrease compared to the control group. STZ injected group given EMGHT and Rehmannia Radix showed significant increase in the aminopyrine demethylase activity, and showed significant decrease in the aniline hydroxylase activity compared to the control group. 8. For the content changes in hepatic protein bound-SH and nonprotein bound-SH, againg group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase compared to the control group. 9. For the content changes in hepatic glutathione level, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase compared to the control group. 10. For the changes in hepatic glutathione S-transferase activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase and decrease, respectively, compared to the control group. 11. For the changes in hepatic glutathione reductase activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase compared to the control group, while $\gamma$-Glutamylcystein synthetase activity did not show significant changes. 12. For the changes in hepatic superoxide dismutase activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease compared to the control group. From the above results, the antioxidant effects of EMGHT and Rehmannia Radix were proved, as well as the role of Rehmannia Radix, a chief of EMGHT, was examined. In addition, since no change was reconized as the quantity of Rehmannia Radix and the order herbs increased, the reasonableness on EMGHT was proven with respect to its composition and quantity. Thus, the significance of EMGHT could be objectively exmined in terms of its composition and quantity. Considering animals used in the experiment, there were obvious changes in aging rats and pathologically induced rats than in normal rats. Consequently, it was noticeable that EMGHT and Rehmannia Radix were working selectively on the subjects.

• Journal of Family Resource Management and Policy Review
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• v.12 no.2
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• pp.31-55
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• 2008

Human capital theory and social capital theory provide a framework for analyzing economic well-being. The purpose of this study was to investigate the effects of human capital and social capital on the economic well-being of the elderly. The data from the 1st wave of KLoSA (Korean Longitudinal Study of Aging) were used (n=3,426). The major findings were as follows: First, human capital and social capital are both resources that can contribute to increasing the economic well-being of the elderly. Second, the effects of human capital on the economic well-being of the elderly were relatively higher than the effects of social capital. Third, the relative contributions of human capital and social capital to increasing economic well-being varied by sex, age, and region. Based on the empirical results, the implications for social investment in human capital and social capital were provided.

• Korean Chemical Engineering Research
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• v.46 no.3
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• pp.545-549
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• 2008

The surface characteristics of calcined ${\gamma}-Al_2O_3$ particles as well as ${\gamma}-AlO$(OH) sol particles were controlled by aging in the boehmite sol preparation. As a result of the study, the IEPs of ${\gamma}-AlO$(OH) particles were decreased from pH 9.25 to pH 8.70 and those of the calcined ${\gamma}-Al_2O_3$ particles were decreased from pH 9.90 to pH 8.86 by the increase of the aging times. As a result of the acidic and basic characterization of the calcined ${\gamma}-Al_2O_3$ particles by the aging, the amount of acid sites was decreased from 0.1367 mmol/g to 0.0783 mmol/g by the increase of the aging times and Hammett acidity, $H_o$ was showed the acidic strength of 4.8 or above. On the other hand, the amount of basic sites was decreased from 0.4399 mmol/g to 0.3074 mmol/g by the increase of the aging times. Based on these results, we proposed the fact that the aging step in the sol-gel process was an important step to control the surface characterization of ${\gamma}-Al_2O_3$ particles including acidity and basicity.

• Korean Journal of Family Social Work
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• no.54
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• pp.187-224
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• 2016

This study aims to investigate the effect of psychosocial aging on age integration and the moderating effect of Familism and Family solidarity. In particular, this study has significance for establishing a basis of practical and political intervention in family level for improving age integration. We employed data from the 'Ageing Society Awareness Investigation' funded by Korean National Research Foundation in 2014. Our analysis sample consisted of 702 adults who were from 40 to 90 years old. Also, this study conducted descriptive statistics and multiple regression analysis by using STATA13. First of all, the lower psychosocial aging awareness is the higher age integration awareness. Familism and family solidarity were not a significant predictor for age integration. However, the interaction effects between familism as well as family solidarity and psychosocial aging ware statistically associated with age integration. That is to say that as psychosocial aging is negative, when decrease age integration, the net moderating effects of familism and family solidarity were found between age integration and psychosocial aging. Based on the results, this study provides implications that reinforcing family value and promoting interaction and solidarity with family members are positively contributed to age integration awareness at this point of negative psychosocial aging.

• Molecules and Cells
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• v.41 no.12
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• pp.1061-1071
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• 2018

From Xenopus embryo studies, the BMP4/Smad1-targeted gene circuit is a key signaling pathway for specifying the cell fate between the ectoderm and neuro-ectoderm as well as the ventral and dorsal mesoderm. In this context, several BMP4/Smad1 target transcriptional factors have been identified as repressors of the neuro-ectoderm. However, none of these direct target transcription factors in this pathway, including GATA1b, Msx1 and Ventx1.1 have yet been proven as direct repressors of early neuro-ectodermal gene expression. In order to demonstrate that Ventx1.1 is a direct repressor of neuro-ectoderm genes, a genome-wide Xenopus ChIP-Seq of Ventx1.1 was performed. In this study, we demonstrated that Ventx1.1 bound to the Ventx1.1 response cis-acting element 1 and 2 (VRE1 and VRE2) on the promoter for zic3, which is a key early neuro-ectoderm gene, and this Ventx1.1 binding led to repression of zic3 transcription. Site-directed mutagenesis of VRE1 and VRE2 within zic3 promoter completely abolished the repression caused by Ventx1.1. In addition, we found both the positive and negative regulation of zic3 promoter activity by FoxD5b and Xcad2, respectively, and that these occur through the VREs and via modulation of Ventx1.1 levels. Taken together, the results demonstrate that the BMP4/Smad1 target gene, Ventx1.1, is a direct repressor of neuro-ectodermal gene zic3 during early Xenopus embryogenesis.

• Proceedings of the Korea Concrete Institute Conference
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• 2000.10a
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• pp.173-178
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• 2000

New prediction model is investigated estimating splitting tensile strength and modulus of elasticity with curing temperature and aging. New prediction model is based on the model which was proposed to predict compressive strength, and splitting tensile strength and modulus of elasticity calculated by this model are compared with experimental values. New prediction model well estimated splittinge tensile strength and elastic modulus as well as compressive strength.

• Journal of Families and Better Life
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• v.26 no.5
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• pp.315-332
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• 2008

The purpose of this study was to investigate the relative effects of human capital and social capital on the economic well-being of late middle-aged Koreans. The data from the first wave of KLoSA (Korean Longitudinal Study of Aging) aged 50-64 were used (n=4,040). The major findings were as follows: First, human capital and social capital are both resources that can contribute to increasing the economic well-being of the middle-aged. Second, the relative contribution of human capital to the economic well-being of the middle-aged varied by the level of social capital, including formal network and informal network. Third, the relative contribution of social capital to the economic well-being of the middle-aged varied by the level of human capital, including employment type and educational attainment. Based on empirical results, the implications for social investment in human capital and social capital were provided.

• Biomedical Science Letters
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• v.3 no.2
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• pp.161-168
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• 1997

The measurement of many biochemical changes that could be appeared as aging will be resulted in the very useful and basal marker to maintain healthy life and to predict the health condition and the retardation of the aging. We classified the geriatrics into the normal and same aged dementia on the based of clinical diagnostic as well as MMSE evaluation. And then we were collected blood samples from both groups and examined 13 biochemical assays to screen any valuable biochemical index for dementia. Among 13 assays, several assay data showed the statistically significant differences between two groups. The values of serum albumin, APase, and GOT were significantly decreased in demented group compared to control. On the other hand, the values of glucose and LDH were increased in dementia compared to control. Additionally, the value of Pi was increased but the values of calcium and GPT were decreased, without significant difference (p＞0.05). The values of other assays such as bilirubin, BUN, cholesterol, creatinine and total protein did not show any statistically significant differences. Conclusively it may be suggested that dementia might be resulted in the variable biochemical changes which could be affected by many environmental factors as well as dementia itself.

• Korean Journal of Plant Resources
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• v.32 no.3
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• pp.207-219
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• 2019

Ultraviolet (UV) radiation is associated with the development of extrinsic skin aging. We performed in vivo assays in order to investigate the protective effect of a combination of grapefruit and rosemary extracts (cG&Re) on UVB-induced skin aging. The results indicated that cG&Re displayed elastase inhibitory activity in a dose-dependent manner. Topical application of cG&Re mitigated photo-aging related lesions such as skin erythema and thickening in photo-aged BALB/c mice dorsal skin, by preventing UVB-induced collagen degradation. Immunohistochemical analyses revealed that cG&Re stimulated SIRT-1 expression, and suppressed MMP-1 and $IL-1{\beta}$ expression. It was observed that expression of MMP-1 and -13 mRNA was downregulated in the cG&Re-treated group. Furthermore, cG&Re treatment drastically suppressed protein expression of MMP-1 and regulated the phosphorylation of p-38 kinase. As expected, oral administration of cG&Re resulted in the same SIRT-1, MMP-1, and $IL-1{\beta}$ expression patterns observed upon topical application of cG&Re in the UV-induced mice model. Overall, the current results demonstrated that cG&Re attenuated both the downregulation of MMP-1 expression and up-regulation of SIRT-1 expression, as well as decreased phosphorylation of MAPK in UVB-induced skin ageing mice model, suggesting that cG&Re might be used as an internal food ingredient for beauty-purposes as well as a functional food material.

• Food Science and Biotechnology
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• v.17 no.1
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• pp.20-25
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• 2008

Effects of commercial and lab-generated gellan gums on the textural properties, structure, and aging of wheat and maize starch gels were investigated using a rapid visco-analyzer (RVA), rheometer, scanning electron microscope (SEM), and X-ray diffractometer. Gellan and guar gums increased the peak and final viscosities, but xanthan gum and gum arabic reduced them. The maize starch had higher breakdown viscosity than the wheat starch, regardless of the type of gum. The hardness of all starch gels increased during storage, but their cohesiveness and springiness decreased. The degree of the gel hardness showed higher in maize starch than in wheat starch and the effect of gum addition had a difference with gum type. The wheat starch-guar and -gellan gum mixed gels showed higher elasticity and cohesiveness after storage. The starch-gellan gum mixed gels had dense and stable network structures, and were well maintained even after 7 days of storage. Most of the gums had anti-aging effect on X-ray diffraction pattern of starch gels.